IEEE transactions on ultrasonics, ferroelectrics, and frequency control最新文献

{"title":"Enhanced Performance of 200-kHz PMN-PT Crystal Transducers Through Medium-Temperature AC Poling and Electrically Parallel Stacking","authors":"Zibo Jiang;Kaijia Wu;Zuo-Guang Ye","doi":"10.1109/TUFFC.2025.3570735","DOIUrl":"10.1109/TUFFC.2025.3570735","url":null,"abstract":"Despite their excellent piezoelectric properties, relaxor-based ferroelectric crystals have not been widely used in medium- to low-frequency ultrasound transducers because of the low sensitivity arising from a low capacitance and the low signal intensity due to a weak coercive field of the piezoelectric materials. In this study, a new type of transducer has been designed and fabricated by stacking two PMN-0.27PT crystals of opposite polarizations poled under optimized poling conditions, which exhibits an enhanced element capacitance and improved piezoelectric performance, leading to a better sensitivity and a broader bandwidth. It is found that using the optimized condition of low-voltage alternative current poling (ACP) (square wave 205 Vrms/mm, three cycles at 0.1 Hz) at a medium temperature of <inline-formula> <tex-math>$65~^{circ }$ </tex-math></inline-formula>C [medium-temperature low-voltage ACP MT-LV ACP)], the relative permittivity of the crystal is increased by 16%, the electromechancial coupling factor increased by 6%, and the piezoelectric coefficient increased by 27%, compared with the conventional direct current poling at room temperature (RT DCP). The 200-kHz single-element transducer fabricated from the MT-LV ACP single-layer PMN-0.27PT crystal exhibits a −6-dB bandwidth that is increased by 6.4% and a receiver free field voltage response that is increased by 23.6%, respectively, compared with a similar transducer made from RT DCP single-layer PMN-0.27PT. In addition, the transducer fabricated from two stacked PMN-0.27PT platelets of identical thicknesses but opposite poling directions not only produce similar center frequency and bandwidth as the transducer made from single layer crystal of the same height but also produce quadrupled element capacitance, which leads to a much better electrical impedance match, resulting in a sensitivity increase up to 224%.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"72 7","pages":"979-986"},"PeriodicalIF":3.0,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Handheld Large 2-D Array With Azimuthal Planewave and Row-Multiplexed Elevation Beamforming Enabled by Local ASIC Electronics","authors":"Robert Wodnicki;Josquin Foiret;Baoqiang Liu;Ning Lu;Xin Sun;Junhang Zhang;Haochen Kang;Lei Fu;Christophe Notard;Mathieu Legros;Chi-Feng Chang;Jesse T. Yen;Qifa Zhou;Katherine W. Ferrara","doi":"10.1109/TUFFC.2025.3570732","DOIUrl":"10.1109/TUFFC.2025.3570732","url":null,"abstract":"Large-aperture 2-D arrays benefit from improved lateral resolution at depth, due to the dependence of beamwidth on the inverse of the aperture width, and improved contrast resolution due to electronic focusing. We have been developing modular large-aperture multirow 1024 (64 azimuth <inline-formula> <tex-math>$times 16$ </tex-math></inline-formula> elevation) element, 2-D arrays based on custom-designed and locally integrated application-specific integrated circuit (ASIC) multiplexing devices. The implemented handheld large-array prototype probe for human imaging consists of multiple rows with multiplexed synthetic aperture in elevation and planewave transmits in azimuth. The pitch of the acoustic array is <inline-formula> <tex-math>$650~mu $ </tex-math></inline-formula>m in azimuth by <inline-formula> <tex-math>$1000~mu $ </tex-math></inline-formula>m in elevation, with a 2.4 MHz fractional bandwidth (FBW =88%) center frequency and total active aperture of <inline-formula> <tex-math>$42times 16$ </tex-math></inline-formula> mm. We interfaced the large aperture array and multiplexing ASICs, along with local preamplifier devices for improved sensitivity, and a local FPGA for digital ASIC control, to a configurable ultrasound imaging platform and demonstrate 2-D orthogonal and full 3D beamformed imaging. The implemented imaging prototype includes local buffering for improved sensitivity of the high-impedance 2-D array elements, and realizes penetration down to 140 mm, experimental lateral/axial resolution at 67 mm of 1.1/0.4 mm, and maximum experimental CNR of 2.1 for 8 mm cylindrical cysts and 1.7 for 10 mm spherical cysts. We demonstrate in vivo imaging of liver in human volunteers utilizing a hermetically sealed and safety-validated handheld prototype of the large 2-D array. Preliminary results are promising for clinical imaging in future studies.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"72 7","pages":"962-978"},"PeriodicalIF":3.0,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated Microbubble Discrimination in Ultrasound Localization Microscopy by Vision Transformer","authors":"Renxian Wang;Wei-Ning Lee","doi":"10.1109/TUFFC.2025.3570496","DOIUrl":"10.1109/TUFFC.2025.3570496","url":null,"abstract":"Ultrasound localization microscopy (ULM) has revolutionized microvascular imaging by breaking the acoustic diffraction limit. However, different ULM workflows depend heavily on distinct prior knowledge, such as the impulse response and empirical selection of parameters (e.g., the number of microbubbles (MBs) per frame M), or the consistency of training-test dataset in deep learning (DL)-based studies. We hereby propose a general ULM pipeline that reduces priors. Our approach leverages a DL model that simultaneously distills MB signals and reduces speckles from every frame without estimating the impulse response and M. Our method features an efficient channel attention Vision Transformer (ViT) and a progressive learning strategy, enabling it to learn global information through training on progressively increasing patch sizes. Ample synthetic data were generated using the k-Wave toolbox to simulate various MB patterns, thus overcoming the deficiency of labeled data. The ViT output was further processed by a standard radial symmetry (RS) method for subpixel localization. Our method performed well on model-unseen public datasets: one in silico dataset with ground truth (GT) and four in vivo datasets of mouse tumor, rat brain, rat brain bolus, and rat kidney. Our pipeline outperformed conventional ULM, achieving higher positive predictive values (precision in DL, 0.88–0.41 versus 0.83–0.16) and improved accuracy (root-mean-square errors (RMSEs): 0.25–<inline-formula> <tex-math>$0.14~lambda $ </tex-math></inline-formula> versus 0.31–<inline-formula> <tex-math>$0.13~lambda $ </tex-math></inline-formula>) across a range of signal-to-noise ratios (SNRs) from 60 to 10 dB. Our model could detect more vessels in diverse in vivo datasets while achieving comparable resolutions to the standard method. The proposed ViT-based model, seamlessly integrated with state-of-the-art downstream ULM steps, improved the overall ULM performance with no priors.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"72 8","pages":"1134-1146"},"PeriodicalIF":3.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Phase Unwrapping on Multitarget Acoustic Lenses for Transcranial Holography","authors":"D. Attali;T. Tiennot;M. Tanter;J. F. Aubry","doi":"10.1109/TUFFC.2025.3570231","DOIUrl":"10.1109/TUFFC.2025.3570231","url":null,"abstract":"Acoustic lenses have been introduced recently to compensate for the phase distortions induced by the propagation across a human skull for ultrasonic deep-brain stimulation in humans. In this study, we present bifocal lenses that compensate for human skull aberrations and allow simultaneous targeting of multiple structures deep in the brain. We investigated the impact of phase unwrapping in the design of the lenses and how this process improves the distribution of pressure produced in <inline-formula> <tex-math>${n} =5$ </tex-math></inline-formula> human skulls for two different spatial arrangements of the targets. The results show that unwrapping the phase computed during the design increases the fidelity of the pressure field generated across the human skulls. The spatial precision is on average improved by 73%, and out-of-target energy deposition is on average reduced by 58%. The results presented in this study highlight the importance of phase unwrapping to optimize the safety and efficacy of future transcranial ultrasound stimulations (TUSs) targeting multiple regions.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"72 7","pages":"945-951"},"PeriodicalIF":3.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROTEUS: A Physically Realistic Contrast-Enhanced Ultrasound Simulator—Part II: Imaging Applications","authors":"Baptiste Heiles;Nathan Blanken;Alina Kuliesh;Michel Versluis;Kartik Jain;Guillaume Lajoinie;David Maresca","doi":"10.1109/TUFFC.2025.3566437","DOIUrl":"10.1109/TUFFC.2025.3566437","url":null,"abstract":"The development of new imaging paradigms in the field of contrast-enhanced ultrasound (CEUS) is hindered by the difficulty to control complex experimental variables in a laboratory setting, such as vascular geometries, nonlinear ultrasound wave propagation in tissue, or microbubble positions within vessels as a function of time. This development would greatly benefit from the ability to control and reproduce independently these conditions in a simulated environment. Here, we report a physically realistic CEUS simulator, PROTEUS, that generates synthetic contrast-enhanced radio frequency (RF) data. In this article, we show that PROTEUS enables flexible investigations of imaging parameters on CEUS, including innovative transducer architecture, such as row-column addressed arrays, microbubble size distribution, pulse sequences, and vascular geometry. We demonstrate how PROTEUS can emulate various 2-D and 3-D imaging modes, such as pulse inversion (PI) or amplitude modulation (AM), echo particle image velocimetry (PIV), or ultrasound localization microscopy (ULM). Finally, in an investigative simulation case study, we evaluate the impact of microbubble size distribution on ULM on a simulated set of 15000 frames. It is released as an open-source tool for the scientific community.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"72 7","pages":"866-878"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patch Fusion: A Novel Ultrafast Multi-Frequency Ultrasound Fusion Imaging Method for Pedicle Screw Navigation","authors":"Xiangxin Li;Xueru Yang;Jiaqi Li;Yang Jiao;Jun Shen;Yaoyao Cui;Weiwei Shao","doi":"10.1109/TUFFC.2025.3549842","DOIUrl":"10.1109/TUFFC.2025.3549842","url":null,"abstract":"Intraosseous ultrasound imaging is valuable for guiding pedicle screw placement in surgery. However, single-frequency ultrasound, whether low or high, often fails to provide both adequate imaging resolution and depth simultaneously. To address this limitation, we introduce a novel ultrafast multi-frequency ultrasound patch fusion imaging method for pedicle screw navigation. This approach combines the strengths of both high-frequency and low-frequency ultrasound images, greatly enhancing the detail and clarity of the resulting images while significantly reducing the time required for image fusion. We validated our method through simulation and ex vivo experiments, using metrics such as information entropy (IE), spatial frequency (SF), and average gradient (AG) to assess the quality of the fused images. We also recorded the algorithm’s execution time. The results demonstrate that our fusion method substantially improves image richness and clarity, enabling a more comprehensive and accurate assessment of the pedicle screw track. Importantly, it also reduces fusion time compared to previous methods, making real-time clinical multi-frequency ultrasound fusion imaging a viable possibility. The in vivo experimental results of the sheep spinal pedicle screw track further demonstrate the capabilities of the patch fusion method in visualizing the internal conditions of the pedicle screw track and meeting the requirements for real-time fusion imaging. The proposed approach offers substantial support in surgical real-time navigation and ongoing monitoring within the domains of orthopedics and surgery.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"72 4","pages":"467-478"},"PeriodicalIF":3.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive Transmit Sequencing for Robust Flow Monitoring in Cross-Sectional Doppler","authors":"Luuk van Knippenberg;R. Arthur Bouwman;Ruud J. G. van Sloun;Massimo Mischi","doi":"10.1109/TUFFC.2025.3549637","DOIUrl":"10.1109/TUFFC.2025.3549637","url":null,"abstract":"Doppler ultrasound is a noninvasive imaging technique that measures blood flow velocity and is commonly used in cardiac evaluation and vascular assessment. Compared to the conventional longitudinal view, cross-sectional Doppler is more robust to motion, making it more suitable for monitoring applications. In this article, an adaptive framework is presented to automatically monitor flow in the common carotid artery using cross-sectional Doppler. Based on vessel segmentation and geometry estimation, transmit parameters such as the focal point, steering angle, and aperture width are adaptively adjusted to optimize the Doppler angle and maximize signal-to-noise ratio (SNR). The velocity profile is estimated using multiple gates along a single line, resulting in velocity estimates with high temporal resolution. The effect and optimal settings of relevant nonadaptive ultrasound parameters are explored through a design of experiments (DoE), making use of simulated and phantom data. These optimal parameters result in accurate estimates of average velocity with a mean error of 0.8% in silico and 1.6% in vitro. In addition, velocity estimates show a reduced variance and improved temporal resolution compared to conventional line-by-line scanning. Feasibility of the method is also demonstrated in vivo, where a diverse range of velocity profiles was observed. These findings suggest that this method could be feasible for automatic flow monitoring or cardiac output estimation through hemodynamic modeling.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"72 4","pages":"515-529"},"PeriodicalIF":3.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wideband Surface Acoustic Wave Resonator With Good Temperature Stability Using LiNbO3 on Glass","authors":"Yong Guo;Michio Kadota;Yuji Ohashi;Shuji Tanaka","doi":"10.1109/TUFFC.2025.3548977","DOIUrl":"10.1109/TUFFC.2025.3548977","url":null,"abstract":"Currently, wideband surface acoustic wave (SAW) devices are in demand. However, SAW resonators with a large coupling factor have a large negative temperature coefficient of frequency (TCF). In this work, we developed a new hetero acoustic layer (HAL) structure combining LiNbO3 (LN) and a glass with a low coefficient of thermal expansion (CTE), called ABC-G glass, to obtain the resonator with both large bandwidth (BW) and low TCF. The bulk and leaky SAW (LSAW) velocities of ABC-G glass were measured by ultrasonic microspectroscopy (UMS) technology, and its positive temperature coefficient of velocity (TCV) was confirmed. The (0°, 101°, 0°) and (0°, 120°, 0°) LNs are selected for experiments. The measured results show impedance ratio (Z-ratio) and BW as high as 82 dB and 12%, respectively. The measured TCFs reach −27 ppm/°C and −24 ppm/°C at resonance and antiresonance frequency, respectively, which are significantly improved compared with LN/Quartz (Qz). Ladder filters composed of three LN/ABC-G resonators are prototyped using a T-type configuration, and the insertion loss lower than 1 dB with a fractional bandwidth (FBW) of 15.0% was demonstrated. At the same time, no spurious response was observed up to 10 GHz. The results shown in this work prove the high performance of the LN/ABC-G structure in applications requiring good temperature stability, large BW, and out-of-band spurious-free characteristics.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"72 5","pages":"663-673"},"PeriodicalIF":3.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zig-Zag ScAlN 12-Layer for Shear Mode BAW Transformer Application in Rectenna","authors":"Sarina Kinoshita;Rei Karasawa;Yohkoh Shimano;Momoka Matsumura;Takahiko Yanagitani","doi":"10.1109/TUFFC.2025.3546780","DOIUrl":"10.1109/TUFFC.2025.3546780","url":null,"abstract":"Wireless power transfer (WPT) with rectennas is important for IoT sensor applications. Miniature GHz voltage transformers are more attractive than a large-size charge pump to operate the rectifiers efficiently. In this study, GHz bulk acoustic wave (BAW) piezoelectric transformers based on c-axis zig-zag polarization-inverted ScAlN thin films are proposed. The capacitive impedance (<inline-formula> <tex-math>${Z}_{C}$ </tex-math></inline-formula>) of n-layer c-axis zig-zag multilayers resonator is n-times larger than that of single-layer resonator. Therefore, shear mode operation in the c-axis zig-zag structure acts as a piezoelectric transformer. To demonstrate this principle, c-axis zig-zag ScAlN multilayers are grown using glancing angle sputtering deposition (GLAD). 12-layer c-axis 40°–50° zig-zag structure is clearly observed by scanning electron microscopy (SEM) and XRD pole figure analysis. The open-circuit voltage gain approaching +15 dB in 600 MHz range in the high-overtone bulk acoustic resonator (HBAR) type transformer based on polarization-inverted 12-layer thin film is observed. The experimental results and the theoretical predictions computed by Mason’s equivalent circuit model considering the effect of the polarization-inverted structure are in good agreement.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"72 4","pages":"547-554"},"PeriodicalIF":3.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10919215","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Innovative Ultrasound Research Platform Integrating an Open Scanner and a 3072-Element Dense Array","authors":"Lorenzo Castrignano;Piero Tortoli;Valentino Meacci;Alessandro Dallai;Marco Crocco;Enrico Boni;Alessandro Ramalli","doi":"10.1109/TUFFC.2025.3568197","DOIUrl":"10.1109/TUFFC.2025.3568197","url":null,"abstract":"High-end 4-D ultrasound (US) imaging systems typically use probes based on 2-D arrays containing thousands of transducers. Application specific integrated circuits (ASICs), embedded in the probe, manage the numerous transducers, significantly reducing the number of channels needed for the associated scanner. Unfortunately, the closed architecture of these high-end systems prevents research activities, such as the experimental testing of new imaging methods. This article presents the development and application of a novel 4-D US imaging research platform that combines the ULA-OP 256 open scanner and the Adult 4-D Premium transesophageal probe, integrating a rectangular 3072-transducer array. The hardware, software, and firmware developments specifically made on the scanner are described. The functionality of the novel system is demonstrated by comparing simulated and experimental acoustic fields when transmitting focused wide beams (FWBs) and planar diverging waves (PDWs). The latter beams are exploited for high-frame-rate imaging, demonstrating the platform capable of reconstructing, in real time, up to over 800 frames/s over arbitrary planes. In vivo, bi-plane, B-mode images from the carotid artery of a healthy volunteer have been obtained together with dynamic multigate spectral Doppler (MSD) images. The novel platform uniquely integrates the benefits of a programmable open scanner with a high-density 2-D array. By enabling the real-time evaluation of innovative 4-D imaging and Doppler methods, it has the potential to significantly impact applications so far tested with 2-D probes containing a limited number of elements.","PeriodicalId":13322,"journal":{"name":"IEEE transactions on ultrasonics, ferroelectrics, and frequency control","volume":"72 7","pages":"952-961"},"PeriodicalIF":3.0,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}