Hormone Molecular Biology and Clinical Investigation最新文献_第5页

Unilateral ovarian agenesis with ipsilateral tubal presence - report of a case. 单侧卵巢发育不全伴同侧输卵管1例报告。

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Hormone Molecular Biology and Clinical Investigation Pub Date : 2023-06-01 DOI: 10.1515/hmbci-2022-0068

Nikolaos Machairiotis, Rita Variawa, Christos Arnaoutoglou, Paul Zarogoulidis, Stewart Disu

引用次数: 0

Distinct urinary progesterone metabolite profiles during the luteal phase. 黄体期不同的尿黄体酮代谢物谱。

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Hormone Molecular Biology and Clinical Investigation Pub Date : 2023-06-01 DOI: 10.1515/hmbci-2022-0065

Saman Abdullah, Thomas Bouchard, René Leiva, Hans Boehringer, Jean Iwaz, René Ecochard

{"title":"Distinct urinary progesterone metabolite profiles during the luteal phase.","authors":"Saman Abdullah, Thomas Bouchard, René Leiva, Hans Boehringer, Jean Iwaz, René Ecochard","doi":"10.1515/hmbci-2022-0065","DOIUrl":"https://doi.org/10.1515/hmbci-2022-0065","url":null,"abstract":"Objectives: During normal menstrual cycles, serum levels of progesterone vary widely between cycles of same woman and between women. This study investigated the profiles of pregnanediol during the luteal phase.Methods: Data stemmed from a previous multicenter prospective observational study and concerned 107 women (who contributed 326 menstrual cycles). The study analyzed changes in observed cervical mucus discharge, various hormones in first morning urine, and serum progesterone. Transvaginal ultrasonography and cervical mucus helped identifying the day of ovulation. Changes in pregnanediol glucuronide levels during the luteal phase were examined and classified according to the length of that phase, a location parameter, and a scale parameter. Associations between nine pregnanediol glucuronide profiles and other hormone profiles were examined.Results: Low periovulatory pregnanediol glucuronide levels and low periovulatory luteinizing hormone levels were associated with delayed increases in pregnanediol glucuronide after ovulation. That 'delayed increase profile' was more frequently associated with cycles with prolonged high LH levels than in cycles with rapid pregnanediol glucuronide increases. A 'plateau-like profile' during the luteal phase was associated with longer cycles, cycles with higher estrone-3-glucuronide and pregnanediol glucuronide during the preovulatory phase, and cycles with higher periovulatory pregnanediol glucuronide levels.Conclusions: Distinct profiles of urinary progesterone levels are displayed during the luteal phase. These profiles relate to early hormone changes during the menstrual cycle. In everyday clinical practice, these findings provide further evidence for recommending progesterone test seven days after the mucus peak day. The search for other correlations and associations is underway.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9723303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Brown adipose tissue as an endocrine organ: updates on the emerging role of batokines. 褐色脂肪组织作为内分泌器官:细胞因子新作用的最新进展。

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Hormone Molecular Biology and Clinical Investigation Pub Date : 2023-06-01 DOI: 10.1515/hmbci-2022-0044

Fabiane Ferreira Martins, Vanessa Souza-Mello, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda

{"title":"Brown adipose tissue as an endocrine organ: updates on the emerging role of batokines.","authors":"Fabiane Ferreira Martins, Vanessa Souza-Mello, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda","doi":"10.1515/hmbci-2022-0044","DOIUrl":"https://doi.org/10.1515/hmbci-2022-0044","url":null,"abstract":"Brown adipose tissue (BAT) remains active in adults, oxidizing fatty acids or glucose and releasing energy in the form of heat. Brown adipocytes and enhanced thermogenesis are targets for treating obesity and its comorbidities. BAT shows high synthesis activity and secretes several signaling molecules. The brown adipokines, or batokines, take action in an autocrine, paracrine, and endocrine manner. Batokines have a role in the homeostasis of the cardiovascular system, central nervous system, white adipose tissue, liver, and skeletal muscle and exert beneficial effects on BAT. The systemic function of batokines gives BAT an endocrine organ profile. Besides, the batokines Fibroblast Growth Factor-21, Vascular Endothelial Growth Factor A, Bone Morphogenetic Protein 8, Neuregulin 4, Myostatin, and Interleukin-6 emerge as targets to treat obesity and its comorbidities, deserving attention. This review outlines the role of six emerging batokines on BAT and their cross-talk with other organs, focusing on their physiological significance and diet-induced changes.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9729692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Association of pro-inflammatory cytokines, inflammatory proteins with atherosclerosis index in obese male subjects. 肥胖男性受试者中促炎细胞因子、炎症蛋白与动脉粥样硬化指数的关系

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Hormone Molecular Biology and Clinical Investigation Pub Date : 2023-06-01 DOI: 10.1515/hmbci-2022-0022

Farhad Alizadeh, Fariba Mirzaie Bavil, Rana Keyhanmanesh, Hajie Lotfi, Fariba Ghiasi

{"title":"Association of pro-inflammatory cytokines, inflammatory proteins with atherosclerosis index in obese male subjects.","authors":"Farhad Alizadeh, Fariba Mirzaie Bavil, Rana Keyhanmanesh, Hajie Lotfi, Fariba Ghiasi","doi":"10.1515/hmbci-2022-0022","DOIUrl":"https://doi.org/10.1515/hmbci-2022-0022","url":null,"abstract":"Objectives: Investigation the association of pro-inflammatory markers interleukin (IL)-1β and IL- 10 expression, serum levels of C-reactive protein (CRP), cyclooxygenase-2 (COX2), High-density lipoprotein (HDL), Apolipoprotein A1 (ApoA1), and ATP Binding Cassette Subfamily A Member 1 (ABCA1) inflammatory proteins with atherosclerosis index (homocysteine) in normal-weight and obese male subjects.Methods: 59 males including 30 obese (Body mass index (BMI) of ≥30 kg/m2) and 29 normal-weight (BMI of 18.5-24.9 kg/m2) were joined to this study. Plasma levels of IL-1β and IL-10 (pg/mL), CRP (pg/mL), COX-2 (ng/mL), APOA1 (mg/dL), ABCA1 (ng/mL), HDL, Cholesterol, and Triglyceride (TG) (mg/dL), and homocysteine (µmol/L) was measured. Association of these biomarkers with homocysteine was determined.Results: Obese subjects had higher serum levels of IL10, IL1β, CRP, COX-2, TG, and cholesterol concentrations (all p<0.05 except IL-10 and cholesterol) and low levels of HDL, APOA1, and ABCA1 (non-significant differences) in comparison to normal-weight group. Homocysteine levels were high in obese men with no significant differences between the two groups. In obese subjects, homocysteine had a significant inverse correlation with APOA1, ABCA1, and HDL, and a strong and moderate positive correlation was found with CRP and TG levels, respectively.Conclusions: High level of homocysteine and its correlation with inflammation proteins and markers in obese subjects appear to be contributed with atherosclerosis development.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10108767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Zuranolone and its role in treating major depressive disorder: a narrative review. 舒拉诺酮及其在治疗重度抑郁症中的作用:综述。

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Hormone Molecular Biology and Clinical Investigation Pub Date : 2023-06-01 DOI: 10.1515/hmbci-2022-0042

Muneeza Ali, Irfan Ullah, Mufaddal Najmuddin Diwan, Alifiya Aamir, Hashir Ali Awan, Abdul Waris Durrani, Qudrat Ullah Qudrat, Sheikh Shoib, Domenico De Berardis

{"title":"Zuranolone and its role in treating major depressive disorder: a narrative review.","authors":"Muneeza Ali, Irfan Ullah, Mufaddal Najmuddin Diwan, Alifiya Aamir, Hashir Ali Awan, Abdul Waris Durrani, Qudrat Ullah Qudrat, Sheikh Shoib, Domenico De Berardis","doi":"10.1515/hmbci-2022-0042","DOIUrl":"https://doi.org/10.1515/hmbci-2022-0042","url":null,"abstract":"Major Depressive Disorder (MDD) is a mood disorder classified as a persistent depressive mood and loss of interest lasting for more than two weeks and accompanied by a list of symptoms outlined in the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) diagnostic criteria. MDD affects approximately 264 million people worldwide and is the most prevailing form of neuropsychiatric disorder. Owing to the probable hypothesized pathophysiology of MDD being an outcome of abnormalities in the amino acid neurotransmitter system, including glutamate (the primary excitatory neurotransmitter) and γ-aminobutyric acid (GABA), SAGE-217 (Zuranolone) is being evaluated as a possible therapeutic treatment for MDD. Zuranolone is a synthetic, neuroactive steroid (NAS) and positive allosteric modulator (PMA) of GABAA receptors, regulating both synaptic and extra-synaptic release of GABA. It is administered as a once-daily oral dose for 2 weeks due to its low-moderate clearance. A change in total HAM-D score from baseline was the primary end-point of all the trials. A phase II trial conducted to evaluate the efficacy and safety of Zuranolone (30 mg, once-daily dose), described a significant reduction in total HAM-D score at day 14 and reported the drug to be well tolerated with headache, dizziness, nausea, and somnolence as the most common adverse events (AE). Additional phase III trials were also conducted to evaluate similar outcomes, the interim topline results of which have been released. Consequently, this article attempts to briefly analyze the pharmacology of Zuranolone, review the available clinical data and outcomes regarding its use, and evaluate its place as a prospective novel therapy in the effective management of MDD.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9736098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The role of gut microbiota in etiopathogenesis of long COVID syndrome. 肠道菌群在长COVID综合征发病机制中的作用。

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Hormone Molecular Biology and Clinical Investigation Pub Date : 2023-06-01 DOI: 10.1515/hmbci-2022-0079

Priya Kaushik, Mithlesh Kumari, Naveen Kumar Singh, Arpita Suri

引用次数: 0

Bambusa vulgaris leaves reverse mitochondria dysfunction in diabetic rats through modulation of mitochondria biogenic genes. 竹叶通过调节线粒体生物基因逆转糖尿病大鼠线粒体功能障碍。

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Hormone Molecular Biology and Clinical Investigation Pub Date : 2023-06-01 DOI: 10.1515/hmbci-2022-0053

Olusola Olalekan Elekofehinti, Yetunde Victoria Aladenika, Opeyemi Iwaloye, Enoabasi Ima-Abasi Okon, Isaac Gbadura Adanlawo

{"title":"Bambusa vulgaris leaves reverse mitochondria dysfunction in diabetic rats through modulation of mitochondria biogenic genes.","authors":"Olusola Olalekan Elekofehinti, Yetunde Victoria Aladenika, Opeyemi Iwaloye, Enoabasi Ima-Abasi Okon, Isaac Gbadura Adanlawo","doi":"10.1515/hmbci-2022-0053","DOIUrl":"https://doi.org/10.1515/hmbci-2022-0053","url":null,"abstract":"Objectives: There is evidence that mitochondrial dysfunction mediated by hyperglycemia increases the incidence of diabetes and age-related insulin resistance. Thus, maintaining mitochondrial integrity may provide alternative therapeutic approach in diabetes treatment. This study aimed to evaluate the effect of Bambusa vulgaris leaf extract on mitochondrial biogenesis in the pancreas of diabetic rats.Methods: 11 weeks old male rats (n=30) were purchased, and sorted into the following groups: control, diabetic control, diabetes + metformin (100 mg/kg), diabetes + Aq. B. vulgaris (100 mg/kg), diabetes + Aq. B. vulgaris (200 mg/kg), and diabetes + Aq. B. vulgaris (300 mg/kg). Diabetes was induced in the rats by a single dose of 65 mg/kg streptozotocin (STZ). The mRNA expression of genes related to mitochondria biogenesis (pgc-1α, Nrf2, GSK3β, AMPK and SIRT2) and genes of Nrf2-Keap1-ARE signaling pathway were determined by reverse transcriptase polymerase chain reaction. Molecular docking studies including lock and key docking and prime MM-GBSA were incorporated to identify the lead chemical compounds in Bambusa vulgari.Results: The results showed that B. vulgaris leaf extract promotes mitochondrial biogenesis via altering the mRNA expression of mitochondrial master regulator pgc-1α, other upstream genes, and the Nrf2-Keap1-ARE antioxidant pathway. Through molecular docking results, cryptochlorogenic acid, hesperidin, orientin, vitexin, scopolin, and neochlorogenic were found as the crucial chemicals in B. vulgaris with the most modulating effect on PGC-1α, AMPK, and GSK3.Conclusions: This study thus suggests that B. vulgaris leaf extract restores the integrity of mitochondria in diabetic rats.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10108763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of encomir-93 mimic transfection on the expression of miR-93 and PSA and androgen receptor in prostate cancer LNcap cell line. encomir-93模拟转染对前列腺癌症LNcap细胞系中miR-93、PSA和雄激素受体表达的影响。

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Hormone Molecular Biology and Clinical Investigation Pub Date : 2023-03-31 eCollection Date: 2023-09-01 DOI: 10.1515/hmbci-2022-0096

Hossein Mokhtari, Ali Ebrahimi, Mohaddeseh Nejati, Zeinab Barartabar, Mehdi Damchi, Abbas Khonakdar-Tarsi, Mahlagha Zahedi

{"title":"The effect of encomir-93 mimic transfection on the expression of miR-93 and PSA and androgen receptor in prostate cancer LNcap cell line.","authors":"Hossein Mokhtari, Ali Ebrahimi, Mohaddeseh Nejati, Zeinab Barartabar, Mehdi Damchi, Abbas Khonakdar-Tarsi, Mahlagha Zahedi","doi":"10.1515/hmbci-2022-0096","DOIUrl":"10.1515/hmbci-2022-0096","url":null,"abstract":"Objectives: Prostate cancer (PCa) is one of the most common cancers in men with high mortality rate which is a major concern for men's health. However, the molecular mechanisms remain poorly understood. miR-93 is an important oncogene which may have important function in prostate cancer.So, this study aimed to predict that encomir-93 mimic transfection on the expression of miR-93 and PSA and AR in prostate cancer LNcap cell line.Methods: Lymph node carcinoma of the prostate (LNCaP) was cultured and then miR-93 mimics was designed, synthesized and the transfected to LNCaP. The expression level of prostate-specific antigen (PSA) and androgen receptor (AR) was determined via Real-time PCR after treated with 15 pmol of miR-93 mimics.Results: miR-93 mimic transfection led to significant increase in PSA and AR expression in comparison with control group (p≤0.05).Conclusions: The miR-93 and its target genes has important role in PCa progression via enhancement in PSA and AR expression. Further research on the function of the miR-93 and its target genes in tumorgenesis and progression PCa could be helpful for the treatment of prostate cancer.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9557936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of four-week home-based exercise program on immune response, fat and muscle mass in subjects recovered from COVID-19. 为期四周的家庭锻炼计划对新冠肺炎康复受试者免疫反应、脂肪和肌肉质量的影响。

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Hormone Molecular Biology and Clinical Investigation Pub Date : 2023-03-06 eCollection Date: 2023-09-01 DOI: 10.1515/hmbci-2022-0057

Peyman Ghasemi, Hossein Shirvani, Alireza Shamsoddini

{"title":"Effect of four-week home-based exercise program on immune response, fat and muscle mass in subjects recovered from COVID-19.","authors":"Peyman Ghasemi, Hossein Shirvani, Alireza Shamsoddini","doi":"10.1515/hmbci-2022-0057","DOIUrl":"10.1515/hmbci-2022-0057","url":null,"abstract":"Objectives: A rehabilitation program for patients with COVID-19 may be required to improve related side effects. This study aimed to investigate the effect of a four-week home workout on body composition and serum levels of IL-6 and cortisol in men recovering from COVID-19.Methods: The present study is quasi-experimental. To this end, 45 healthy individuals in Tehran were purposefully divided into three groups: those who recovered after COVID-19 (n=30), including two groups of exercise and non-exercise, and individuals who did not have COVID-19 (control) (15=n). The four-week training program included three days of training per week with Traband resistance stretches, weight body training, and cardio exercises. The smirnov-Kolmogorov test was employed for data normality. A one-way analysis of variance test will be used to compare both the mean of variables in groups and the mean of variables before and after the exercise, correlated t-test was employed at a significance level of 0.05.Results: The results showed that serum levels of interleukin 6 and cortisol were significantly reduced in the recovered training group (p=0.001) and the non-trained recovery group (p=0.001) and a significant difference was observed between the groups (p=0.001). Furthermore, only in the recovered training group, did the fat percentage (p=0.001) and muscle mass (p=0.001) respectively decreased and increased.Conclusions: Four-week home training improves body composition by reducing body fat percentage and increasing muscle mass. In addition, lowering interleukin-6 and cortisol leads to reduced inflammation, faster recovery, and increased immunity.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10833228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the relationship between betatrophin and certain key enzymes involved in carbohydrate and lipid metabolism in insulin-resistant mice. β营养素与胰岛素抵抗小鼠碳水化合物和脂质代谢中某些关键酶之间关系的研究。

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Hormone Molecular Biology and Clinical Investigation Pub Date : 2023-03-06 eCollection Date: 2023-09-01 DOI: 10.1515/hmbci-2022-0104

Funda Bulut Arikan, Mustafa Ulas, Yasemin Ustundag, Hakan Boyunaga, Nermin Dindar Badem

{"title":"Investigation of the relationship between betatrophin and certain key enzymes involved in carbohydrate and lipid metabolism in insulin-resistant mice.","authors":"Funda Bulut Arikan, Mustafa Ulas, Yasemin Ustundag, Hakan Boyunaga, Nermin Dindar Badem","doi":"10.1515/hmbci-2022-0104","DOIUrl":"10.1515/hmbci-2022-0104","url":null,"abstract":"Objectives: The present study sought to examine the relationship of betatrophin with certain key enzymes, namely lactate dehydrogenase-5 (LDH5), citrate synthase (CS), and acetyl-CoA carboxylase-1 (ACC1), in insulin-resistant mice.Methods: Eight-week-old male C57BL6/J mice were used in this study (experimental group n=10 and control group n=10). S961 was administered using an osmotic pump to induce insulin resistance in the mice. The betatrophin, LDH5, CS, and ACC1 expression levels were determined from the livers of the mice using the real-time polymerase chain reaction (RT-PCR) method. Moreover, biochemical parameters such as the serum betatrophin, fasting glucose, insulin, triglyceride, total cholesterol, and high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol levels were analyzed.Results: The betatrophin expression and serum betatrophin (p=0.000), fasting glucose, insulin, triglyceride (p≤0.001), and total cholesterol (p=0.013) levels were increased in the experimental group. In addition, the CS gene expression level was statistically significantly decreased in the experimental group (p=0.01). Although strong correlation was found between the expression and serum betatrophin and triglyceride levels, no correlation was found between the betatrophin gene expression and the LDH5, ACC1, and CS gene expression levels.Conclusions: The betatrophin level appears to play an important role in the regulation of triglyceride metabolism, while insulin resistance increases both the betatrophin gene expression and serum levels and decreases the CS expression level. The findings suggest that betatrophin may not regulate carbohydrate metabolism through CS and LDH5 or lipid metabolism directly through the ACC1 enzyme.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10833229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0