Hormone Molecular Biology and Clinical Investigation最新文献

Sex hormone therapy and kidney function: a double-edged Sword? 性激素治疗与肾功能：一把双刃剑？

IF 1.3

Hormone Molecular Biology and Clinical Investigation Pub Date : 2025-10-07 DOI: 10.1515/hmbci-2025-0050

Nidhi Rohan Purandare, Arti M Hajarnavis

引用次数: 0

Leptin in colorectal cancer: literature review. 结直肠癌中的瘦素：文献综述。

IF 1.3

Hormone Molecular Biology and Clinical Investigation Pub Date : 2025-08-29 eCollection Date: 2025-09-01 DOI: 10.1515/hmbci-2025-0027

Dhouha Bacha, Khouloud Ayed, Rahma Boughriba, Rym Akrout, Marwa Weslati, Asma Gati

{"title":"Leptin in colorectal cancer: literature review.","authors":"Dhouha Bacha, Khouloud Ayed, Rahma Boughriba, Rym Akrout, Marwa Weslati, Asma Gati","doi":"10.1515/hmbci-2025-0027","DOIUrl":"10.1515/hmbci-2025-0027","url":null,"abstract":"Introduction: The aim of this review was to review and summarize the current evidence regarding the expression and role of leptin and its receptor (LEPR) in colorectal cancer (CRC). This includes discussing their involvement in carcinogenesis, progression, and prognosis, as well as assessing their potential as biomarkers and therapeutic targets.Content: We conducted a scoping literature review using several databases. We included studies in English or French that analyzed the expression of leptin and LEPR in the serum or tissue of CRC patients. Additionally, the GEPIA2 platform was employed to investigate the association between leptin and LEPR expression levels and overall survival, as well as their expression across pathological stages and microsatellite subtypes in CRC.Summary: A total of 76 eligible studies published between 1994 and 2024 were included. Analyses through immunohistochemical methods, transcriptomics, and serum measurements indicated elevated expression of leptin and LEPR in CRC. However, findings regarding their prognostic value varied: some studies reported a link between high leptin and LEPR levels and poor prognosis, while others found no correlation or even suggested favorable outcomes. This variability in results can be attributed to differences in methodology, patient diversity, and genetic polymorphisms.Outlook: The leptin-LEPR system seems to play a significant role in the development and progression of CRC, but its exact prognostic impact remains uncertain due to inconsistent findings. Further standardized and large-scale studies are necessary to clarify its clinical relevance. The leptin-LEPR axis shows promise as a biomarker and potential therapeutic target, particularly in the context of obesity-related CRC.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"103-117"},"PeriodicalIF":1.3,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Voluntary exercise prevents high-fat diet-induced male infertility in rats by preserving blood-testis barrier integrity and sperm parameters. 通过保持血睾丸屏障的完整性和精子参数，自愿运动可以预防高脂肪饮食引起的雄性不育。

IF 1.3

Hormone Molecular Biology and Clinical Investigation Pub Date : 2025-08-11 eCollection Date: 2025-09-01 DOI: 10.1515/hmbci-2025-0026

Uldouz Kharazi, Noushin Salmani, Farnaz Oghbaei, Gholam Reza Hamidian, Saber Ghaderpour, Fariba Ghiasi, Rana Keyhanmanesh

{"title":"Voluntary exercise prevents high-fat diet-induced male infertility in rats by preserving blood-testis barrier integrity and sperm parameters.","authors":"Uldouz Kharazi, Noushin Salmani, Farnaz Oghbaei, Gholam Reza Hamidian, Saber Ghaderpour, Fariba Ghiasi, Rana Keyhanmanesh","doi":"10.1515/hmbci-2025-0026","DOIUrl":"10.1515/hmbci-2025-0026","url":null,"abstract":"Objectives: Obesity is one of the risk factors that can cause male infertility through various mechanisms. Appropriate exercise can prevent and treat diseases. The study aimed to evaluate the effect of voluntary exercise on the subfertility induced by a high-fat diet in male rats.Methods: 40 male Wistar rats were randomly divided into four groups: control(C), voluntary wheel-running exercise (Ex), high-fat diet (HFD), and high-fat diet combined with voluntary wheel-running exercise (HFD-Ex). The rats in the HFD groups were fed with a high-fat diet for 10 weeks. Voluntary wheel-running exercise was conducted for 10 weeks. After 10weeks, blood samples, hypothalamus, epididymis, and testis were collected to assess the sperm parameters, hypothalamic levels of Kisspeptin, Kisspeptin receptors, and leptin, testicular expression of ZO-1, Claudin-3, and Claudin-11, serum levels of gonadotropins, testosterone, and leptin, as well as testicular levels of IL-6 and TNF-α. The integrity of the blood-testis barrier was evaluated using light microscopy after FITC injection.Results: An increase in sperm malformation, serum level of leptin, BTB permeability, and testicular level of TNF-α and IL-6 were observed in the HFD group. Hypothalamic protein levels of Kiss and KissR, serum levels of testosterone, and testicular expression of ZO-1, Claudin-3, and Claudin-11 were significantly lower in HFD rats compared to the control group. Voluntary exercise prevented an increase in sperm malformation, serum level of leptin, BTB permeability, and testicular level of TNF-α and IL-6.Conclusions: Voluntary exercise might prevent high-fat diet-induced male infertility by preserving the BTB's integrity and improving sperm parameters.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"119-131"},"PeriodicalIF":1.3,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-specific vitamin D biomarkers in cardiovascular risk: beyond genetics toward personalized prevention. 心血管风险的性别特异性维生素D生物标志物：超越遗传学走向个性化预防。

IF 1.3

Hormone Molecular Biology and Clinical Investigation Pub Date : 2025-07-28 eCollection Date: 2025-09-01 DOI: 10.1515/hmbci-2025-0033

Anna Vittoria Mattioli

引用次数: 0

Vitamin D binding protein polymorphism is associated with body weight in females. 维生素D结合蛋白多态性与女性体重有关。

IF 1.3

Hormone Molecular Biology and Clinical Investigation Pub Date : 2025-07-02 eCollection Date: 2025-09-01 DOI: 10.1515/hmbci-2025-0028

Joris R Delanghe, Frederic Clement, Marijn M Speeckaert, Daniel Duprez

{"title":"Vitamin D binding protein polymorphism is associated with body weight in females.","authors":"Joris R Delanghe, Frederic Clement, Marijn M Speeckaert, Daniel Duprez","doi":"10.1515/hmbci-2025-0028","DOIUrl":"10.1515/hmbci-2025-0028","url":null,"abstract":"Objectives: Vitamin D binding protein (DBP) polymorphism has been linked to parameters related to metabolism, but the problem in hypertensive patients has not been well characterized. The current study sought to characterize the distribution of DBP phenotypes in patients diagnosed with essential hypertension, and evaluate the possible relationships with cardiovascular risk.Methods: We studied 411 Caucasian patients with essential hypertension. DBP phenotypes were determined using polyacrylamide gel electrophoresis on serum samples. A review of clinical and laboratory measurements for each patient including blood pressure, serum lipids, and body mass index (BMI), as well as rates of diabetes diagnosis, was conducted and compared across DBP phenotypes. A matched control group (n=141) was utilized for initial comparisons.Results: DBP phenotype distribution in the study population was consistent with Hardy-Weinberg equilibrium and parallelled the control group. We found no significant differences for systolic and diastolic blood pressure, total cholesterol, HDL, LDL, lipoprotein(a), or other demographic variables, between DBP phenotypes. Unexpectedly, DBP 2-2 phenotype was associated with a significantly higher BMI, and a greater diabetes prevalence in patients, especially in females. Notably, serum triglyceride levels in females classified as DBP 2-2 were also significantly elevated suggesting the possible metabolic consequences are gender specific.Conclusions: DBP 2-2 phenotype appears to be linked to adverse metabolic features in hypertensive patients, particularly among women. These findings support a potential role for DBP genetic variation as a determinant of obesity and diabetes risk, highlighting the need to consider sex-specific genetic influences in metabolic syndrome risk assessments.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"133-138"},"PeriodicalIF":1.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview of the relationship between melatonin and drug resistance in cancers. 褪黑素与癌症耐药关系综述。

IF 1.1

Hormone Molecular Biology and Clinical Investigation Pub Date : 2025-05-22 eCollection Date: 2025-06-01 DOI: 10.1515/hmbci-2025-0016

Ahmad Fazilat, Salomeh Roshani, Fatemeh Mortazavi Moghadam, Mohammad Valilo

{"title":"An overview of the relationship between melatonin and drug resistance in cancers.","authors":"Ahmad Fazilat, Salomeh Roshani, Fatemeh Mortazavi Moghadam, Mohammad Valilo","doi":"10.1515/hmbci-2025-0016","DOIUrl":"10.1515/hmbci-2025-0016","url":null,"abstract":"The most common methods of treating cancer are surgery, chemotherapy, and radiotherapy. However, given that some cancers are not operable, the best method is chemotherapy and radiotherapy. Over time, people become resistant to chemotherapy drugs, and increasing the dose of the drug leads to damage to normal cells. In this article, various sources such as Google Scholar, PubMed, and Semantic Scholar were used, and articles between 1997 and 2025 that were relevant to our topic were selected. Various factors are involved in drug resistance. Melatonin is a hormone that has various roles in the body. One of its most important functions is regulating the circadian rhythm of sleep and its anti-inflammatory and antioxidant properties. According to studies, melatonin plays a role in the treatment of some diseases and cancers. The roles of melatonin in cancer treatment include anti-apoptotic, anti-angiogenic, and anti-migratory effects, as well as drug resistance and cell cycle regulation. As mentioned, one of the main reasons for the failure of cancer treatment is drug resistance, and the role of melatonin in drug resistance in cancers has been proven. Therefore, in this study, our goal is to investigate the mechanisms through which melatonin plays a role in drug resistance in different types of cancer.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"67-75"},"PeriodicalIF":1.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The salivary cortisol classification based on the heart rate variability. 基于心率变异性的唾液皮质醇分类。

IF 1.3

Hormone Molecular Biology and Clinical Investigation Pub Date : 2025-04-15 eCollection Date: 2025-09-01 DOI: 10.1515/hmbci-2025-0009

Leila Simorgh, Gila Pirzad Jahromi, Sousan Salari, Boshra Hatef

{"title":"The salivary cortisol classification based on the heart rate variability.","authors":"Leila Simorgh, Gila Pirzad Jahromi, Sousan Salari, Boshra Hatef","doi":"10.1515/hmbci-2025-0009","DOIUrl":"10.1515/hmbci-2025-0009","url":null,"abstract":"Objectives: Stress is a physiological state that is essential for the survival of living organisms. Heart rate variability (HRV) and cortisol hormone are indicators of the stress system. According to research, it has been demonstrated that the activation of the stress system is not consciously controlled by the individual, but rather occurs subconsciously. It is a novel concept to employ HRV indexes to assess the level of cortisol concentration as a more reliable indicator of stress system activation, as opposed to relying solely on the individual's emotional state.Methods: In order to understand the relationship between stress and cortisol secretion and its effect on electrophysiological biomarkers like HRV, the algorithms were designed using machine learning algorithms such as SVM, XGB, and MLP in the 634 adult healthy men (20-50 years old). Trait social stress test was utilized to make wide range of cortisol concentration from no to moderate stress.Results: These algorithms classified cortisol level between 9:00 AM and 2:00 PM in the optimal (5-15 ng/mL), non (less than 5 and more than 15 ng/mL) range, using HRV indexes (12 features). The XBG algorithm could achieve best classification with an accuracy rate of 99 % and an F1 rate of 99 %. They also indicated the state of an individual's stress system by indicating the concentration level of cortisol, which is its fundamental indicator.Conclusions: In addition to classifying stress, the HRV can also classify salivary cortisol in adult health men.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"139-145"},"PeriodicalIF":1.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

False positive hCG testing and upper urinary tract infection. hCG假阳性和上尿路感染。

IF 1.3

Hormone Molecular Biology and Clinical Investigation Pub Date : 2025-03-03 eCollection Date: 2025-09-01 DOI: 10.1515/hmbci-2024-0080

Joris R Delanghe, Valerie Pede, Sylvie Mulliez, Hilde Vanpoucke, Marijn M Speeckaert, Danielle Vandenweghe, Kris Gevaert

引用次数: 0

Differential levels of thyroid hormones, cortisol, and apolipoprotein M in fatty liver disease. 脂肪肝患者甲状腺激素、皮质醇和载脂蛋白M的差异水平

IF 1.1

Hormone Molecular Biology and Clinical Investigation Pub Date : 2025-02-19 DOI: 10.1515/hmbci-2024-0074

Amir Mohammad Zargar, Heidar Tayebinia, Maryam Hasanzarrini, Mohamad Bahiraei, Sina Mohagheghi

{"title":"Differential levels of thyroid hormones, cortisol, and apolipoprotein M in fatty liver disease.","authors":"Amir Mohammad Zargar, Heidar Tayebinia, Maryam Hasanzarrini, Mohamad Bahiraei, Sina Mohagheghi","doi":"10.1515/hmbci-2024-0074","DOIUrl":"10.1515/hmbci-2024-0074","url":null,"abstract":"Objectives: Non-alcoholic fatty liver disease (NAFLD), recently reclassified as metabolic dysfunction-associated fatty liver disease (MAFLD), can also manifest in patients classified as non-MAFLD who do not meet MAFLD criteria. The involvement of cortisol and thyroid hormones may play a role in the pathogenesis of FLD by modifying the metabolism of specific lipoproteins, particularly apolipoprotein M (Apo M). This study investigated cortisol and thyroid hormones levels and Apo M gene expression in white blood cells (WBCs) of individuals with MAFLD, non-MAFLD, and healthy controls.Methods: The serum and WBCs of the study subjects were collected from patients with FLD (n=99) including 58 MAFLD and 41 non-MAFLD and healthy individuals (n=23). To investigate the gene expression of Apo M and thyroid and cortisol hormones, qRT-PCR and ELISA methods were used, respectively.Results: The Apo M gene expression was significantly lower in FLD patients, both non-MAFLD, and MAFLD patients compared to the control group (p<0.05). Total T4 and TSH hormone levels in the MAFLD patients were significantly decreased and increased compared to the control group, respectively (p<0.05). The cortisol level was significantly elevated in the FLD and MAFLD patients compared to the control group (p<0.01).Conclusions: Alterations in Apo M gene expression also cortisol and thyroid hormones levels in non-MAFLD patients were milder than MAFLD patients when compared to the control. Also, likely Apo M may be involved in FLD pathogenesis.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of serum levels of cGAMP in the context of COVID-19 infection, atherosclerosis, sterile inflammation, and functional endothelial biomarkers in patients with coronary heart disease and healthy volunteers. 冠心病患者和健康志愿者血清cGAMP水平与COVID-19感染、动脉粥样硬化、无菌炎症和功能性内皮生物标志物的关系

IF 1.1

Hormone Molecular Biology and Clinical Investigation Pub Date : 2025-02-04 eCollection Date: 2025-06-01 DOI: 10.1515/hmbci-2024-0073

Nadezhda G Gumanova, Natalya L Bogdanova, Alexander Yu Gorshkov

{"title":"Associations of serum levels of cGAMP in the context of COVID-19 infection, atherosclerosis, sterile inflammation, and functional endothelial biomarkers in patients with coronary heart disease and healthy volunteers.","authors":"Nadezhda G Gumanova, Natalya L Bogdanova, Alexander Yu Gorshkov","doi":"10.1515/hmbci-2024-0073","DOIUrl":"10.1515/hmbci-2024-0073","url":null,"abstract":"Objectives: The present study evaluated the relationships of the serum levels of the cyclic dinucleotide 2'3'-cyclic GMP-AMP (cGAMP) marker of activation of pattern-recognition receptors with immunoglobulin G antibodies against severe acute respiratory syndrome-linked coronavirus (IgG-SARS)-positive status and endothelial dysfunction.Methods: Selected groups from two cohorts (cohort 1 of 307 healthy volunteers and cohort 2 of 218 coronary heart disease [CHD] patients). COVID-19 infection was confirmed by detection of IgG-SARS against SARS-CoV-2 S1 protein receptor-binding domain. Cohort 1 was examined for systematic coronary risk evaluation by European Society of Cardiology (SCORE) starting from 2019 before the onset of the COVID-19 pandemic. Cohort 2 was processed starting from 2017 (three years prior to the COVID-19 pandemic) in a hospital setting to undergo coronary angiography to assess coronary lesions as Gensini score. The levels of cGAMP and endothelial markers (nitrate and nitrite combined as NOx and endothelin-1) were assessed in the serum to evaluate the associations with IgG-SARS status, SCORE, and extent of coronary lesions by correlation and receiver operating characteristic analyses.Results: Serum cGAMP did not discriminate between SARS-positive and SARS-negative healthy subject of cohort 1. Moreover, the level of cGAMP was not associated with endothelial biomarkers in healthy subjects. However, Serum cGAMP was associated with atherosclerosis, with area under the curve 0.69 (95 % CI 0.587-0.806; p=0.001), and with endothelial markers in cohort 2.Conclusions: Low cGAMP was associated with atherosclerosis in CHD patients, suggesting that cGAMP is a new biomarker in the context of sterile inflammation.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"93-101"},"PeriodicalIF":1.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0