Hormone Molecular Biology and Clinical Investigation最新文献

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Vitamin D binding protein polymorphism is associated with body weight in females. 维生素D结合蛋白多态性与女性体重有关。
IF 1.1
Hormone Molecular Biology and Clinical Investigation Pub Date : 2025-07-02 DOI: 10.1515/hmbci-2025-0028
Joris R Delanghe, Frederic Clement, Marijn M Speeckaert, Daniel Duprez
{"title":"Vitamin D binding protein polymorphism is associated with body weight in females.","authors":"Joris R Delanghe, Frederic Clement, Marijn M Speeckaert, Daniel Duprez","doi":"10.1515/hmbci-2025-0028","DOIUrl":"https://doi.org/10.1515/hmbci-2025-0028","url":null,"abstract":"<p><strong>Objectives: </strong>Vitamin D binding protein (DBP) polymorphism has been linked to parameters related to metabolism, but the problem in hypertensive patients has not been well characterized. The current study sought to characterize the distribution of DBP phenotypes in patients diagnosed with essential hypertension, and evaluate the possible relationships with cardiovascular risk.</p><p><strong>Methods: </strong>We studied 411 Caucasian patients with essential hypertension. DBP phenotypes were determined using polyacrylamide gel electrophoresis on serum samples. A review of clinical and laboratory measurements for each patient including blood pressure, serum lipids, and body mass index (BMI), as well as rates of diabetes diagnosis, was conducted and compared across DBP phenotypes. A matched control group (n=141) was utilized for initial comparisons.</p><p><strong>Results: </strong>DBP phenotype distribution in the study population was consistent with Hardy-Weinberg equilibrium and parallelled the control group. We found no significant differences for systolic and diastolic blood pressure, total cholesterol, HDL, LDL, lipoprotein(a), or other demographic variables, between DBP phenotypes. Unexpectedly, DBP 2-2 phenotype was associated with a significantly higher BMI, and a greater diabetes prevalence in patients, especially in females. Notably, serum triglyceride levels in females classified as DBP 2-2 were also significantly elevated suggesting the possible metabolic consequences are gender specific.</p><p><strong>Conclusions: </strong>DBP 2-2 phenotype appears to be linked to adverse metabolic features in hypertensive patients, particularly among women. These findings support a potential role for <i>DBP</i> genetic variation as a determinant of obesity and diabetes risk, highlighting the need to consider sex-specific genetic influences in metabolic syndrome risk assessments.</p>","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An overview of the relationship between melatonin and drug resistance in cancers. 褪黑素与癌症耐药关系综述。
IF 1.1
Hormone Molecular Biology and Clinical Investigation Pub Date : 2025-05-22 eCollection Date: 2025-06-01 DOI: 10.1515/hmbci-2025-0016
Ahmad Fazilat, Salomeh Roshani, Fatemeh Mortazavi Moghadam, Mohammad Valilo
{"title":"An overview of the relationship between melatonin and drug resistance in cancers.","authors":"Ahmad Fazilat, Salomeh Roshani, Fatemeh Mortazavi Moghadam, Mohammad Valilo","doi":"10.1515/hmbci-2025-0016","DOIUrl":"10.1515/hmbci-2025-0016","url":null,"abstract":"<p><p>The most common methods of treating cancer are surgery, chemotherapy, and radiotherapy. However, given that some cancers are not operable, the best method is chemotherapy and radiotherapy. Over time, people become resistant to chemotherapy drugs, and increasing the dose of the drug leads to damage to normal cells. In this article, various sources such as Google Scholar, PubMed, and Semantic Scholar were used, and articles between 1997 and 2025 that were relevant to our topic were selected. Various factors are involved in drug resistance. Melatonin is a hormone that has various roles in the body. One of its most important functions is regulating the circadian rhythm of sleep and its anti-inflammatory and antioxidant properties. According to studies, melatonin plays a role in the treatment of some diseases and cancers. The roles of melatonin in cancer treatment include anti-apoptotic, anti-angiogenic, and anti-migratory effects, as well as drug resistance and cell cycle regulation. As mentioned, one of the main reasons for the failure of cancer treatment is drug resistance, and the role of melatonin in drug resistance in cancers has been proven. Therefore, in this study, our goal is to investigate the mechanisms through which melatonin plays a role in drug resistance in different types of cancer.</p>","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"67-75"},"PeriodicalIF":1.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The salivary cortisol classification based on the heart rate variability. 基于心率变异性的唾液皮质醇分类。
IF 1.1
Hormone Molecular Biology and Clinical Investigation Pub Date : 2025-04-15 DOI: 10.1515/hmbci-2025-0009
Leila Simorgh, Gila Pirzad Jahromi, Sousan Salari, Boshra Hatef
{"title":"The salivary cortisol classification based on the heart rate variability.","authors":"Leila Simorgh, Gila Pirzad Jahromi, Sousan Salari, Boshra Hatef","doi":"10.1515/hmbci-2025-0009","DOIUrl":"https://doi.org/10.1515/hmbci-2025-0009","url":null,"abstract":"<p><strong>Objectives: </strong>Stress is a physiological state that is essential for the survival of living organisms. Heart rate variability (HRV) and cortisol hormone are indicators of the stress system. According to research, it has been demonstrated that the activation of the stress system is not consciously controlled by the individual, but rather occurs subconsciously. It is a novel concept to employ HRV indexes to assess the level of cortisol concentration as a more reliable indicator of stress system activation, as opposed to relying solely on the individual's emotional state.</p><p><strong>Methods: </strong>In order to understand the relationship between stress and cortisol secretion and its effect on electrophysiological biomarkers like HRV, the algorithms were designed using machine learning algorithms such as SVM, XGB, and MLP in the 634 adult healthy men (20-50 years old). Trait social stress test was utilized to make wide range of cortisol concentration from no to moderate stress.</p><p><strong>Results: </strong>These algorithms classified cortisol level between 9:00 AM and 2:00 PM in the optimal (5-15 ng/mL), non (less than 5 and more than 15 ng/mL) range, using HRV indexes (12 features). The XBG algorithm could achieve best classification with an accuracy rate of 99 % and an F1 rate of 99 %. They also indicated the state of an individual's stress system by indicating the concentration level of cortisol, which is its fundamental indicator.</p><p><strong>Conclusions: </strong>In addition to classifying stress, the HRV can also classify salivary cortisol in adult health men.</p>","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
False positive hCG testing and upper urinary tract infection. hCG假阳性和上尿路感染。
IF 1.1
Hormone Molecular Biology and Clinical Investigation Pub Date : 2025-03-03 DOI: 10.1515/hmbci-2024-0080
Joris R Delanghe, Valerie Pede, Sylvie Mulliez, Hilde Vanpoucke, Marijn M Speeckaert, Danielle Vandenweghe, Kris Gevaert
{"title":"False positive hCG testing and upper urinary tract infection.","authors":"Joris R Delanghe, Valerie Pede, Sylvie Mulliez, Hilde Vanpoucke, Marijn M Speeckaert, Danielle Vandenweghe, Kris Gevaert","doi":"10.1515/hmbci-2024-0080","DOIUrl":"https://doi.org/10.1515/hmbci-2024-0080","url":null,"abstract":"<p><strong>Objectives: </strong>Human chorionic gonadotropin (hCG) assays are commonly used as a pregnancy test. False-positive human chorionic gonadotropin (hCG) values in urine were reported in 15 patients (nine males and six females) presenting with urinary tract infection.</p><p><strong>Methods: </strong>Extopic hCG production and presence of heterophilic antibodies were excluded as potential causes of interference.</p><p><strong>Results: </strong>Orbitrap mass spectrometry revealed the presence of uromodulin, an abundant urinary glycoprotein, as the likely cause of the interference. Falsely elevated hCG values correlated well with urinary alpha 1 microglobulin (a tubular protein) concentrations and with the urinary leukocyte count. The false positive hCG signal disappeared after antibiotic administration.</p><p><strong>Conclusions: </strong>These data suggest that false-positive hCG test results in urine may occur in patients presenting with upper urinary tract infections due to uromodulin interference.</p>","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential levels of thyroid hormones, cortisol, and apolipoprotein M in fatty liver disease. 脂肪肝患者甲状腺激素、皮质醇和载脂蛋白M的差异水平
IF 1.1
Hormone Molecular Biology and Clinical Investigation Pub Date : 2025-02-19 DOI: 10.1515/hmbci-2024-0074
Amir Mohammad Zargar, Heidar Tayebinia, Maryam Hasanzarrini, Mohamad Bahiraei, Sina Mohagheghi
{"title":"Differential levels of thyroid hormones, cortisol, and apolipoprotein M in fatty liver disease.","authors":"Amir Mohammad Zargar, Heidar Tayebinia, Maryam Hasanzarrini, Mohamad Bahiraei, Sina Mohagheghi","doi":"10.1515/hmbci-2024-0074","DOIUrl":"10.1515/hmbci-2024-0074","url":null,"abstract":"<p><strong>Objectives: </strong>Non-alcoholic fatty liver disease (NAFLD), recently reclassified as metabolic dysfunction-associated fatty liver disease (MAFLD), can also manifest in patients classified as non-MAFLD who do not meet MAFLD criteria. The involvement of cortisol and thyroid hormones may play a role in the pathogenesis of FLD by modifying the metabolism of specific lipoproteins, particularly <i>apolipoprotein M</i> (<i>Apo M</i>). This study investigated cortisol and thyroid hormones levels and <i>Apo M</i> gene expression in white blood cells (WBCs) of individuals with MAFLD, non-MAFLD, and healthy controls.</p><p><strong>Methods: </strong>The serum and WBCs of the study subjects were collected from patients with FLD (n=99) including 58 MAFLD and 41 non-MAFLD and healthy individuals (n=23). To investigate the gene expression of <i>Apo M</i> and thyroid and cortisol hormones, qRT-PCR and ELISA methods were used, respectively.</p><p><strong>Results: </strong>The <i>Apo M</i> gene expression was significantly lower in FLD patients, both non-MAFLD, and MAFLD patients compared to the control group (p<0.05). Total T4 and TSH hormone levels in the MAFLD patients were significantly decreased and increased compared to the control group, respectively (p<0.05). The cortisol level was significantly elevated in the FLD and MAFLD patients compared to the control group (p<0.01).</p><p><strong>Conclusions: </strong>Alterations in <i>Apo M</i> gene expression also cortisol and thyroid hormones levels in non-MAFLD patients were milder than MAFLD patients when compared to the control. Also, likely <i>Apo M</i> may be involved in FLD pathogenesis.</p>","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations of serum levels of cGAMP in the context of COVID-19 infection, atherosclerosis, sterile inflammation, and functional endothelial biomarkers in patients with coronary heart disease and healthy volunteers. 冠心病患者和健康志愿者血清cGAMP水平与COVID-19感染、动脉粥样硬化、无菌炎症和功能性内皮生物标志物的关系
IF 1.1
Hormone Molecular Biology and Clinical Investigation Pub Date : 2025-02-04 eCollection Date: 2025-06-01 DOI: 10.1515/hmbci-2024-0073
Nadezhda G Gumanova, Natalya L Bogdanova, Alexander Yu Gorshkov
{"title":"Associations of serum levels of cGAMP in the context of COVID-19 infection, atherosclerosis, sterile inflammation, and functional endothelial biomarkers in patients with coronary heart disease and healthy volunteers.","authors":"Nadezhda G Gumanova, Natalya L Bogdanova, Alexander Yu Gorshkov","doi":"10.1515/hmbci-2024-0073","DOIUrl":"10.1515/hmbci-2024-0073","url":null,"abstract":"<p><strong>Objectives: </strong>The present study evaluated the relationships of the serum levels of the cyclic dinucleotide 2'3'-cyclic GMP-AMP (cGAMP) marker of activation of pattern-recognition receptors with immunoglobulin G antibodies against severe acute respiratory syndrome-linked coronavirus (IgG-SARS)-positive status and endothelial dysfunction.</p><p><strong>Methods: </strong>Selected groups from two cohorts (cohort 1 of 307 healthy volunteers and cohort 2 of 218 coronary heart disease [CHD] patients). COVID-19 infection was confirmed by detection of IgG-SARS against SARS-CoV-2 S1 protein receptor-binding domain. Cohort 1 was examined for systematic coronary risk evaluation by European Society of Cardiology (SCORE) starting from 2019 before the onset of the COVID-19 pandemic. Cohort 2 was processed starting from 2017 (three years prior to the COVID-19 pandemic) in a hospital setting to undergo coronary angiography to assess coronary lesions as Gensini score. The levels of cGAMP and endothelial markers (nitrate and nitrite combined as NOx and endothelin-1) were assessed in the serum to evaluate the associations with IgG-SARS status, SCORE, and extent of coronary lesions by correlation and receiver operating characteristic analyses.</p><p><strong>Results: </strong>Serum cGAMP did not discriminate between SARS-positive and SARS-negative healthy subject of cohort 1. Moreover, the level of cGAMP was not associated with endothelial biomarkers in healthy subjects. However, Serum cGAMP was associated with atherosclerosis, with area under the curve 0.69 (95 % CI 0.587-0.806; p=0.001), and with endothelial markers in cohort 2.</p><p><strong>Conclusions: </strong>Low cGAMP was associated with atherosclerosis in CHD patients, suggesting that cGAMP is a new biomarker in the context of sterile inflammation.</p>","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"93-101"},"PeriodicalIF":1.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hormonal disorders in autism spectrum disorders. 自闭症谱系障碍中的激素紊乱。
IF 1.1
Hormone Molecular Biology and Clinical Investigation Pub Date : 2025-01-06 eCollection Date: 2025-06-01 DOI: 10.1515/hmbci-2024-0078
Solmaz Jalilzadeh Khalet Abad, Galavizh Kalashipour Chir, Parivash Heydari, Ahmad Fazilat, Fatemeh Mortazavi Moghadam, Mohammad Valilo
{"title":"Hormonal disorders in autism spectrum disorders.","authors":"Solmaz Jalilzadeh Khalet Abad, Galavizh Kalashipour Chir, Parivash Heydari, Ahmad Fazilat, Fatemeh Mortazavi Moghadam, Mohammad Valilo","doi":"10.1515/hmbci-2024-0078","DOIUrl":"10.1515/hmbci-2024-0078","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) is a pervasive neurobehavioral condition characterized by disruption of behavioral and emotional patterns in individuals with this condition. Given that various environmental and genetic factors play a fundamental role in the pathophysiology of ASD, it can be said that ASD is a multifaceted disease. This study used scientific databases including Google Scholar, PubMed, Scopus, and Semantic Scholar. In this review, we aimed to select manuscripts based on our field and relevant to the topic of our article. Emerging studies have shown that many neural, anatomical, and chemical factors play a role in the development of ASD. In this regard, an increasing body of studies has pointed out the relationship between chemical factors, including hormones, which play an important role in ASD. These hormones include melatonin, serotonin, thyroid, oxytocin, vasopressin, insulin-like growth hormone (IGF-1), etc. For instance, IGF-1 levels are low in ASD individuals, or melatonin levels are reduced in ASD individuals. Therefore, with take into account these findings, in this review, we decided to check over the association of these hormones to ASD and have a concise overview of their potential as therapeutic solutions to reduce the effects of ASD.</p>","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"57-66"},"PeriodicalIF":1.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crosstalk between miRNAs and signaling pathways in the development of drug resistance in breast cancer. 乳腺癌耐药发展中mirna与信号通路间的串扰
IF 1.1
Hormone Molecular Biology and Clinical Investigation Pub Date : 2024-12-13 eCollection Date: 2025-06-01 DOI: 10.1515/hmbci-2024-0066
Reza Amiri, Poorya Najjari Nabi, Ahmad Fazilat, Fatemeh Roshani, Alireza Nouhi Kararoudi, Mohsen Hemmati-Dinarvand, Mohammad Valilo
{"title":"Crosstalk between miRNAs and signaling pathways in the development of drug resistance in breast cancer.","authors":"Reza Amiri, Poorya Najjari Nabi, Ahmad Fazilat, Fatemeh Roshani, Alireza Nouhi Kararoudi, Mohsen Hemmati-Dinarvand, Mohammad Valilo","doi":"10.1515/hmbci-2024-0066","DOIUrl":"10.1515/hmbci-2024-0066","url":null,"abstract":"<p><p>One of the biggest challenges of today's society is cancer, which imposes a significant financial, emotional and spiritual burden on human life. Breast cancer (BC) is one of the most common cancers that affects people in society, especially women, and due to advanced treatment strategies and primary prevention, it is still the second cause of cancer-related deaths in society. Various genetic and environmental factors are involved in the development of BC. MicroRNAs (miRNA)s are non-coding RNAs, that the degradation or inhibition of them plays an important role in the prevention or development of cancer by modulating many cellular pathways including apoptosis, drug resistance, and tumorigenesis. Drug resistance is one of the important defense mechanisms of cancer cells against anticancer drugs and is considered one of the main causes of cancer treatment failure. Different miRNAs, including mir-7, mir-21, mir-31, and mir-124 control different cell activities, including drug resistance, through different pathways, including PI3K/AKT/mTOR, TGF-β, STAT3, and NF-kB. Therefore, cell signaling pathways are one of the important factors that miRNAs control cellular activities. Hence, in this study, we decided to highlight an overview of the relationship between miRNAs and signaling pathways in the development of drug resistance in BC.</p>","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"47-55"},"PeriodicalIF":1.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endothelial cell phenotype is linked to endothelial dysfunction in individuals with a family history of type 2 diabetes. 内皮细胞表型与 2 型糖尿病家族史患者的内皮功能障碍有关。
IF 1.1
Hormone Molecular Biology and Clinical Investigation Pub Date : 2024-11-25 eCollection Date: 2025-06-01 DOI: 10.1515/hmbci-2024-0070
Noé Alvarado-Vásquez, Bettina Sommer, María Eva González-Trujano
{"title":"Endothelial cell phenotype is linked to endothelial dysfunction in individuals with a family history of type 2 diabetes.","authors":"Noé Alvarado-Vásquez, Bettina Sommer, María Eva González-Trujano","doi":"10.1515/hmbci-2024-0070","DOIUrl":"10.1515/hmbci-2024-0070","url":null,"abstract":"<p><strong>Objectives: </strong>The patient's family history of type 2 diabetes (FH-DM2) has been negatively associated with the functionality of endothelial cells (ECs). Our objectives in this work were to use human umbilical vein endothelial cells (HUVECs) as a model, to substantiate whether FH-DM2 influences endothelial phenotype and impairs NO and ROS synthesis, cell metabolism, and mitochondrial activity of ECs from individuals with FH-DM2.</p><p><strong>Methods: </strong>In this study were evaluated the synthesis of reactive oxygen species (ROS) and nitric oxide (NO), mitochondrial membrane potential (MMP), mRNA of eNOS, glucose consumption, and lactate synthesis in HUVECs from newborns with FH-DM2. Furthermore, we also evaluated EC complexity and cell size through flow cytometry.</p><p><strong>Results: </strong>Our results showed significant differences in HUVECs with FH-DM2, regarding their complexity and cell size, in the synthesis of ROS (p<0.01), and NO (p<0.05); they also reflected diminished glucose consumption and slight changes in the lactate levels.</p><p><strong>Conclusion: </strong>In conclusion, our results showed that HUVECs from children with FH-DM2 have a reduced capability of synthesizing ROS and NO, which might be linked to the metabolism of endothelial cells. These results are relevant since early endothelial dysfunction has been reported in individuals with FH-DM2, and could be used to establish preventive measures to reduce the risk of developing atherosclerosis or cardiovascular diseases in healthy individuals, but with this family background.</p>","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"85-92"},"PeriodicalIF":1.1,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Climate change, vitamin D and the viking abandonment in Greenland. 气候变化、维生素 D 和格陵兰的维京遗弃。
IF 1.1
Hormone Molecular Biology and Clinical Investigation Pub Date : 2024-11-15 eCollection Date: 2025-03-01 DOI: 10.1515/hmbci-2024-0068
Joris Delanghe, Marijn Speeckaert, Marc De Buyzere
{"title":"Climate change, vitamin D and the viking abandonment in Greenland.","authors":"Joris Delanghe, Marijn Speeckaert, Marc De Buyzere","doi":"10.1515/hmbci-2024-0068","DOIUrl":"10.1515/hmbci-2024-0068","url":null,"abstract":"","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"1-2"},"PeriodicalIF":1.1,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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