Hormone Molecular Biology and Clinical Investigation最新文献_第2页

Association of vitamin D, HbA1c, and pain severity in T2DM patients with peripheral neuropathy. 伴有周围神经病变的T2DM患者的维生素D、HbA1c和疼痛严重程度的相关性

IF 1.9

Hormone Molecular Biology and Clinical Investigation Pub Date : 2026-07-08 eCollection Date: 2026-09-01 DOI: 10.1515/hmbci-2026-0035

Alan Bapeer Hassan, Ali Hussein Ahmad Al Dosky, Deldar Morad Abdulah

{"title":"Association of vitamin D, HbA1c, and pain severity in T2DM patients with peripheral neuropathy.","authors":"Alan Bapeer Hassan, Ali Hussein Ahmad Al Dosky, Deldar Morad Abdulah","doi":"10.1515/hmbci-2026-0035","DOIUrl":"10.1515/hmbci-2026-0035","url":null,"abstract":"Objectives: To evaluate the association of vitamin D linked with HbA1c level and pain severity in T2DM patients with peripheral neuropathy.Methods: In this cross-sectional study, we included 51 patients diagnosed with T2DM and peripheral neuropathy from a main diabetes center in Kurdistan Region-Iraq.Results: The study included 51 participants, predominantly female (82.35 %), with a mean age of 55.9 ± 7.55 years. Most participants had low educational attainment, with 74.51 % being illiterate, and 76.47 % were housewives. Disease duration was commonly 1-5 and 11-15 years (25.49 % each). Half of the patients used oral antidiabetic drugs, while 41.18 % used combined therapy. Medication adherence was high (94 %), and metformin use averaged 11.61 years. Statins were used by 66.67 %, and most participants were non-smokers (90.20 %). Lifestyle patterns were suboptimal, with limited fish intake and low physical activity. Obesity was prevalent (60.78 %), and glycemic control was poor, with mean fasting glucose of 225.43 mg/dL and HbA1c of 10.42 %. Vitamin D deficiency was universal. A significant association was found between pain severity, lower vitamin D, and higher HbA1c, while no associations were observed with demographic or lifestyle factors.Conclusions: The study highlights a high burden of uncontrolled diabetes, obesity, and vitamin D deficiency among predominantly female patients. Severe neuropathic pain is significantly associated with poor glycemic control and low vitamin D levels.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"131-140"},"PeriodicalIF":1.9,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148404580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic burden is independently and linearly associated with lower testosterone levels: evidence from NHANES. 代谢负担与低睾酮水平独立且线性相关：来自NHANES的证据。

IF 1.9

Hormone Molecular Biology and Clinical Investigation Pub Date : 2026-06-26 eCollection Date: 2026-09-01 DOI: 10.1515/hmbci-2026-0021

Yavuz Güler

{"title":"Metabolic burden is independently and linearly associated with lower testosterone levels: evidence from NHANES.","authors":"Yavuz Güler","doi":"10.1515/hmbci-2026-0021","DOIUrl":"10.1515/hmbci-2026-0021","url":null,"abstract":"Objectives: Testosterone deficiency and metabolic dysfunction frequently coexist in aging men; however, whether metabolic impairment is associated with a progressive decline in testosterone across the metabolic spectrum remains unclear.Methods: We analyzed 2,192 U.S. men aged ≥40 years from the National Health and Nutrition Examination Survey (NHANES). Metabolic burden was assessed using the triglyceride-glucose (TyG) index. Survey-weighted linear regression models were used to evaluate the association between TyG and log-transformed total testosterone after adjustment for age, HDL cholesterol, diabetes, and smoking. Dose-response relationships were further examined using quartiles and restricted cubic spline analyses.Results: Higher TyG levels were independently associated with lower testosterone concentrations. In fully adjusted models, each 1-unit increase in TyG was associated with an approximately 12 % decrease in testosterone (p<0.001). Compared with the lowest TyG quartile, men in the highest quartile had approximately 19 % lower testosterone levels. Spline analysis demonstrated a consistent inverse association without significant nonlinearity (p for nonlinearity=0.21), supporting a graded and continuous relationship across the metabolic spectrum.Conclusions: Higher metabolic burden was independently associated with lower total testosterone levels in middle-aged and older men. However, due to the cross-sectional design and absence of SHBG/free testosterone measurements, these findings should be interpreted cautiously and require confirmation in longitudinal studies.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"123-129"},"PeriodicalIF":1.9,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148317016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Vitamin B12 supplementation on glycemic control, albuminuria and peripheral neuropathy in diabetes mellitus patients - a cross sectional study. 补充维生素B12对糖尿病患者血糖控制、蛋白尿和周围神经病变的影响——一项横断面研究

IF 1.9

Hormone Molecular Biology and Clinical Investigation Pub Date : 2026-06-24 eCollection Date: 2026-09-01 DOI: 10.1515/hmbci-2026-0016

Rahul Kumar, Pinky Garg, Mansi Modi, Deepak Das, Harshvardan Singh

{"title":"Effect of Vitamin B12 supplementation on glycemic control, albuminuria and peripheral neuropathy in diabetes mellitus patients - a cross sectional study.","authors":"Rahul Kumar, Pinky Garg, Mansi Modi, Deepak Das, Harshvardan Singh","doi":"10.1515/hmbci-2026-0016","DOIUrl":"10.1515/hmbci-2026-0016","url":null,"abstract":"Objectives: Type 2 Diabetes Mellitus (T2DM) is a global health challenge linked to microvascular complications like neuropathy and nephropathy. Metformin, first-line therapy, is associated with Vitamin B12 deficiency, potentially worsening neurological outcomes. This study assessed B12 supplementation's association with glycemic control, albuminuria, and peripheral neuropathy.Methods: A cross-sectional study at Hindu Rao Hospital, New Delhi, included 151 T2DM patients (≥30 years) on B12 supplementation. Serum B12, HbA1c, and urinary albumin-creatinine ratio (ACR) were measured. Neuropathy was evaluated using the Diabetic Neuropathy Symptom (DNS) score. Analysis used SPSS v23; (p<0.05) was significant.Results: Mean age was 50.79 ± 9.60 years (63.6 % female). Neuropathy prevalence (DNS≥1) was 76.8 %. Mean B12 was 452.25 ± 360.86 pg/mL. B12 levels differed significantly across glycemic groups (p<0.001), highest in HbA1c>8.5 %. Neuropathy associated with B12 levels (p=0.027) and oral hypoglycemic use (p=0.010). Logistic regression showed higher B12 paradoxically linked to neuropathy (AOR=1.003; (p=0.023)). No ACR difference (p=0.879).Conclusions: B12 shows complex ties to neuropathy and glycemic control in supplemented T2DM patients. Elevated serum levels may not indicate functional adequacy; monitoring functional markers like homocysteine or methylmalonic acid is recommended.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"115-122"},"PeriodicalIF":1.9,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of Notch signaling in cancer drug resistance. Notch信号在肿瘤耐药中的作用机制。

IF 1.9

Hormone Molecular Biology and Clinical Investigation Pub Date : 2026-06-03 eCollection Date: 2026-06-01 DOI: 10.1515/hmbci-2026-0008

Ahmad Fazilat, Fatemeh Mortazavi Moghadam, Salomeh Roshani, Farhad Sheikhnia, Masoud Ojarudi, Maryam Rahnama, Mohammad Valilo

{"title":"Mechanisms of Notch signaling in cancer drug resistance.","authors":"Ahmad Fazilat, Fatemeh Mortazavi Moghadam, Salomeh Roshani, Farhad Sheikhnia, Masoud Ojarudi, Maryam Rahnama, Mohammad Valilo","doi":"10.1515/hmbci-2026-0008","DOIUrl":"10.1515/hmbci-2026-0008","url":null,"abstract":"One of the most common treatments used for cancer is chemotherapy. Different drugs are used in chemotherapy depending on the type of cancer. In this regard, one of the most basic problems in chemotherapy is drug resistance, in which people undergoing treatment develop resistance to chemotherapy drugs over time. Therefore, the drug dose must be increased over time or the interval between treatments must be reduced, which leads to side effects and damage to normal cells and tissues. Various factors play a role in drug resistance, including ATP-binding cassette (ABC) transporters, which lead to drug resistance by transporting these drugs outside the cell. Also, various factors, including signaling pathways and heat shock proteins (HSP), can play an effective role in drug resistance by interfering with these pumps or other factors involved in drug resistance. A body of studies indicated that, one of the most important signaling pathways that involved in drug resistance is Notch pathway. This pathway plays a fundamental role in drug resistance in cancers by interfering with various mechanisms. Therefore, in this study, our goal is to investigate the role of Notch pathway mechanisms in drug resistance in different cancers.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"39-47"},"PeriodicalIF":1.9,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148143257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indications that the direct effects of supplemented vitamin D3 on the adrenal cortex are of secondary importance for glucocorticoid output. 有迹象表明，补充维生素D3对肾上腺皮质的直接影响对糖皮质激素的输出是次要的。

IF 1.9

Hormone Molecular Biology and Clinical Investigation Pub Date : 2026-05-27 eCollection Date: 2026-06-01 DOI: 10.1515/hmbci-2026-0005

Vladimir Ajdžanović, Branka Šošić-Jurjević, Marko Miler, Branko Filipović

{"title":"Indications that the direct effects of supplemented vitamin D3 on the adrenal cortex are of secondary importance for glucocorticoid output.","authors":"Vladimir Ajdžanović, Branka Šošić-Jurjević, Marko Miler, Branko Filipović","doi":"10.1515/hmbci-2026-0005","DOIUrl":"10.1515/hmbci-2026-0005","url":null,"abstract":"Vitamin D3 supplementation is beneficial for various symptoms of aging and may stabilize hypothalamic-pituitary-adrenal (HPA) axis function. Systemic and local metabolic activation of vitamin D3 are essential for its acquisition of physiological activity and subsequent direct action. We reasonably believe that the direct effect of the active metabolite of vitamin D3 on the adrenal cortex is of secondary importance for glucocorticoid output, compared to the indirect, pituitary-mediated mechanism of its action. The initially decreased blood level of adrenocorticotropic hormone (ACTH), after the experimental application of vitamin D3, physiologically dominantly acts as a feed-forward mechanism that allows for subsequent increased secretion of stored corticosterone, from the lipid-droplets of adrenocortical zona fasciculata (ZF) cells. The observed absence of changes in mitochondrial dimensions and immunoexpression of 3β-hydroxysteroid dehydrogenase (3β-HSD) enzyme in ZF adrenocortical cells, indicating that glucocorticoid production is not intensified, devalues an alternative direct effect of the physiologically active form of vitamin D3 on the adrenal cortex. To verify our concept, specific (structural and expression) in vivo studies are needed, which investigate the effects of vitamin D3 application on the upper parts of the HPA axis. If it is confirmed that the dominant mechanism of action of supplemented vitamin D3 on glucocorticoid output is indirect (pituitary-mediated), and bearing in mind the pulsatile nature of ACTH-glucocorticoid secretion, the hourly and daily schedule of some therapeutic vitamin D3 administration could be more precisely adjusted.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"81-85"},"PeriodicalIF":1.9,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148029796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic hormones, nitric oxide signaling components, and inflammation markers crosstalk in coronary artery disease. 代谢激素、一氧化氮信号成分和炎症标志物在冠状动脉疾病中相互作用。

IF 1.9

Hormone Molecular Biology and Clinical Investigation Pub Date : 2026-05-26 Print Date: 2026-06-24 DOI: 10.1515/hmbci-2025-0084

Nadezhda G Gumanova, Natalya L Bogdanova, Anton R Kiselev

{"title":"Metabolic hormones, nitric oxide signaling components, and inflammation markers crosstalk in coronary artery disease.","authors":"Nadezhda G Gumanova, Natalya L Bogdanova, Anton R Kiselev","doi":"10.1515/hmbci-2025-0084","DOIUrl":"10.1515/hmbci-2025-0084","url":null,"abstract":"Objectives: To assess the crosstalk between the serum levels of the metabolic hormones, NO-signaling components, and inflammation markers in patients with coronary artery disease (CAD) with 3-year follow-up.Methods: A total of 218 included patients underwent coronary angiography and a phone survey with a 3-year follow-up, which included records of cardiovascular (CV) events. Gensini score was evaluated to quantify atherosclerosis. NO-synthases (NOS) were profiled by an Explorer antibody array (Full Moon Biosystems, USA). ELISA was used to assay NOS, endothelin-1, leptin, adiponectin, and cGAMP in the whole cohort. C-reactive protein (CRP), glucose, and insulin were measured according to a routine analysis. Serum NOx were measured spectrophotometrically under diet in a hospital setting. Spearman correlation analysis, ROC-analysis, and logistic regressions were used to evaluate the associations between analytes, Gensini score, and CV-events.Results: Correlation analysis reveals a complex network in which leptin deficiency appears to be a central, unfavorable and independent factor linked to CV-events. A pathological cycle involved hormone levels, imbalanced NOS isoforms and endothelin, metabolic factors, and CRP as inflammation marker. The direct pro-atherogenic roles of glucose, insulin, and CRP, and the protective potential of adiponectin and NOx were revealed.Conclusions: Atherosclerosis was linked to a decrease in NOx. Elevated NOS isoforms may compensate for impaired NOS activity in atherosclerosis. Specific changes in the levels of NOS and NOx may be linked to the signaling pathways contributing to atherosclerosis and point to the correction of these changes using exogenous nitrate as dietary supplement.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"69-79"},"PeriodicalIF":1.9,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dienogest-associated capillaroscopic abnormalities: a case report and narrative review of progestin microvascular effects. 孕酮相关的毛细血管镜异常：一例报告和黄体酮微血管效应的叙述回顾。

IF 1.9

Hormone Molecular Biology and Clinical Investigation Pub Date : 2026-05-25 eCollection Date: 2026-06-01 DOI: 10.1515/hmbci-2025-0029

Angelo Nigro

引用次数: 0

Interaction of thyroid hormonal imbalance, obesity, and Y-chromosomal gene dysregulation in male infertility: a case-control study. 男性不育症中甲状腺激素失衡、肥胖和y染色体基因失调的相互作用：一项病例对照研究。

IF 1.9

Hormone Molecular Biology and Clinical Investigation Pub Date : 2026-04-10 eCollection Date: 2026-06-01 DOI: 10.1515/hmbci-2026-0004

Kanchana Sreekumaran Nair Bindhu, Magesh Vadivelu, Nalini Devarajan, Jeyapal Vidhyadharan, Sreeshma Purushothaman Pillai, Ajitha E Veluthakunju, Dinesh Roy Divakaran

{"title":"Interaction of thyroid hormonal imbalance, obesity, and Y-chromosomal gene dysregulation in male infertility: a case-control study.","authors":"Kanchana Sreekumaran Nair Bindhu, Magesh Vadivelu, Nalini Devarajan, Jeyapal Vidhyadharan, Sreeshma Purushothaman Pillai, Ajitha E Veluthakunju, Dinesh Roy Divakaran","doi":"10.1515/hmbci-2026-0004","DOIUrl":"10.1515/hmbci-2026-0004","url":null,"abstract":"Objectives: This study aimed to investigate the association between thyroid hormone disturbances, obesity-related parameters, and the expression profiles of Y-linked spermatogenic genes (AZFa, AZFb, and AZFc) in infertile men, and to determine whether endocrine and metabolic alterations predict AZF gene dysregulation.Methods: A case-control study included 150 infertile men and 150 fertile controls. Anthropometric indices and hormonal, biochemical, and inflammatory markers were assessed. Relative expression levels of AZFa, AZFb, and AZFc genes were quantified using qRT-PCR and the 2ˆ-ΔΔCT method. Correlation analysis, LASSO regression, and ROC curve modeling were performed to identify predictors of AZF gene downregulation.Results: Infertile men had significantly higher BMI, waist circumference, and thyroid-stimulating hormone (TSH) levels, with reduced triiodothyronine (T3) and thyroxine (T4) concentrations (p<0.001). AZFa, AZFb, and AZFc expression levels were significantly decreased and negatively correlated with TSH, BMI, and inflammatory cytokines. A combined model of TSH, BMI, and interleukin-6 demonstrated the highest diagnostic accuracy (AUC=0.88), with 86 % sensitivity and 80 % specificity.Conclusions: Thyroid dysfunction, obesity, and systemic inflammation synergistically downregulate AZF gene expression and impair spermatogenesis. Integrating endocrine, metabolic, inflammatory, and molecular markers may improve diagnostic precision and personalized management of male infertility.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"49-58"},"PeriodicalIF":1.9,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of blood biomarkers with p53 gene expression in male infertility. 男性不育症中血液生物标志物与p53基因表达的关系

IF 1.9

Hormone Molecular Biology and Clinical Investigation Pub Date : 2026-04-09 eCollection Date: 2026-06-01 DOI: 10.1515/hmbci-2026-0003

Aswathi Ramachandran Krishnakumary, Natrajan Muninathan, Arumugam Suresh, Mohanalakshmi Parthasarathy, Dinesh Roy Divakaran

{"title":"Association of blood biomarkers with p53 gene expression in male infertility.","authors":"Aswathi Ramachandran Krishnakumary, Natrajan Muninathan, Arumugam Suresh, Mohanalakshmi Parthasarathy, Dinesh Roy Divakaran","doi":"10.1515/hmbci-2026-0003","DOIUrl":"10.1515/hmbci-2026-0003","url":null,"abstract":"Objectives: To investigate the association between p53 gene expression, prostate-specific antigen (PSA), and oxidative stress markers (sialic acid and vitamin C) in infertile men.Methods: This case-control study involved 150 infertile men and 150 fertile controls from Kerala, India. Serum sialic acid, PSA, and vitamin C were measured by ELISA, and p53 expression was quantified by real-time PCR (2-ΔΔCt method). Non-parametric tests, correlation analyses, regression models, and ROC curves were used to assess associations, predictive value, and diagnostic performance.Results: Infertile men showed significantly lower serum sialic acid and vitamin C levels and higher PSA concentrations and p53 gene expression than fertile controls (all p<0.05). p53 expression was significantly associated with PSA, sialic acid, and vitamin C in infertile men. Although no biomarker independently predicted infertility in logistic regression, robust linear regression identified vitamin C as a strong negative predictor and PSA as a positive predictor of p53 expression. ROC analysis revealed moderate discriminative ability for vitamin C, PSA, and sialic acid, while p53 expression alone showed limited diagnostic accuracy.Conclusions: The concurrent elevation of p53 expression, increased PSA levels, and antioxidant depletion in infertile men reflects activation of cancer-related cellular stress and genomic surveillance pathways rather than evidence of malignancy.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"59-67"},"PeriodicalIF":1.9,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adrenocortical tissue dynamics and corticosteroid perturbation upon the experimental male estrogenization: reflections from animal and in vitro data about human treatment. 实验性雄性雌激素的肾上腺皮质组织动力学和皮质类固醇摄动：从动物和体外数据对人类治疗的反思。

IF 1.9

Hormone Molecular Biology and Clinical Investigation Pub Date : 2026-01-09 eCollection Date: 2026-03-01 DOI: 10.1515/hmbci-2025-0074

Vladimir Ajdžanović, Pavle Ćosić, Marko Miler, Branko Filipović, Milica Manojlović-Stojanoski

{"title":"Adrenocortical tissue dynamics and corticosteroid perturbation upon the experimental male estrogenization: reflections from animal and in vitro data about human treatment.","authors":"Vladimir Ajdžanović, Pavle Ćosić, Marko Miler, Branko Filipović, Milica Manojlović-Stojanoski","doi":"10.1515/hmbci-2025-0074","DOIUrl":"10.1515/hmbci-2025-0074","url":null,"abstract":"The current topic of sex reassignment is often under strong ideological influence and requires an impartial scientific approach. Considering the importance of corticosteroid status during male-to-female transition for numerous health aspects, here we focus on the 'transitional' functional histology of the hypothalamic-pituitary-adrenal (HPA) axis and corticosteroid output, from the perspective of our experimental experience and the available literature, both experimentally and clinically oriented. In a model of orchidectomized, estradiol-treated adult male rats we observed an increase in aldosterone secretion, as well as in corticosterone synthesis and secretion, but also a decrease in DHEA secretion, all of which were accompanied by expansive changes in adrenal tissue. Available experimental and clinical literature data support our findings. It is known that glucocorticoid excess increases the risk of metabolic complications, elevated blood aldosterone levels may underlie systemic hypertension, while reduced DHEA secretion is associated with various physical and mental issues. These health risks should be kept in mind before possibly starting the male-to-female transition through orchidectomy and estradiol administration.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"27-31"},"PeriodicalIF":1.9,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0