Hormone Molecular Biology and Clinical Investigation最新文献_第3页

Association of angiotensin converting enzyme gene insertion/deletion polymorphism with diabetic retinopathy in middle-aged Indians with type 2 diabetes mellitus. 患有 2 型糖尿病的印度中年人血管紧张素转换酶基因插入/缺失多态性与糖尿病视网膜病变的关系。

IF 1.1

Hormone Molecular Biology and Clinical Investigation Pub Date : 2024-07-30 DOI: 10.1515/hmbci-2023-0081

Pramita Dutta, Sambuddha Ghosh, Anindya Dasgupta, Swati Majumder

{"title":"Association of angiotensin converting enzyme gene insertion/deletion polymorphism with diabetic retinopathy in middle-aged Indians with type 2 diabetes mellitus.","authors":"Pramita Dutta, Sambuddha Ghosh, Anindya Dasgupta, Swati Majumder","doi":"10.1515/hmbci-2023-0081","DOIUrl":"https://doi.org/10.1515/hmbci-2023-0081","url":null,"abstract":"Objectives: There are conflicting reports regarding the association of angiotensin 1 converting enzyme (ACE) gene polymorphism with diabetic retinopathy (DR). We compared ACE gene insertion/deletion (I/D) polymorphism between patients with and without DR in a middle-aged Indian population. The secondary outcome measure was the comparison of ACE gene I/D polymorphism in different grades of DR severity.Methods: Institutional cross-sectional case-control study with middle-aged (45-64 years) type 2 diabetes patients from Eastern India with DR (DR group) and without DR (NODR group). Polymerase chain reaction (PCR) was used to determine the ACE gene I/D polymorphism through primers flanking the polymorphic region of 287 bp Alu repeat sequence in intron 16.Results: Genotyping for the ACE gene I/D polymorphisms were done for 107 patients in each group. The presence of DR had no significant association with the prevalence of ACE I/D genotype compared to those without DR either in the recessive model (p=0.588) or in the dominant model (p=0.891). The allele contrast was also similar between DR and NODR (p=0.837) groups. The severity of retinopathy was associated with the ACE I/D genotype in the recessive model (p=0.043) but not in the dominant model (p=0.136). However, the severity of retinopathy was associated with allele contrast (p=0.016).Conclusions: The ACE gene polymorphism was not associated with diabetic retinopathy in middle-aged Indian patients with type 2 diabetes in our study. However, the severity of DR was associated with the ACE gene polymorphism in these patients.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential therapeutic properties of broccoli extract and soy isoflavones on improvement endometriosis and involved oxidative parameters. 西兰花提取物和大豆异黄酮对改善子宫内膜异位症和相关氧化参数的潜在治疗作用。

IF 1.1

Hormone Molecular Biology and Clinical Investigation Pub Date : 2024-07-23 DOI: 10.1515/hmbci-2023-0071

Soudabeh Sabetian, Parimah Archin Dialameh, Nader Tanideh, Behrooz Gharesifard, Moslem Ahmadi, Maryam Valibeigi, Perikala Vijayananda Kumar, Sarah Siahbani, Bahia Namavar Jahromi

{"title":"Potential therapeutic properties of broccoli extract and soy isoflavones on improvement endometriosis and involved oxidative parameters.","authors":"Soudabeh Sabetian, Parimah Archin Dialameh, Nader Tanideh, Behrooz Gharesifard, Moslem Ahmadi, Maryam Valibeigi, Perikala Vijayananda Kumar, Sarah Siahbani, Bahia Namavar Jahromi","doi":"10.1515/hmbci-2023-0071","DOIUrl":"https://doi.org/10.1515/hmbci-2023-0071","url":null,"abstract":"Objectives: In Endometriosis is a gynecological disorder characterized by the growth of endometrial tissue outside the uterine cavity that is associated with chronic pelvic pain and subfertility. The purpose of the study was to investigate the effect of broccoli extract (BE) alone and in combination with soy isoflavones (SI) on endometrial implants in female rat.Methods: In this study, endometriosis was induced surgically in 40 mature female rats. The rats were divided into 5 groups that were treated by oral gavage for 6 weeks with 0.5 mL of saline 0.9 %/day (control group), BE (3,000 mg/kg/day), SI (50 mg/kg/day), BE/soy isoflavones (BE 3000 mg/kg/day + soy isoflavones 50 mg/kg/day) and diphereline as a standard medication (3 mg/kg) intramuscularly. At the end of treatments, the volume and histopathology of the endometrial implants were compared among the 5 groups. The serum levels of oxidative parameters including superoxide dismutase (SOD), malondialdehyde (MDA) and tumor necrosis factor alpha (TNF-α) were also compared between the groups. The volume of the implants significantly decreased in diphereline group (p=0.002).Results: The histopathological grade of endometrial implants in BE/SI and diphereline group were significantly decreased compared to the control group (p=0.001). The serum levels of SOD in BE group were enhanced significantly in comparison to the control group (p=0.034).Conclusions: BE in combination with SI decreased the growth and histopathologic grades of transplanted endometrial implants. These herbal compounds may have the potential therapeutic effect to be used as an alternative medication for the treatment of endometriosis.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The evaluation of melatonin and EGF interaction on breast cancer metastasis. 评估褪黑激素和表皮生长因子对乳腺癌转移的相互作用

IF 1.1

Hormone Molecular Biology and Clinical Investigation Pub Date : 2024-07-23 DOI: 10.1515/hmbci-2023-0082

Moloud Akbarzadeh, Vahid Vahedian, Zahraa Hamid Abudulmohesen, Parvin Ghadimi, Nazila Fathi Maroufi, Ali Farzaneh, Sepideh Bastani, Neda Roshanravan, Abbas Pirpour Tazehkand, Amir Fattahi, Yousef Faridvand, Mehdi Talebi, Davoud Farajzadeh, Maryam Akbarzadeh

{"title":"The evaluation of melatonin and EGF interaction on breast cancer metastasis.","authors":"Moloud Akbarzadeh, Vahid Vahedian, Zahraa Hamid Abudulmohesen, Parvin Ghadimi, Nazila Fathi Maroufi, Ali Farzaneh, Sepideh Bastani, Neda Roshanravan, Abbas Pirpour Tazehkand, Amir Fattahi, Yousef Faridvand, Mehdi Talebi, Davoud Farajzadeh, Maryam Akbarzadeh","doi":"10.1515/hmbci-2023-0082","DOIUrl":"https://doi.org/10.1515/hmbci-2023-0082","url":null,"abstract":"Objectives: Metastasis in breast cancer is the first cause of death in patients. The epidermal growth factor (EGF) increases cancer cells' invasion, and migration. Melatonin's inhibitory effects on various types of cancer were confirmed. This study aimed to investigate whether melatonin could apply its impact through the EGF-related pathways or not.Methods: First, MDA-MB-231 and MCF7 cells were cultured, and then melatonin effects on cell viability were determined by MTT assay. Transwell invasion assay was applied to identify the invasiveness of these breast cancer cell lines under treatment of EGF and melatonin. Real-time RT-PCR then investigated the expression of MMP9 and MMP2 in determined groups. Cell proliferation was also assayed under EGF and melatonin treatment using Ki67 assessment by flow cytometry.Results: The rate of invasion and migration of EGF-treated cells increased in both groups, in which melatonin caused increased invasion by EGF just in MCF7 cells. MMP9 and MMP2 expression increased significantly in both cell lines under EGF treatment, and melatonin increased these genes' expression in both cell lines (p<0.05). EGF increased the MMP9 and MMP2 gene expression, and melatonin increased EGF-induced expression (p<0.05). The EGF reduced the expression of the Ki67 protein in the MCF7 cell line, which was negatively affected by melatonin and EGF. In contrast, along with melatonin, EGF did not affect the proliferation of the MDA-MB-231 cell line.Conclusions: The results of this study show that melatonin in the presence of EGF does not show the anti-cancer properties previously described for this substance.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Randomized, double-blind clinical trial evaluating the impact of freeze-dried garlic extract capsules on blood pressure, lipid profile, and nitric oxide levels in individuals at risk for hypertension. 随机双盲临床试验，评估冻干大蒜提取物胶囊对高血压高危人群的血压、血脂和一氧化氮水平的影响。

IF 1.1

Hormone Molecular Biology and Clinical Investigation Pub Date : 2024-07-15 eCollection Date: 2024-12-01 DOI: 10.1515/hmbci-2024-0019

Elham Rahmatinia, Bardia Amidi, Narges Naderi, Saeedeh Ahmadipour, Hasan Ahmadvand, Mohammad-Taha Pahlevan-Fallahy, Vajihe Ghorbanzadeh, Afshin Nazari

{"title":"Randomized, double-blind clinical trial evaluating the impact of freeze-dried garlic extract capsules on blood pressure, lipid profile, and nitric oxide levels in individuals at risk for hypertension.","authors":"Elham Rahmatinia, Bardia Amidi, Narges Naderi, Saeedeh Ahmadipour, Hasan Ahmadvand, Mohammad-Taha Pahlevan-Fallahy, Vajihe Ghorbanzadeh, Afshin Nazari","doi":"10.1515/hmbci-2024-0019","DOIUrl":"10.1515/hmbci-2024-0019","url":null,"abstract":"Objectives: Hypertension, substantially heightens the risk of cardiovascular disease. This study aims to evaluate the effectiveness of freeze-dried garlic extract in blood pressure and lipid profiles in prehypertensive individuals.Methods: Participants (age of 30-70 years) were allocated to intervention (n=47) or control (n=49) groups. The intervention group received two capsules of freeze-dried garlic extract daily for eight weeks, while the control group received identical placebo capsules. Primary outcomes, SBP, DBP, PP, MAP, TC, TG, LDL and HDL levels, serum NO levels, were assessed at baseline, four weeks, and eight weeks.Results: At the end of study, results showed significant changes in the values of SBP, DBP, and MAP except for PP. In comparison to those who received the placebo, a significant drop in SBP, DBP (p<0.001), and MAP (p<0.001) was observed in the intervention group. Also, there were significant changes in TG, LDL, TC, and HDL levels in the interventional group. A noticeable decline was reported in TG (p<0.001), LDL (p<0.001), and TC (p<0.001), while HDL levels increased (p<0.001) in the intervention group compared to those receiving the placebo. Following garlic supplementation, a significant increase in blood NO levels was reported in the intervention group (p<0.001).Conclusions: The study showed that garlic supplementation was effective in lowering blood pressure, improving lipid profile, and increasing nitric oxide levels in prehypertensive participants. These results indicate that garlic could be a valuable complementary therapy for managing prehypertension.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"139-147"},"PeriodicalIF":1.1,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Second to fourth digit ratio (2D:4D) as the 'anatomical marker' and reproductive 'hormonal fingerprint' in the occurrence dental plaque accumulation. 第二位数字与第四位数字之比（2D:4D）是牙菌斑堆积的 "解剖标记 "和生殖 "激素指纹"。

IF 1.1

Hormone Molecular Biology and Clinical Investigation Pub Date : 2024-05-10 eCollection Date: 2024-06-01 DOI: 10.1515/hmbci-2023-0063

Sulagna Dutta, Chin Win Nie, Amrita Sarna, Padmini Hari, Pallav Sengupta

{"title":"Second to fourth digit ratio (2D:4D) as the 'anatomical marker' and reproductive 'hormonal fingerprint' in the occurrence dental plaque accumulation.","authors":"Sulagna Dutta, Chin Win Nie, Amrita Sarna, Padmini Hari, Pallav Sengupta","doi":"10.1515/hmbci-2023-0063","DOIUrl":"10.1515/hmbci-2023-0063","url":null,"abstract":"Objectives: Digit ratio (2D:4D), as endocrine fingerprint, can indicate prenatal androgen exposure. It serves as an anatomical marker for various systemic diseases and a few studies relating it to oral health. The present study aims to evaluate the association between digit ratio and susceptibility to dental plaque formation.Methods: The study was conducted on young adults aged between 18 and 25 years. Digit ratio and reproductive hormones were measured; dental plaque score and gingival index (GI) were recorded. Data were analysed using the MedCalc. v.20.Results: Male and female participants were categorized into two groups based on their digit ratios being either above or below the calculated average (0.99 for females, 0.98 for males). Those with a digit ratio below the average had a significantly higher mean dental plaque score (p < 0.0001) than those with ratios at or above the average. However, there was no significant difference in the GI between the two groups. Reproductive hormone profiles varied significantly between the higher and lower digit ratio groups for both sexes.Conclusions: Digit ratio may find potential to be used as an anatomical marker to identify the susceptibility to dental plaque build-up.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"41-47"},"PeriodicalIF":1.1,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140898197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

D-dimer - a multifaceted molecule. D-二聚体--一种多方面的分子。

IF 1.1

Hormone Molecular Biology and Clinical Investigation Pub Date : 2024-05-09 eCollection Date: 2024-06-01 DOI: 10.1515/hmbci-2022-0093

Devika Tayal, Prerna Jain, Binita Goswami

{"title":"D-dimer - a multifaceted molecule.","authors":"Devika Tayal, Prerna Jain, Binita Goswami","doi":"10.1515/hmbci-2022-0093","DOIUrl":"10.1515/hmbci-2022-0093","url":null,"abstract":"D-dimer, a universally unique marker for fibrin degradation, is generated through the enzymatic interplay of thrombin, factor XIIIa, and plasmin. The emergence of D-dimer-containing fibrin molecules occurs in both intravascular and extravascular spaces during pivotal physiological processes like haemostasis, thrombosis, and tissue repair. Given the inherently physiological nature of fibrin formation and fibrinolysis, basal levels of D-dimer fragments are present in plasma. Beyond its role as a marker of routine physiological processes, aberrations in D-dimer levels are indicative of a spectrum of conditions, both non-pathological and pathological. The clinical utility of D-dimer has been firmly established, particularly in scenarios like venous thromboembolism (VTE), pulmonary embolism (PE), deep vein thrombosis (DVT), and disseminated intravascular coagulation (DIC). Additionally, recent applications have extended to assess the prognosis of COVID-19. While D-dimer is commonly associated with thrombotic conditions, its elevation is not confined to these conditions alone. Elevated D-dimer levels are observed across various diseases, where its significance extends beyond diagnostic indicators to prognostic implications.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"75-84"},"PeriodicalIF":1.1,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140876324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative study of radioprotective effects of endurance training in irradiation-induced nephropathy of rat model. 耐力训练对辐照诱导的大鼠肾病模型的放射保护作用比较研究

IF 1

Hormone Molecular Biology and Clinical Investigation Pub Date : 2024-04-01 eCollection Date: 2024-03-01 DOI: 10.1515/hmbci-2022-0094

Mohammad Parastesh, Shiva Molavi, Samira Moghadasi

{"title":"Comparative study of radioprotective effects of endurance training in irradiation-induced nephropathy of rat model.","authors":"Mohammad Parastesh, Shiva Molavi, Samira Moghadasi","doi":"10.1515/hmbci-2022-0094","DOIUrl":"10.1515/hmbci-2022-0094","url":null,"abstract":"Objectives: Considering the antioxidant properties of endurance training, this study aimed to investigate the effects of endurance training on serum levels of oxidative stress and structural changes in the kidney tissue of rats exposed to X-ray irradiation.Methods: In this experimental study, 24 rats weighing 220±20 g were randomly divided into four groups (healthy control, healthy with moderate-intensity continuous training, X-ray control, and X-ray with moderate-intensity continuous training). The two groups of rats were irradiated with 4 Gy X-rays. The two training groups also performed moderate-intensity continuous training for 10 weeks. Twenty-four hour after the last training session, the blood serum of rats was collected and kidney tissue was isolated for stereological studies.Results: In this study, X-ray irradiation of the whole body of rats caused a significant increase in kidney volume, cortex volume, interstitial tissue volume, glomerular volume, and serum level of MDA (p≤0.05), but the medulla volume, volume of proximal tubules (total volume, volume of epithelium, and lumen), volume of distal tubules (total volume, volume of epithelium, and lumen), and the length of the proximal and distal tubules had no effect. In addition, TAC and SOD levels were significantly decreased in the radiation control group. Furthermore, performing endurance training in X-ray-irradiated rats significantly reduced kidney volume, cortex volume, glomerular volume, and serum MDA level (p≤0.05).Conclusions: Moderate-intensity continuous training can improve the rate of destruction of kidney tissue in rats exposed to X-rays by reducing oxidative stress and subsequently increasing antioxidant capacity.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"17-25"},"PeriodicalIF":1.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140318199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of serum NF-κB levels with peripheral neuropathy in type 2 diabetes mellitus patients: a pilot study. 2 型糖尿病患者血清 NF-κB 水平与周围神经病变的关系：一项试点研究。

IF 1

Hormone Molecular Biology and Clinical Investigation Pub Date : 2024-03-21 eCollection Date: 2024-03-01 DOI: 10.1515/hmbci-2022-0105

Nibedita Priyadarsini, Madumathy Ramachandran, Kishore K Behera, Sheetal Kiran, Sujata Devi

{"title":"Association of serum NF-κB levels with peripheral neuropathy in type 2 diabetes mellitus patients: a pilot study.","authors":"Nibedita Priyadarsini, Madumathy Ramachandran, Kishore K Behera, Sheetal Kiran, Sujata Devi","doi":"10.1515/hmbci-2022-0105","DOIUrl":"10.1515/hmbci-2022-0105","url":null,"abstract":"Objectives: Hyperglycaemia-induced inflammation plays a vital role in the development of diabetic peripheral neuropathy (DPN). Recent evidences had reported the involvement of the transcription factor nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) in diabetic experimental models. So, this pilot study aimed to evaluate serum NF-κB levels in DPN patients.Methods: We recruited 50 T2DM patients, of which 25 were T2DM with neuropathy and 25 were T2DM without neuropathy. In all the participants peripheral neuropathy was diagnosed based on Total neuropathy score (TNS). Serum NF-κB levels were measured by ELISA.Results: We observed that the serum NF-κB levels were higher in DPN patients in comparison to T2DM patients without neuropathy. On spearman correlation, a positive correlation was found between serum NF-κB levels and TNS in the DPN group (r=0.741, p<0.001). The regression model shows the TNS to be an independent determinant of serum NF-κB levels after adjustment for potential confounders like age, duration of diabetes, and HbA1C (B=81.34; p<0.001).Conclusions: NF-κB activation plays a key role in promoting inflammation which is associated with the progression of DPN. In this respect, the study of NF-κB levels in serum may be an additional diagnostic marker for DPN.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"27-33"},"PeriodicalIF":1.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140174500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

microRNAs, oxidative stress, and genotoxicity as the main inducers in the pathobiology of cancer development. 微小核糖核酸、氧化应激和基因毒性是癌症发展病理生物学的主要诱因。

IF 1.1

Hormone Molecular Biology and Clinical Investigation Pub Date : 2024-03-21 eCollection Date: 2024-06-01 DOI: 10.1515/hmbci-2023-0012

Sogand Vahidi, Shahram Agah, Ebrahim Mirzajani, Elahe Asghari Gharakhyli, Seyedeh Elham Norollahi, Morteza Rahbar Taramsari, Kosar Babaei, Ali Akbar Samadani

{"title":"microRNAs, oxidative stress, and genotoxicity as the main inducers in the pathobiology of cancer development.","authors":"Sogand Vahidi, Shahram Agah, Ebrahim Mirzajani, Elahe Asghari Gharakhyli, Seyedeh Elham Norollahi, Morteza Rahbar Taramsari, Kosar Babaei, Ali Akbar Samadani","doi":"10.1515/hmbci-2023-0012","DOIUrl":"10.1515/hmbci-2023-0012","url":null,"abstract":"Cancer is one of the most serious leading causes of death in the world. Many eclectic factors are involved in cancer progression including genetic and epigenetic alongside environmental ones. In this account, the performance and fluctuations of microRNAs are significant in cancer diagnosis and treatment, particularly as diagnostic biomarkers in oncology. So, microRNAs manage and control the gene expression after transcription by mRNA degradation, or also they can inhibit their translation. Conspicuously, these molecular structures take part in controlling the cellular, physiological and pathological functions, which many of them can accomplish as tumor inhibitors or oncogenes. Relatively, Oxidative stress is defined as the inequality between the creation of reactive oxygen species (ROS) and the body's ability to detoxify the reactive mediators or repair the resulting injury. ROS and microRNAs have been recognized as main cancer promoters and possible treatment targets. Importantly, genotoxicity has been established as the primary reason for many diseases as well as several malignancies. The procedures have no obvious link with mutagenicity and influence the organization, accuracy of the information, or fragmentation of DNA. Conclusively, mutations in these patterns can lead to carcinogenesis. In this review article, we report the impressive and practical roles of microRNAs, oxidative stress, and genotoxicity in the pathobiology of cancer development in conjunction with their importance as reliable cancer biomarkers and their association with circulating miRNA, exosomes and exosomal miRNAs, RNA remodeling, DNA methylation, and other molecular elements in oncology.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"55-73"},"PeriodicalIF":1.1,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140174501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The nongenomic neuroprotective effects of estrogen, E2-BSA, and G1 following traumatic brain injury: PI3K/Akt and histopathological study. 脑外伤后雌激素、E2-BSA 和 G1 的非基因组神经保护作用：PI3K/Akt和组织病理学研究。

IF 1

Hormone Molecular Biology and Clinical Investigation Pub Date : 2024-03-20 eCollection Date: 2024-03-01 DOI: 10.1515/hmbci-2023-0066

Ladan Amirkhosravi, Mohammad Khaksari, Mojgan Sanjari, Parisa Khorasani

{"title":"The nongenomic neuroprotective effects of estrogen, E2-BSA, and G1 following traumatic brain injury: PI3K/Akt and histopathological study.","authors":"Ladan Amirkhosravi, Mohammad Khaksari, Mojgan Sanjari, Parisa Khorasani","doi":"10.1515/hmbci-2023-0066","DOIUrl":"10.1515/hmbci-2023-0066","url":null,"abstract":"Objectives: Studies suggest that both genomic and nongenomic pathways are involved in mediating the salutary effects of steroids following traumatic brain injury (TBI). This study investigated the nongenomic effects of 17β-estradiol (E2) mediated by the PI3K/p-Akt pathway after TBI.Methods: Ovariectomized rats were apportioned to E2, E2-BSA (E2 conjugated to bovine serum albumin), G1 [G-protein-coupled estrogen receptor agonist (GPER)] or their vehicle was injected following TBI, whereas ICI (classical estrogen receptor antagonist), G15 (GPER antagonist), ICI + G15, and their vehicles were injected before the induction of TBI and injection of drugs. Diffuse TBI was induced by the Marmarou model. Evans blue (EBC, 5 h), brain water contents (BWC), histopathological changes, and brain PI3K and p-Akt protein expressions were measured 24 h after TBI. The veterinary comma scale (VCS) was assessed before and at different times after TBI.Results: The results showed a reduction in BWC and EBC and increased VCS in the E2, E2-BSA, and G1 groups. Also, E2, E2-BSA, and G1 reduced brain edema, inflammation, and apoptosis. The ICI and G15 inhibited the beneficial effects of E2, E2-BSA, and G1 on these parameters. All drugs, following TBI, prevented the reduction of brain PI3K/p-Akt expression. The individual or combined use of ICI and G15 eliminated the beneficial effects of E2, E2-BSA, and G1 on PI3K/p-Akt expressions.Conclusions: These findings indicated that PI3K/p-Akt pathway plays a critical role in mediating the salutary effects of estradiol on histopathological changes and neurological outcomes following TBI, suggesting that GPER and classic ERs are involved in regulating the expression of PI3K/p-Akt.","PeriodicalId":13224,"journal":{"name":"Hormone Molecular Biology and Clinical Investigation","volume":" ","pages":"1-15"},"PeriodicalIF":1.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140174502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0