Association of serum NF-κB levels with peripheral neuropathy in type 2 diabetes mellitus patients: a pilot study.

IF 1.1 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Hormone Molecular Biology and Clinical Investigation Pub Date : 2024-03-21 eCollection Date: 2024-03-01 DOI:10.1515/hmbci-2022-0105

Nibedita Priyadarsini, Madumathy Ramachandran, Kishore K Behera, Sheetal Kiran, Sujata Devi

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引用次数: 0

Abstract

Objectives: Hyperglycaemia-induced inflammation plays a vital role in the development of diabetic peripheral neuropathy (DPN). Recent evidences had reported the involvement of the transcription factor nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) in diabetic experimental models. So, this pilot study aimed to evaluate serum NF-κB levels in DPN patients.

Methods: We recruited 50 T2DM patients, of which 25 were T2DM with neuropathy and 25 were T2DM without neuropathy. In all the participants peripheral neuropathy was diagnosed based on Total neuropathy score (TNS). Serum NF-κB levels were measured by ELISA.

Results: We observed that the serum NF-κB levels were higher in DPN patients in comparison to T2DM patients without neuropathy. On spearman correlation, a positive correlation was found between serum NF-κB levels and TNS in the DPN group (r=0.741, p<0.001). The regression model shows the TNS to be an independent determinant of serum NF-κB levels after adjustment for potential confounders like age, duration of diabetes, and HbA1C (B=81.34; p<0.001).

Conclusions: NF-κB activation plays a key role in promoting inflammation which is associated with the progression of DPN. In this respect, the study of NF-κB levels in serum may be an additional diagnostic marker for DPN.

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2 型糖尿病患者血清 NF-κB 水平与周围神经病变的关系：一项试点研究。

目的：高血糖诱发的炎症在糖尿病周围神经病变（DPN）的发展过程中起着至关重要的作用。最近有证据表明，活化 B 细胞的核因子卡巴轻链增强子（NF-κB）转录因子参与了糖尿病实验模型。因此，本试验性研究旨在评估 DPN 患者的血清 NF-κB 水平：我们招募了 50 名 T2DM 患者，其中 25 名是有神经病变的 T2DM 患者，25 名是没有神经病变的 T2DM 患者。所有参与者的周围神经病变均根据总神经病变评分（TNS）进行诊断。血清 NF-κB 水平通过 ELISA 检测：我们观察到，与没有神经病变的 T2DM 患者相比，DPN 患者的血清 NF-κB 水平更高。在矛曼相关性研究中，我们发现 DPN 组血清 NF-κB 水平与 TNS 呈正相关（r=0.741，p 结论：NF-κB 水平与 TNS 呈正相关：NF-κB活化在促进炎症中起着关键作用，而炎症与DPN的进展有关。因此，研究血清中的 NF-κB 水平可能是诊断 DPN 的另一个指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hormone Molecular Biology and Clinical Investigation BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.60

自引率

0.00%

发文量

期刊介绍： Hormone Molecular Biology and Clinical Investigation (HMBCI) is dedicated to the provision of basic data on molecular aspects of hormones in physiology and pathophysiology. The journal covers the treatment of major diseases, such as endocrine cancers (breast, prostate, endometrium, ovary), renal and lymphoid carcinoma, hypertension, cardiovascular systems, osteoporosis, hormone deficiency in menopause and andropause, obesity, diabetes, brain and related diseases, metabolic syndrome, sexual dysfunction, fetal and pregnancy diseases, as well as the treatment of dysfunctions and deficiencies. HMBCI covers new data on the different steps and factors involved in the mechanism of hormone action. It will equally examine the relation of hormones with the immune system and its environment, as well as new developments in hormone measurements. HMBCI is a blind peer reviewed journal and publishes in English: Original articles, Reviews, Mini Reviews, Short Communications, Case Reports, Letters to the Editor and Opinion papers. Ahead-of-print publishing ensures faster processing of fully proof-read, DOI-citable articles.