Exercise modulation in inflammation and metabolic hormonal disorders of COVID-19 to decrease risk factors in coronary heart disease.

IF 1.1 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Hormone Molecular Biology and Clinical Investigation Pub Date : 2023-06-01 DOI:10.1515/hmbci-2022-0040

Sahar Avazpour, Amin Amini, Hossein Shirvani, Ehsan Arabzadeh

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引用次数: 1

Abstract

Objectives: Sedentary life style separated during COVID-19 pandemic. Patients with cardiovascular diseases (CVD) are vulnerable with sedentary life style. Therefore, the aim of this study was to investigate the effect of 8 weeks of combined and high intensity interval training (HIIT) on C Reactive protein, galectin-3, leptin, fibrinogen and insulin resistance index in coronary heart disease after COVID-19.

Methods: Thirty-six cardiovascular patients (55.14 ± 1.4 years, 78.6 ± 5.1 kg) were divided into three groups of combined exercise (n=13), HIIT (n=12) and control group (n=11). Combined exercise consisted of aerobic (4 weeks) and aerobic + HIIT exercise (4 weeks), three sessions per weeks. The protocol of the HIIT group included performing high intensity interval training, three sessions per weeks for 8 weeks. Blood samples were taken 24 h before the first training session and 48 h after the last training. C Reactive protein (CRP), galectin-3, leptin, fibrinogen measured with ELISA kit.

Results: CRP, galectin-3 and fibrinogen decreased significantly after 8 weeks of combined training and HIIT (compare to pre-test). Also, insulin resistance index after 8 weeks of combined exercise showed a significant decrease compare to pre-test (p<0.05). After 8 weeks, CRP, galectin-3 and insulin resistance significantly decreased compare to control group (p<0.05).

Conclusions: In the patient with CVD, combined exercise training may be more effective than HIIT in reducing metabolic and heart risk factors after an epidemic such as COVID-19. However, change of leptin need to more studies.

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运动调节COVID-19的炎症和代谢激素紊乱以减少冠心病的危险因素

目的:在COVID-19大流行期间分离的久坐生活方式。心血管疾病(CVD)患者易患久坐不动的生活方式。因此，本研究旨在探讨8周联合高强度间歇训练(HIIT)对COVID-19后冠心病患者C反应蛋白、半乳糖凝集素-3、瘦素、纤维蛋白原和胰岛素抵抗指数的影响。方法:36例心血管患者(55.14±1.4岁，78.6±5.1 kg)分为联合运动组(n=13)、HIIT组(n=12)和对照组(n=11)。联合运动包括有氧运动(4周)和有氧+ HIIT运动(4周)，每周三次。HIIT组的方案包括进行高强度间歇训练，每周三次，持续8周。在第一次训练前24小时和最后一次训练后48小时采集血样。用ELISA试剂盒测定C反应蛋白(CRP)、半凝集素-3、瘦素、纤维蛋白原。结果:训练与HIIT联合训练8周后，CRP、半凝集素-3和纤维蛋白原显著降低(与试验前相比)。同时，与试验前相比，联合运动8周后胰岛素抵抗指数显著降低(p结论:在CVD患者中，联合运动训练可能比HIIT更有效地降低COVID-19等流行病后的代谢和心脏危险因素。然而，瘦素的变化需要更多的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hormone Molecular Biology and Clinical Investigation BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.60

自引率

0.00%

发文量

期刊介绍： Hormone Molecular Biology and Clinical Investigation (HMBCI) is dedicated to the provision of basic data on molecular aspects of hormones in physiology and pathophysiology. The journal covers the treatment of major diseases, such as endocrine cancers (breast, prostate, endometrium, ovary), renal and lymphoid carcinoma, hypertension, cardiovascular systems, osteoporosis, hormone deficiency in menopause and andropause, obesity, diabetes, brain and related diseases, metabolic syndrome, sexual dysfunction, fetal and pregnancy diseases, as well as the treatment of dysfunctions and deficiencies. HMBCI covers new data on the different steps and factors involved in the mechanism of hormone action. It will equally examine the relation of hormones with the immune system and its environment, as well as new developments in hormone measurements. HMBCI is a blind peer reviewed journal and publishes in English: Original articles, Reviews, Mini Reviews, Short Communications, Case Reports, Letters to the Editor and Opinion papers. Ahead-of-print publishing ensures faster processing of fully proof-read, DOI-citable articles.