Brown adipose tissue as an endocrine organ: updates on the emerging role of batokines.

IF 1.1 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Hormone Molecular Biology and Clinical Investigation Pub Date : 2023-06-01 DOI:10.1515/hmbci-2022-0044

Fabiane Ferreira Martins, Vanessa Souza-Mello, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda

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引用次数: 7

Abstract

Brown adipose tissue (BAT) remains active in adults, oxidizing fatty acids or glucose and releasing energy in the form of heat. Brown adipocytes and enhanced thermogenesis are targets for treating obesity and its comorbidities. BAT shows high synthesis activity and secretes several signaling molecules. The brown adipokines, or batokines, take action in an autocrine, paracrine, and endocrine manner. Batokines have a role in the homeostasis of the cardiovascular system, central nervous system, white adipose tissue, liver, and skeletal muscle and exert beneficial effects on BAT. The systemic function of batokines gives BAT an endocrine organ profile. Besides, the batokines Fibroblast Growth Factor-21, Vascular Endothelial Growth Factor A, Bone Morphogenetic Protein 8, Neuregulin 4, Myostatin, and Interleukin-6 emerge as targets to treat obesity and its comorbidities, deserving attention. This review outlines the role of six emerging batokines on BAT and their cross-talk with other organs, focusing on their physiological significance and diet-induced changes.

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褐色脂肪组织作为内分泌器官:细胞因子新作用的最新进展。

棕色脂肪组织(BAT)在成年人体内保持活性，氧化脂肪酸或葡萄糖，并以热的形式释放能量。褐色脂肪细胞和增强产热作用是治疗肥胖及其合并症的靶点。BAT具有较高的合成活性，并分泌多种信号分子。棕色脂肪因子或脂肪因子以自分泌、旁分泌和内分泌的方式起作用。Batokines在心血管系统、中枢神经系统、白色脂肪组织、肝脏和骨骼肌的稳态中发挥作用，并对BAT发挥有益作用。batokines的系统功能使BAT具有内分泌器官的特征。此外，成纤维细胞生长因子-21、血管内皮生长因子A、骨形态发生蛋白8、神经调节蛋白4、肌生长抑制素和白细胞介素-6等细胞因子成为治疗肥胖及其合并症的靶点，值得关注。本文综述了六种新兴的batokines在BAT中的作用及其与其他器官的相互作用，重点介绍了它们的生理意义和饮食诱导的变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hormone Molecular Biology and Clinical Investigation BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.60

自引率

0.00%

发文量

期刊介绍： Hormone Molecular Biology and Clinical Investigation (HMBCI) is dedicated to the provision of basic data on molecular aspects of hormones in physiology and pathophysiology. The journal covers the treatment of major diseases, such as endocrine cancers (breast, prostate, endometrium, ovary), renal and lymphoid carcinoma, hypertension, cardiovascular systems, osteoporosis, hormone deficiency in menopause and andropause, obesity, diabetes, brain and related diseases, metabolic syndrome, sexual dysfunction, fetal and pregnancy diseases, as well as the treatment of dysfunctions and deficiencies. HMBCI covers new data on the different steps and factors involved in the mechanism of hormone action. It will equally examine the relation of hormones with the immune system and its environment, as well as new developments in hormone measurements. HMBCI is a blind peer reviewed journal and publishes in English: Original articles, Reviews, Mini Reviews, Short Communications, Case Reports, Letters to the Editor and Opinion papers. Ahead-of-print publishing ensures faster processing of fully proof-read, DOI-citable articles.