Exploration of meteorin-like peptide (metrnl) predictors in type 2 diabetic patients: the potential role of irisin, and other biochemical parameters.

IF 1.1 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Hormone Molecular Biology and Clinical Investigation Pub Date : 2023-06-01 DOI:10.1515/hmbci-2022-0037

Yaser Khajebishak, Amir Hossein Faghfouri, Ali Soleimani, Sadra Madani, Laleh Payahoo

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引用次数: 1

Abstract

Objectives: Meteorin-like peptide (Metrnl), the newly discovered adipokines involves in glucose and lipid metabolism and energy homeostasis. The aim of the present study was to explore the potential predictors of Metrnl by emphasizing the Irisin, glycemic indices, and lipid profile biomarkers in type 2 diabetic patients.

Methods: This cross-sectional study was carried out on 32 obese types 2 diabetic patients, 31 healthy obese, and 30 healthy normal weight people between August 2020 and March 2021. Serum Metrnl and Irisin, fasting blood glucose (FBS), fasting insulin (FI), fasting insulin (FI), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), HbA_1c and eAG levels were measured in a standard manner. To assay insulin resistance and insulin sensitivity, the homeostatic model assessment insulin resistance (HOMA-IR) and quantitative check index (QUICKI) model were used. Quantile regression analysis with the backward elimination method was used to explore predictors. The significant level was defined as p<0.05.

Results: Between variables entered into the model, only the group item showed to be the main predictor of Metrnl in type 2 diabetic patients. Besides, the serum level of Irisin was lower in diabetic patients, and a significant difference was detected between obese diabetic patients and the normal weight group (p=0.024).

Conclusions: Given the multi-causality of diabetes and also the possible therapeutic role of Metrnl in the management of type 2 diabetic patients' abnormalities, designing future studies are needed to discover other predictors of Metrnl and the related mechanisms of Metrnl in the management of diabetes.

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2型糖尿病患者流星样肽(metrnl)预测因子的探索:鸢尾素和其他生化参数的潜在作用

目的:流星蛋白样肽(Metrnl)是一种新发现的脂肪因子，参与糖脂代谢和能量稳态。本研究的目的是通过强调2型糖尿病患者的鸢尾素、血糖指数和脂质谱生物标志物来探索潜在的预测因子。方法:本研究于2020年8月至2021年3月对32例肥胖2型糖尿病患者、31例健康肥胖者和30例健康正常体重者进行横断面研究。按标准方法测定血清Metrnl、Irisin、空腹血糖(FBS)、空腹胰岛素(FI)、空腹胰岛素(FI)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、HbA1c、eAG水平。采用胰岛素抵抗稳态模型(HOMA-IR)和定量检查指数(QUICKI)模型测定胰岛素抵抗和胰岛素敏感性。采用分位数回归分析和反向消去法探讨预测因素。结果:在输入模型的变量中，只有组项显示为2型糖尿病患者Metrnl的主要预测因子。糖尿病患者血清鸢尾素水平较低，肥胖糖尿病患者与正常体重糖尿病患者血清鸢尾素水平差异有统计学意义(p=0.024)。结论:考虑到糖尿病的多因果关系，以及Metrnl在2型糖尿病患者异常管理中的可能治疗作用，需要设计未来的研究，以发现Metrnl的其他预测因素以及Metrnl在糖尿病管理中的相关机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hormone Molecular Biology and Clinical Investigation BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.60

自引率

0.00%

发文量

期刊介绍： Hormone Molecular Biology and Clinical Investigation (HMBCI) is dedicated to the provision of basic data on molecular aspects of hormones in physiology and pathophysiology. The journal covers the treatment of major diseases, such as endocrine cancers (breast, prostate, endometrium, ovary), renal and lymphoid carcinoma, hypertension, cardiovascular systems, osteoporosis, hormone deficiency in menopause and andropause, obesity, diabetes, brain and related diseases, metabolic syndrome, sexual dysfunction, fetal and pregnancy diseases, as well as the treatment of dysfunctions and deficiencies. HMBCI covers new data on the different steps and factors involved in the mechanism of hormone action. It will equally examine the relation of hormones with the immune system and its environment, as well as new developments in hormone measurements. HMBCI is a blind peer reviewed journal and publishes in English: Original articles, Reviews, Mini Reviews, Short Communications, Case Reports, Letters to the Editor and Opinion papers. Ahead-of-print publishing ensures faster processing of fully proof-read, DOI-citable articles.