Hippocampus最新文献_第6页

Hippocampal NOP Receptor Activation Impairs Object Recognition Memory Acquisition. 海马NOP受体激活损害物体识别记忆获取。

IF 2.9 3区医学

Hippocampus Pub Date : 2026-05-01 DOI: 10.1002/hipo.70104

Lucas Ribeiro, Rodrigo Orvate, Johseph P de Souza, Ana Luizi Baracho, Gênedy Apolinario, Martín Cammarota, Janine I Rossato

{"title":"Hippocampal NOP Receptor Activation Impairs Object Recognition Memory Acquisition.","authors":"Lucas Ribeiro, Rodrigo Orvate, Johseph P de Souza, Ana Luizi Baracho, Gênedy Apolinario, Martín Cammarota, Janine I Rossato","doi":"10.1002/hipo.70104","DOIUrl":"10.1002/hipo.70104","url":null,"abstract":"Nociceptin/orphanin FQ (N/OFQ), the endogenous ligand of the NOP receptor, modulates learning and memory, yet its precise hippocampal function remains unclear. Here, we examined how activation of hippocampal NOP receptors influences distinct stages of object recognition memory (ORM) processing. Adult male Wistar rats trained in the novel object recognition task received bilateral intra-dorsal CA1 infusions of N/OFQ either 20 min before or 5 min after training, or 20 min before a 1-day retention test. Pre-training N/OFQ infusion markedly impaired ORM retention without affecting locomotor or exploratory behavior, whereas post-training or pre-test infusions had no effect, even at more than threefold higher. The selective NOP receptor antagonist UFP-101 completely blocked the amnesic effect of N/OFQ but had no influence alone. Pre-training N/OFQ administration also failed to alter performance in the step-down inhibitory avoidance task, excluding sensory or motivational confounds. Thus, hippocampal NOP receptor activation selectively disrupts ORM acquisition while sparing consolidation and recall, identifying the N/OFQ-NOP system as a negative modulator of hippocampal encoding mechanisms critical for recognition memory formation.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"36 3","pages":"e70104"},"PeriodicalIF":2.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148005247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissociable Mechanisms Underlie Differences Between Memory and Metamemory in Older Adults: The Differentiating Role of Anxiety and Depression Symptoms. 老年人记忆和元记忆差异的可解离机制：焦虑和抑郁症状的区分作用

IF 2.9 3区医学

Hippocampus Pub Date : 2026-05-01 DOI: 10.1002/hipo.70100

Jennifer L Crawford, Alex A Adornato, Johanna Matulonis, Xi Chen, Jacob M Hooker, Anne S Berry

{"title":"Dissociable Mechanisms Underlie Differences Between Memory and Metamemory in Older Adults: The Differentiating Role of Anxiety and Depression Symptoms.","authors":"Jennifer L Crawford, Alex A Adornato, Johanna Matulonis, Xi Chen, Jacob M Hooker, Anne S Berry","doi":"10.1002/hipo.70100","DOIUrl":"10.1002/hipo.70100","url":null,"abstract":"The ability to remember (i.e., memory ability) and to accurately discern memory function (i.e., metamemory) are both important facets of cognition. In the present study, we examined the shared and distinct sources of variance across memory ability and metamemory using psychometrically validated measures of memory ability, metamemory, and anxiety and depression symptoms in conjunction with multimodal imaging (i.e., structural MRI, tau PET) in a sample of cognitively normal older adults (N = 72). Replicating a growing body of work, we found that metamemory was more tightly linked to anxiety and depression symptoms relative to objective measures of memory ability. Our results also revealed that the hippocampus was a critical locus of both memory ability and metamemory-hippocampal volume was positively associated with memory ability, but not metamemory, whereas increased hippocampal tau pathology exacerbated the negative effect of anxiety and depression symptoms on metamemory. Importantly, we also found that after controlling for anxiety and depression symptoms and tau burden, there was a positive association between memory ability and metamemory. Our findings also demonstrated the importance of assessing different facets of metamemory; self-reported memory contentment and ability, but not strategy use, showed the strongest relationships with both anxiety and depression symptoms and hippocampal tau burden. Together, these results suggest that both shared and distinct mechanisms underlie memory ability and metamemory processes in older adults. Chiefly, this work highlights the potential of metamemory measures as sensitive tools to understand affective processes that occur in both healthy and pathological aging, independent of memory ability.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"36 3","pages":"e70100"},"PeriodicalIF":2.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Dentate Gyrus Grows Throughout Life Despite Turnover of Developmentally-Born Neurons. 尽管发育中出生的神经元不断更新，但齿状回在整个生命过程中都在生长。

IF 2.9 3区医学

Hippocampus Pub Date : 2026-05-01 DOI: 10.1002/hipo.70099

Tina Ciric, Shaina P Cahill, Tyler Lin, Si-Ah Choi, Jason S Snyder

{"title":"The Dentate Gyrus Grows Throughout Life Despite Turnover of Developmentally-Born Neurons.","authors":"Tina Ciric, Shaina P Cahill, Tyler Lin, Si-Ah Choi, Jason S Snyder","doi":"10.1002/hipo.70099","DOIUrl":"10.1002/hipo.70099","url":null,"abstract":"Adult-born hippocampal neurons are highly plastic but there remains uncertainty about the magnitude of neurogenesis and its long-term functional consequences. Theoretical predictions indicate that adult neurogenesis should lead to substantial growth of the dentate gyrus (DG) granule cell population. However, in practice, most studies find no changes in total cell number across adulthood. This discrepancy may partly be a sensitivity issue, where small sample sizes and the examination of older age windows (when neurogenesis is reduced) have prevented detection. However, neurogenic growth could also be masked by the turnover of developmentally-born DG neurons, which are known to die off in normal aging. To address the question of how neuronal birth and loss impacts DG population dynamics, here we quantified numbers of developmentally-born neurons, proliferating Ki67+ cells (as a proxy for adult-born neurons), and total DG neurons from 2-18 months of age in the rat. We estimate that over this timeframe 670,000 adult-born neurons are added (30% of the total population). Consistent with neurogenic growth, the total number of DG neurons increased across adulthood. However, net growth was only 385,000 cells, which is less than predicted by adult neurogenesis alone. Indeed, 20% of developmentally-born neurons were lost over the same interval, and so we propose that the difference is explained by neuronal turnover. Neuronal persistence and turnover may be relevant for theories of hippocampal long-term memory, as well as for understanding psychiatric conditions that are characterized by hippocampal plasticity and atrophy.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"36 3","pages":"e70099"},"PeriodicalIF":2.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative and Morphometric Measures in the Human Hippocampal Tail Using Ex Vivo Imaging Validated With Histology. 用离体成像和组织学验证对人类海马尾进行定量和形态测量。

IF 2.9 3区医学

Hippocampus Pub Date : 2026-05-01 DOI: 10.1002/hipo.70101

Anne M Alexander, Emma W Rosenblum, Nathaniel Mercaldo, Erin-Marie C Smith, Chiara Mauri, Bruce Fischl, Ruopeng Wang, Matthew P Frosch, André J W van der Kouwe, Jean C Augustinack

{"title":"Quantitative and Morphometric Measures in the Human Hippocampal Tail Using Ex Vivo Imaging Validated With Histology.","authors":"Anne M Alexander, Emma W Rosenblum, Nathaniel Mercaldo, Erin-Marie C Smith, Chiara Mauri, Bruce Fischl, Ruopeng Wang, Matthew P Frosch, André J W van der Kouwe, Jean C Augustinack","doi":"10.1002/hipo.70101","DOIUrl":"10.1002/hipo.70101","url":null,"abstract":"The human hippocampal tail is the posterior-most portion of the hippocampus and has been implicated in brain disorders, such as depression, panic disorder, and epilepsy. The tail's clinical relevance and volumetric variability exhibit a need for improved characterization with high-resolution imaging and histology at baseline. MRI provides three-dimensional context without missing slices and histology validates with architecture; combining these methods provides an optimal approach. Twenty control brain hemispheres were evaluated, including 10 males and 10 females. We scanned the hemispheres using ex vivo MRI at 120 μm isotropic resolution. The tissue was then processed and histologically stained. We manually labeled the hippocampal tail in high-resolution MRI, using six distinct coronal levels of the tail as guideposts, validating histologically. The volume and length of the tails were calculated using 3D MRI reconstructions; the median tail volume (median ± interquartile range) of our sample set was 715.6 ± 227.5 mm3. These data contribute a validated hippocampal tail volume. We calculated and quantified the medial flexure of the tail and compared sex as a biological variable. Male tail samples exhibited significantly larger angles than female samples (Mann-Whitney U test, p = 0.01). Our findings enable precise hippocampal tail delineation and may facilitate future research on function and mental health disorders.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"36 3","pages":"e70101"},"PeriodicalIF":2.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13168921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147928945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological Profile of Early Sharp Waves in the Neonatal Rat Hippocampus. 新生大鼠海马早期锐波的药理学特征。

IF 2.9 3区医学

Hippocampus Pub Date : 2026-05-01 DOI: 10.1002/hipo.70098

Dmitrii Shipkov, Daria Vinokurova, Karina Tukhvatullina, Guzel Valeeva

{"title":"Pharmacological Profile of Early Sharp Waves in the Neonatal Rat Hippocampus.","authors":"Dmitrii Shipkov, Daria Vinokurova, Karina Tukhvatullina, Guzel Valeeva","doi":"10.1002/hipo.70098","DOIUrl":"10.1002/hipo.70098","url":null,"abstract":"Early activity patterns support the development of neuronal networks by promoting synaptic plasticity. In the hippocampus of neonatal rats and mice in vivo, early sharp waves (eSPWs) are the first pattern of synchronized network activity. The activation of glutamate- and GABA(A)-mediated synaptic currents was described during eSPWs. However, the contribution of different receptor subtypes to eSPW generation is still obscure. To explore the receptor mechanisms of eSPW generation we used a «superfused hippocampus» preparation, which allows a drug application directly to the large area of the hippocampal surface in vivo. Using silicon probe recordings from the superfused hippocampus of neonatal Wistar rats, we assessed electrophysiological properties of eSPWs in control conditions and during the superfusion with glutamate and GABA receptor antagonists. We showed that blocking the AMPA/kainate and NMDA glutamate receptors reduced to a different degree the eSPW frequency and neuronal firing associated with eSPWs. Only when applied simultaneously did the AMPA/kainate and NMDA receptor antagonists completely suppress eSPWs. At the same time, GABA(A) receptors appeared to have a limited role in eSPW generation as eSPWs persisted after GABA(A) receptor blockade alternating with recurrent epileptiform discharges; yet, eSPW amplitude was reduced after epileptiform activity onset. We also observed no changes in eSPW properties produced by blocking the GABA(B) receptors. Taken together, our findings reveal a predominant involvement of AMPA/kainate and NMDA glutamate receptors in eSPW generation and emphasize the role of eSPWs in providing conditions for NMDA receptor-mediated plasticity in the developing hippocampus.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"36 3","pages":"e70098"},"PeriodicalIF":2.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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IF 2.7 3区医学

Hippocampus Pub Date : 2026-04-19

引用次数: 0

IF 2.7 3区医学

Hippocampus Pub Date : 2026-04-19

引用次数: 0

IF 2.7 3区医学

Hippocampus Pub Date : 2026-04-19

引用次数: 0

IF 2.7 3区医学

Hippocampus Pub Date : 2026-04-19