Hippocampus最新文献

{"title":"Correction to “A complex relation between levels of adult hippocampal neurogenesis and expression of the immature neuron marker doublecortin”","authors":"","doi":"10.1002/hipo.23590","DOIUrl":"10.1002/hipo.23590","url":null,"abstract":"<p>Mendez-David, I., David, D. J., Deloménie, C., Tritschler, L., Beaulieu, J.-M., Colle, R., Corruble, E., Gardier, A. M., &amp; Hen, R. (2023). A complex relation between levels of adult hippocampal neurogenesis and expression of the immature neuron marker doublecortin. <i>Hippocampus</i>, <i>33</i>(10), 1075–1093. https://doi.org/10.1002/hipo.23568</p><p>In the originally published version of the article, Laurent Tritschler was incorrectly spelled as Laurent Tritchler. The online version of this article has been corrected accordingly.</p><p>We apologize for this error.</p>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"34 2","pages":"123"},"PeriodicalIF":3.5,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.23590","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138459694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information - Editorial Board","authors":"","doi":"10.1002/hipo.23446","DOIUrl":"https://doi.org/10.1002/hipo.23446","url":null,"abstract":"","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"33 12","pages":"1233"},"PeriodicalIF":3.5,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.23446","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138431785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational models can distinguish the contribution from different mechanisms to familiarity recognition","authors":"John Read,&nbsp;Emma Delhaye,&nbsp;Jacques Sougné","doi":"10.1002/hipo.23588","DOIUrl":"10.1002/hipo.23588","url":null,"abstract":"<p>Familiarity is the strange feeling of knowing that something has already been seen in our past. Over the past decades, several attempts have been made to model familiarity using artificial neural networks. Recently, two learning algorithms successfully reproduced the functioning of the perirhinal cortex, a key structure involved during familiarity: Hebbian and anti-Hebbian learning. However, performance of these learning rules is very different from one to another thus raising the question of their complementarity. In this work, we designed two distinct computational models that combined Deep Learning and a Hebbian learning rule to reproduce familiarity on natural images, the Hebbian model and the anti-Hebbian model, respectively. We compared the performance of both models during different simulations to highlight the inner functioning of both learning rules. We showed that the anti-Hebbian model fits human behavioral data whereas the Hebbian model fails to fit the data under large training set sizes. Besides, we observed that only our Hebbian model is highly sensitive to homogeneity between images. Taken together, we interpreted these results considering the distinction between absolute and relative familiarity. With our framework, we proposed a novel way to distinguish the contribution of these familiarity mechanisms to the overall feeling of familiarity. By viewing them as complementary, our two models allow us to make new testable predictions that could be of interest to shed light on the familiarity phenomenon.</p>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"34 1","pages":"36-50"},"PeriodicalIF":3.5,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138176045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal TMEM55B overexpression in the 5XFAD mouse model of Alzheimer's disease","authors":"Kristian F. Odfalk,&nbsp;Jessica L. Wickline,&nbsp;Sabrina Smith,&nbsp;Radek Dobrowolski,&nbsp;Sarah C. Hopp","doi":"10.1002/hipo.23586","DOIUrl":"10.1002/hipo.23586","url":null,"abstract":"<p>Dysfunction of the endosomal-lysosomal network is a notable feature of Alzheimer's disease (AD) pathology. Dysfunctional endo-lysosomal vacuoles accumulate in dystrophic neurites surrounding amyloid β (Aβ) plaques and may be involved in the pathogenesis and progression of Aβ aggregates. Trafficking and thus maturation of these dysfunctional vacuoles is disrupted in the vicinity of Aβ plaques. Transmembrane protein 55B (TMEM55B), also known as phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 (PIP4P1) is an endo-lysosomal membrane protein that is necessary for appropriate trafficking of endo-lysosomes. The present study tested whether overexpression of TMEM55B in the hippocampus could prevent plaque-associated axonal accumulation of dysfunctional endo-lysosomes, reduce Aβ plaque load, and prevent hippocampal-dependent learning and memory deficits in the 5XFAD mouse models of Aβ plaque pathology. Immunohistochemical analyses revealed a modest but significant reduction in the accumulation of endo-lysosomes in dystrophic neurites surrounding Aβ plaques, but there was no change in hippocampal-dependent memory or plaque load. Overall, these data indicate a potential role for TMEM55B in reducing endo-lysosomal dysfunction during AD-like Aβ pathology.</p>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"34 1","pages":"29-35"},"PeriodicalIF":3.5,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92153743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Granule cells perform frequency-dependent pattern separation in a computational model of the dentate gyrus","authors":"Selena Singh,&nbsp;Suzanna Becker,&nbsp;Thomas Trappenberg,&nbsp;Abraham Nunes","doi":"10.1002/hipo.23585","DOIUrl":"10.1002/hipo.23585","url":null,"abstract":"<p>Mnemonic discrimination (MD) may be dependent on oscillatory perforant path input frequencies to the hippocampus in a “U”-shaped fashion, where some studies show that slow and fast input frequencies support MD, while other studies show that intermediate frequencies disrupt MD. We hypothesize that pattern separation (PS) underlies frequency-dependent MD performance. We aim to study, in a computational model of the hippocampal dentate gyrus (DG), the network and cellular mechanisms governing this putative “U”-shaped PS relationship. We implemented a biophysical model of the DG that produces the hypothesized “U”-shaped input frequency–PS relationship, and its associated oscillatory electrophysiological signatures. We subsequently evaluated the network's PS ability using an adapted spatiotemporal task. We undertook systematic lesion studies to identify the network-level mechanisms driving the “U”-shaped input frequency-PS relationship. A minimal circuit of a single granule cell (GC) stimulated with oscillatory inputs was also used to study potential cellular-level mechanisms. Lesioning synapses onto GCs did not impact the “U”-shaped input frequency–PS relationship. Furthermore, GC inhibition limits PS performance for fast frequency inputs, while enhancing PS for slow frequency inputs. GC interspike interval was found to be input frequency dependent in a “U”-shaped fashion, paralleling frequency-dependent PS observed at the network level. Additionally, GCs showed an attenuated firing response for fast frequency inputs. We conclude that independent of network-level inhibition, GCs may intrinsically be capable of producing a “U”-shaped input frequency-PS relationship. GCs may preferentially decorrelate slow and fast inputs via spike timing reorganization and high frequency filtering.</p>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"34 1","pages":"14-28"},"PeriodicalIF":3.5,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.23585","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72209144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticonvulsant effect of equilibrative nucleoside transporters 1 inhibitor in a mouse model of Dravet syndrome","authors":"Shih-Yin Ho,&nbsp;I-Chun Chen,&nbsp;Che-Wen Tsai,&nbsp;Kai-Chieh Chang,&nbsp;Chun-Jung Lin,&nbsp;Yijuang Chern,&nbsp;Horng-Huei Liou","doi":"10.1002/hipo.23584","DOIUrl":"10.1002/hipo.23584","url":null,"abstract":"<p>There are limited therapeutic options for patients with Dravet syndrome (DS). The equilibrative nucleoside transporters 1 (ENT1) mediate both the influx and efflux of adenosine across the cell membrane exerted beneficial effects in the treatment of epilepsy. This study aimed to evaluate the anticonvulsant effect of the ENT1 inhibitor in an animal model of DS (Scn1a^E1099X/+ mice). J7 (5 mg/kg) treatment was efficacious in elevating seizure threshold in Scn1a^E1099X/+ mice after hyperthermia exposure. Moreover, the J7 treatment significantly reduced the frequency of spontaneous excitatory post-synaptic currents (sEPSCs, ~35% reduction) without affecting the amplitude in dentate gyrus (DG) granule cells. Pretreatment with the adenosine A1 receptor (A1R) antagonist, DPCPX, abolished the J7 effects on sEPSCs. These observations suggest that the J7 shows an anticonvulsant effect in hyperthermia-induced seizures in Scn1a^E1099X/+ mice. This effect possibly acts on presynaptic A1R-mediated signaling modulation in granule cells.</p>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"34 1","pages":"7-13"},"PeriodicalIF":3.5,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71481010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived plausibility modulates hippocampal activity in episodic counterfactual thinking","authors":"Kaylee Miceli,&nbsp;Ricardo Morales-Torres,&nbsp;Ari Khoudary,&nbsp;Leonard Faul,&nbsp;Natasha Parikh,&nbsp;Felipe De Brigard","doi":"10.1002/hipo.23583","DOIUrl":"10.1002/hipo.23583","url":null,"abstract":"<p>Episodic counterfactual thinking (ECT) consists of imagining alternative outcomes to past personal events. Previous research has shown that ECT shares common neural substrates with episodic future thinking (EFT): our ability to imagine possible future events. Both ECT and EFT have been shown to critically depend on the hippocampus, and past research has explored hippocampal engagement as a function of the perceived plausibility of an imagined future event. However, the extent to which the hippocampus is modulated by perceived plausibility during ECT is unknown. In this study, we combine two functional magnetic resonance imaging datasets to investigate whether perceived plausibility modulates hippocampal activity during ECT. Our results indicate that plausibility parametrically modulates hippocampal activity during ECT, and that such modulation is confined to the left anterior portion of the hippocampus. Moreover, our results indicate that this modulation is positive, such that increased activity in the left anterior hippocampus is associated with higher ratings of ECT plausibility. We suggest that neither effort nor difficulty alone can account for these results, and instead suggest possible alternatives to explain the role of the hippocampus during the construction of plausible and implausible ECT.</p>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"34 1","pages":"2-6"},"PeriodicalIF":3.5,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71412049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related differences in hippocampal subfield volumes across the human lifespan: A meta-analysis","authors":"Roya Homayouni,&nbsp;Kelsey L. Canada,&nbsp;Samaah Saifullah,&nbsp;Da' Jonae Foster,&nbsp;Charlotte Thill,&nbsp;Naftali Raz,&nbsp;Ana M. Daugherty,&nbsp;Noa Ofen","doi":"10.1002/hipo.23582","DOIUrl":"10.1002/hipo.23582","url":null,"abstract":"<p>The human hippocampus (Hc) is critical for memory function across the lifespan. It is comprised of cytoarchitectonically distinct subfields: dentate gyrus (DG), cornu ammonis sectors (CA) 1-4, and subiculum, each of which may be differentially susceptible to neurodevelopmental and neurodegenerative mechanisms. Identifying age-related differences in Hc subfield volumes can provide insights into neural mechanisms of memory function across the lifespan. Limited evidence suggests that DG and CA3 volumes differ across development while other regions remain relatively stable, and studies of adulthood implicate a downward trend in all subfield volumes with prominent age effects on CA1. Due to differences in methods and limited sampling for any single study, the magnitude of age effects on Hc subfield volumes and their probable lifespan trajectories remain unclear. Here, we conducted a meta-analysis on cross-sectional studies (<i>n</i> = 48,278 participants, ages = 4–94 years) to examine the association between age and Hc subfield volumes in development (<i>n</i> = 11 studies), adulthood (<i>n</i> = 30 studies), and a combined lifespan sample (<i>n</i> = 41 studies) while adjusting estimates for sample sizes. In development, age was positively associated with DG and CA3-4 volumes, whereas in adulthood a negative association was observed with all subfield volumes. Notably, the observed age effects were not different across subfield volumes within each age group. All subfield volumes showed a nonlinear age pattern across the lifespan with DG and CA3-4 volumes showing a more distinct age trajectory as compared to the other subfields. Lastly, among all the study-level variables, only female percentage of the study sample moderated the age effect on CA1 volume: a higher female-to-male ratio in the study sample was linked to the greater negative association between age and CA1 volume. These results document that Hc subfield volumes differ as a function of age offering broader implications for constructing theoretical models of lifespan memory development.</p>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"33 12","pages":"1292-1315"},"PeriodicalIF":3.5,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50161493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information - Editorial Board","authors":"","doi":"10.1002/hipo.23453","DOIUrl":"https://doi.org/10.1002/hipo.23453","url":null,"abstract":"","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"33 11","pages":"1159"},"PeriodicalIF":3.5,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.23453","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50137932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A thalamo-parietal cortex circuit is critical for place-action coordination","authors":"Christine M. Simmons,&nbsp;Shawn C. Moseley,&nbsp;Jordan D. Ogg,&nbsp;Xinyu Zhou,&nbsp;Madeline Johnson,&nbsp;Wei Wu,&nbsp;Benjamin J. Clark,&nbsp;Aaron A. Wilber","doi":"10.1002/hipo.23578","DOIUrl":"10.1002/hipo.23578","url":null,"abstract":"<p>The anterior and lateral thalamus (ALT) contains head direction cells that signal the directional orientation of an individual within the environment. ALT has direct and indirect connections with the parietal cortex (PC), an area hypothesized to play a role in coordinating viewer-dependent and viewer-independent spatial reference frames. This coordination between reference frames would allow an individual to translate movements toward a desired location from memory. Thus, ALT-PC functional connectivity would be critical for moving toward remembered allocentric locations. This hypothesis was tested in rats with a place-action task that requires associating an appropriate action (left or right turn) with a spatial location. There are four arms, each offset by 90°, positioned around a central starting point. A trial begins in the central starting point. After exiting a pseudorandomly selected arm, the rat had to displace the correct object covering one of two (left versus right) feeding stations to receive a reward. For a pair of arms facing opposite directions, the reward was located on the left, and for the other pair, the reward was located on the right. Thus, each reward location had a different combination of allocentric location and egocentric action. Removal of an object was scored as correct or incorrect. Trials in which the rat did not displace any objects were scored as “no selection” trials. After an object was removed, the rat returned to the center starting position and the maze was reset for the next trial. To investigate the role of the ALT-PC network, muscimol inactivation infusions targeted bilateral PC, bilateral ALT, or the ALT-PC network. Muscimol sessions were counterbalanced and compared to saline sessions within the same animal. All inactivations resulted in decreased accuracy, but only bilateral PC inactivations resulted in increased non selecting, increased errors, and longer latency responses on the remaining trials. Thus, the ALT-PC circuit is critical for linking an action with a spatial location for successful navigation.</p>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"33 12","pages":"1252-1266"},"PeriodicalIF":3.5,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41119110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}