Hippocampus最新文献_第10页

Issue Information - Editorial Board 期刊信息 - 编辑委员会

IF 3.5 3区医学

Hippocampus Pub Date : 2023-12-21 DOI: 10.1002/hipo.23554

引用次数: 0

Hippocampal parvalbumin and perineuronal nets: Possible involvement in anxiety-like behavior in rats 海马副白蛋白和神经元周围网：可能参与大鼠的焦虑样行为

IF 3.5 3区医学

Hippocampus Pub Date : 2023-12-15 DOI: 10.1002/hipo.23595

Zhixin Fan, Xiayu Gong, Hanfang Xu, Yue Qu, Bozhi Li, Lanxin Li, Yuqi Yan, Lili Wu, Can Yan

{"title":"Hippocampal parvalbumin and perineuronal nets: Possible involvement in anxiety-like behavior in rats","authors":"Zhixin Fan, Xiayu Gong, Hanfang Xu, Yue Qu, Bozhi Li, Lanxin Li, Yuqi Yan, Lili Wu, Can Yan","doi":"10.1002/hipo.23595","DOIUrl":"10.1002/hipo.23595","url":null,"abstract":"The excitatory-inhibitory imbalance has been considered an important mechanism underlying stress-related psychiatric disorders. In the present study, rats were exposed to 6 days of inescapable foot shock (IFS) to induce stress. The open field test and elevated plus maze test showed that IFS-exposed rats exhibited increased anxiety-like behavior. Immunofluorescence showed that IFS rats had a decreased density of GAD67-immunoreactive interneurons in the dorsal hippocampal CA1 region, while no significant change in the density of CaMKIIα-immunoreactive glutamatergic neurons was seen. We investigated the expression of different interneuron subtype markers, including parvalbumin (PV), somatostatin (SST), and calretinin (CR), and noted a marked decline in the density of PV-immunoreactive interneurons in the dorsal CA1 region of IFS rats. The perineuronal net (PNN) is a specialized extracellular matrix structure primarily around PV interneurons. We used Wisteria floribunda agglutinin lectin to label the PNNs and observed that IFS rats had an increased proportion of PNN-coated PV-positive interneurons in CA1. The number of PSD95-positive excitatory synaptic puncta on the soma of PNN-free PV-positive interneurons was significantly higher than that of PNN-coated PV-positive interneurons. Our findings suggest that the effect of IFS on the hippocampal GABAergic interneurons could be cell-type-specific. Loss of PV phenotype in the dorsal hippocampal CA1 region may contribute to anxiety in rats. The dysregulated PV-PNN relationship in CA1 after traumatic stress exposure might represent one of the neurobiological correlates of the observed anxiety-like behavior.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"34 3","pages":"156-165"},"PeriodicalIF":3.5,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138685963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The medial prefrontal cortex during flexible decisions: Evidence for its role in distinct working memory processes 灵活决策过程中的内侧前额叶皮层：在不同工作记忆过程中发挥作用的证据

IF 3.5 3区医学

Hippocampus Pub Date : 2023-12-14 DOI: 10.1002/hipo.23594

Kevan Kidder, Ryan Gillis, Jesse Miles, Sheri J. Y. Mizumori

{"title":"The medial prefrontal cortex during flexible decisions: Evidence for its role in distinct working memory processes","authors":"Kevan Kidder, Ryan Gillis, Jesse Miles, Sheri J. Y. Mizumori","doi":"10.1002/hipo.23594","DOIUrl":"10.1002/hipo.23594","url":null,"abstract":"During decisions that involve working memory, task-related information must be encoded, maintained across delays, and retrieved. Few studies have attempted to causally disambiguate how different brain structures contribute to each of these components of working memory. In the present study, we used transient optogenetic disruptions of rat medial prefrontal cortex (mPFC) during a serial spatial reversal learning (SSRL) task to test its role in these specific working memory processes. By analyzing numerous performance metrics, we found: (1) mPFC disruption impaired performance during only the choice epoch of initial discrimination learning of the SSRL task; (2) mPFC disruption impaired performance in dissociable ways across all task epochs (delay, choice, return) during flexible decision-making; (3) mPFC disruption resulted in a reduction of the typical vicarious-trial-and-error rate modulation that was related to changes in task demands. Taken together, these findings suggest that the mPFC plays an outsized role in working memory retrieval, becomes involved in encoding and maintenance when recent memories conflict with task demands, and enables animals to flexibly utilize working memory to update behavior as environments change.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"34 3","pages":"141-155"},"PeriodicalIF":3.5,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138628136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Object-place-context learning impairment correlates with spatial learning impairment in aged Long–Evans rats 物体-空间-情境学习障碍与老年长耳大鼠的空间学习障碍有关

IF 3.5 3区医学

Hippocampus Pub Date : 2023-12-11 DOI: 10.1002/hipo.23591

Yuxi Chen, Audrey Branch, Cecelia Shuai, Michela Gallagher, James J. Knierim

{"title":"Object-place-context learning impairment correlates with spatial learning impairment in aged Long–Evans rats","authors":"Yuxi Chen, Audrey Branch, Cecelia Shuai, Michela Gallagher, James J. Knierim","doi":"10.1002/hipo.23591","DOIUrl":"10.1002/hipo.23591","url":null,"abstract":"The hippocampal formation is vulnerable to the process of normal aging. In humans, the extent of this age-related deterioration varies among individuals. Long–Evans rats replicate these individual differences as they age, and therefore they serve as a valuable model system to study aging in the absence of neurodegenerative diseases. In the Morris water maze, aged memory-unimpaired (AU) rats navigate to remembered goal locations as effectively as young rats and demonstrate minimal alterations in physiological markers of synaptic plasticity, whereas aged memory-impaired (AI) rats show impairments in both spatial navigation skills and cellular and molecular markers of plasticity. The present study investigates whether another cognitive domain is affected similarly to navigation in aged Long–Evans rats. We tested the ability of young, AU, and AI animals to recognize novel object-place-context (OPC) configurations and found that performance on the novel OPC recognition paradigm was significantly correlated with performance on the Morris water maze. In the first OPC test, young and AU rats, but not AI rats, successfully recognized and preferentially explored objects in novel OPC configurations. In a second test with new OPC configurations, all age groups showed similar OPC associative recognition memory. The results demonstrated similarities in the behavioral expression of associative, episodic-like memory between young and AU rats and revealed age-related, individual differences in functional decline in both navigation and episodic-like memory abilities.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"34 2","pages":"88-99"},"PeriodicalIF":3.5,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138566534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impacted spike frequency adaptation associated with reduction of KCNQ2/3 exacerbates seizure activity in temporal lobe epilepsy 与KCNQ2/3减少相关的冲击尖峰频率适应加剧了颞叶癫痫的发作活动。

IF 3.5 3区医学

Hippocampus Pub Date : 2023-12-04 DOI: 10.1002/hipo.23587

Shicheng Jiang, Bei Liu, Kaiwen Lin, Lianjun Li, Rongrong Li, Shuo Tan, Xinyu Zhang, Lei Jiang, Hong Ni, Yuanyuan Wang, Haihu Ding, Jing Hu, Hao Qian, Rongjing Ge

{"title":"Impacted spike frequency adaptation associated with reduction of KCNQ2/3 exacerbates seizure activity in temporal lobe epilepsy","authors":"Shicheng Jiang, Bei Liu, Kaiwen Lin, Lianjun Li, Rongrong Li, Shuo Tan, Xinyu Zhang, Lei Jiang, Hong Ni, Yuanyuan Wang, Haihu Ding, Jing Hu, Hao Qian, Rongjing Ge","doi":"10.1002/hipo.23587","DOIUrl":"10.1002/hipo.23587","url":null,"abstract":"Numerous epilepsy-related genes have been identified in recent decades by unbiased genome-wide screens. However, the available druggable targets for temporal lobe epilepsy (TLE) remain limited. Furthermore, a substantial pool of candidate genes potentially applicable to TLE therapy awaits further validation. In this study, we reveal the significant role of KCNQ2 and KCNQ3, two M-type potassium channel genes, in the onset of seizures in TLE. Our investigation began with a quantitative analysis of two publicly available TLE patient databases to establish a correlation between seizure onset and the downregulated expression of KCNQ2/3. We then replicated these pathological changes in a pilocarpine seizure mouse model and observed a decrease in spike frequency adaptation due to the affected M-currents in dentate gyrus granule neurons. In addition, we performed a small-scale simulation of the dentate gyrus network and confirmed that the impaired spike frequency adaptation of granule cells facilitated epileptiform activity throughout the network. This, in turn, resulted in prolonged seizure duration and reduced interictal intervals. Our findings shed light on an underlying mechanism contributing to ictogenesis in the TLE hippocampus and suggest a promising target for the development of antiepileptic drugs.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"34 2","pages":"58-72"},"PeriodicalIF":3.5,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138482351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A configural context signal simultaneously but separably drives positioning and orientation of hippocampal place fields 一个构形上下文信号同时但分离地驱动海马位置场的定位和定向。

IF 3.5 3区医学

Hippocampus Pub Date : 2023-12-02 DOI: 10.1002/hipo.23589

Han Yin Cheng, Dorothy W. Overington, Kate J. Jeffery

{"title":"A configural context signal simultaneously but separably drives positioning and orientation of hippocampal place fields","authors":"Han Yin Cheng, Dorothy W. Overington, Kate J. Jeffery","doi":"10.1002/hipo.23589","DOIUrl":"10.1002/hipo.23589","url":null,"abstract":"Effective self-localization requires that the brain can resolve ambiguities in incoming sensory information arising from self-similarities (symmetries) in the environment structure. We investigated how place cells use environmental cues to resolve the ambiguity of a rotationally symmetric environment, by recording from hippocampal CA1 in rats exploring a “2-box.” This apparatus comprises two adjacent rectangular compartments, identical but with directionally opposed layouts (cue card at one end and central connecting doorway) and distinguished by their odor contexts (lemon vs. vanilla). Despite the structural and visual rotational symmetry of the boxes, no place cells rotated their place fields. The majority changed their firing fields (remapped) between boxes but some repeated them, maintaining a translational symmetry and thus adopting a relationship to the layout that was conditional on the odor. In general, the place field ensemble maintained a stable relationship to environment orientation as defined by the odors, but sometimes the whole ensemble rotated its firing en bloc, decoupling from the odor context cues. While the individual elements of these observations—odor remapping, place field repetition, ensemble rotation, and decoupling from context—have been reported in isolation, the combination in the one experiment is incompletely explained within current models. We redress this by proposing a model in which odor cues enter into a three-way association with layout cues and head direction, creating a configural context signal that facilitates two separate processes: place field orientation and place field positioning. This configuration can subsequently still function in the absence of one of its components, explaining the ensemble decoupling from odor. We speculate that these interactions occur in retrosplenial cortex, because it has previously been implicated in context processing, and all the relevant signals converge here.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"34 2","pages":"73-87"},"PeriodicalIF":3.5,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.23589","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “A complex relation between levels of adult hippocampal neurogenesis and expression of the immature neuron marker doublecortin” 修正“成人海马神经发生水平与未成熟神经元标记物双皮质素表达之间的复杂关系”。

IF 3.5 3区医学

Hippocampus Pub Date : 2023-11-30 DOI: 10.1002/hipo.23590

引用次数: 0

Issue Information - Editorial Board 发行信息-编辑委员会

IF 3.5 3区医学

Hippocampus Pub Date : 2023-11-22 DOI: 10.1002/hipo.23446

引用次数: 0

Computational models can distinguish the contribution from different mechanisms to familiarity recognition 计算模型可以区分不同机制对熟悉度识别的贡献。

IF 3.5 3区医学

Hippocampus Pub Date : 2023-11-20 DOI: 10.1002/hipo.23588

John Read, Emma Delhaye, Jacques Sougné

{"title":"Computational models can distinguish the contribution from different mechanisms to familiarity recognition","authors":"John Read, Emma Delhaye, Jacques Sougné","doi":"10.1002/hipo.23588","DOIUrl":"10.1002/hipo.23588","url":null,"abstract":"Familiarity is the strange feeling of knowing that something has already been seen in our past. Over the past decades, several attempts have been made to model familiarity using artificial neural networks. Recently, two learning algorithms successfully reproduced the functioning of the perirhinal cortex, a key structure involved during familiarity: Hebbian and anti-Hebbian learning. However, performance of these learning rules is very different from one to another thus raising the question of their complementarity. In this work, we designed two distinct computational models that combined Deep Learning and a Hebbian learning rule to reproduce familiarity on natural images, the Hebbian model and the anti-Hebbian model, respectively. We compared the performance of both models during different simulations to highlight the inner functioning of both learning rules. We showed that the anti-Hebbian model fits human behavioral data whereas the Hebbian model fails to fit the data under large training set sizes. Besides, we observed that only our Hebbian model is highly sensitive to homogeneity between images. Taken together, we interpreted these results considering the distinction between absolute and relative familiarity. With our framework, we proposed a novel way to distinguish the contribution of these familiarity mechanisms to the overall feeling of familiarity. By viewing them as complementary, our two models allow us to make new testable predictions that could be of interest to shed light on the familiarity phenomenon.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"34 1","pages":"36-50"},"PeriodicalIF":3.5,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138176045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hippocampal TMEM55B overexpression in the 5XFAD mouse model of Alzheimer's disease 阿尔茨海默病小鼠5XFAD模型海马TMEM55B过表达

IF 3.5 3区医学

Hippocampus Pub Date : 2023-11-14 DOI: 10.1002/hipo.23586

Kristian F. Odfalk, Jessica L. Wickline, Sabrina Smith, Radek Dobrowolski, Sarah C. Hopp

{"title":"Hippocampal TMEM55B overexpression in the 5XFAD mouse model of Alzheimer's disease","authors":"Kristian F. Odfalk, Jessica L. Wickline, Sabrina Smith, Radek Dobrowolski, Sarah C. Hopp","doi":"10.1002/hipo.23586","DOIUrl":"10.1002/hipo.23586","url":null,"abstract":"Dysfunction of the endosomal-lysosomal network is a notable feature of Alzheimer's disease (AD) pathology. Dysfunctional endo-lysosomal vacuoles accumulate in dystrophic neurites surrounding amyloid β (Aβ) plaques and may be involved in the pathogenesis and progression of Aβ aggregates. Trafficking and thus maturation of these dysfunctional vacuoles is disrupted in the vicinity of Aβ plaques. Transmembrane protein 55B (TMEM55B), also known as phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 (PIP4P1) is an endo-lysosomal membrane protein that is necessary for appropriate trafficking of endo-lysosomes. The present study tested whether overexpression of TMEM55B in the hippocampus could prevent plaque-associated axonal accumulation of dysfunctional endo-lysosomes, reduce Aβ plaque load, and prevent hippocampal-dependent learning and memory deficits in the 5XFAD mouse models of Aβ plaque pathology. Immunohistochemical analyses revealed a modest but significant reduction in the accumulation of endo-lysosomes in dystrophic neurites surrounding Aβ plaques, but there was no change in hippocampal-dependent memory or plaque load. Overall, these data indicate a potential role for TMEM55B in reducing endo-lysosomal dysfunction during AD-like Aβ pathology.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"34 1","pages":"29-35"},"PeriodicalIF":3.5,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92153743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0