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The Discovery of Head Direction Cells: A Personal Account
IF 2.4 3区 医学
Hippocampus Pub Date : 2024-12-20 DOI: 10.1002/hipo.23670
Jeffrey S. Taube
{"title":"The Discovery of Head Direction Cells: A Personal Account","authors":"Jeffrey S. Taube","doi":"10.1002/hipo.23670","DOIUrl":"https://doi.org/10.1002/hipo.23670","url":null,"abstract":"<div>\u0000 \u0000 <p>This article is my recollection of events surrounding the discovery of head direction (HD) cells by Jim Ranck in 1984 and the first journal publications 6 years later. Ranck first described the fundamental properties of HD cells qualitatively in a <i>Society for Neuroscience</i> abstract (1984) and in the proceedings to a conference. Ranck, however, was convinced by Bob Muller, a faculty colleague in the lab, to delay writing up Jim's discovery until they developed a two-spot video tracking system, which would enable proper quantitative analyses. The development of this system was complex and was still undergoing development when I arrived in the Brooklyn lab in 1986. By this time, Jim had begun to refocus his efforts on thinking about the relationship between space and manifolds and was no longer engaged in active research. It thus befell me (unintentionally) to complete the recordings of these fascinating cells. This endeavor involved recording additional HD cells with the new video tracking system, monitoring the cells' responses following a series of environmental manipulations, and performing quantitative analyses on the data. Throughout 1987, I recorded most of the cells that would form the basis for our 1990 papers published in the <i>Journal of Neuroscience</i>. Along the way, there were many events and emotions: luck, excitement, humor, frustration, tutorials, unintended outcomes, and long-lasting friendships. I was guided and supported during this time by both Bob Muller and John Kubie, but remain forever grateful to Jim for this wonderful opportunity.</p>\u0000 </div>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flexible and Adaptive Behavioral Strategies: A Personal Journey
IF 2.4 3区 医学
Hippocampus Pub Date : 2024-12-20 DOI: 10.1002/hipo.23675
Sheri J. Y. Mizumori
{"title":"Flexible and Adaptive Behavioral Strategies: A Personal Journey","authors":"Sheri J. Y. Mizumori","doi":"10.1002/hipo.23675","DOIUrl":"https://doi.org/10.1002/hipo.23675","url":null,"abstract":"<div>\u0000 \u0000 <p>The ground-breaking research of patient H.M. brought to light the importance of the hippocampus for our memories of everyday and special events. Three quarters of a century of intense neurobiological and neuropsychological research would follow as scientists sought to understand why the hippocampus is such an important memory structure in the brain. Navigating a career during this time required adaptive research strategies as new evidence emerged. Although exciting progress has been made, complex challenges remain.</p>\u0000 </div>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142861879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Linking Anxiolytic Action to Hippocampal “Theta”—A Personal History
IF 2.4 3区 医学
Hippocampus Pub Date : 2024-12-20 DOI: 10.1002/hipo.23653
N. McNaughton
{"title":"Linking Anxiolytic Action to Hippocampal “Theta”—A Personal History","authors":"N. McNaughton","doi":"10.1002/hipo.23653","DOIUrl":"https://doi.org/10.1002/hipo.23653","url":null,"abstract":"<div>\u0000 \u0000 <p>This paper provides a personal history of work starting with the discovery that anxiolytic drugs reduce hippocampal theta frequency. It includes parallel work on septal elicitation of theta carried out in Jeffrey Gray's laboratory in Oxford; a statement of my original scientific perspective on the work; and a description of later work in my laboratory in New Zealand confirming the function of theta rhythmicity per se and its mediation of the effects of anxiolytic drugs on behavior. I finish with comments on risk management with such experiments and their use in larger scale theory development.</p>\u0000 </div>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142861903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unweaving the Cognitive Map: A Personal History
IF 2.4 3区 医学
Hippocampus Pub Date : 2024-12-19 DOI: 10.1002/hipo.23674
Kate J. Jeffery
{"title":"Unweaving the Cognitive Map: A Personal History","authors":"Kate J. Jeffery","doi":"10.1002/hipo.23674","DOIUrl":"10.1002/hipo.23674","url":null,"abstract":"<p>I have been incredibly fortunate to have worked in the field of hippocampal spatial coding during three of its most exciting decades, the 1990s, 2000s, and 2010s. During this time I had a ringside view of some of the foundational discoveries that were made which have transformed our understanding of the hippocampal system and its role in cognition (especially spatial cognition) and memory. These discoveries inspired me in my own lab over the years to pursue three broad lines of enquiry—3D spatial encoding, context and the sense of direction—which are outlined here. If some of my personal recollections are a little inaccurate (such is the nature of episodic memory!) I apologize in advance.</p>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.23674","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Inhibition to Exciting Science
IF 2.4 3区 医学
Hippocampus Pub Date : 2024-12-19 DOI: 10.1002/hipo.23659
György Buzsáki
{"title":"From Inhibition to Exciting Science","authors":"György Buzsáki","doi":"10.1002/hipo.23659","DOIUrl":"10.1002/hipo.23659","url":null,"abstract":"<div>\u0000 \u0000 <p>I am lucky to be part of the hippocampus story, if not from the beginning but at least in its formative decades. Being part of this community is a true privilege. As I try to illustrate below, science is made by scientists. My fierce competitors over the years have become my close friends. I hope the field of hippocampus research will stay that way forever.</p>\u0000 </div>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hippocampal Discoveries: Spatial View Cells, Connectivity, and Computations for Memory and Navigation, in Primates Including Humans
IF 2.4 3区 医学
Hippocampus Pub Date : 2024-12-17 DOI: 10.1002/hipo.23666
Edmund T. Rolls
{"title":"Hippocampal Discoveries: Spatial View Cells, Connectivity, and Computations for Memory and Navigation, in Primates Including Humans","authors":"Edmund T. Rolls","doi":"10.1002/hipo.23666","DOIUrl":"10.1002/hipo.23666","url":null,"abstract":"<p>Two key series of discoveries about the hippocampus are described. One is the discovery of hippocampal spatial view cells in primates. This discovery opens the way to a much better understanding of human episodic memory, for episodic memory prototypically involves a memory of where people or objects or rewards have been seen in locations “out there” which could never be implemented by the place cells that encode the location of a rat or mouse. Further, spatial view cells are valuable for navigation using vision and viewed landmarks, and provide for much richer, vision-based, navigation than the place to place self-motion update performed by rats and mice who live in dark underground tunnels. Spatial view cells thus offer a revolution in our understanding of the functions of the hippocampus in memory and navigation in humans and other primates with well-developed foveate vision. The second discovery describes a computational theory of the hippocampal-neocortical memory system that includes the only quantitative theory of how information is recalled from the hippocampus to the neocortex. It is shown how foundations for this research were the discovery of reward neurons for food reward, and non-reward, in the primate orbitofrontal cortex, and representations of value including of monetary value in the human orbitofrontal cortex; and the discovery of face identity and face expression cells in the primate inferior temporal visual cortex and how they represent transform-invariant information. This research illustrates how in order to understand a brain computation, a whole series of integrated interdisciplinary discoveries is needed to build a theory of the operation of each neural system.</p>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.23666","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mental Time Travel: A Retrospective 心理时空旅行：回顾。
IF 2.4 3区 医学
Hippocampus Pub Date : 2024-12-16 DOI: 10.1002/hipo.23661
A. David Redish
{"title":"Mental Time Travel: A Retrospective","authors":"A. David Redish","doi":"10.1002/hipo.23661","DOIUrl":"10.1002/hipo.23661","url":null,"abstract":"<p>Because imagination activates the same neural circuits used in understanding the present, one can access that imagination even in non-linguistic animals through decoding techniques applied to large neural ensembles. This personal retrospective traces the history of the initial discovery that hippocampal theta sequences sweep forward to goals during moments of deliberation and discusses the history that was necessary to put ourselves in the position to recognize this signal. It also discusses how that discovery fits into the larger picture of hippocampal function and the concept of cognition as computation.</p>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.23661","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuronal ‘Ensemble’ Recording and the Search for the Cell Assembly: A Personal History
IF 2.4 3区 医学
Hippocampus Pub Date : 2024-12-16 DOI: 10.1002/hipo.23669
Bruce L. McNaughton
{"title":"Neuronal ‘Ensemble’ Recording and the Search for the Cell Assembly: A Personal History","authors":"Bruce L. McNaughton","doi":"10.1002/hipo.23669","DOIUrl":"10.1002/hipo.23669","url":null,"abstract":"<p>This contribution is part of the special issue on the <i>Hippocampus</i> focused on personal histories of advances in knowledge on the hippocampus and related structures. An account is offered of the author's role in the development of neural ensemble recording: stereo recording (stereotrodes, tetrodes) and the use of this approach to search for evidence of Hebb's “cell assemblies” and “phase sequences”, the holy grail of the neuroscience of learning and memory.</p>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.23669","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibitory Postsynaptic Potentials Participate in Intracellular and Extracellular Theta Rhythms in the Hippocampus: A Personal Narrative 抑制性突触后电位参与海马的细胞内和细胞外 Theta 节律：个人叙事。
IF 2.4 3区 医学
Hippocampus Pub Date : 2024-12-13 DOI: 10.1002/hipo.23660
L. Stan Leung, Chi Yiu Conrad Yim
{"title":"Inhibitory Postsynaptic Potentials Participate in Intracellular and Extracellular Theta Rhythms in the Hippocampus: A Personal Narrative","authors":"L. Stan Leung,&nbsp;Chi Yiu Conrad Yim","doi":"10.1002/hipo.23660","DOIUrl":"10.1002/hipo.23660","url":null,"abstract":"<div>\u0000 \u0000 <p>The hypothesis that the hippocampal theta rhythm consists of inhibitory postsynaptic potentials (IPSPs) was critical for understanding the theta rhythm. The dominant views in the early 1980s were that intracellularly recorded theta consisted of excitatory postsynaptic potentials (EPSPs) with little participation by IPSPs, and that IPSPs generated a closed monopolar field in the hippocampus. I (Leung) conceived of a new model for generation of the hippocampal theta rhythm, with theta-rhythmic IPSPs as an essential component, and thus sought to reinvestigate the relation between theta and IPSPs quantitatively with intracellular and extracellular recordings. The intracellular recordings were performed by Leung and Yim in the laboratory of Kris Krnjević at McGill University. Using protocols of passing steady-state holding currents and injection of chloride ions, the intracellular theta and IPSP in a CA1 neuron typically showed the same reversal potential and correlated change in amplitude. Low-intensity stimulation of the alveus evoked an antidromic action potential in CA1 neurons, identifying them as pyramidal cells with output axons in the alveus, which then activated a feedback IPSP with almost no excitatory component. Theta-rhythmic somatic inhibition, together with phase-shifted theta-rhythmic distal apical dendritic excitation were proposed as the two dipoles that generate a gradual extracellular theta phase shift in the CA1 apical dendritic layer. The distal apical excitation driven by the entorhinal cortex was proposed to be atropine-resistant and dominated during walking in rats. Other than serving a conventional role in limiting excitation, rhythmic proximal inhibition and distal dendritic excitation provide varying phasic modulation along the soma-dendritic axis of pyramidal cells, resulting in theta phase-dependent synaptic plasticity and gamma oscillations, which are likely involved in cognitive processing.</p>\u0000 </div>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pursuing Synaptic Plasticity From Cortex to LTP in the Hippocampus 在海马中追求从皮层到 LTP 的突触可塑性
IF 2.4 3区 医学
Hippocampus Pub Date : 2024-12-13 DOI: 10.1002/hipo.23665
Tim Bliss
{"title":"Pursuing Synaptic Plasticity From Cortex to LTP in the Hippocampus","authors":"Tim Bliss","doi":"10.1002/hipo.23665","DOIUrl":"10.1002/hipo.23665","url":null,"abstract":"<p>Here I describe how an interest in synaptic plasticity took me from a PhD at McGill, where I worked on activity-dependent plasticity in the responses of single units in the association cortex of anesthetized cats, to a collaboration with Terje Lømo in Per Andersen's laboratory in Oslo in 1968–9. There we followed up on Lømo's discovery of LTP, published as an abstract in 1966, to produce the first detailed description of the phenomenon. Later, in London, Tony Gardner-Medwin and I showed that LTP lasting for days could be obtained in the awake rabbit. The two papers were published together in the <i>Journal of Physiology</i> in 1973. I relate how difficulties in replicating our results in English rabbits, and the failure of the first attempts to obtain LTP in slices of the dentate gyrus, led to my abandoning work on LTP for a few years, returning to the fray in the late 1970s through a collaboration with Graham Goddard at Dalhousie University in Halifax, Canada.</p>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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