Hippocampus最新文献

{"title":"Differential Astrocyte-Supplied NMDAR Co-Agonist for CA1 Versus Dentate Gyrus Long-Term Potentiation","authors":"Shruthi Sateesh,&nbsp;Wickliffe C. Abraham","doi":"10.1002/hipo.70029","DOIUrl":"https://doi.org/10.1002/hipo.70029","url":null,"abstract":"<p>In the hippocampus, there is a region- and synapse-specific N-methyl-D-aspartate receptor (NMDAR) co-agonist preference for induction of long-term potentiation (LTP). Schaffer collateral (SC)-CA1 synapses, enriched in GluN2A-containing NMDARs, favor D-serine, while medial perforant path (MPP) to dentate gyrus (DG) synapses that are rich in GluN2B-containing NMDARs prefer glycine for LTP induction. This study investigated the role of astrocytes in providing these co-agonists. We confirmed in rat hippocampal slices that exogenous D-serine (10 μM) is sufficient to restore LTP at SC-CA1 synapses blocked under astrocyte calcium (Ca²⁺) -clamp conditions, consistent with previous findings. However, exogenous glycine (10 μM) also rescued the LTP. In contrast, at MPP-DG synapses, 100 μM exogenous glycine, but not 10 μM nor 100 μM D-serine, restored the LTP blocked by astrocyte Ca²⁺-clamping. Our findings support the view that, as for serine in CA1, astrocytes are the cellular source of the glycine required for LTP induction at MPP-DG synapses.</p>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.70029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal Morphological Alterations and Oxidative Stress in Autism Spectrum Disorder Model Induced by Prenatal Exposure to Valproic Acid in Male and Female Mice","authors":"Zineb Bouargane,&nbsp;Fatima-Zahra Lamghari Moubarrad,&nbsp;Youssef Anouar,&nbsp;Loubna Boukhzar,&nbsp;Mohammed Bennis,&nbsp;Saadia Ba-M'Hamed","doi":"10.1002/hipo.70024","DOIUrl":"https://doi.org/10.1002/hipo.70024","url":null,"abstract":"<div>\u0000 \u0000 <p>Valproic acid (VPA), a first-line antiepileptic and mood-stabilizing drug, has been linked to congenital malformations, cognitive disabilities, and an elevated risk of autism spectrum disorder (ASD) when used during pregnancy. ASD is a lifelong developmental disorder characterized by impaired social interaction, repetitive behaviors, and cognitive deficits, with a higher prevalence in males. Growing evidence highlights that hippocampal circuits, particularly CA1 and dentate gyrus (DG) subregions, are crucial for cognitive and social functions often impaired in ASD. Notably, VPA exposure at embryonic day 12.5 (E12.5) coincides with critical neurodevelopmental processes in the hippocampus, making it highly susceptible to oxidative damage and structural disruptions. Using a mouse model of ASD induced by a single prenatal VPA injection (400 mg/kg) at E12.5, this study assessed morphological and oxidative changes in the hippocampus. Male and female offspring were evaluated for core behavioral and cognitive alterations of ASD. After the behavioral tests, their brains were processed for Golgi-Cox staining and antioxidant enzyme dosage. The results showed that prenatal exposure to VPA indeed induces ASD-like behaviors, including reduced sociability, increased repetitive behaviors, and impaired working memory. Sholl analysis showed increased dendritic branching in granule and CA1 pyramidal neurons of VPA male mice, while VPA female mice exhibited hypoarborization in dentate gyrus granule cells. Both male and female VPA mice displayed higher dendritic spine density. Concurrently, oxidative stress was increased in the hippocampi of the VPA mice, as evidenced by alterations in oxidative stress biomarkers. Our work underscores gender differences in the effects of prenatal VPA exposure and points to a possible role for hippocampal neuron morphology and oxidative stress in the pathophysiology of ASD.</p>\u0000 </div>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144573824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-State Functional Connectivity With the Anterior and Posterior Hippocampus: An Analysis of fMRI Data From the Human Connectome Project","authors":"Haley A. Fritch,&nbsp;Ashley C. Steinkrauss,&nbsp;Scott D. Slotnick","doi":"10.1002/hipo.70023","DOIUrl":"https://doi.org/10.1002/hipo.70023","url":null,"abstract":"<div>\u0000 \u0000 <p>The anterior and posterior hippocampus exhibit distinct patterns of connectivity and are consequently hypothesized to have distinct functions. While there is evidence that the posterior hippocampus interacts with the default network and the anterior hippocampus interacts with the attention network during memory processes, there are conflicting hypotheses regarding connectivity between the hippocampus and other brain regions during rest. If hippocampal connectivity during rest parallels connectivity during memory, we would expect the anterior hippocampus and posterior hippocampus to have preferential connectivity with the attention network and the default network, respectively. Alternatively, given the association between the hippocampus and the default network, both regions of the hippocampus may have similar levels of connectivity with the default network. We used data from the Human Connectome Project (with 864 participants) to investigate resting-state functional connectivity with the anterior and posterior hippocampus and evaluated the degree of overlap between these patterns of connectivity and the attention network and default network. In direct opposition to the connectivity pattern during memory, resting-state data revealed preferential connectivity between the anterior hippocampus and the default network and between the posterior hippocampus and the attention network. These findings indicate that connectivity with the anterior and posterior hippocampus may differ between rest and active memory processing. One possible explanation for this discrepancy is that, during rest, the specific connectivity patterns supporting memory are less engaged. This does not imply an overall suppression of hippocampal connectivity but rather a relative reduction in engagement with the attention and default networks compared to task-based memory states. Such a shift may facilitate more dynamic network reconfiguration during memory encoding and retrieval.</p>\u0000 </div>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144573883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPRESSION OF CONCERN: Acetyl-L-Carnitine-Mediated Neuroprotection During Hypoxia Is Attributed to ERK1/2-Nrf2-Regulated Mitochondrial Biosynthesis","authors":"","doi":"10.1002/hipo.70022","DOIUrl":"https://doi.org/10.1002/hipo.70022","url":null,"abstract":"<p>\u0000 <b>EXPRESSION OF CONCERN:</b> <span>K. B. Hota</span>, <span>S. K. Hota</span>, <span>O. P. Chaurasia</span> and <span>S. B. Singh</span>, “ <span>Acetyl-L-Carnitine-Mediated Neuroprotection During Hypoxia Is Attributed to ERK1/2-Nrf2-Regulated Mitochondrial Biosynthesis</span>,” <i>Hippocampus</i> <span>22</span>, no. <span>4</span> (<span>2012</span>): <span>723</span>–<span>736</span>, https://doi.org/10.1002/hipo.20934.\u0000 </p><p>This Expression of Concern is for the above article, published online on 03 May 2011 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief and Wiley Periodicals LLC. The Expression of Concern has been agreed upon due to overlaps observed within the images presented in Figure 1D(i). The authors provided an explanation, and although the original images for this figure were no longer accessible, the authors provided some alternative data. Despite this, doubts still remained. Although the conclusions are not believed to be affected, the journal is issuing this Expression of Concern to alert readers to the inappropriate modifications made to Figure 1D(i).</p>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic α5-GABA-A Receptor Potentiation Promotes Mouse Adult Hippocampal Neurogenesis","authors":"Thomas D. Prevot,&nbsp;Michael Marcotte,&nbsp;Denis J. David,&nbsp;Indira Mendez-David,&nbsp;Md Yeunus Mian,&nbsp;James M. Cook,&nbsp;Jean-Philippe Guilloux,&nbsp;Etienne Sibille","doi":"10.1002/hipo.70019","DOIUrl":"https://doi.org/10.1002/hipo.70019","url":null,"abstract":"<p>Several lines of evidence implicate adult hippocampal neurogenesis (AHN) in cognitive functions, in mood- and anxiety-related behaviors, and in the therapeutic effects of antidepressants. Augmenting α5-γ-Aminobutyric acid type A (GABAA) receptor function has shown neurotrophic effects in stress and aged models, but its impact on mouse AHN remains unknown. Adult male 129S6/SvEvTac mice (<i>n</i> = 30 total) were treated for 6 weeks with GL-II-73, an α5-GABAA-R-positive allosteric modulator (α5-PAM) [30 mg/kg, per os, (P.O.)] or fluoxetine, a prototypical selective serotonin reuptake inhibitor known to increase AHN (18 mg/kg, P.O.). Proliferation in the subgranular zone of the dentate gyrus (DG) was assessed by the level of Ki67, a marker of dividing cells; survival of the young neurons was assessed by retention of the 5-Bromo-2´-Deoxyuridine (BrdU) nucleotide analog injected 2 weeks before sacrifice. Finally, maturation of young adult-born neurons was evaluated by measuring the fraction of BrdU-positive cells that are also DCX and/or NeuN-positive, capturing overall maturation and speed of maturation. Similarly to fluoxetine, a chronic treatment with GL-II-73 stimulated all stages of AHN, significantly increasing neuronal progenitor proliferation, survival of adult-born granule cells, and maturation of young neurons in the DG of the hippocampus. Chronic treatment with GL-II-73, a α5-GABAA-R-positive allosteric modulator, increased AHN, including cellular proliferation, survival, and maturation of newborn neurons, to levels comparable to fluoxetine.</p>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.70019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover Image, Volume 35, Issue 4","authors":"","doi":"10.1002/hipo.70020","DOIUrl":"https://doi.org/10.1002/hipo.70020","url":null,"abstract":"<p>The cover image is based on the article <i>Loss of NFIA Impairs Adult Hippocampal Neurogenesis</i> by Mi Wang et al., https://doi.org/10.1002/hipo.70016.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Leitmotifs—The Structure and Activity Patterns of Neuronal Networks. By Roger Traub and Andreas Draguhn, Cham, Switzerland: Springer Nature, 2024. ISBN: 978-3-03-154536-8","authors":"Sten Grillner","doi":"10.1002/hipo.70018","DOIUrl":"https://doi.org/10.1002/hipo.70018","url":null,"abstract":"","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information - Editorial Board","authors":"","doi":"10.1002/hipo.23616","DOIUrl":"https://doi.org/10.1002/hipo.23616","url":null,"abstract":"","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.23616","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144197220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving Engrams Demand Changes in Effective Cues","authors":"Juan Linde-Domingo,&nbsp;Casper Kerrén","doi":"10.1002/hipo.70015","DOIUrl":"https://doi.org/10.1002/hipo.70015","url":null,"abstract":"<p>A longstanding principle in episodic memory research, known as the encoding specificity hypothesis, holds that an effective retrieval cue should closely match the original encoding conditions. This principle assumes that a successful retrieval cue remains static over time. Despite the broad acceptance of this idea, it conflicts with one of the most well-established findings in memory research: The dynamic and ever-changing nature of episodic memories. In this article, we propose that the most effective retrieval cue should engage with the current state of the memory, which may have shifted significantly since encoding. By redefining the criteria for successful recall, we challenge a core principle of the field and open new avenues for exploring memory accessibility, offering fresh insights into both theoretical, and applied domains.</p>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.70015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Theory and Model of Scene Representations With Hippocampal Spatial View Cells","authors":"Edmund T. Rolls","doi":"10.1002/hipo.70013","DOIUrl":"https://doi.org/10.1002/hipo.70013","url":null,"abstract":"<p>A theory and network model are presented of how scene representations are built by forming spatial view cells in the ventromedial visual cortical scene pathway to the hippocampus in primates including humans. Layer 1, corresponding to V1–V4, connects to Layer 2 in the retrosplenial scene area and uses competitive learning to form visual feature combination neurons for the part of the scene being fixated, a visual fixation scene patch. In Layer 3, corresponding to the parahippocampal scene area and hippocampus, the visual fixation scene patches are stitched together to form whole scene representations. This is performed with a continuous attractor network for a whole scene made from the overlapping Gaussian receptive fields of the neurons as the head rotates to view the whole scene. In addition, in Layer 3, gain modulation by gaze direction maps visual fixation scene patches to the correct part of the whole scene representation when saccades are made. Each neuron in Layer 3 is thus a spatial view cell that responds to a location in a viewed scene based on visual features in a part of the scene. The novel conceptual advances are that this theory shows how scene representations may be built in primates, including humans, based on features in spatial scenes that anchor the scene representation to the world being viewed (to allocentric, world-based, space); and how gaze direction contributes to this. This offers a revolutionary approach to understanding the spatial representations for navigation and episodic memory in primates, including humans.</p>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.70013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}