Hippocampus最新文献_第2页

Synaptic Potentiation in Hippocampus by eEF2K Inhibitor A484954 eEF2K抑制剂A484954对海马突触增强的影响。

IF 2.7 3区医学

Hippocampus Pub Date : 2026-03-27 DOI: 10.1002/hipo.70091

Qian Yang, Tian Li, Hannah M. Jester, Qiang Su, Xueyan Zhou, Alexey G. Ryazanov, Tao Ma

{"title":"Synaptic Potentiation in Hippocampus by eEF2K Inhibitor A484954","authors":"Qian Yang, Tian Li, Hannah M. Jester, Qiang Su, Xueyan Zhou, Alexey G. Ryazanov, Tao Ma","doi":"10.1002/hipo.70091","DOIUrl":"10.1002/hipo.70091","url":null,"abstract":"An important mechanism controlling protein synthesis is through phosphorylation of the eukaryotic elongation factor 2 (eEF2) by its kinase eEF2K. Hyperphosphorylation of eEF2 is linked to many neuronal diseases characterized by cognitive impairments. Consistently, recent studies show that the inhibition of the eEF2K signaling via genetic or pharmacological approaches can alleviate synaptic failure and dementia syndromes in mouse models of Alzheimer's disease (AD) and related dementias (ADRDs). One commonly used tool to study eEF2K signaling is A-484954 (or AG), a small molecule compound that is considered a highly selective and potent eEF2K antagonist. Here we reported that the AG compound (at three doses) can induce chemical long-term potentiation (LTP) in acute hippocampal slices from mice. Taking advantage of two transgenic mouse models with eEF2K knockout or overexpression, we further demonstrated that eEF2K-independent mechanisms contribute to chemical LTP induced by AG (dose-dependent). Our data suggest cautious interpretation of findings on neuronal effects of eEF2K inhibitors such as AG. Future investigations are warranted to elucidate the detailed molecular mechanisms underlying the effects of AG compound and other eEF2K inhibitors on synaptic and cognitive function.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"36 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13031159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147528481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information - Editorial Board 发行信息-编辑委员会

IF 2.7 3区医学

Hippocampus Pub Date : 2026-03-27 DOI: 10.1002/hipo.70094

引用次数: 0

Rescaling of Distance Judgments With Geometric and Contextual Changes 几何和语境变化下距离判断的重新缩放。

IF 2.7 3区医学

Hippocampus Pub Date : 2026-03-10 DOI: 10.1002/hipo.70088

Ernest Simons, Caswell Barry, Caroline Whyatt, Rebecca Knight

{"title":"Rescaling of Distance Judgments With Geometric and Contextual Changes","authors":"Ernest Simons, Caswell Barry, Caroline Whyatt, Rebecca Knight","doi":"10.1002/hipo.70088","DOIUrl":"10.1002/hipo.70088","url":null,"abstract":"Grid cells have been identified in the entorhinal cortex of rodents and humans, as well as other mammals. In rodents, these “distance computing” neurons exhibit altered firing fields in response to environmental manipulations, including changes to geometry or specific contextual cues (e.g., color). The current study investigated whether these neurophysiological observations in rodents could predict human behavior in a distance judgment task under various environmental manipulations. Participants (n = 51) completed 22 trials involving distance traversal, memorisation, and distance replication across five experimental conditions: control (no manipulation), contextual manipulation (novel environment), and geometric manipulations (local expansion and contraction; global expansion and contraction). Results demonstrated that environmental expansions led to significant overestimations in distance judgments, consistent with rodent grid cell data. Global geometric manipulations yielded significant overestimations compared to the control condition. For the local manipulations, judgments were least accurate when made in the vicinity of the local manipulation. These behavioral patterns are consistent with localized deformations in spatial representations, as would be predicted from rodent grid cell studies. As hypothesized, changes to the environmental context (the novel environment condition) also resulted in significant distance overestimations. In conclusion, environmental manipulations influenced the accuracy of human distance judgments in a manner paralleling the firing field changes observed in rodent grid cells under similar environmental alterations. These findings demonstrate behavioral parallels between human distance estimation and rodent grid cell responses to environmental manipulations, suggesting possible commonalities in spatial processing across species.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"36 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12975663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147432649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic Updating of Cognitive Maps via Traces of Experience in the Subiculum 认知地图的动态更新通过经验的痕迹在耻骨下。

IF 2.7 3区医学

Hippocampus Pub Date : 2026-03-02 DOI: 10.1002/hipo.70078

Fei Wang, Andrej Bicanski

{"title":"Dynamic Updating of Cognitive Maps via Traces of Experience in the Subiculum","authors":"Fei Wang, Andrej Bicanski","doi":"10.1002/hipo.70078","DOIUrl":"10.1002/hipo.70078","url":null,"abstract":"In the classical view of hippocampal function, the subiculum is assigned the role of the output layer. In spatial paradigms, some subiculum neurons manifest as so-called boundary vector cells (BVCs), firing in response to boundaries at specific allocentric directions and distances. More recently, it has been shown that some subiculum BVCs can be classified as vector trace cells (VTCs), which exhibit traces of activity after a boundary/object has been removed. Here, we propose a model of processing within subiculum that accounts for VTCs, taking into account proximodistal differences in subiculum (pSub vs. dSub) and CA1. dSub neurons receive feedforward input, either in the form of perceptual information (from BVCs in pSub) or mnemonic information (from place cells in CA1). Mismatch between these two inputs updates associative memory encoded in the synapses between CA1 and dSub. With a range of learning rates, the model captures the majority of experimental findings, including the distribution of VTCs along the proximodistal axis, the percentage of VTCs across different cue types, and the hours-long persistence of the vector trace. Incorporating experimentally reported effects of inserted objects/rewards on place cells (place field shift), we also explain why VTCs have longer tuning distances after cue removal. This adds predictive character to subiculum traces and suggests the online use of mnemonic content during navigation. Our model suggests that mismatch detection for updating spatial memory content provides a mechanistic explanation for findings in the CA1–subiculum pathway. This work constitutes the first dedicated circuit-level model of computation within the subiculum, consistent with known effects in CA1, and provides a potential framework to extend the canonical model of hippocampal function with a subiculum component.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"36 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12953219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Canonical Subiculum Circuit Organization and Function 非规范下神经回路的组织与功能。

IF 2.7 3区医学

Hippocampus Pub Date : 2026-02-27 DOI: 10.1002/hipo.70087

Pan Gao, Wenhao Cao, Douglas A. Nitz, Xiangmin Xu

{"title":"Non-Canonical Subiculum Circuit Organization and Function","authors":"Pan Gao, Wenhao Cao, Douglas A. Nitz, Xiangmin Xu","doi":"10.1002/hipo.70087","DOIUrl":"10.1002/hipo.70087","url":null,"abstract":"The subiculum is highly interconnected with the hippocampus, sub-regions of the thalamus, and the entorhinal and retrosplenial cortices. Together, these regions form a distributed network that plays critical roles in spatial cognition and learning and memory. Despite recent discoveries detailing subiculum's circuitry and neural dynamics, a unique role for subiculum in this system has yet to be determined. Traditionally, the subiculum has been considered the “fourth leg” and output region of the trisynaptic pathway. However, recent evidence highlights the subiculum as a site of integration, receiving and redistributing outputs from the hippocampus, anterior thalamus, retrosplenial cortex, and entorhinal cortex. We review how these afferents may explain the diverse forms of spatial and directional tuning observed in the subiculum, including location coding, boundary-related signals, axis of travel, and head orientation. We also discuss more recently identified “non-canonical” connections that suggest additional roles for the subiculum in refining hippocampal processing. Together, these findings call for a reconceptualization of the subiculum's role in spatial cognition, memory, and integration across thalamic, cortical, and hippocampal networks.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"36 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147305113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gaussian Process Inference Reveals Non-Separability of Position and Velocity Tuning in Grid Cells 高斯过程推理揭示了网格单元中位置和速度调整的不可分性。

IF 2.7 3区医学

Hippocampus Pub Date : 2026-02-25 DOI: 10.1002/hipo.70083

Linnie J. Warton, Surya Ganguli, Lisa M. Giocomo

{"title":"Gaussian Process Inference Reveals Non-Separability of Position and Velocity Tuning in Grid Cells","authors":"Linnie J. Warton, Surya Ganguli, Lisa M. Giocomo","doi":"10.1002/hipo.70083","DOIUrl":"10.1002/hipo.70083","url":null,"abstract":"Grid cells in medial entorhinal cortex (MEC) support spatial navigation by responding to multiple variables, including position, speed, and head direction. While tuning curves for each of these variables have been examined individually at the level of single cells, less is known about the conjunctive coding of grid cells for these properties. To investigate this, we analyzed neural recordings of freely foraging rats and constructed four-dimensional (4D) tuning curves across 2D position and 2D velocity. In order to combat the sparse sampling of such a large behavioral space, we applied Gaussian Process (GP) methods to estimate firing rates at un-sampled points. Comparing GP model-derived tuning curves to those predicted by a fully separable model revealed that some cells exhibited significant non-separability of position and velocity tuning, and suggested a data coverage threshold necessary to observe this non-separability. In summary, our use of GPs allowed us to distinguish interactions in position-velocity tuning across a 4D behavioral space that have not been apparent in 2D analyses.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"36 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.70083","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147283474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subiculum Encodes Environmental Structure 下骨编码环境结构。

IF 2.7 3区医学

Hippocampus Pub Date : 2026-02-22 DOI: 10.1002/hipo.70086

Ryan Place, Emily Xu, Yanjun Sun, Jacob Olson, Douglas Nitz

引用次数: 0

Layer-Specific Astrocyte Morphological Responses in the CA3 Hippocampus Region During Piry Virus-Induced Encephalitis 皮炎病毒诱发脑炎时CA3海马区星形细胞的层特异性形态学反应。

IF 2.7 3区医学

Hippocampus Pub Date : 2026-02-22 DOI: 10.1002/hipo.70085

Diego de Almeida Miranda, Aline Andrade de Sousa, Renata Rodrigues dos Reis, Zaire Alves dos Santos, José Antonio Picanço Diniz, Pedro Fernando da Costa Vasconcelos, Cristovam Guerreiro Diniz, Daniel Clive Anthony, Dora Brites, Cristovam Wanderley Picanço Diniz, Daniel Guerreiro Diniz

{"title":"Layer-Specific Astrocyte Morphological Responses in the CA3 Hippocampus Region During Piry Virus-Induced Encephalitis","authors":"Diego de Almeida Miranda, Aline Andrade de Sousa, Renata Rodrigues dos Reis, Zaire Alves dos Santos, José Antonio Picanço Diniz, Pedro Fernando da Costa Vasconcelos, Cristovam Guerreiro Diniz, Daniel Clive Anthony, Dora Brites, Cristovam Wanderley Picanço Diniz, Daniel Guerreiro Diniz","doi":"10.1002/hipo.70085","DOIUrl":"10.1002/hipo.70085","url":null,"abstract":"Astrocytes from distinct hippocampal layers exhibit region-specific morphological traits, which may be influenced by their local microenvironment. During viral encephalitis, these cells undergo dynamic changes that can reflect layer-specific vulnerability. In this study, we characterized whether astrocytes from different CA3 hippocampal layers display distinct morphological responses to Piry virus-induced encephalitis. Adult female Swiss mice were intranasally inoculated with the Piry virus and sacrificed at 20- or 40-days post-infection (dpi). GFAP+ astrocytes from the Stratum lacunosum-moleculare (SLM) and Stratum oriens (SO) were three-dimensionally reconstructed. Morphometric data were evaluated using hierarchical clustering, linear discriminant analysis (LDA), and generalized linear models. Immunohistochemistry confirmed widespread viral neuroinvasion across olfactory and limbic regions. Hierarchical clustering identified 3–4 morphotypes per layer and time point with robust internal consistency, and LDA validated cluster assignments with high accuracy (> 91%). At 20 dpi, SLM astrocytes displayed significantly greater morphological complexity than SO astrocytes, whereas at 40 dpi responses were more heterogeneous, indicating temporal diversification of astrocytic reactivity. These findings provide an observational description of layer- and time-dependent astrocyte morphological plasticity during viral encephalitis. They underscore the value of morphometric and multivariate analyses for dissecting glial heterogeneity, while highlighting the need for future studies to determine the functional significance of these morphotypes.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"36 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12926523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147270803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular Risk Indices Differentially Linked to Hippocampal Subfield Volumes: A Comparison Between Younger and Older Adults 心血管风险指数与海马亚区容量的差异相关：年轻人和老年人的比较

IF 2.7 3区医学

Hippocampus Pub Date : 2026-02-16 DOI: 10.1002/hipo.70082

Roya Homayouni, Samaah Saifullah, Bradley P. Sutton, Ana M. Daugherty

{"title":"Cardiovascular Risk Indices Differentially Linked to Hippocampal Subfield Volumes: A Comparison Between Younger and Older Adults","authors":"Roya Homayouni, Samaah Saifullah, Bradley P. Sutton, Ana M. Daugherty","doi":"10.1002/hipo.70082","DOIUrl":"10.1002/hipo.70082","url":null,"abstract":"<div>\u0000 \u0000 The hippocampus, a key neural structure supporting episodic memory, comprises distinct subfields including the dentate gyrus (DG), Cornu Ammonis (CA1–3), and subiculum. Hippocampal subfields typically show age-related volumetric decline across adulthood, but the regional aging may be differentially vulnerable to cardiovascular risk factors. Here, we examined the association between hippocampal subfield volumes and cardiovascular risk indices—hypertension, blood pressure variation (BPV), body mass index (BMI), and waist-to-hip ratio—in groups of younger (n = 37, ages 18–29 years) and older adults (n = 22, ages 60–79 years). The findings revealed a specific link between cardiovascular health and hippocampal subfield volumes, with the subiculum showing greater sensitivity. Among younger adults, hypertension predicted smaller subiculum, while higher BMI correlated with larger CA1–2 volumes. For older adults, higher BPV predicted smaller subiculum volume, independent of hypertension that correlated with larger regional volume. Age moderated the relation between all indices and subiculum volume except waist-to-hip ratio. These findings highlight age-dependent, subfield-specific risk factors for hippocampal aging and underscore the potential for identifying sensitive periods for both risk and protection against late-life cognitive decline.\u0000 </div>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"36 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146201462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

(Remembering) Vector Coding of Boundaries and Objects in the Subiculum （记住）耻骨下边界和对象的矢量编码。

IF 2.7 3区医学

Hippocampus Pub Date : 2026-02-16 DOI: 10.1002/hipo.70074

Colin Lever

引用次数: 0