Hippocampus最新文献_第3页

Sparsity of Population Activity in the Hippocampus Is Task-Invariant Across the Trisynaptic Circuit and Dorsoventral Axis

IF 2.4 3区医学

Hippocampus Pub Date : 2024-12-02 DOI: 10.1002/hipo.23651

J. Quinn Lee, Matt Nielsen, Rebecca McHugh, Erik Morgan, Nancy S. Hong, Robert J. Sutherland, Robert J. McDonald

{"title":"Sparsity of Population Activity in the Hippocampus Is Task-Invariant Across the Trisynaptic Circuit and Dorsoventral Axis","authors":"J. Quinn Lee, Matt Nielsen, Rebecca McHugh, Erik Morgan, Nancy S. Hong, Robert J. Sutherland, Robert J. McDonald","doi":"10.1002/hipo.23651","DOIUrl":"https://doi.org/10.1002/hipo.23651","url":null,"abstract":"Evidence from neurophysiological and genetic studies demonstrates that activity sparsity—the proportion of neurons that are active at a given time in a population—systematically varies across the canonical trisynaptic circuit of the hippocampus. Recent work has also shown that sparsity varies across the hippocampal dorsoventral (long) axis, wherein activity is sparser in ventral than dorsal regions. While the hippocampus has a critical role in long-term memory (LTM), whether sparsity across the trisynaptic circuit and hippocampal long axis is task-dependent or invariant remains unknown. Importantly, representational sparsity has significant implications for neural computation and theoretical models of learning and memory within and beyond the hippocampus. Here we used functional molecular imaging to quantify sparsity in the rat hippocampus during performance of the Morris water task (MWT) and contextual fear discrimination (CFD) – two popular and distinct assays of LTM. We found that activity sparsity is highly reliable across memory tasks, wherein activity increases sequentially across the trisynaptic circuit (DG < CA3 < CA1) and decreases across the long axis (ventral<dorsal). These results have important implications for models of hippocampal function and suggest that activity sparsity is a preserved property in the hippocampal system across cognitive settings.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.23651","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142762106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Issue Information - Editorial Board

IF 2.4 3区医学

Hippocampus Pub Date : 2024-11-28 DOI: 10.1002/hipo.23613

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Decreases in K63 Polyubiquitination in the Hippocampus Promote the Formation of Contextual Fear Memories in Both Males and Females

IF 2.4 3区医学

Hippocampus Pub Date : 2024-11-28 DOI: 10.1002/hipo.23650

Natalie J. Preveza, Gueladouan Setenet, Phillip Gwin, Yeeun Bae, Morgan B. Patrick, Adam Cummings, Jennifer R. Abraham, W. Keith Ray, Richard F. Helm, Timothy J. Jarome

{"title":"Decreases in K63 Polyubiquitination in the Hippocampus Promote the Formation of Contextual Fear Memories in Both Males and Females","authors":"Natalie J. Preveza, Gueladouan Setenet, Phillip Gwin, Yeeun Bae, Morgan B. Patrick, Adam Cummings, Jennifer R. Abraham, W. Keith Ray, Richard F. Helm, Timothy J. Jarome","doi":"10.1002/hipo.23650","DOIUrl":"https://doi.org/10.1002/hipo.23650","url":null,"abstract":"<div>\u0000 \u0000 Over 90% of protein degradation in eukaryotic cells occurs through the ubiquitin-proteasome system (UPS). In this system, the ubiquitin protein can bind to a substrate on its own or it can form a chain with multiple ubiquitin molecules in a process called polyubiquitination. There are 8 different sites on ubiquitin at which polyubiquitin chains can be formed, the second most abundant of which, lysine-63 (K63), is independent of the degradation process, though this mark has rarely been studied in the brain or during learning-dependent synaptic plasticity. Recently, we found that knockdown of K63 polyubiquitination in the amygdala selectively impaired contextual fear memory formation in female, but not male, rats. It is unknown, however, whether the sex-specific requirement of K63 polyubiquitination occurs in other brain regions that are required for contextual fear memory formation, including the hippocampus. Here, we found that CRISPR-dCas13-mediated knockdown of K63 polyubiquitination in the hippocampus significantly enhanced contextual fear memory in both male and female rats, a result that is in striking contrast to what we observed in the amygdala for both sex-specificity and directionality. Using unbiased proteomics, we found that following fear conditioning K63 polyubiquitination was primarily decreased at target proteins in the hippocampus of both males and females. Importantly, the target proteins and downstream functional pathways influenced by K63 polyubiquitination changes diverged significantly by sex. Together, these data suggest that unlike what we previously reported in the amygdala, decreases in K63 polyubiquitination in the hippocampus are a critical regulator of memory formation in the hippocampus of both males and females.\u0000 </div>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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CORRECTION to “RETRACTION: Hippocampus of Ames Dwarf Mice is Resistant to β-Amyloid-Induced Tau Hyperphosphorylation and Changes in Apoptosis-Regulatory Protein Levels” 更正：艾姆斯侏儒小鼠的海马对β-淀粉样蛋白诱导的Tau过度磷酸化和凋亡调节蛋白水平的变化具有抵抗力"。

IF 2.4 3区医学

Hippocampus Pub Date : 2024-11-26 DOI: 10.1002/hipo.23649

{"title":"CORRECTION to “RETRACTION: Hippocampus of Ames Dwarf Mice is Resistant to β-Amyloid-Induced Tau Hyperphosphorylation and Changes in Apoptosis-Regulatory Protein Levels”","authors":"","doi":"10.1002/hipo.23649","DOIUrl":"10.1002/hipo.23649","url":null,"abstract":"M. Schrag, S. Sharma, H. Brown-Borg, and O. Ghribi, “RETRACTION: Hippocampus of Ames Dwarf Mice is Resistant to β-Amyloid-Induced Tau Hyperphosphorylation and Changes in Apoptosis-Regulatory Protein Levels,” Hippocampus 18, no. 3 (2007): 239–244, https://doi.org/10.1002/hipo.23626.In the above retraction notice, it was erroneously stated that Holly Brown-Borg did not respond. Brown-Borg did respond, and was unaware of Ghribi's actions and not in any way involved. Brown-Borg agrees with this decision.The corrected retraction notice is:The above article, published online on November 13, 2007 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Michael E. Hasselmo, and Wiley Periodicals LLC. The retraction has been agreed upon following an investigation by the authors' institution, the University of North Dakota, which determined that this article contains data that the corresponding author, Othman Ghribi, had fabricated. Matthew Schrag and Holly Brown-Borg were unaware of Ghribi's actions and not in any way involved, and they agree with this decision. Sunita Sharma and Othman Ghribi did not respond.The online version of this retraction has been corrected accordingly.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"35 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.23649","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Issue Information - Editorial Board 期刊信息 - 编辑委员会

IF 2.4 3区医学

Hippocampus Pub Date : 2024-11-15 DOI: 10.1002/hipo.23565

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Supramammillary Theta Oscillations in Water Maze Learning 水迷宫学习中的颞上θ振荡

IF 2.4 3区医学

Hippocampus Pub Date : 2024-11-05 DOI: 10.1002/hipo.23646

Calvin K. Young, Ming Ruan, Neil McNaughton

{"title":"Supramammillary Theta Oscillations in Water Maze Learning","authors":"Calvin K. Young, Ming Ruan, Neil McNaughton","doi":"10.1002/hipo.23646","DOIUrl":"10.1002/hipo.23646","url":null,"abstract":"<div>\u0000 \u0000 The supramammillary nucleus (SuM) in the hypothalamus, in conjunction with the hippocampus (HPC), has been implicated through theta oscillations in various brain functions ranging from locomotion to learning and memory. While the indispensable role of the SuM in HPC theta generation in anesthetized animals is well-characterized, the SuM is not always necessary for HPC theta in awake animals. This raises questions on the precise behavioral relevance of SuM theta activity and its interaction with HPC theta activity. We used simultaneously recorded SuM and HPC local field potentials (LFPs) in a one-day water maze (WM) learning paradigm in rats (n = 8), to show that theta activities recorded from the SuM itself were not positively correlated with locomotor (swimming) speed nor acceleration, but the individual relationship between acceleration and SuM theta frequency is correlated with WM learning rates. In contrast, we found that SuM-HPC theta phase coherence is strongly correlated with swimming speed and acceleration, but these do not relate to WM learning. SuM-HPC-directed coherence analysis demonstrated no swimming kinetics nor learning rate associations, but revealed that periods of high SuM-HPC theta phase coherence are driven by the SuM at relatively low (~6.2 Hz) frequencies. Additionally, we demonstrate that the SuM and the HPC also engage in non-random, non-coherent phase coupling modes where either structure preferentially displays a ± 2 Hz difference with the other. Our data indicate SuM theta LFPs do not appear to be related to either speed coding or spatial learning in swimming rats and display non-random out-of-phase theta frequency coupling with the HPC.\u0000 </div>","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"34 12","pages":"767-776"},"PeriodicalIF":2.4,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Dissecting the Hippocampal Regulation of Approach-Avoidance Conflict: Integrative Perspectives From Optogenetics, Stress Response, and Epigenetics 剖析海马体对接近-回避冲突的调控：来自光遗传学、应激反应和表观遗传学的综合视角。

IF 2.4 3区医学

Hippocampus Pub Date : 2024-11-04 DOI: 10.1002/hipo.23647

C. Forastieri, E. Romito, A. Paplekaj, E. Battaglioli, F. Rusconi

{"title":"Dissecting the Hippocampal Regulation of Approach-Avoidance Conflict: Integrative Perspectives From Optogenetics, Stress Response, and Epigenetics","authors":"C. Forastieri, E. Romito, A. Paplekaj, E. Battaglioli, F. Rusconi","doi":"10.1002/hipo.23647","DOIUrl":"10.1002/hipo.23647","url":null,"abstract":"Psychiatric disorders are multifactorial conditions without clear biomarkers, influenced by genetic, environmental, and developmental factors. Understanding these disorders requires identifying specific endophenotypes that help break down their complexity. Here, we undertake an in-depth analysis of one such endophenotype, namely imbalanced approach-avoidance conflict (AAC), reviewing its significant dependency on the hippocampus. Imbalanced AAC is a transdiagnostic endophenotype, being a feature of many psychiatric conditions in humans. However, it is predominantly examined in preclinical research through paradigms that subject rodents to conflict-laden scenarios. This review offers an original perspective by discussing the AAC through three distinct lights: optogenetic modulation of the AAC, which updates our understanding of the hippocampal contribution to behavioral inhibition; the impact of environmental stress, which exacerbates conflict and strengthens the stress-psychopathology axis; and inherent epigenetic aspects, which uncover crucial molecular underpinnings of environmental (mal) adaptation. By integrating these perspectives, in this review we aim to underline a cross-species causal nexus between heightened hippocampal activity and avoidance behavior. In addition, we suggest a rationale to explore epigenetic pharmacology as a potential strategy to tackle AAC-related psychopathology. This review assumes greater significance when viewed through the lens of advancing AAC-centric diagnostics in human subjects. Unlike traditional questionnaires, which struggle to accurately measure individual differences in AAC-related dimensions, new approaches using virtual reality and computer games show promise in better focusing the magnitude of AAC contribution to psychopathology.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"34 12","pages":"753-766"},"PeriodicalIF":2.4,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.23647","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Distinct Ventral Hippocampus Network Properties in Dissociated Cultures 分离培养物中不同的海马体腹侧网络特性

IF 2.4 3区医学

Hippocampus Pub Date : 2024-11-02 DOI: 10.1002/hipo.23648

Menahem Segal

{"title":"Distinct Ventral Hippocampus Network Properties in Dissociated Cultures","authors":"Menahem Segal","doi":"10.1002/hipo.23648","DOIUrl":"10.1002/hipo.23648","url":null,"abstract":"Extensive research has been focused in the past century on structural, physiological, and molecular attributes of the hippocampus. This interest was created by the unique involvement of the hippocampus in cognitive and affective functions of the brain. Functional analysis revealed that the hippocampus has divergent properties along its axial dimension to the extent that the dorsal sector (dorsal hippocampus, DH) has different connections with the rest of the brain than those of the ventral sector (VH). Still, longitudinal pathways connect the DH with the VH and dampen the functional differences between the sectors. To be able to identify the intrinsic functional difference between the DH and VH, we produced dissociated monolayer cultures from prenatal DH and VH and examined their properties at 10–20 days after plating by imaging the spontaneous activity of the network using Fluo-2 AM, a calcium indicator. Surprisingly, while DH and VH sectors produced dissociated cultures with similar morphological attributes, VH cultures were more active spontaneously than DH cultures. Furthermore, when stimulated to produce action potentials, VH neurons triggered network bursts in postsynaptic neurons more often than DH cultures. Finally, in both DH and VH cultures, electrical stimulation of single cells produced network bursts in response to a burst of action potentials rather than to single spikes. These experiments indicate that even in dissociated cultures, neurons of the VH are more excitable and sensitive to electrical stimulation than DH; hence, they are more likely to generate network bursts and epileptic seizures, as suggested for in vivo brains.","PeriodicalId":13171,"journal":{"name":"Hippocampus","volume":"34 12","pages":"744-752"},"PeriodicalIF":2.4,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.23648","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Cover Image, Volume 34, Issue 11 封面图片，第 34 卷第 11 期

IF 2.4 3区医学

Hippocampus Pub Date : 2024-10-18 DOI: 10.1002/hipo.23645

Loïc J. Chareyron, W. K. Kling Chong, Tina Banks, Neil Burgess, Richard C. Saunders, Faraneh Vargha-Khadem

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IF 2.4 3区医学

Hippocampus Pub Date : 2024-10-18 DOI: 10.1002/hipo.23564

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