{"title":"Layered Analysis of Injury in the Rat Esophagus Induced by Photodynamic Therapy Using Two-Photon Microscopy","authors":"Shanlin Yang;Ying Wang;Hongyou Zhao;Defu Chen;Haixia Qiu;Wenzhuo Qiu;Aimin Wang;Jing Zeng;Quanbo Ji;Ying Gu","doi":"10.1109/JSTQE.2025.3593926","DOIUrl":"https://doi.org/10.1109/JSTQE.2025.3593926","url":null,"abstract":"The esophagus is characterized by a multi-layered structure with compositional differences in each layer, resulting in layer-specific damage thresholds to photodynamic therapy (PDT). Accurate and efficient evaluation of the damages in each layer of healthy tissues is crucial for a successful PDT treatment when eradicating tumors in esophagus. However, conducting a comprehensive assessment of damage to each layer requires the integration of multiple traditional methods, which can be both time-consuming and labor-intensive. Here, we employed two-photon microscopy (TPM) to image rat esophageal sections and fresh samples with full-layer damage induced by PDT. We find that TPM can precisely identify injuries in each layer of the esophagus, including cellular hyperplasia, lamina propria detachment, loosened and tortuous collagen fibers, as well as vacuolated and atrophied muscle fibers, which are consistent with the detection results of traditional methods. Moreover, TPM possesses unique capabilities not present in traditional methods. For example, TPM successfully detected enhanced perinuclear fluorescence in necrotic esophageal epithelial cells, performed quantitative analysis of collagen fiber changes, and enabled three-dimensional (3D) visualization of structural and morphological alterations caused by the damage. Together, our findings demonstrate that TPM serves as an effective tool for evaluating layer-specific effects induced by PDT, and is expected to have a long-term influence for enhancing the targeting accuracy of PDT in tumor treatment of hollow organs.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"32 4: Adv. Biophoton. in Emerg. Biomed. Tech. and Dev","pages":"1-13"},"PeriodicalIF":5.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144843039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"3D Dirac Semimetal Metamaterial Supported Terahertz Tunable Dual-Functional Polarization Converter","authors":"Shilin Liu;Wenhan Cao;Jiaxin Li;Xiaoyong He","doi":"10.1109/JSTQE.2025.3592331","DOIUrl":"https://doi.org/10.1109/JSTQE.2025.3592331","url":null,"abstract":"Currently, the use of metamaterials (MMs) to dynamically manipulate the polarization state of terahertz (THz) waves is of great interest for applications such as conveying information and target detection. However, it remains a key challenge to integrate tunable and multiple functions into a single MM device. Based on a 3D Dirac semimetal (DSM)-Teflon-graphene multilayered structure, the propagation performance of the dual-functional polarization converter (DPC) has been investigated in the THz regime, which can achieve cross-polarized reflection or transmission conveniently by adjusting the Fermi level of the graphene inserted into the dielectric space layer. Particularly, at a large Fermi level of 1.0 eV, the proposed DPC realizes a broadband cross-polarized reflection at 0.94-2.17 THz with polarization conversion ratio more than 0.9, and the maximum amplitude modulation depth (MD) of the cross-polarization resonance is 29.2% by adjusting the 3D DSM Fermi level in the range of 0.01-0.15 eV. Meanwhile, if the Fermi level is zero, two obvious cross-polarized transmission peaks can be observed at 1.14 THz and 1.92 THz, and the corresponding amplitude MDs are 49.0% and 62.6% respectively, by varying the 3D DSM Fermi level. Additionally, with a thin layer of 3D DSM as a tunable substrate, the maximum MD amplitude of the cross-polarized reflection curve reaches 52% by changing the Fermi level in the range of 0.01-0.15 eV. These results are very helpful in understanding the tunable mechanisms of 3D DSM plasmonic devices and aiding the design of THz multi-functional devices, such as polarizers, wave plates, and modulators.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"31 5: Quantum Materials and Quantum Devices","pages":"1-8"},"PeriodicalIF":5.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144773228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correlation of Hemodynamic Responses Measured on Human Head by Diffuse Correlation Spectroscopy and BOLD MRI","authors":"Neda Mogharari;Michal Kacprzak;Kamil Lipinski;Adam Liebert;Stanislaw Wojtkiewicz","doi":"10.1109/JSTQE.2025.3589169","DOIUrl":"https://doi.org/10.1109/JSTQE.2025.3589169","url":null,"abstract":"In this study, first we compared the performance of continuous wave diffuse correlation spectroscopy (cw-DCS) and time domain diffuse correlation spectroscopy (td-DCS) in assessing the dynamic of scatterers during series of measurements on two-layered phantoms. Then, we compared the blood flow index (BFI) measured by DCS techniques and evaluated its correlation with the blood oxygenation level–dependent (BOLD) signal measured by magnetic resonance imaging (MRI) during respiratory challenges, including breath-holding (BH) and hyperventilation (HV). We found a good agreement between the amplitude changes of BFIs and BOLD signal in response to BH and HV maneuvers. Moreover, we observed positive correlations between the BFIs and BOLD signal changes in response to these respiratory challenges. Notably, during BH, BFI changes preceded the BOLD signal (on average by about 2.7 s), while during HV, the responses were nearly simultaneous (delay about 0.2 s). These results support the potential of DCS techniques as a complementary tool in assessing cerebral hemodynamic. However, to make these optical techniques practically useful, further improvements in hardware—especially in coherence length and pulse width of the td-DCS laser source is necessary.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"31 4: Adv. in Neurophoton. for Non-Inv. Brain Mon.","pages":"1-15"},"PeriodicalIF":5.1,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=11089953","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144781887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeffrey W. Nicholson;Andrew Grimes;Benyuan Zhu;Cang Jin;Venkatapuram S. Sudarshanam;Anand Hariharan;David J. DiGiovanni
{"title":"High-Power Fiber Lasers for Free-Space Optical Communication Uplinks","authors":"Jeffrey W. Nicholson;Andrew Grimes;Benyuan Zhu;Cang Jin;Venkatapuram S. Sudarshanam;Anand Hariharan;David J. DiGiovanni","doi":"10.1109/JSTQE.2025.3590645","DOIUrl":"https://doi.org/10.1109/JSTQE.2025.3590645","url":null,"abstract":"Ground to satellite optical uplinks are a critical part of the infrastructure in the growing satellite network using free-space optical communications. Because of distortions to the free space optical beam caused by scattering, absorption and turbulence in the atmosphere, the optical power requirements for the uplink are higher than other parts of the system. Fiber lasers are expected to be a key component in the uplink transmitter, due to their robust nature, ability to operate at high average power with excellent beam quality, and high efficiency. This work will provide a brief overview of considerations for optical ground stations, and review of potential fiber laser sources for free space optical communications systems. Detailed results will be presented on a very-large mode area Er-doped fiber amplifier, core pumped by a 1480 nm Raman fiber laser, capable of operating at 100 W average power. Bit error rate testing results for the system at operating powers of up to 90 W will be presented.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"32 1: Advances in Free Space Laser Communications","pages":"1-10"},"PeriodicalIF":5.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144843118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carmen Álvarez Roa;Yunus Can Gültekin;Kaiquan Wu;Cornelis Willem Korevaar;Alex Alvarado
{"title":"On Error Rate Approximations for FSO Systems With Weak Turbulence and Pointing Errors","authors":"Carmen Álvarez Roa;Yunus Can Gültekin;Kaiquan Wu;Cornelis Willem Korevaar;Alex Alvarado","doi":"10.1109/JSTQE.2025.3590410","DOIUrl":"https://doi.org/10.1109/JSTQE.2025.3590410","url":null,"abstract":"Atmospheric attenuation, atmospheric turbulence, geometric spread, and pointing errors, degrade the performance of free-space optical transmission. In the weak turbulence regime, the probability density function describing the distribution of the channel fading coefficient that models these four effects is known in the literature. This function is an integral equation, which makes it difficult to find simple analytical expressions of important performance metrics such as the bit error rate (BER) and symbol error rate (SER). In this paper, we present simple and accurate approximations of the average BER and SER for pulse-amplitude modulation (PAM) in the weak turbulence regime for an intensity modulation and direct detection system. Our numerical results show that the proposed expressions exhibit excellent accuracy when compared against Monte Carlo simulations. To demonstrate the usefulness of the developed approximations, we perform two asymptotic analyses. First, we investigate the additional transmit power required to maintain the same SER when the spectral efficiency increases by 1 b/symbol. Second, we study the asymptotic behavior of our SER approximation for dense PAM constellations and high transmit power.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"32 1: Advances in Free Space Laser Communications","pages":"1-15"},"PeriodicalIF":5.1,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144998205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unpolarized Nonreciprocal Thermal Emitters Based on Generalized Transverse Magneto-Optical Effect","authors":"Wentian Zhang;Zhenhao Li;Tianji Liu;Wei Li","doi":"10.1109/JSTQE.2025.3590100","DOIUrl":"https://doi.org/10.1109/JSTQE.2025.3590100","url":null,"abstract":"In optics and thermal photonics, reciprocity governs and constrains the transportation of light and thermal radiation. Transverse magneto-optical effect is the main mechanism to break reciprocity in propagation, reflection, absorption, and emission. However, it is well-recognized that transverse magneto-optical effect is only valid for transverse magnetic polarization, which is the fundamental constraint in realizing unpolarized or polarization-independent nonreciprocal photonics and thermal photonics. Although the recent reports demonstrate the dual-polarized nonreciprocal thermal emitters based on the rotated incident plane and multimode interaction, it is still unclear the general principle behind a myriad of magnetic configurations and microstructures. More importantly, current dual-polarized thermal emitters are still limited with the non-overlapping angular and spectral properties for both polarizations. In this paper, we reveal the transversal inhomogeneity and the transverse wave nature of light are the generation mechanism of dual-polarized nonreciprocity in arbitrary magneto-optical structures, which is the manifestation of the generalized transverse magneto-optical effect. Moreover, one-dimensional Weyl-semimetal materials-based grating is designed to demonstrate the strong and broadband nonreciprocal thermal radiation, exhibiting an enhanced nonreciprocal radiative heat transfer efficiency superior to the ideal single-polarized nonreciprocal thermal emitters. Our results pave the avenue to unpolarized nonreciprocal photonics and thermal photonics.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"31 6: Photon. for Climate Chng. Mitigation and Adapt.","pages":"1-8"},"PeriodicalIF":5.1,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=11082672","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144739807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simultaneous Optical Measurement of Hemoglobin, Cerebral Blood Flow, and Cytochrome-C-Oxidase Changes Via Wavelength Time-Multiplexed Speckle Sensing","authors":"Tamar Dror;Victoria Tarle;Georgina Leadley;Gemma Bale;Nisan Ozana","doi":"10.1109/JSTQE.2025.3588298","DOIUrl":"https://doi.org/10.1109/JSTQE.2025.3588298","url":null,"abstract":"Monitoring cytochrome-c oxidase (CCO) alongside changes in hemoglobin (Hb) concentration and cerebral blood flow (CBF) offers significant advantages for assessing metabolic activity non-invasively in real time. In this study, we present a five-wavelength laser system synchronized with CMOS cameras, enabling simultaneous measurements of functional near-infrared spectroscopy (fNIRS), CCO and speckle contrast optical spectroscopy (SCOS) changes. We first validated the performance of our time-multiplexed laser system by comparing it with a five-LED setup and a broadband system in phantom measurements, demonstrating strong correlations across all modalities. Subsequently, we applied our system in human studies to capture concurrent hemodynamic and metabolic responses, including variations induced by cardiac and breath holding in CCO, Hb, and CBF.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"31 4: Adv. in Neurophoton. for Non-Inv. Brain Mon.","pages":"1-8"},"PeriodicalIF":5.1,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144868175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Do Hyeon Kim;Hyunkyu Kwak;Min Seok Kim;Young Min Song
{"title":"Advanced Transparent Radiative Coolers: Materials, Design, and Applications","authors":"Do Hyeon Kim;Hyunkyu Kwak;Min Seok Kim;Young Min Song","doi":"10.1109/JSTQE.2025.3585564","DOIUrl":"https://doi.org/10.1109/JSTQE.2025.3585564","url":null,"abstract":"Passive radiative cooling is a sustainable approach to cool surfaces by thermal emission, without consuming external energy. Conventional radiative coolers provide broadband solar reflection to suppress solar heating but result in opaque surfaces, limiting their applications which require visible transparency. Transparent radiative coolers address these limitations by combining visible transparency and strong thermal emissions. This review presents a comprehensive overview of the principles and material/design challenges associated with transparent radiative coolers. We highlight recent advances in material platforms, including transparent ceramics and polymers, and explore photonic design strategies for achieving spectral selectivity. Key applications in buildings, automotive windows, solar cells, greenhouse films, and displays are discussed, demonstrating significant cooling performance and energy savings. We also outline current achievements and discuss the outlook for integrating these advanced cooling films into sustainable technologies.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"31 6: Photon. for Climate Chng. Mitigation and Adapt.","pages":"1-14"},"PeriodicalIF":4.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144646446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Two-Way Analysis of Brain Synchrony: Assessing Brain-Event Relationships Using Information Metrics","authors":"Satoshi Morimoto;Yasuyo Minagawa","doi":"10.1109/JSTQE.2025.3582203","DOIUrl":"https://doi.org/10.1109/JSTQE.2025.3582203","url":null,"abstract":"Functional near-infrared spectroscopy (fNIRS) is well-suited for hyperscanning in naturalistic situations, offering significant potential for assessing social brain function in everyday life. Previous studies have reported inter-brain synchrony during social interactions and sought to explore its mechanisms by correlating behavioral events with brain signals. However, commonly used regression analyses, such as Generalized Linear Models (GLM), rely on target events hypothesized as explanatory variables. This reliance introduces a dependency on the researcher’s assumptions, which can compromise replicability in social neuroscience. While such dependency may be less problematic in strictly controlled experimental paradigms focused on specific hypotheses, it poses significant challenges in naturalistic experiments like social interactions, where numerous events and signals may serve as potential explanatory variables. To address this limitation, we introduced a new approach: signed-normalized mutual information for wavelet transform coherence (WTC-sNMI). This method enables a two-way analysis to evaluate relationships between event sequences and brain synchrony. Through simulations and real-data applications, we evaluated the performance of the proposed method. The results showed that WTC-sNMI analysis performed comparably to regression analysis in detecting both inter-brain synchrony and within-brain synchrony (i.e., brain connectivity). Moreover, applying WTC-sNMI to a tapping dataset revealed the expected patterns of synchrony between the lateral sides of the motor area. These findings validate the effectiveness of WTC-sNMI as a robust two-way analytical tool for studying brain-event relationships.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"31 4: Adv. in Neurophoton. for Non-Inv. Brain Mon.","pages":"1-12"},"PeriodicalIF":4.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144536313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"256 × 2 InGaAsP/InP Geiger-Mode Avalanche Photodiode Arrays With a Triple-Stage Timing to Digital Converter","authors":"Yingjie Ma;Jingxian Bao;Mengxuan Liu;Lixia Zheng;Haiyong Zhu;Junliang Liu;Yakui Dong;Wei Kong;Ruikai Xue;Yi Gu;Genghua Huang;Weifeng Sun;Xue Li;Haimei Gong;Jiaxiong Fang","doi":"10.1109/JSTQE.2025.3581720","DOIUrl":"https://doi.org/10.1109/JSTQE.2025.3581720","url":null,"abstract":"256 × 2 InGaAsP/InP Geiger-mode avalanche photodiode (GmAPD) arrays and a matched readout circuit with a triple-stage timing to digital converter (TDC) are realized. Pixels run asynchronously within the range gate of each frame, allowing measuring the time of flight of up to three reflected laser echoes. A mean array timing precision of 1 ns and a minimum hold-off time (T<sub>hoff</sub>) of 64 ns are achieved. The measured mean dark count rates are 2.5, 1.0 and 0.5 kHz for the first, the second and the third stage TDC, respectively, under a mean photon detection efficiency (PDE) of 33.1% at 1064 nm, −20 °C and a T<sub>hoff</sub> of 320 ns. While the cumulative afterpulsing probability (APP) exhibits strongly V<sub>o</sub>- and T<sub>hoff</sub>-dependent behaviors and a temperature-insensitive nature from −20 °C to 20 °C, a cumulative APP of 15% is obtained under a PDE of 20% and a T<sub>hoff</sub> of 1 μs. Photon count rate measurements indicate trade-off between the photon blockage and the increased afterpulsing probability under shorter T<sub>hoff</sub>. Furthermore, capabilities of parallel acquirement of three-dimensional laser point cloud and two-dimensional photon count images are also demonstrated, highlights the superiorities of this multi-TDC scheme in both active and passive imaging under strong background interference.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"31 5: Quantum Materials and Quantum Devices","pages":"1-11"},"PeriodicalIF":4.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}