{"title":"IEEE Journal of Selected Topics in Quantum Electronics Publication Information","authors":"","doi":"10.1109/JSTQE.2026.3721922","DOIUrl":"https://doi.org/10.1109/JSTQE.2026.3721922","url":null,"abstract":"","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"32 4: Adv. Biophoton. in Emerg. Biomed. Tech. and Dev","pages":"0001401-0001401"},"PeriodicalIF":4.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=11737670","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149188452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IEEE Journal of Selected Topics in Quantum Electronics Edics","authors":"","doi":"10.1109/JSTQE.2026.3721968","DOIUrl":"https://doi.org/10.1109/JSTQE.2026.3721968","url":null,"abstract":"","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"32 4: Adv. Biophoton. in Emerg. Biomed. Tech. and Dev","pages":"0001601-0001601"},"PeriodicalIF":4.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=11737664","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149188181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A High Depth-Resolution, Reconfigurable Raman Spectroscopy Based on Programmable Cone-Shell Excitation","authors":"Yuetian Ren;Yue Yang;Shuaihang Luo;Zheng Zhou;Keren Chen;Zejun Yan;Wei Qian;Shuo Chen","doi":"10.1109/JSTQE.2026.3687637","DOIUrl":"https://doi.org/10.1109/JSTQE.2026.3687637","url":null,"abstract":"An enhanced depth-resolution Raman spectroscopy technique with rapid acquisition is proposed, leveraging spatial light modulator (SLM) based programmable cone-shell excitation and compressive sensing. To tackle the issues of inadequate depth resolution, substantial signal interference, and inefficient acquisition in conventional point-by-point scanning Raman detection (i.e., detection of one depth at a time), this study employs an SLM and an axicon lens to form a programmable cone-shell excitation with high and flexible depth selectivity, and uses the compressive sensing algorithm to reconstruct the sparsely collected Raman data, thus significantly improving depth resolution and detection time efficiency. The two-layer agar phantom experiment demonstrates that the proposed method can achieve better depth sensitivity and resolution, a peak signal-to-noise ratio (PSNR) close to 20 dB, and a detection time efficiency of approximately 500 times better than that of the conventional method. This study presents an efficient and non-contact Raman detection approach for rapidly and precisely examining different depths in layered tissues like skin, which significantly enhances the Raman technique’s potential for clinical applications.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"32 4: Adv. Biophoton. in Emerg. Biomed. Tech. and Dev","pages":"3500110-3500110"},"PeriodicalIF":4.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148504429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Methylene Blue-Loaded Nanocomposites Based SERS Immunoassay Sensor for Highly Sensitive NMP22 Detection","authors":"Hongguo Wei;Fan Xu;Junhao Wang;Shichao Du;Deliang Li;Keren Chen;Zejun Yan;Wei Qian;Shuo Chen","doi":"10.1109/JSTQE.2026.3655314","DOIUrl":"https://doi.org/10.1109/JSTQE.2026.3655314","url":null,"abstract":"Nuclear matrix protein 22 (NMP22) is a crucial biomarker for bladder cancer (BC) diagnosis. However, its detection remains challenging due to the limitations of conventional diagnostic methods, including high costs, complex operations, insufficient sensitivity, and long analysis time. To address these issues, we developed an advanced SERS immunoassay sensor that combines magnetic Fe<sub>3</sub>O<sub>4</sub> nanocomposites (Fe<sub>3</sub>O<sub>4</sub>@Ab) and MB@Ab (methylene blue with antibody) nanocomposites for highly sensitive NMP22 detection. The Fe<sub>3</sub>O<sub>4</sub> magnetic nanocomposites enable rapid target separation through their superparamagnetic properties. The MB@Ab nanocomposites utilize an organic-inorganic hybrid structure to achieve high-density loading of Raman-active MB molecules and simultaneously synthesized silver colloid as SERS enhancement substrate, thereby significantly enhances the detected Raman signals to improve detection sensitivity of NMP22. The proposed SERS immunoassay sensor achieves high detection sensitivity with a detection limit of 0.34 pg/mL and excellent detection specificity for NMP22 among common tumor markers and interfering substances in urine. Experimental validation using human urine samples confirms the stable performance in complex matrices with high reproducibility. The proposed SERS immunoassay sensor, with its exceptional sensitivity, ease of use, excellent repeatability, reliable clinical validation for NMP22 detection and potential adaptability to other tumor markers, demonstrates its significant advantages in early BC diagnosis and also holds great potential for widespread applications of diagnosing other tumors.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"32 4: Adv. Biophoton. in Emerg. Biomed. Tech. and Dev","pages":"1-8"},"PeriodicalIF":4.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148506859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Call for Papers: Selected Topics in Quantum Computing Perspective Papers","authors":"","doi":"10.1109/JSTQE.2026.3737923","DOIUrl":"https://doi.org/10.1109/JSTQE.2026.3737923","url":null,"abstract":"","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"32 4: Adv. Biophoton. in Emerg. Biomed. Tech. and Dev","pages":"9800801-9800801"},"PeriodicalIF":4.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=11737669","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149188438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rapid Dispersion Compensation and Dispersion Measurement in Optical Coherence Tomography","authors":"Duohao Zhao;Sainan Wang;Haozhe Zhong;Liangqi Cao;Jianfeng Huang;Qin Li;Xiao Zhang","doi":"10.1109/JSTQE.2026.3673708","DOIUrl":"https://doi.org/10.1109/JSTQE.2026.3673708","url":null,"abstract":"Dispersion mismatch in optical coherence tomography (OCT) degrades image quality and the resolution for biological microstructures. Traditional compensation strategies predominantly rely on exhaustive search (ES) algorithms, which is computationally inefficient and time-consuming. In addition, the lack of efficient dispersion measurement methods for biological samples limits clinical OCT applications. This study proposes a rapid dispersion compensation and measurement strategy that improves both compensation efficiency and measurement accuracy. For compensation, a dual-stage collaborative optimization framework integrating coarse ES with the Nelder-Mead (NM) simplex algorithm is developed, enabling global localization followed by efficient local refinement. Compared with ES and goldensection search (GSS), the proposed strategy reduces convergence time by 98.2% and 68.2%, respectively, without accuracy degradation. For dispersion measurement, experiments on optical glasses within the same framework show good agreement with the ground truth. For 1 mm thick BaF2 and H-K9L glasses, errors of the extracted dispersion coefficients are 2.97 fs<sup>2</sup>/mm and 1.45 fs<sup>2</sup>/mm, respectively. In vivo imaging further demonstrates rapid operation in complex biological tissues, with a typical operation time required for dispersion measurement as low as 0.9 s for anterior chamber analysis and 0.5 s for retinal imaging on a laptop using an unoptimized single-threaded program. The proposed strategy integrates high compensation efficiency with accurate extraction capabilities, offering a robust solution for clinical OCT imaging and disease screening based on tissue dispersion characterization.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"32 4: Adv. Biophoton. in Emerg. Biomed. Tech. and Dev","pages":"1-10"},"PeriodicalIF":4.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148506281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isabella A. Serebryakova;Yuriy I. Surkov;Elina A. Genina;Yana K. Kuzinova;Olga M. Konopatskova;Valery V. Tuchin
{"title":"Multimodal Ultrasound/Optical Method for Basal Cell Carcinoma Recognition Using Machine Learning","authors":"Isabella A. Serebryakova;Yuriy I. Surkov;Elina A. Genina;Yana K. Kuzinova;Olga M. Konopatskova;Valery V. Tuchin","doi":"10.1109/JSTQE.2026.3670391","DOIUrl":"https://doi.org/10.1109/JSTQE.2026.3670391","url":null,"abstract":"The development of noninvasive methods for diagnosing skin diseases is a major problem in modern medicine. This paper presents an advanced multimodal approach that integrates Optical Coherence Tomography, Diffuse Reflectance Spectroscopy, and High Frequency Ultrasound data. Image processing, spectral and texture analysis, and machine learning techniques, including gradient boosting and fusion algorithms for unimodal classifiers, were used to analyze the data. The developed multimodal model provides high accuracy (96%) in differentiating benign and malignant neoplasms, demonstrating significant potential for clinical diagnostics. These results highlight the importance of integrating data from multiple modalities to improve diagnostic accuracy and reliability for skin neoplasms.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"32 4: Adv. Biophoton. in Emerg. Biomed. Tech. and Dev","pages":"1-9"},"PeriodicalIF":4.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148506393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Call for Papers: Special Issue on Advances in Multifunctional Optical Spectrometers","authors":"","doi":"10.1109/JSTQE.2026.3737927","DOIUrl":"https://doi.org/10.1109/JSTQE.2026.3737927","url":null,"abstract":"","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"32 4: Adv. Biophoton. in Emerg. Biomed. Tech. and Dev","pages":"9801001-9801001"},"PeriodicalIF":4.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=11737665","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149188146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fiber-Based Rolling-Shutter Interferometric Laser Speckle Spectroscopy","authors":"Shira Tziony;Sammy Apsel;Xiaojun Cheng;Nisan Ozana","doi":"10.1109/JSTQE.2025.3649193","DOIUrl":"https://doi.org/10.1109/JSTQE.2025.3649193","url":null,"abstract":"In this study, we present a fiber-based wearable interferometric laser speckle spectroscopy system, leveraging a rolling-shutter (RS) camera for sensing acoustic vibrations at high frame rate. We demonstrate the feasibility of using wearable fiber-coupled RS imaging to detect acoustic signatures from carotid artery blood flow and assess the signal-to-noise ratio (SNR) enhancement achieved through heterodyne interferometric detection. The system features a compact wearable probe with optical fibers that deliver laser light and collect backscattered signals from the skin surface, enabling localized acoustic measurements of the carotid artery. We further integrated an interferometric setup with a reference arm to enable heterodyne detection that enhances sensitivity to vibrations. Experimental results show that the interferometric system improves the SNR by approximately 24 dB when the detection fiber is positioned 7 mm above the skin. These findings underscore the potential of RS-camera-based speckle sensing in wearable platforms for noninvasive blood flow monitoring and broadband acoustic detection, with the interferometric enhancement significantly improving signal robustness and detectability.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"32 4: Adv. Biophoton. in Emerg. Biomed. Tech. and Dev","pages":"1-13"},"PeriodicalIF":4.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148504644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial Interview: Proliferating Free-Space Laser Communications for Space-Based Networks and Scientific Exploration","authors":"Bryan S. Robinson","doi":"10.1109/JSTQE.2026.3664943","DOIUrl":"https://doi.org/10.1109/JSTQE.2026.3664943","url":null,"abstract":"","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"32 1: Advances in Free Space Laser Communications","pages":"1-2"},"PeriodicalIF":5.1,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=11433117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147440688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}