IEEE Journal of Selected Topics in Quantum Electronics最新文献

Targeted ROI Scanning Strategy for OCTA with Uniform Spatial-Temporal Sampling 均匀时空采样OCTA的目标ROI扫描策略

IF 4.5 2区工程技术

IEEE Journal of Selected Topics in Quantum Electronics Pub Date : 2026-07-01 Epub Date: 2026-03-12 DOI: 10.1109/JSTQE.2026.3673571

Duo-Hao Zhao;Hao-Zhe Zhong;Shi-Ming Li;Jun-Xiu Zhang;Sai-Nan Wang;Wen-Xin Zhang;Liang-Qi Cao;Jian-Feng Huang;Jia-Cheng Zhang;Qin Li;Xiao Zhang

{"title":"Targeted ROI Scanning Strategy for OCTA with Uniform Spatial-Temporal Sampling","authors":"Duo-Hao Zhao;Hao-Zhe Zhong;Shi-Ming Li;Jun-Xiu Zhang;Sai-Nan Wang;Wen-Xin Zhang;Liang-Qi Cao;Jian-Feng Huang;Jia-Cheng Zhang;Qin Li;Xiao Zhang","doi":"10.1109/JSTQE.2026.3673571","DOIUrl":"https://doi.org/10.1109/JSTQE.2026.3673571","url":null,"abstract":"Optical coherence tomography angiography (OCTA) is a non-invasive imaging technique that provides depth-resolved visualization of microvascular networks without exogenous contrast agents. However, traditional scanning strategies suffer from limitations including non-uniform sampling, incompatible with the BM-scan mode, inflexible field of view (FOV) shapes and data redundancy due to unnecessary coverage of non-target areas. To address these issues, this study proposes a novel targeted ROI scanning strategy for OCTA that enables customizable FOVs while ensuring uniform spatial and temporal sampling. It discretizes the ROI into evenly distributed sampling points, groups them into equivalent B-scans, and employs a dynamic timing mechanism with flyback compensation to maintain consistent inter-frame intervals. This mechanism supports the widely used BM-scan protocol and avoids the need for post-acquisition resampling, thereby reducing interpolation artifacts and improving computational efficiency. Simulations and in vivo experiments on animal anterior segments and retinas demonstrate that the proposed strategy enables circular FOVs and achieves imaging quality comparable to the traditional raster scanning strategy, while reducing the scanning area to 81.1%, achieving an 18.9% reduction in acquisition time and a 23.3% improvement in scanning efficiency. In summary, the proposed strategy provides a framework with the potential for customizable FOVs and achieves high efficiency without compromising imaging quality, making it highly suitable for OCTA scientific research and clinical diagnosis.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"32 4: Adv. Biophoton. in Emerg. Biomed. Tech. and Dev","pages":"1-9"},"PeriodicalIF":4.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148505711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stimulation of Tumor Growth and Angiogenesis With Energy-Dependent Photobiomodulation 利用能量依赖性光生物调节刺激肿瘤生长和血管生成

IF 4.5 2区工程技术

IEEE Journal of Selected Topics in Quantum Electronics Pub Date : 2026-07-01 Epub Date: 2026-01-14 DOI: 10.1109/JSTQE.2026.3654023

Jihye Jo;Myungji Kang;Hyun Wook Kang

{"title":"Stimulation of Tumor Growth and Angiogenesis With Energy-Dependent Photobiomodulation","authors":"Jihye Jo;Myungji Kang;Hyun Wook Kang","doi":"10.1109/JSTQE.2026.3654023","DOIUrl":"https://doi.org/10.1109/JSTQE.2026.3654023","url":null,"abstract":"Photobiomodulation (PBM) has emerged as a supportive treatment for managing side effects of cancer radiation therapy. However, its safety and potential tumor-stimulating effects under specific irradiation conditions remain unclear. This study aims to evaluate the energy-dependent effects of 808 nm PBM on cellular proliferation, tumor growth, and angiogenesis in vitro and in vivo. B16F10 melanoma cells and tumor-bearing mice were irradiated with 808 nm laser at various energy densities of 0, 5, 10, and 50 J/cm2. In vitro tests revealed that 808 nm PBM significantly increased cell viability to 108% and 108% at 5 and 10 J/cm2, respectively, compared to the control group. In vivo tests demonstrated that 808 nm PBM at 5 J/cm2 induced the greatest tumor growth, with a 100-fold increase in relative tumor volume 10 days after the laser irradiation. Histological and western blot analyses confirmed significantly upregulated expression of VEGF and HIF-1α, markers of angiogenesis, and ERK1/2, a key mediator of cell proliferation, in tumors exposed to 5 J/cm2. These findings suggest that 808 nm PBM at a low energy density can stimulate melanoma tumor progression by promoting angiogenesis and cellular proliferation, highlighting the significance of optimizing the energy density and the necessity for establishing safety guidelines for oncologic PBM applications.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"32 4: Adv. Biophoton. in Emerg. Biomed. Tech. and Dev","pages":"1-7"},"PeriodicalIF":4.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148507846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IEEE Journal of Selected Topics in Quantum Electronics Information for Authors IEEE量子电子信息专题杂志

IF 4.5 2区工程技术

IEEE Journal of Selected Topics in Quantum Electronics Pub Date : 2026-07-01 Epub Date: 2026-10-14 DOI: 10.1109/JSTQE.2026.3721966

引用次数: 0

Unified Vibrational and Multiphoton Label-Free Nonlinear Microscopy for Simultaneous Chemical and Structural Imaging 用于同时化学和结构成像的统一振动和多光子无标记非线性显微镜。

IF 4.5 2区工程技术

IEEE Journal of Selected Topics in Quantum Electronics Pub Date : 2026-07-01 Epub Date: 2026-01-05 DOI: 10.1109/JSTQE.2025.3650148

Alejandro De la Cadena;Edita Aksamitiene;Stephen A. Boppart

{"title":"Unified Vibrational and Multiphoton Label-Free Nonlinear Microscopy for Simultaneous Chemical and Structural Imaging","authors":"Alejandro De la Cadena;Edita Aksamitiene;Stephen A. Boppart","doi":"10.1109/JSTQE.2025.3650148","DOIUrl":"10.1109/JSTQE.2025.3650148","url":null,"abstract":"Nonlinear microscopy enables label-free imaging by deriving contrast from the intrinsic spectroscopic responses of specimens, thereby offering a valuable tool for biomedical applications. Often, clinical imaging systems implement either multiphoton or vibrational contrast, not both. Consequently, most clinically deployed label-free nonlinear microscopes lack a robust, complementary contrast palette suitable for investigating the morphofunctional features of heterogeneous specimens. This deficiency limits not only the analytical capabilities of the nonlinear microscope but also its diagnostic utility. A main reason for this disregard is that the various imaging modalities impose distinct and stringent requirements on the excitation source and the detection chain. In this contribution, we propose a strategy that targets <italic>both multiphoton and vibrational contrasts to achieve a robust, complementary contrast palette. The approach emerges from a systematic investigation of readout schemes and provides engineering criteria to tailor the detection chain and thus maximize quantitative performance. In concert with this detection strategy, we present a compact laser source that drives vibrational coherences while simultaneously exciting multiphoton signals. We validate the resulting imaging platform using two rodent case studies: one involving a naturally occurring metastatic cancer in a mouse and another relying on an allogeneic mammary cancer model in a rat. Owing to its dimensions, cost, and versatility, we anticipate that this biophotonics tool will readily find its way into clinical applications.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"32 4: Adv. Biophoton. in Emerg. Biomed. Tech. and Dev","pages":"1-12"},"PeriodicalIF":4.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147432616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Call for Papers: Special Issue on Photonic Thermal Devices 征文：光子热器件特刊

IF 4.5 2区工程技术

IEEE Journal of Selected Topics in Quantum Electronics Pub Date : 2026-07-01 Epub Date: 2026-10-14 DOI: 10.1109/JSTQE.2026.3737925

引用次数: 0

Holographic Imaging Optofluidic Platform for Particles’ Three-Dimensional Location and Reconstruction With Physics-Aware Strategy 基于物理感知策略的粒子三维定位与重构全息成像光流平台

IF 4.5 2区工程技术

IEEE Journal of Selected Topics in Quantum Electronics Pub Date : 2026-07-01 Epub Date: 2026-03-29 DOI: 10.1109/JSTQE.2026.3694073

Tianqi Hong;Meimei Peng;Marek Smieja;Qiyin Fang

{"title":"Holographic Imaging Optofluidic Platform for Particles’ Three-Dimensional Location and Reconstruction With Physics-Aware Strategy","authors":"Tianqi Hong;Meimei Peng;Marek Smieja;Qiyin Fang","doi":"10.1109/JSTQE.2026.3694073","DOIUrl":"https://doi.org/10.1109/JSTQE.2026.3694073","url":null,"abstract":"Digital holographic imaging is a label-free, non-invasive imaging technique that can capture three-dimensional locational and morphological information of cells/particles. Applying artificial intelligence to holographic reconstruction has significantly enhanced the speed and accuracy for applications such as cell/particle tracking and profiling. However, existing data-driven learning methods typically require massive amounts of training data with diverse environmental conditions. To achieve high fidelity, extracting three-dimensional information from intensity shot noise in the data remains a challenge. This study developed a physics-aware strategy that mitigates noise in three-dimensional location and reconstruction. The model was trained using a physics-aware strategy and images synthetically generated without the need for experiments or real-world samples. The performance of the strategy was validated using experimentally acquired low-resolution and noisy holograms of micro particles in an optofluidic chip. Results showed that high-quality three-dimensional location and reconstruction can be successfully extracted. It demonstrated comparable precision, but with higher speed, compared to conventional methods. The developed strategy improves its interpretability without access to experimental data during training. This solution can be used in an integrated holographic imaging optofluidic chip offering high throughput, which is particularly well-suited for point-of-care testing applications.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"32 4: Adv. Biophoton. in Emerg. Biomed. Tech. and Dev","pages":"7101109-7101109"},"PeriodicalIF":4.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148506580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Advanced Biophotonics in Emerging Biomedical Technologies and Devices 社论：新兴生物医学技术和设备中的先进生物光子学

IF 4.5 2区工程技术

IEEE Journal of Selected Topics in Quantum Electronics Pub Date : 2026-07-01 Epub Date: 2026-08-19 DOI: 10.1109/JSTQE.2026.3714566

David Nolte;J. Quincy Brown;Guanying Chen;Brian Cunningham;Xudong Sherman Fan;Honghui He;Manoj Varma;Sharon Weiss

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Automated Optofluidic Analysis of Single Extracellular Vesicles for Organoid Culture Monitoring 用于类器官培养监测的单个细胞外囊泡的自动光流分析

IF 4.5 2区工程技术

IEEE Journal of Selected Topics in Quantum Electronics Pub Date : 2026-07-01 Epub Date: 2026-03-10 DOI: 10.1109/JSTQE.2026.3672359

Ravipa Losakul;Kateryna Voitiuk;Ruiting Xu;Spencer T. Seiler;Viktor Yurevych;Thomas D. Yuzvinsky;Andy Wang;Ivana Pačar;David Haussler;Sofie R. Salama;Mircea Teodorescu;Holger Schmidt

{"title":"Automated Optofluidic Analysis of Single Extracellular Vesicles for Organoid Culture Monitoring","authors":"Ravipa Losakul;Kateryna Voitiuk;Ruiting Xu;Spencer T. Seiler;Viktor Yurevych;Thomas D. Yuzvinsky;Andy Wang;Ivana Pačar;David Haussler;Sofie R. Salama;Mircea Teodorescu;Holger Schmidt","doi":"10.1109/JSTQE.2026.3672359","DOIUrl":"https://doi.org/10.1109/JSTQE.2026.3672359","url":null,"abstract":"Advances in organoid-on-chip technology are transforming culturing methods by enabling precise control over biochemical environments and sustained nutrient delivery. Conventional methods for assessing organoid health are invasive, requiring skilled manual handling and sacrificing the tissue for analysis. We present a fully automated, integrated system for noninvasive extraction, labeling, and optical analysis of extracellular vesicles (EVs) secreted by 3D organoid cultures. EVs contain important molecular biomarker cargo, such as nucleic acids and proteins, enabling real-time insight on the health of their cell of origin. Using a polydimethylsiloxane (PDMS) optofluidic biosensor, we demonstrate: (1) optical detection of single EVs derived from organoid culture; (2) on-chip sample processing and counting of single EVs; and (3) automating conditioned media delivery, on-chip sample preparation, and optical detection of EVs in a single integrated system. Together, these results showcase a noninvasive approach to monitoring organoid health through EV signatures present in conditioned media. The integrated platform based on a modular optofluidic analysis chip further offers a foundation for integrating a variety of downstream analysis techniques, advancing continuous organoid-on-a-chip monitoring.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"32 4: Adv. Biophoton. in Emerg. Biomed. Tech. and Dev","pages":"1-11"},"PeriodicalIF":4.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148507122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial Interview: Perspectives on the Future of Biophotonics: Innovation, Industry, and Emerging Biomedical Applications 编辑访谈：对未来生物光子学的展望：创新、产业和新兴生物医学应用

IF 4.5 2区工程技术

IEEE Journal of Selected Topics in Quantum Electronics Pub Date : 2026-07-01 Epub Date: 2026-09-10 DOI: 10.1109/JSTQE.2026.3721223

Brian W. Pogue;David C. Duffy

引用次数: 0

High Space-Bandwidth Product Label-Free Examination of iPSC-Derived Brain Organoids via Fourier Ptychographic Microscopy 傅立叶显微成像技术对ipsc衍生脑类器官的高空间带宽无标签检测

IF 4.5 2区工程技术

IEEE Journal of Selected Topics in Quantum Electronics Pub Date : 2026-07-01 Epub Date: 2026-01-02 DOI: 10.1109/JSTQE.2025.3650095

Mikolaj Krysa;Mikolaj Rogalski;Piotr Arcab;Pawel Goclowski;Kamil Kalinowski;Piotr Zdańkowski;Vishesh K. Dubey;Mukesh Varshney;Balpreet S. Ahluwalia;Maciej Trusiak

{"title":"High Space-Bandwidth Product Label-Free Examination of iPSC-Derived Brain Organoids via Fourier Ptychographic Microscopy","authors":"Mikolaj Krysa;Mikolaj Rogalski;Piotr Arcab;Pawel Goclowski;Kamil Kalinowski;Piotr Zdańkowski;Vishesh K. Dubey;Mukesh Varshney;Balpreet S. Ahluwalia;Maciej Trusiak","doi":"10.1109/JSTQE.2025.3650095","DOIUrl":"https://doi.org/10.1109/JSTQE.2025.3650095","url":null,"abstract":"Fourier ptychographic microscopy (FPM) is a promising quantitative phase imaging technique that enables high-resolution, label-free imaging over a large field-of-view. Here, we present the first application of FPM for the quantitative analysis of human brain organoid slices, providing a powerful, cost-effective, and label-free enhancement to the current gold-standard fluorescence microscopy. Brain organoids, prepared as thin (5 μm) slices, were imaged with a custom-built FPM system consisting of a standard light microscope (4x, 0.2 NA objective) and a 7 × 7 LED array. This configuration achieved a synthetic numerical aperture of 0.54 and a spatial resolution of approximately 488 nm across an area of 2.077 × 3.65 mm. Fluorescence microscopy was used in parallel for neurons, astrocytes, and nuclei labeling, providing rich fluorescence imaging. Moreover, we designed an automated method to merge classical resolution fluorescence images to visualize the whole brain organoid and align it with the numerically increased space-bandwidth product FPM image. The provided alignment method enables rich phase-fluorescence correlative imaging. Based on the segmentation performed on the stitched fluorescence images, we devised a quantitative phase analysis revealing a higher mean optical thickness of the nuclei versus astrocytes and neurons. Notably, nuclei located in neurogenic regions consistently exhibited significantly higher phase values (optical path difference) compared to nuclei elsewhere, suggesting cell-type-specific biophysical signatures. The label-free, quantitative, and high-throughput capabilities of the FPM approach demonstrated here make it a powerful and accessible tool for future structural and functional studies of whole-section brain organoid development and disease modeling studies.","PeriodicalId":13094,"journal":{"name":"IEEE Journal of Selected Topics in Quantum Electronics","volume":"32 4: Adv. Biophoton. in Emerg. Biomed. Tech. and Dev","pages":"1-12"},"PeriodicalIF":4.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148506868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0