Human Fertility最新文献_第6页

Higher chromosomal abnormality rate in blastocysts from a subset of patients with pericentric inversion (Inv) 1 variant. 包心倒位（Inv）1 变异患者的囊胚染色体异常率较高。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-02-20 DOI: 10.1080/14647273.2023.2179896

Miaomiao Jia, Xia Xue

{"title":"Higher chromosomal abnormality rate in blastocysts from a subset of patients with pericentric inversion (Inv) 1 variant.","authors":"Miaomiao Jia, Xia Xue","doi":"10.1080/14647273.2023.2179896","DOIUrl":"10.1080/14647273.2023.2179896","url":null,"abstract":"The purpose of this study was to evaluate the incidence of unbalanced chromosome rearrangement in blastocyst-stage embryos from carriers of pericentric inversion of chromosome 1 (PEI-1). A total of 98 embryos from 22 PEI-1 carriers were tested for unbalanced rearrangements, originating from inversion carriers, and overall aneuploidy. Logistic regression analysis indicated that the ratio of inverted segment size to chromosome length was a statistically significant risk factor for unbalanced chromosome rearrangement from PEI-1 carriers (p = 0.003). The optimal cut-off values to predict the risk of unbalanced chromosome rearrangement was 36%, with the incidence being 2.0% in the <36% group and 32.7% in the ≥36% group. The unbalanced embryo rate was 24.4% in male carriers compared to 12.3% in female carriers. Inter-chromosomal effect analysis was performed using 98 blastocysts from PEI-1 carriers and 116 blastocysts from age-matched controls. PEI-1 carriers had similar sporadic aneuploidy rates compared to those of age-matched controls at 32.7 vs. 31.9%, respectively. In conclusion, the risk of unbalanced chromosome rearrangement is affected by inverted segment size in PEI-1 carriers.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":" ","pages":"1307-1312"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10757878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nuclear sperm integrity and ICSI prognosis in Tunisian patients with MMAF syndrome (multiple morphological abnormalities of the sperm flagella). 突尼斯 MMAF 综合征（精子鞭毛多种形态异常）患者的核精子完整性和 ICSI 预后。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-09-06 DOI: 10.1080/14647273.2023.2251679

Asma Braham, Houda Ghedir, Myriam Beya Ben Khedher, Mounir Ajina, Ali Saad, Samira Ibala-Romdhane

{"title":"Nuclear sperm integrity and ICSI prognosis in Tunisian patients with MMAF syndrome (multiple morphological abnormalities of the sperm flagella).","authors":"Asma Braham, Houda Ghedir, Myriam Beya Ben Khedher, Mounir Ajina, Ali Saad, Samira Ibala-Romdhane","doi":"10.1080/14647273.2023.2251679","DOIUrl":"10.1080/14647273.2023.2251679","url":null,"abstract":"Multiple Morphological Abnormalities of the Sperm Flagella (MMAF) is a severe form of teratozoospermia associated with several sperm flagellar abnormalities. The study included 52 patients with MMAF syndrome and a control group of 25 fertile men. The impact of nuclear sperm quality on intracytoplasmic sperm injection (ICSI) results was studied in 20 couples. TUNEL assay was used to assess sperm DNA fragmentation and aniline-blue staining was used to assess chromatin condensation. To investigate chromosomal meiotic segregation, we used fluorescence in situ hybridization (FISH). Semen morphology analysis revealed a mosaic of multiple flagella morphological abnormalities, including 46.73% short flagella, 16.22% bent flagella, 22.07% coiled flagella, and 10.90% absent flagella, all of which were associated with a high percentage of sperm head abnormalities. The mean DNA fragmentation index was substantially higher in patients compared to controls (p = 0.001), whereas the rate of aniline blue-reacted spermatozoa was not significantly different. There was a significant difference in aneuploidy frequencies between the two groups (p < 0.05). Infertile males with MMAF syndrome had lower sperm nuclear quality, which affected ICSI results. As a result, better sperm selection procedures are being employed to increase the success rate of assisted reproductive technologies (ART).","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":" ","pages":"1429-1438"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10153547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive bioinformation analysis of differentially expressed genes in recurrent pregnancy loss. 复发性流产差异表达基因的综合生物信息分析。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2022-03-21 DOI: 10.1080/14647273.2022.2045636

Huaibin Wang, Zhao Liu, Lijun Meng, Xiujun Zhang

{"title":"Comprehensive bioinformation analysis of differentially expressed genes in recurrent pregnancy loss.","authors":"Huaibin Wang, Zhao Liu, Lijun Meng, Xiujun Zhang","doi":"10.1080/14647273.2022.2045636","DOIUrl":"10.1080/14647273.2022.2045636","url":null,"abstract":"Recurrent pregnancy loss (RPL) occurs frequently, and its causes are complex. The aetiology of nearly 50% of RPL cases is still unknown. This study aimed to ascertain differentially expressed genes (DEGs) and pathways by comprehensive bioinformatics analysis. We downloaded the gene expression microarray of GSE165004 from the Gene Expression Omnibus (GEO). Gene ontology (GO) analysis and Kyoto Encyclopaedia of Gene and Genome (KEGG) pathway enrichment analyses were performed on selected genes by using the R Programming Language. A protein-protein interaction (PPI) network was constructed with the Retrieval of Interacting Genes (STRING). Our analysis revealed that 1,869 genes were differentially expressed in RPL and control groups. GO analysis revealed that the interferon type 1 and the glycoprotein-related biological processes played irreplaceable roles, meanwhile KEGG enrichment analysis also revealed that the cAMP signalling pathway and the prolactin signalling pathway played important roles. In the following study, we found that there were many DEGs in the RPL group that were closely related to endometrial decidualization, such as IL17RD, IL16, SOX4, CREBBP, and POFUT1 as well as Notch1 and RBPJ in the Notch signalling pathway family were down-regulated in the RPL group. The results provided valuable information on the pathogenesis of RPL.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"1 1","pages":"1015-1022"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43557052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inequalities in assisted reproduction technology utilisation between the G20 countries. 二十国集团（G20）国家在辅助生殖技术利用方面的不平等。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2021-12-17 DOI: 10.1080/14647273.2021.2017025

Amir Lass, Geffen Lass

{"title":"Inequalities in assisted reproduction technology utilisation between the G20 countries.","authors":"Amir Lass, Geffen Lass","doi":"10.1080/14647273.2021.2017025","DOIUrl":"10.1080/14647273.2021.2017025","url":null,"abstract":"Large global inequalities in assisted reproduction technology (ART) utilisation have existed ever since the introduction of ART. The reasons for these inequalities are multifactorial and include national wealth and affordability, pronatalist policies, regulatory differences in provision, and sociocultural components such as racial, gender and educational inequalities. Examining ART utilisation across the largest world economies (G20 countries) in 2016 (the most recent year with publically available data) reveals significant inequality, which is highly correlated to gross domestic product per capita, a measure of national wealth, and to provision of government funding and/or insurance coverage for in vitro fertilisation and intracytoplasmic sperm injection. A strong negative correlation with the Gender Inequality Index is also noted. The gap in ART utilisation rate will only begin to close once the majority of nations introduce more affordable ART treatment, instigate pronatalist policies, and implement changes in education, attitudes and behaviours to minimise racial and gender inequalities; however, achieving all of these changes may be a very difficult target to attain for many poorer economies, regardless of their size.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":" ","pages":"1374-1379"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39731534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive models for starting dose of gonadotropin in controlled ovarian hyperstimulation: review and progress update. 控制卵巢过度刺激中促性腺激素起始剂量的预测模型:综述和最新进展。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2024-01-24 DOI: 10.1080/14647273.2023.2285937

Xiaoxiao Guo, Hao Zhan, Xianghui Zhang, Yiwei Pang, Huishu Xu, Baolin Zhang, Kaixue Lao, Peihui Ding, Yanlin Wang, Lei Han

引用次数: 0

Response to Hasdemir et al. (2023) COVID-19 vaccinations on menstrual cycle and serum anti-Mullerian hormone levels. 回应 Hasdemir 等人（2023 年）COVID-19 疫苗接种对月经周期和血清抗穆勒氏管激素水平的影响。

IF 2.1 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-05-02 DOI: 10.1080/14647273.2023.2200980

Amnuay Kleebayoon, Viroj Wiwanitkit

引用次数: 0

The case for reframing known donation. 重构已知捐赠的理由。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-01-23 DOI: 10.1080/14647273.2022.2145242

Leah Gilman, Petra Nordqvist

{"title":"The case for reframing known donation.","authors":"Leah Gilman, Petra Nordqvist","doi":"10.1080/14647273.2022.2145242","DOIUrl":"10.1080/14647273.2022.2145242","url":null,"abstract":"Contemporary UK egg and sperm donation exists in two predominant forms: (i) clinic-based, identity-release donation; and (ii) known donation, which can take place either inside or outside of the clinic context. Regulatory and clinical discussions of the latter currently focus, almost exclusively, on risk whereas identity-release is widely presented as the default route for both donors and recipients. Consequently, there is little support available for those potential donors and recipient parents who might prefer a known donor arrangement. In this commentary, we reflect on our sociological research with donors and parents through donor conception and argue that there are a number of reasons why known donation may, in some contexts, offer advantages over identity-release donation. Whilst this research also demonstrates that there can be challenges involved in known donation, these are not inevitable nor are challenges absent from identity-release routes. It is timely and important to question whether the current de-valuing of known donation compared with identity-release donation holds up to academic scrutiny. We argue for a more balanced approach in which the benefits and challenges of both known and identity-release routes are discussed with donors and recipients and for increased support for known donation in clinics and by regulatory bodies.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":" ","pages":"1385-1392"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9127231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endometriosis affects the number of retrieved oocytes but not early embryonic development and live birth: a retrospective analysis of 716 IVF cycles. 子宫内膜异位症会影响取出的卵母细胞数量，但不会影响早期胚胎发育和活产：对 716 个试管婴儿周期的回顾性分析。

IF 2.1 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-05-04 DOI: 10.1080/14647273.2023.2200979

Alessandro Bartolacci, Miriam dell'Aquila, Giovanni Coticchio, Giulia Intra, Federica Parodi, Gilda Patria, Carlotta Zacà, Andrea Borini

{"title":"Endometriosis affects the number of retrieved oocytes but not early embryonic development and live birth: a retrospective analysis of 716 IVF cycles.","authors":"Alessandro Bartolacci, Miriam dell'Aquila, Giovanni Coticchio, Giulia Intra, Federica Parodi, Gilda Patria, Carlotta Zacà, Andrea Borini","doi":"10.1080/14647273.2023.2200979","DOIUrl":"10.1080/14647273.2023.2200979","url":null,"abstract":"To investigate the potential effect of endometriosis on embryo development and clinical outcomes, a retrospective analysis of 716 women undergoing their first standard in vitro fertilization (sIVF) cycles (205 endometriosis and 511 with tubal factor infertility) was performed. The endometriosis group included women with an ultrasonographic or surgical diagnosis. Control subjects were women diagnosed with tubal factor infertility by laparoscopy or hysterosalpingogram. The primary outcome of the study was live birth. Cumulative live birth was also assessed in a subgroups analysis. After adjusting for confounders we found no significant difference in fertilization rate, blastulation, top-quality blastocyst, live birth, cumulative live birth (subgroups analysis) and miscarriage rate. In the endometriosis group, the number of retrieved oocytes was smaller (6.94 ± 4.06 Vs 7.50 ± 4.6, adjusted p < 0.05). We observed a statistically significant difference in the percentage of day-3 embryos with ≥8 blastomeres (33.12 ± 22.72 endometriosis vs, 40.77 ± 27.62 tubal factor, adjusted p < 0.01) and a negative correlation between the presence of endometriomas and a number of retrieved oocytes [B coefficient =-1.41, 95%CI (-2.31-0.51), adjusted p = 0.002]. Our results suggest that endometriosis affects the number of retrieved oocytes but not embryo development and live birth.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":" ","pages":"1469-1476"},"PeriodicalIF":2.1,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9461630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of the pathophysiology and evidence-based management of varicoceles and pelvic congestion syndrome. 综述精索静脉曲张和盆腔充血综合征的病理生理学和循证管理。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-05-16 DOI: 10.1080/14647273.2023.2212846

Matteo Galea, Mark R Brincat, Jean Calleja-Agius

引用次数: 0

Allan Pacey: Thank you from Human Fertility and the BFS. 艾伦-佩西（Allan Pacey）：感谢人类生育研究中心和英国科学基金会。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-12-21 DOI: 10.1080/14647273.2023.2278920

Mark Hamilton, Abha Maheshwari

引用次数: 0