Human Fertility最新文献_第6页

The case for reframing known donation. 重构已知捐赠的理由。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-01-23 DOI: 10.1080/14647273.2022.2145242

Leah Gilman, Petra Nordqvist

{"title":"The case for reframing known donation.","authors":"Leah Gilman, Petra Nordqvist","doi":"10.1080/14647273.2022.2145242","DOIUrl":"10.1080/14647273.2022.2145242","url":null,"abstract":"Contemporary UK egg and sperm donation exists in two predominant forms: (i) clinic-based, identity-release donation; and (ii) known donation, which can take place either inside or outside of the clinic context. Regulatory and clinical discussions of the latter currently focus, almost exclusively, on risk whereas identity-release is widely presented as the default route for both donors and recipients. Consequently, there is little support available for those potential donors and recipient parents who might prefer a known donor arrangement. In this commentary, we reflect on our sociological research with donors and parents through donor conception and argue that there are a number of reasons why known donation may, in some contexts, offer advantages over identity-release donation. Whilst this research also demonstrates that there can be challenges involved in known donation, these are not inevitable nor are challenges absent from identity-release routes. It is timely and important to question whether the current de-valuing of known donation compared with identity-release donation holds up to academic scrutiny. We argue for a more balanced approach in which the benefits and challenges of both known and identity-release routes are discussed with donors and recipients and for increased support for known donation in clinics and by regulatory bodies.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":" ","pages":"1385-1392"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9127231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endometriosis affects the number of retrieved oocytes but not early embryonic development and live birth: a retrospective analysis of 716 IVF cycles. 子宫内膜异位症会影响取出的卵母细胞数量，但不会影响早期胚胎发育和活产：对 716 个试管婴儿周期的回顾性分析。

IF 2.1 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-05-04 DOI: 10.1080/14647273.2023.2200979

Alessandro Bartolacci, Miriam dell'Aquila, Giovanni Coticchio, Giulia Intra, Federica Parodi, Gilda Patria, Carlotta Zacà, Andrea Borini

{"title":"Endometriosis affects the number of retrieved oocytes but not early embryonic development and live birth: a retrospective analysis of 716 IVF cycles.","authors":"Alessandro Bartolacci, Miriam dell'Aquila, Giovanni Coticchio, Giulia Intra, Federica Parodi, Gilda Patria, Carlotta Zacà, Andrea Borini","doi":"10.1080/14647273.2023.2200979","DOIUrl":"10.1080/14647273.2023.2200979","url":null,"abstract":"To investigate the potential effect of endometriosis on embryo development and clinical outcomes, a retrospective analysis of 716 women undergoing their first standard in vitro fertilization (sIVF) cycles (205 endometriosis and 511 with tubal factor infertility) was performed. The endometriosis group included women with an ultrasonographic or surgical diagnosis. Control subjects were women diagnosed with tubal factor infertility by laparoscopy or hysterosalpingogram. The primary outcome of the study was live birth. Cumulative live birth was also assessed in a subgroups analysis. After adjusting for confounders we found no significant difference in fertilization rate, blastulation, top-quality blastocyst, live birth, cumulative live birth (subgroups analysis) and miscarriage rate. In the endometriosis group, the number of retrieved oocytes was smaller (6.94 ± 4.06 Vs 7.50 ± 4.6, adjusted p < 0.05). We observed a statistically significant difference in the percentage of day-3 embryos with ≥8 blastomeres (33.12 ± 22.72 endometriosis vs, 40.77 ± 27.62 tubal factor, adjusted p < 0.01) and a negative correlation between the presence of endometriomas and a number of retrieved oocytes [B coefficient =-1.41, 95%CI (-2.31-0.51), adjusted p = 0.002]. Our results suggest that endometriosis affects the number of retrieved oocytes but not embryo development and live birth.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":" ","pages":"1469-1476"},"PeriodicalIF":2.1,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9461630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of the pathophysiology and evidence-based management of varicoceles and pelvic congestion syndrome. 综述精索静脉曲张和盆腔充血综合征的病理生理学和循证管理。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-05-16 DOI: 10.1080/14647273.2023.2212846

Matteo Galea, Mark R Brincat, Jean Calleja-Agius

引用次数: 0

Allan Pacey: Thank you from Human Fertility and the BFS. 艾伦-佩西（Allan Pacey）：感谢人类生育研究中心和英国科学基金会。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-12-21 DOI: 10.1080/14647273.2023.2278920

Mark Hamilton, Abha Maheshwari

引用次数: 0

15 and 30 min of immobilization after IUI: a randomized control trial. 人工授精后固定 15 分钟和 30 分钟：随机对照试验。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-03-21 DOI: 10.1080/14647273.2023.2191346

Yang Mengye, Tang Yan, Qian Jiarong, Liu Qing, Niu Fangfang, Zhang Yan

{"title":"15 and 30 min of immobilization after IUI: a randomized control trial.","authors":"Yang Mengye, Tang Yan, Qian Jiarong, Liu Qing, Niu Fangfang, Zhang Yan","doi":"10.1080/14647273.2023.2191346","DOIUrl":"10.1080/14647273.2023.2191346","url":null,"abstract":"The purpose of this study is to provide evidence for better guidance related to bed rest after intrauterine insemination (IUI). We conducted a randomized trial to compare the effect of 15 min versus 30 min of bed rest after IUI on pregnancy rate. A total of 204 couples were recruited from May 2021 to December 2021 and randomized to remain in the supine position for either 15 or 30 min after the procedure. The outcomes were the clinical pregnancy rate and comfort level after IUI. Ultimately, 198 couples were included in the analysis. The 15-min immobilization group consisted of 100 couples (226 cycles), and the 30-min immobilization group consisted of 98 couples (225 cycles). The clinical pregnancy rate per couple in the 15-min immobilization group (26 of 100) was not different from that in the 30-min immobilization group (23 of 98). With the use of discrete-time survival analysis, the cumulative probability of clinical pregnancy also showed no difference between these two groups. Based on the literature and on our study, the possible beneficial effect of 30-min immobilization after IUI is at least questionable, and a shorter time could be implemented depending on the results of a systematic review and the individual patient data from the currently executed trials.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":" ","pages":"1354-1360"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9516067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is there a relationship between morphokinetic parameters and neonatal sex in fresh embryo transfers? 新鲜胚胎移植的形态动力学参数与新生儿性别之间有关系吗？

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-03-21 DOI: 10.1080/14647273.2023.2190043

Avital Wertheimer, Onit Sapir, Assaf Ben Meir, Iris Har-Vardi, Alyssa Hochberg, Avi Ben-Haroush, Roni Garor, Tamar Margalit, Tzippy Schohat, Yoel Shufaro

{"title":"Is there a relationship between morphokinetic parameters and neonatal sex in fresh embryo transfers?","authors":"Avital Wertheimer, Onit Sapir, Assaf Ben Meir, Iris Har-Vardi, Alyssa Hochberg, Avi Ben-Haroush, Roni Garor, Tamar Margalit, Tzippy Schohat, Yoel Shufaro","doi":"10.1080/14647273.2023.2190043","DOIUrl":"10.1080/14647273.2023.2190043","url":null,"abstract":"To investigate whether morphokinetic parameters differ between male and female embryos in IVF embryos resulting in live births, a retrospective cohort study was undertaken. Files of all live births resulting from a single embryo transfer (SET) cultured in time-lapse incubators between 2013 and 2019 in two tertiary care centres were reviewed. The study group consisted of 187 SETs resulted in 187 live births, of which 100 were females (53.5%) and 87 were males (46.5%). Embryo selection for transfer was based on the known implantation data (KID) score provided by the Embryoscope and morphological assessment by experienced embryologists. Neonatal sex was confirmed through live birth documentation. Morphokinetic parameters and day 3 and day 5 KID scores of male and female embryos were compared. Maternal baseline and treatment characteristics were similar between groups. Morphokinetic time-lapse parameters of male and female embryos including: pronuclei fading; cleavage timings (t2-t9); second and third cell cycle durations; synchrony of the second and third cleavages; late morphokinetic parameters and KID scores did not differ between groups. In conclusion, time-lapse morphokinetic parameters and embryo selection methods do not seem to differ between male and female embryos, and their utilization does not bias towards any neonatal sex.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":" ","pages":"1340-1346"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9516068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ovarian sensitivity index can be used as a more sensitive indicator than follicular output rate to predict IVF/ICSI outcomes in patients of normal expected ovarian response stimulated with GnRH antagonist protocol. 卵巢敏感性指数可作为比卵泡排出率更灵敏的指标，用于预测使用 GnRH 拮抗剂方案刺激的正常预期卵巢反应患者的 IVF/ICSI 结果。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-01-17 DOI: 10.1080/14647273.2023.2164869

Fen Hu, Xiaocheng Wang, Haiying Ren, Yasu Lv, Huanhuan Li, Shan Liu, Wenhui Zhou

{"title":"Ovarian sensitivity index can be used as a more sensitive indicator than follicular output rate to predict IVF/ICSI outcomes in patients of normal expected ovarian response stimulated with GnRH antagonist protocol.","authors":"Fen Hu, Xiaocheng Wang, Haiying Ren, Yasu Lv, Huanhuan Li, Shan Liu, Wenhui Zhou","doi":"10.1080/14647273.2023.2164869","DOIUrl":"10.1080/14647273.2023.2164869","url":null,"abstract":"This retrospective study was performed to investigate the predictive power of the Ovarian Sensitivity Index (OSI) for IVF/ICSI outcomes in infertile patients who were of normal expected ovarian response. A total of 912 infertile patients who underwent GnRH antagonist protocol between January 2017 to August 2019 at the Medical Center for Human Reproduction, Beijing Chao-Yang Hospital were included. All patients completed the full oocyte retrieval cycle and either had a live birth or had no embryos left. OSI was significantly lower in patients with a live birth (196.0 ± 120.4 in the live birth group vs 276.4 ± 235.7 in the non-live birth group, p < 0.001) while follicular output rate (FORT, defined as the ratio of pre-ovulatory follicle count on hCG day x 100/small antral follicle count at baseline) showed no significant difference. Patients were divided into low, average and high OSI groups and analysed in tertiles. From the low to the high OSI group, the cumulative live birth rate (CLBR) decreased dramatically (72.7 vs 67.2 vs 54.8%, p < 0.001). Multivariate regression analysis showed that OSI was an independent factor affecting CLBR (OR: 0.996, 95%CI: 0.995-0.998, p < 0.001) in our study population. In conclusion, OSI can be used as an independent indicator to distinguish fecundity in infertile patients with normal expected ovarian response and is probably more sensitive than FORT.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":" ","pages":"1264-1270"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10539382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of artificial neural networks in reproductive medicine. 人工神经网络在生殖医学中的应用。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-01-11 DOI: 10.1080/14647273.2022.2156301

Guanghui Yuan, Bohan Lv, Cuifang Hao

引用次数: 0

Weekday vs. weekend oocyte retrievals: is there a difference? 平日与周末取卵：有区别吗？

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-04-27 DOI: 10.1080/14647273.2023.2193908

Miriam Tarrash, Casey Sciandra, Alexandra Peyser, Randi H Goldman, Christine Mullin

{"title":"Weekday vs. weekend oocyte retrievals: is there a difference?","authors":"Miriam Tarrash, Casey Sciandra, Alexandra Peyser, Randi H Goldman, Christine Mullin","doi":"10.1080/14647273.2023.2193908","DOIUrl":"10.1080/14647273.2023.2193908","url":null,"abstract":"The purpose of this study was to evaluate whether there is a difference in procedure duration and time spent in the post anaesthesia care unit (PACU) between weekday (WD) and weekend (WE) oocyte retrievals (ORs). This was a retrospective cohort study of patients compared and stratified based on number of oocytes retrieved (1-10, 11-20, and >20). Student's t-test and linear regression models were used to assess the relationship between AMH, BMI, and a number of oocytes retrieved with the duration of procedure and total time spent in the PACU. 664 patients underwent OR of which 578 met inclusion criteria and were analyzed. There were 501 WD OR cases (86%) and 77 (13%) WE ORs. When stratified by number of oocytes retrieved, there was no difference in procedure duration or PACU time between WD vs. WE OR. Longer procedure times were associated with higher BMI (p = 0.04), AMH (p = 0.01) and oocytes retrieved (p < 0.01). Increased PACU times positively correlated with the number of oocytes retrieved (p = 0.04), but not AMH or BMI. While BMI, AMH, and number of oocytes retrieved are associated with longer intra-operative and post-operative recovery times, there is no difference in procedure or recovery time when comparing WD vs. WE procedures.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":" ","pages":"1368-1373"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9707398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fertility preservation discussions, referral and follow-up in male-to-female and female-to-male adolescent transgender patients. 男变女和女变男青少年变性患者的生育力保护讨论、转诊和随访。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2021-12-17 DOI: 10.1080/14647273.2021.2015804

Allison S Komorowski, Andrew R Fisher, Emily S Jungheim, Christopher S Lewis, Kenan R Omurtag

{"title":"Fertility preservation discussions, referral and follow-up in male-to-female and female-to-male adolescent transgender patients.","authors":"Allison S Komorowski, Andrew R Fisher, Emily S Jungheim, Christopher S Lewis, Kenan R Omurtag","doi":"10.1080/14647273.2021.2015804","DOIUrl":"10.1080/14647273.2021.2015804","url":null,"abstract":"The number of patients seeking transgender healthcare is growing, and there is a potential impact of gender-affirming therapies on fertility. The use of fertility preservation (FP), particularly among transgender adolescents, has been limited. We aimed to examine differences in FP counselling, referral and utilisation between male-to-female (MtF) and female-to-male (FtM) transgender adolescents. A retrospective review of the medical records of patients ages 12-17 seen at an academic medical centre between 2012 and 2017 with a diagnosis of gender dysphoria was conducted. A total of 22 MtF and 45 FtM adolescents were included. The counselling on the potential fertility impact of gender-affirming therapy was documented in 55%, and of those counselled, 73% were counselled before receiving medication. There was no significant difference between the timing of counselling for MtF versus FtM adolescents. Of patients with documented reproductive wishes, 77% reported either desire for adopted children or no desire for biological children. Among patients offered FP referral, 2 (22.2%) MtF and 3 (12.5%) FtM patients accepted; both MtF patients cryopreserved sperm. While most adolescents were counselled on the fertility impact of gender-affirming therapy, there is room for improvement as 45% of patients had no documented counselling. The rate of transgender adolescents pursuing FP consultation and gamete cryopreservation was low, consistent with prior studies in this population.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":" ","pages":"903-907"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39732433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2