Human Fertility最新文献_第7页

Comprehensive bioinformation analysis of differentially expressed genes in recurrent pregnancy loss. 复发性流产差异表达基因的综合生物信息分析。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2022-03-21 DOI: 10.1080/14647273.2022.2045636

Huaibin Wang, Zhao Liu, Lijun Meng, Xiujun Zhang

{"title":"Comprehensive bioinformation analysis of differentially expressed genes in recurrent pregnancy loss.","authors":"Huaibin Wang, Zhao Liu, Lijun Meng, Xiujun Zhang","doi":"10.1080/14647273.2022.2045636","DOIUrl":"10.1080/14647273.2022.2045636","url":null,"abstract":"Recurrent pregnancy loss (RPL) occurs frequently, and its causes are complex. The aetiology of nearly 50% of RPL cases is still unknown. This study aimed to ascertain differentially expressed genes (DEGs) and pathways by comprehensive bioinformatics analysis. We downloaded the gene expression microarray of GSE165004 from the Gene Expression Omnibus (GEO). Gene ontology (GO) analysis and Kyoto Encyclopaedia of Gene and Genome (KEGG) pathway enrichment analyses were performed on selected genes by using the R Programming Language. A protein-protein interaction (PPI) network was constructed with the Retrieval of Interacting Genes (STRING). Our analysis revealed that 1,869 genes were differentially expressed in RPL and control groups. GO analysis revealed that the interferon type 1 and the glycoprotein-related biological processes played irreplaceable roles, meanwhile KEGG enrichment analysis also revealed that the cAMP signalling pathway and the prolactin signalling pathway played important roles. In the following study, we found that there were many DEGs in the RPL group that were closely related to endometrial decidualization, such as IL17RD, IL16, SOX4, CREBBP, and POFUT1 as well as Notch1 and RBPJ in the Notch signalling pathway family were down-regulated in the RPL group. The results provided valuable information on the pathogenesis of RPL.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"1 1","pages":"1015-1022"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43557052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inequalities in assisted reproduction technology utilisation between the G20 countries. 二十国集团（G20）国家在辅助生殖技术利用方面的不平等。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2021-12-17 DOI: 10.1080/14647273.2021.2017025

Amir Lass, Geffen Lass

{"title":"Inequalities in assisted reproduction technology utilisation between the G20 countries.","authors":"Amir Lass, Geffen Lass","doi":"10.1080/14647273.2021.2017025","DOIUrl":"10.1080/14647273.2021.2017025","url":null,"abstract":"Large global inequalities in assisted reproduction technology (ART) utilisation have existed ever since the introduction of ART. The reasons for these inequalities are multifactorial and include national wealth and affordability, pronatalist policies, regulatory differences in provision, and sociocultural components such as racial, gender and educational inequalities. Examining ART utilisation across the largest world economies (G20 countries) in 2016 (the most recent year with publically available data) reveals significant inequality, which is highly correlated to gross domestic product per capita, a measure of national wealth, and to provision of government funding and/or insurance coverage for in vitro fertilisation and intracytoplasmic sperm injection. A strong negative correlation with the Gender Inequality Index is also noted. The gap in ART utilisation rate will only begin to close once the majority of nations introduce more affordable ART treatment, instigate pronatalist policies, and implement changes in education, attitudes and behaviours to minimise racial and gender inequalities; however, achieving all of these changes may be a very difficult target to attain for many poorer economies, regardless of their size.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":" ","pages":"1374-1379"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39731534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive models for starting dose of gonadotropin in controlled ovarian hyperstimulation: review and progress update. 控制卵巢过度刺激中促性腺激素起始剂量的预测模型:综述和最新进展。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2024-01-24 DOI: 10.1080/14647273.2023.2285937

Xiaoxiao Guo, Hao Zhan, Xianghui Zhang, Yiwei Pang, Huishu Xu, Baolin Zhang, Kaixue Lao, Peihui Ding, Yanlin Wang, Lei Han

引用次数: 0

Response to Hasdemir et al. (2023) COVID-19 vaccinations on menstrual cycle and serum anti-Mullerian hormone levels. 回应 Hasdemir 等人（2023 年）COVID-19 疫苗接种对月经周期和血清抗穆勒氏管激素水平的影响。

IF 2.1 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-05-02 DOI: 10.1080/14647273.2023.2200980

Amnuay Kleebayoon, Viroj Wiwanitkit

引用次数: 0

The case for reframing known donation. 重构已知捐赠的理由。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-01-23 DOI: 10.1080/14647273.2022.2145242

Leah Gilman, Petra Nordqvist

{"title":"The case for reframing known donation.","authors":"Leah Gilman, Petra Nordqvist","doi":"10.1080/14647273.2022.2145242","DOIUrl":"10.1080/14647273.2022.2145242","url":null,"abstract":"Contemporary UK egg and sperm donation exists in two predominant forms: (i) clinic-based, identity-release donation; and (ii) known donation, which can take place either inside or outside of the clinic context. Regulatory and clinical discussions of the latter currently focus, almost exclusively, on risk whereas identity-release is widely presented as the default route for both donors and recipients. Consequently, there is little support available for those potential donors and recipient parents who might prefer a known donor arrangement. In this commentary, we reflect on our sociological research with donors and parents through donor conception and argue that there are a number of reasons why known donation may, in some contexts, offer advantages over identity-release donation. Whilst this research also demonstrates that there can be challenges involved in known donation, these are not inevitable nor are challenges absent from identity-release routes. It is timely and important to question whether the current de-valuing of known donation compared with identity-release donation holds up to academic scrutiny. We argue for a more balanced approach in which the benefits and challenges of both known and identity-release routes are discussed with donors and recipients and for increased support for known donation in clinics and by regulatory bodies.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":" ","pages":"1385-1392"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9127231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endometriosis affects the number of retrieved oocytes but not early embryonic development and live birth: a retrospective analysis of 716 IVF cycles. 子宫内膜异位症会影响取出的卵母细胞数量，但不会影响早期胚胎发育和活产：对 716 个试管婴儿周期的回顾性分析。

IF 2.1 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-05-04 DOI: 10.1080/14647273.2023.2200979

Alessandro Bartolacci, Miriam dell'Aquila, Giovanni Coticchio, Giulia Intra, Federica Parodi, Gilda Patria, Carlotta Zacà, Andrea Borini

{"title":"Endometriosis affects the number of retrieved oocytes but not early embryonic development and live birth: a retrospective analysis of 716 IVF cycles.","authors":"Alessandro Bartolacci, Miriam dell'Aquila, Giovanni Coticchio, Giulia Intra, Federica Parodi, Gilda Patria, Carlotta Zacà, Andrea Borini","doi":"10.1080/14647273.2023.2200979","DOIUrl":"10.1080/14647273.2023.2200979","url":null,"abstract":"To investigate the potential effect of endometriosis on embryo development and clinical outcomes, a retrospective analysis of 716 women undergoing their first standard in vitro fertilization (sIVF) cycles (205 endometriosis and 511 with tubal factor infertility) was performed. The endometriosis group included women with an ultrasonographic or surgical diagnosis. Control subjects were women diagnosed with tubal factor infertility by laparoscopy or hysterosalpingogram. The primary outcome of the study was live birth. Cumulative live birth was also assessed in a subgroups analysis. After adjusting for confounders we found no significant difference in fertilization rate, blastulation, top-quality blastocyst, live birth, cumulative live birth (subgroups analysis) and miscarriage rate. In the endometriosis group, the number of retrieved oocytes was smaller (6.94 ± 4.06 Vs 7.50 ± 4.6, adjusted p < 0.05). We observed a statistically significant difference in the percentage of day-3 embryos with ≥8 blastomeres (33.12 ± 22.72 endometriosis vs, 40.77 ± 27.62 tubal factor, adjusted p < 0.01) and a negative correlation between the presence of endometriomas and a number of retrieved oocytes [B coefficient =-1.41, 95%CI (-2.31-0.51), adjusted p = 0.002]. Our results suggest that endometriosis affects the number of retrieved oocytes but not embryo development and live birth.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":" ","pages":"1469-1476"},"PeriodicalIF":2.1,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9461630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of the pathophysiology and evidence-based management of varicoceles and pelvic congestion syndrome. 综述精索静脉曲张和盆腔充血综合征的病理生理学和循证管理。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-05-16 DOI: 10.1080/14647273.2023.2212846

Matteo Galea, Mark R Brincat, Jean Calleja-Agius

引用次数: 0

Allan Pacey: Thank you from Human Fertility and the BFS. 艾伦-佩西（Allan Pacey）：感谢人类生育研究中心和英国科学基金会。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-12-21 DOI: 10.1080/14647273.2023.2278920

Mark Hamilton, Abha Maheshwari

引用次数: 0

15 and 30 min of immobilization after IUI: a randomized control trial. 人工授精后固定 15 分钟和 30 分钟：随机对照试验。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-03-21 DOI: 10.1080/14647273.2023.2191346

Yang Mengye, Tang Yan, Qian Jiarong, Liu Qing, Niu Fangfang, Zhang Yan

{"title":"15 and 30 min of immobilization after IUI: a randomized control trial.","authors":"Yang Mengye, Tang Yan, Qian Jiarong, Liu Qing, Niu Fangfang, Zhang Yan","doi":"10.1080/14647273.2023.2191346","DOIUrl":"10.1080/14647273.2023.2191346","url":null,"abstract":"The purpose of this study is to provide evidence for better guidance related to bed rest after intrauterine insemination (IUI). We conducted a randomized trial to compare the effect of 15 min versus 30 min of bed rest after IUI on pregnancy rate. A total of 204 couples were recruited from May 2021 to December 2021 and randomized to remain in the supine position for either 15 or 30 min after the procedure. The outcomes were the clinical pregnancy rate and comfort level after IUI. Ultimately, 198 couples were included in the analysis. The 15-min immobilization group consisted of 100 couples (226 cycles), and the 30-min immobilization group consisted of 98 couples (225 cycles). The clinical pregnancy rate per couple in the 15-min immobilization group (26 of 100) was not different from that in the 30-min immobilization group (23 of 98). With the use of discrete-time survival analysis, the cumulative probability of clinical pregnancy also showed no difference between these two groups. Based on the literature and on our study, the possible beneficial effect of 30-min immobilization after IUI is at least questionable, and a shorter time could be implemented depending on the results of a systematic review and the individual patient data from the currently executed trials.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":" ","pages":"1354-1360"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9516067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is there a relationship between morphokinetic parameters and neonatal sex in fresh embryo transfers? 新鲜胚胎移植的形态动力学参数与新生儿性别之间有关系吗？

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-03-21 DOI: 10.1080/14647273.2023.2190043

Avital Wertheimer, Onit Sapir, Assaf Ben Meir, Iris Har-Vardi, Alyssa Hochberg, Avi Ben-Haroush, Roni Garor, Tamar Margalit, Tzippy Schohat, Yoel Shufaro

{"title":"Is there a relationship between morphokinetic parameters and neonatal sex in fresh embryo transfers?","authors":"Avital Wertheimer, Onit Sapir, Assaf Ben Meir, Iris Har-Vardi, Alyssa Hochberg, Avi Ben-Haroush, Roni Garor, Tamar Margalit, Tzippy Schohat, Yoel Shufaro","doi":"10.1080/14647273.2023.2190043","DOIUrl":"10.1080/14647273.2023.2190043","url":null,"abstract":"To investigate whether morphokinetic parameters differ between male and female embryos in IVF embryos resulting in live births, a retrospective cohort study was undertaken. Files of all live births resulting from a single embryo transfer (SET) cultured in time-lapse incubators between 2013 and 2019 in two tertiary care centres were reviewed. The study group consisted of 187 SETs resulted in 187 live births, of which 100 were females (53.5%) and 87 were males (46.5%). Embryo selection for transfer was based on the known implantation data (KID) score provided by the Embryoscope and morphological assessment by experienced embryologists. Neonatal sex was confirmed through live birth documentation. Morphokinetic parameters and day 3 and day 5 KID scores of male and female embryos were compared. Maternal baseline and treatment characteristics were similar between groups. Morphokinetic time-lapse parameters of male and female embryos including: pronuclei fading; cleavage timings (t2-t9); second and third cell cycle durations; synchrony of the second and third cleavages; late morphokinetic parameters and KID scores did not differ between groups. In conclusion, time-lapse morphokinetic parameters and embryo selection methods do not seem to differ between male and female embryos, and their utilization does not bias towards any neonatal sex.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":" ","pages":"1340-1346"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9516068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0