Human Fertility最新文献

{"title":"Ctrl + Alt + Conceive: fertility awareness in the age of Artificial Intelligence, how do large language models compare?","authors":"Bola Grace, Jiarui Zhu, Hema Dudakia, Favour Ajao-Rotimi, Nora Colton","doi":"10.1080/14647273.2025.2584673","DOIUrl":"https://doi.org/10.1080/14647273.2025.2584673","url":null,"abstract":"<p><p>Technology continues to change how we manage our health, and recent breakthroughs in Artificial Intelligence have increased the adoption of Large Language Models (LLMs) in healthcare. Since the launch of ChatGPT, LLMs have been increasingly used for health information; this study, therefore, aimed to qualitatively assess fertility information provided by LLMs. Content generated by four LLM platforms: ChatGPT, Gemini, Copilot, Perplexity, were analysed comparatively. Thirty-seven prompts were generated, covering five topics: menstrual cycle, conception, risk factors, assisted reproductive technologies and age-related fertility decline. Prompts were analysed for concordance, comprehensibility and conciseness. Safety warnings for all platforms were recorded. LLM platforms generally provided concordant answers for menstrual cycle, conception, and risk factors. However, content on assisted reproductive technologies was the least accurate. Perplexity provided the highest number of strongly-concordant and poorly-concordant responses. Comprehensibility was similar across platforms. ChatGPT was the most concise. Not all platforms provided warning or safety messages regarding potential inaccuracies. LLMs present an opportunity to expand access to fertility and reproductive health information not only for individuals and patients, but also for clinicians, researchers, educators, charities, reproductive health organisations and policymakers. Nevertheless, attention must be paid to the quality of information generated in order to ensure that professionals have accurate guidance, and that individuals can access quality information to help achieve their desired fertility and reproductive health intentions.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2584673"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145534179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mpox in assisted conception: should we be worried about this monkey wrench?","authors":"Michael B Yakass, Bryan J Woodward","doi":"10.1080/14647273.2024.2441825","DOIUrl":"10.1080/14647273.2024.2441825","url":null,"abstract":"<p><p>Following reports of mpox infections in Europe and the Americas, the World Health Organisation has declared that mpox constitutes a public health emergency of international concern. Since the mpox virus (MPXV) has been detected in semen of MPX-infected men, this puts healthcare professionals in medically assisted reproduction clinics, such as clinical embryologists and andrologists, at risk of MPX infection by handling semen from infected men. This commentary provides information about MPXV and highlights vigilance steps with regards to processing semen, oocytes, pre-implantation embryos and pregnancies of MPXV infected persons.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2441825"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peer reviewers for <i>Human Fertility</i> in 2024.","authors":"","doi":"10.1080/14647273.2025.2455862","DOIUrl":"https://doi.org/10.1080/14647273.2025.2455862","url":null,"abstract":"","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2455862"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Warnock and its contested legacy in relation to donor conceived families: the case for regulatory reform.","authors":"Caroline A B Redhead, Nicola Barker, Marie Fox, Lucy Frith","doi":"10.1080/14647273.2025.2493252","DOIUrl":"10.1080/14647273.2025.2493252","url":null,"abstract":"<p><p>A generation on from the Warnock Report, the regulatory system it proposed remains largely intact, despite significant changes in the fertility sector, legal culture and wider society. In this article, we trace Warnock's legacy, focusing on the context of gamete donor conception. Drawing on illustrative examples from the ConnectedDNA research project, we analyse two aspects of Warnock's proposals - its recommendation that gamete donors should be anonymous and its key assumption that only the 'triad' of donor, recipient(s) and donor-conceived people have an interest in receiving information about each other. The jettisoning of donor anonymity coupled with a questioning of Warnock's assumptions about the meaning of 'family', illustrate the challenges inherent in a key Warnock objective: to 'future proof' fertility law. Both the global market in gametes and embryos and the accessibility of Direct-to-Consumer Genetic Testing (DTCGT) technologies were wholly unforeseen by Warnock. Similarly, contemporary understandings of donation, families, kinship and relatedness exist in tension with Warnock's original assumptions and, thus, with the principles underpinning the legislative framework. Given this, we recommend three specific reforms to the regulation of donor conception: (1) an urgent review and reformulation of information-sharing provisions, particularly with regard to donor-siblings; (2) an expansion of counselling and support provisions for those affected by donor conception; and (3) the effective imposition of a global ten-family limit. More generally, we suggest that piecemeal and <i>ad hoc</i> reforms to the Human Fertilisation and Embryology Act 1990 have often appeared contradictory and have failed to grapple with the global nature of fertility practice. Thus, we conclude by arguing that a comprehensive review of the legislative framework is needed to create a system of legal governance which meets the needs of the donor conceived community and remains fit for purpose in the twenty-first century.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2493252"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Kahana et al. (2024) Enhancing predictions of embryo implantation in thin endometrium: a comparative analysis of endometrial thickness in frozen versus fresh IVF cycles.","authors":"Swati Dhar, Vidyashree Ganesh Poojari, Anjali Mundkur, Prashanth Adiga","doi":"10.1080/14647273.2025.2503885","DOIUrl":"10.1080/14647273.2025.2503885","url":null,"abstract":"","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2503885"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient perceptions on the use of artificial intelligence (AI) in fertility treatment.","authors":"Niamh Fee, Louise E Glover, Renato Bauman, David A Crosby","doi":"10.1080/14647273.2025.2591161","DOIUrl":"https://doi.org/10.1080/14647273.2025.2591161","url":null,"abstract":"<p><p>The objective was to evaluate patient knowledge, attitudes and perceptions on the use of artificial intelligence (AI) technology within a fertility clinic. Patients were undergoing treatment between June 2024 and December 2024. The Main Outcome Measure(s) were Likert Comfort levels scale and Qualitative analysis of responses. Overall, 206 responses were received. While 41% believed that AI could improve outcomes, most (56%) indicated that they 'did not know'. Overall, respondents were comfortable with AI being used in administrative tasks (69%), assisting with clinical decisions (67%) and assisting an embryologist (74%). However, respondents were not comfortable with AI alone performing embryo selection (93.1%), conducting semen analysis (89.2%), sperm selection in ICSI (90.2%) or reporting an ultrasound scan (84.5%). Men were more likely to be comfortable with AI alone determining which embryo to transfer (<i>p</i> = 0.0037), conducting semen analysis (<i>p</i> = 0.01), and sperm selection for ICSI (<i>p</i> = 0.02). Dominant themes regarding the benefits of AI included its use as an assistant, improving efficiency, and reducing error, while dominant themes of patient concerns included human replacement, loss of empathy, and the need for monitoring. Patients have concerns regarding the introduction of AI into fertility care, with men more likely than women to be comfortable.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2591161"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of vitamin D supplementation on frozen embryo transfer cycle outcomes.","authors":"Nikolaos Christoforidis, Michail Papapanou, Dimitrios Michalakis, Marina Dimitraki, Alexia Chatziparasidou, Charalampos Siristatidis","doi":"10.1080/14647273.2025.2493251","DOIUrl":"https://doi.org/10.1080/14647273.2025.2493251","url":null,"abstract":"<p><p>The role of serum 25-OH D3 (D3) in the physiology and regulation of the female genital system has gained significant research interest. Recent data have suggested that sufficient D3 levels are associated with improved outcomes of <i>in vitro</i> fertilization (IVF), although other studies failed to confirm so. Screening for D3 levels before IVF is becoming common practice in many IVF centres, and D3 insufficiency is treated with supplements before treatment. However, little is known about the effect of this intervention on D3 levels during endometrial preparation for frozen-embryo transfer (FET) cycles, especially regarding clinical outcomes. To examine the effect of vitamin D supplementation and the impact of vitamin D status in women undergoing FET cycles, a prospective study of infertile women undergoing FET cycles was carried out. Initial screening of D3 levels was performed in 252 infertile women before a FET cycle, and where insufficiency was found (<30 ng/mL) [115 (45.6%)], supplements were prescribed according to a standardized protocol. Serum D3 levels were measured at three distinct time-points: at the initiation of endometrial preparation (T1), embryo transfer (T2), and beta-hCG testing (T3). We found no significant difference in ongoing pregnancy [40 (34.8%) <i>vs.</i> 51 (37.2%); odds ratio (OR) 0.90, 95% confidence interval (CI) 0.54-1.51; adjusted OR 1.04, 95% CI 0.58-1.83], live birth, positive β-hCG, clinical pregnancy, miscarriage, and ectopic pregnancy rates between D3-insufficient participants at T1 receiving vitamin D and D3-replete ones not receiving any supplementation (<i>p</i>-values >0.05). We also found no significant difference in ongoing pregnancy [21 (30.9%) <i>vs.</i> 66 (40.2%), and 17 (34.0%) <i>vs.</i> 51 (41.5%)] and the rest of the outcomes between D3-insufficient and replete participants at T2 and T3, respectively (<i>p</i>-values >0.05). In conclusion, this prospective cohort study of women undergoing FET cycles found no significant difference in ongoing pregnancy rates between D3-insufficient participants receiving supplementation at the beginning of endometrial preparation and replete ones receiving no supplementation. Large, high-quality trials are required to further investigate this hypothesis and compare the IVF outcomes between replete participants, insufficient participants receiving no supplementation, and insufficient participants receiving supplementation.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2493251"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse impact of paternal age on embryo euploidy: insights from retrospective analysis and interpretable Machine learning.","authors":"Tangyi Geng, Hui Ji, Kai Ding, Ye Yang, Chun Zhao, Junqiang Zhang, Xiufeng Ling, Qiao Zhou","doi":"10.1080/14647273.2025.2522886","DOIUrl":"https://doi.org/10.1080/14647273.2025.2522886","url":null,"abstract":"<p><p>The trend of delayed childbearing has increased the average age of parents, with the impact of paternal age on embryo euploidy remaining controversial. Therefore, this study aimed to investigate the impact of paternal age on embryo euploidy using retrospective clinical data and interpretable machine learning. This retrospective study included 960 couples and 4,718 embryos undergoing preimplantation genetic testing for aneuploidy (PGT-A). Couples were divided into two groups based on paternal age (Group 1 ≥ 40 years and Group 2 < 40 years). Statistical methods, including generalized estimating equation (GEE) and restricted cubic spline, were used to evaluate the relationship between paternal age and embryo euploidy. Interpretable machine learning models were employed to predict the likelihood of having at least one euploid embryo, validating the impact of paternal age on embryo euploidy. 867 and 3,851 blastocysts were selected as Group 1 and control Group 2, respectively. Couples with higher paternal age showed a significantly higher rate of embryo aneuploidy (60.21% vs. 41.03%, <i>P</i> < 0.001). Logistic regression using GEE confirmed the association between paternal age and aneuploidy rate (OR: 1.396, 95% CI: 1.150-1.695, <i>P</i> < 0.01). Combining clinical data analysis and interpretable machine learning models, the study provides evidence that paternal age negatively impacts embryo euploidy, emphasizing the need to consider paternal age in reproductive planning.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2522886"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of combined oral contraceptive pills (COCs) in preventing persistent corpus luteal cysts following oocyte retrieval: a randomized controlled trial.","authors":"Pavarit Humart, Somsin Petyim, Dittakarn Boriboonhirunsan","doi":"10.1080/14647273.2025.2505634","DOIUrl":"10.1080/14647273.2025.2505634","url":null,"abstract":"<p><p>The objective was to compare the preventive effect of combined oral contraceptive pills (COCs) to the expectant management approach on the incident of corpus luteal cysts following oocyte retrieval in in vitro fertilization (IVF). A total of 130 IVF patients at the Infertility Unit of Siriraj Hospital were randomized into two groups following ovarian stimulation and oocyte retrieval. Participants in the study group received COCs containing 0.15 mg desogestrel and 0.02 mg ethinyl oestradiol per pill for 21 days (<i>n</i> = 65), while the comparison group underwent expectant management (<i>n</i> = 65). Transvaginal ultrasonography was performed to detect corpus luteal cysts (mean cyst diameter ≥ 10 mm) at 2 and 4 weeks after oocyte retrieval. Baseline characteristics were similar between groups. At 2 weeks, the incidence of persistent corpus luteal cysts was 58.4% in the COC group and 69.2% in the expectant management group (<i>p</i> = 0.2). A comparable, non-significant difference was also observed at 4 weeks (26.2% vs. 36.9%, <i>p</i> = 0.19). However, the mean cyst diameter at 4 weeks was significantly smaller in the COC group (5.74 mm vs. 9.39 mm, <i>p</i> < 0.01). The use of COCs does not effectively prevent the formation of corpus luteal cysts at 2 and 4 weeks after oocyte retrieval in the IVF process.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2505634"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What are the characteristics, motivations and experiences of people who use online sperm donation platforms? A systematic review and thematic synthesis.","authors":"Francesca Taylor-Phillips, Georgina Forshall, Georgina Jones, Rhys Turner-Moore","doi":"10.1080/14647273.2025.2553529","DOIUrl":"10.1080/14647273.2025.2553529","url":null,"abstract":"<p><p>In recent years, there has been an increase in people using websites, social media groups and mobile apps to connect with potential sperm donors or recipients. We undertook a systematic review of existing research which sought to: explore the characteristics, motivations and experiences of people who use online sperm donation platforms; assess the quality of the existing literature; identify gaps in the evidence base; and make recommendations for future research. Ten academic and grey literature databases and search engines (MEDLINE, CINAHL, PsycINFO, Scopus, Core, Google Scholar, Open Access Theses and Dissertations, NICE Evidence, Open Grey and Google) were searched in December 2019 and again in June 2024. The quality of the studies was assessed using the Mixed Methods Appraisal Tool and we undertook a thematic synthesis of the findings. The searches produced 18,614 results, of which 30 reports were included in the synthesis. The reports were published between 2010 and 2024, by authors from nine countries, and were qualitative (<i>n =</i> 19), quantitative (<i>n =</i> 7) and mixed methods (<i>n =</i> 4) in design. Four themes and two subthemes pertaining to participants' motivations and experiences were constructed from the data. The themes demonstrate that OSD is an improvised practice that is laden with stigma and can produce imbalances of power between donors and recipients. The findings point to a need for further research, including prospective research, to be undertaken with more diverse samples, including populations in the Global South, Black and minority ethnic populations, and inexperienced donors.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2553529"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}