Human Fertility最新文献_第10页

Association of mitochondrial DNA content and embryo morphology in fully expanded euploid blastocysts. 全膨胀整倍体囊胚线粒体DNA含量与胚胎形态的关系。

IF 2.1 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2025-06-02 DOI: 10.1080/14647273.2025.2501547

Ivo Karač, Gary G Ramsey, Romana Gračan, Sanja Vujisić Živković, Kristian Bodulić

{"title":"Association of mitochondrial DNA content and embryo morphology in fully expanded euploid blastocysts.","authors":"Ivo Karač, Gary G Ramsey, Romana Gračan, Sanja Vujisić Živković, Kristian Bodulić","doi":"10.1080/14647273.2025.2501547","DOIUrl":"https://doi.org/10.1080/14647273.2025.2501547","url":null,"abstract":"Over the past two decades, mitochondrial DNA (mtDNA) content has been studied as a potential biomarker for embryo viability and implantation success during in vitro fertilization (IVF) procedures. However, its reliability for embryo selection remains uncertain. Therefore, our study aimed to examine the relationship between blastocyst mtDNA content and blastocyst quality, timing of fully expanded blastocyst formation, and cleavage-stage embryo quality in blastocysts biopsied at the uniform expansion stage. We analyzed bioinformatics data from 125 day-5 and day-6 blastocysts from women aged 18 to 35 years. Each blastocyst was biopsied at expansion stage 4 and classified as euploid through preimplantation genetic testing for aneuploidy using next-generation sequencing. Blastocysts were categorized into four groups based on quality and the day of biopsy. Poor-quality day-6 blastocysts exhibited lower mtDNA levels compared to good-quality day-5 blastocysts (p = 0.006), poor-quality day-5 blastocysts (p = 0.008), and good-quality day-6 blastocysts (p = 0.003). Embryos with day-3 grades lower than 2.5 displayed lower blastocyst mtDNA levels compared to those graded 1 (p < 0.001), 1.5 (p < 0.001), and 2 (p < 0.001). These findings suggest further insights into the interplay between blastocyst mtDNA content and preimplantation embryo morphology. Nonetheless, mtDNA remains an unreliable biomarker for assessing embryo viability, warranting further investigation to determine its clinical relevance.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2501547"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstetric and perinatal outcomes of singleton pregnancy from donated frozen versus fresh oocytes. 捐赠冷冻卵母细胞与新鲜卵母细胞单胎妊娠的产科和围产儿结局。

IF 2.1 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2024-12-11 DOI: 10.1080/14647273.2024.2430234

Yuhuan Wang, Qiaoqiao Ding, Jialin Zou, Yue Niu, Daimin Wei

{"title":"Obstetric and perinatal outcomes of singleton pregnancy from donated frozen versus fresh oocytes.","authors":"Yuhuan Wang, Qiaoqiao Ding, Jialin Zou, Yue Niu, Daimin Wei","doi":"10.1080/14647273.2024.2430234","DOIUrl":"https://doi.org/10.1080/14647273.2024.2430234","url":null,"abstract":"To evaluate whether oocyte cryopreservation affects obstetric and perinatal outcomes, 350 donor oocyte recipients with live-born singletons were divided into three groups: frozen embryo transfer (FET) with fresh oocytes (n = 101), fresh embryo transfer (ET) with frozen oocytes (n = 190), FET with frozen oocytes (n = 59). Gestational age differed significantly (P = 0.025), with the FET with frozen oocytes group showing longer gestational age than FET with fresh oocytes group (276 days vs. 272 days, P = 0.04). Other outcomes were comparable among groups. Subgroup analysis of FET pregnancies revealed no significant differences between frozen and fresh oocyte groups in gestational age (B 1.38, P = 0.749), birth weight (B -0.11, P = 0.530), premature birth rates (6.8% vs. 11.9%, P = 0.746), low birth weight (LBW) (5.1% vs. 12.9%, P = 0.865), macrosomia (5.1% vs. 4.0%, P = 0.976), small for gestational age (SGA) (6.8% vs. 11.9%, P = 0.599), large for gestational age (LGA) (22.0% vs. 18.8%, P = 0.943), gestational diabetes mellitus (GDM) (10.2% vs. 11.9%, P = 0.343), hypertensive disorders of pregnancy (HDP) (8.5% vs. 17.8%, P = 0.143) or placental abnormalities (8.5% vs. 19.8%, P = 0.133). The study confirmed oocyte cryopreservation did not affect birth weight or obstetrical complications in donor oocyte recipients.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2430234"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevention of ovarian hyperstimulation syndrome (OHSS): British Fertility Society policy and practice guideline. 预防卵巢过度刺激综合征（OHSS）：英国生育学会政策和实践指南。

IF 2.1 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2024-12-19 DOI: 10.1080/14647273.2024.2441827

N Tsampras, K Palinska-Rudzka, Y Alebrahim, L Craciunas, R Mathur

{"title":"Prevention of ovarian hyperstimulation syndrome (OHSS): British Fertility Society policy and practice guideline.","authors":"N Tsampras, K Palinska-Rudzka, Y Alebrahim, L Craciunas, R Mathur","doi":"10.1080/14647273.2024.2441827","DOIUrl":"10.1080/14647273.2024.2441827","url":null,"abstract":"This British Fertility Society (BFS) Policy and Practice guideline aims to support clinicians in preventing ovarian hyperstimulation syndrome (OHSS) in patients undergoing gonadotropin ovarian stimulation. A systematic literature search of the medical databases was performed. The Guideline Development Group (GDG) identified the risk factors of OHSS before and during ovarian stimulation. The relation of different pre-treatment measures and different ovarian stimulation protocols with OHSS was evaluated. The optimal monitoring during treatment was assessed. The current evidence on preventive strategies during and after ovarian stimulation and the available adjuvant preventive agents were examined. Based on this, the GDG developed evidence-based, graded recommendations for clinical practice. The evidence was evaluated within context, considering the effectiveness, cost and practical problems of assisted reproductive technology for patients and healthcare providers. Early identification and application of preventive measures identified in this guideline may reduce the incidence of OHSS or reduce its severity. Suggestions for future research on OHSS prevention are provided.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2441827"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enable families with donor-conceived children to tailor their family story. Recommendations for policy and practice regarding legal age limits for accessing donor information in The Netherlands. 使有捐赠孩子的家庭能够定制他们的家庭故事。关于在荷兰获取捐助者信息的法定年龄限制的政策和做法的建议。

IF 2.1 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2025-02-25 DOI: 10.1080/14647273.2025.2470360

A Indekeu, I van Nistelrooij, N O M Woestenburg, A J B M Maas

{"title":"Enable families with donor-conceived children to tailor their family story. Recommendations for policy and practice regarding legal age limits for accessing donor information in The Netherlands.","authors":"A Indekeu, I van Nistelrooij, N O M Woestenburg, A J B M Maas","doi":"10.1080/14647273.2025.2470360","DOIUrl":"10.1080/14647273.2025.2470360","url":null,"abstract":"In 2020, the Dutch government issued a call to investigate age limits for donor-conceived people to access donor information because there was insufficient justification for such limits in the Dutch law. This question is equally important in a changing landscape of donor conception due to searching using direct-to-consumer genetic tests and social media. This paper describes recommendations for policy and practice based on an interdisciplinary (ethical, legal, psychosocial and empirical) research. Findings show that no age limits can be adequately justified, including the current ones. Consequently, we recommended modification of the law by dropping age limits and by making donor information accessible upon the birth of a donor-conceived person. Moreover, we set forth recommendations for due diligence in providing donor information. Integrating donor information into one's life's story is a gradual process that should be tailored to a child's development and individual needs. Because this process is more than a single moment of accessing donor information, we see parents as being best suited to align accessing donor information with their child's needs. We recommend that donor-conceived people, parents and donors are given support in this process, provided by professionals with experience and knowledge about donor conception.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2470360"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the editor. 给编辑的信。

IF 2 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2025-05-23 DOI: 10.1080/14647273.2025.2506175

Adiel Kahana, Ittai Many, Yuval Fouks, Benny Almog, Yoav Baruch, Emily Hamilton, Foad Azem, Yoni Cohen

引用次数: 0

Home-insemination: the motivations and experiences of same-sex and gender diverse couples using self-insemination and known donors to conceive in Aotearoa New Zealand. 家庭人工授精：在新西兰奥特罗阿，同性和性别不同的夫妇使用自我授精和已知捐赠者受孕的动机和经历。

IF 1.5 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2025-10-31 DOI: 10.1080/14647273.2025.2572997

Angela Fyfe, Sonja Goedeke, Elizabeth Du Preez

{"title":"Home-insemination: the motivations and experiences of same-sex and gender diverse couples using self-insemination and known donors to conceive in Aotearoa New Zealand.","authors":"Angela Fyfe, Sonja Goedeke, Elizabeth Du Preez","doi":"10.1080/14647273.2025.2572997","DOIUrl":"https://doi.org/10.1080/14647273.2025.2572997","url":null,"abstract":"Donor conception that occurs outside of clinical fertility settings is understood to be increasingly common, yet research on this practice remains limited. Drawing on interviews with eleven participants, this study explored the motivations and experiences of same-sex and gender diverse couples who used known donors and home insemination methods to conceive. While participants were parents of children conceived after the introduction of the Human Assisted Reproductive Technology [HART] Act (2004) in Aotearoa New Zealand, conception outside regulated settings meant they were not subject to the medical, ethical, or legal procedures implicit within fertility clinics. Four main themes were identified (1) Finding the 'ideal donor'- participants sought donors who were 'good' people; known donors were chosen to enable relational processes and facilitate ongoing connections, (2) Home insemination - perceived as affordable, personal, and offering greater agency; though revealing potential relational awkwardness, (3) Relationship planning/envisaged relationships: not the 'donor dad' - participants constructed donors as 'helping uncles' or extended family members with ongoing, contracted roles, (4) Lack of and need for knowledge, understanding and relevant support for self-insemination using known donors. This study highlights the need for accessible, evidence-based resources and psychosocial support to benefit and protect all donor conception stakeholders.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2572997"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145408813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Switching to intracytoplasmic sperm injection provides no benefit in couples of poor embryonic development in the previous in vitro fertilization cycle. 对于先前体外受精周期中胚胎发育不良的夫妇，改用卵胞浆内单精子注射没有任何益处。

IF 2.1 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2024-12-19 DOI: 10.1080/14647273.2024.2442451

Shuai Liu, Junjie Zhong, Yu Jiang, Lin Wang, Yudi Luo, Bowen Luo, Zengyu Yang

{"title":"Switching to intracytoplasmic sperm injection provides no benefit in couples of poor embryonic development in the previous in vitro fertilization cycle.","authors":"Shuai Liu, Junjie Zhong, Yu Jiang, Lin Wang, Yudi Luo, Bowen Luo, Zengyu Yang","doi":"10.1080/14647273.2024.2442451","DOIUrl":"https://doi.org/10.1080/14647273.2024.2442451","url":null,"abstract":"This study aimed to evaluate the effectiveness of changing the insemination method in women who experienced poor embryonic development during the preceding cycle. A total of 15,886 conventional IVF in 9,311 women, performed between August 2015 and June 2023, were included in this study. Of these, 270 couples experienced IVF failure due to poor embryonic development in the first oocyte retrieval (OR) cycle, which was cancelled before transfer. The patients were stratified based on whether or not they switched to ICSI for subsequent attempts. Cumulative live birth rates (CLBRs) and a series of secondary outcomes were compared. The embryo utilization, high-quality embryo, blastocyst formation, implantation, cumulative clinical pregnancy, CLBR and miscarriage rates were comparable between the two groups, whereas the fertilization rate per oocyte retrieved was significantly lower in the ICSI group during the second OR cycle (60.76% vs. 70.42%, p < 0.001) and all OR cycles (60.02% vs. 71.69%, p < 0.001). Furthermore, the CLBRs in the ICSI and IVF groups after up to seven OR cycles were 41.35% and 36.84%, respectively. Most patients achieved live births during the second OR cycle (58.33%, ICSI vs. 62.86%, IVF). ICSI did not improve clinical or embryonic outcomes in women who experienced poor embryonic development in their preceding cycle.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2442451"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The importance of education, training and continuous performance monitoring to ART professionals, particularly embryologists. 教育、培训和持续绩效监测对抗逆转录病毒治疗专业人员，特别是胚胎学家的重要性。

IF 2.1 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2025-07-20 DOI: 10.1080/14647273.2025.2529372

Martine Nijs, Ellen Armstrong, Steven Fleming

引用次数: 0

A qualitative study of Australian adolescent perceptions of fertility and infertility. 澳大利亚青少年对生育和不孕症的看法的定性研究。

IF 2.1 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2025-05-30 DOI: 10.1080/14647273.2025.2506790

Emmalee A Ford, Ava Medley, Catherine Chojenta, Tanmay Bagade, Sally Sweeney, Jessie M Sutherland

{"title":"A qualitative study of Australian adolescent perceptions of fertility and infertility.","authors":"Emmalee A Ford, Ava Medley, Catherine Chojenta, Tanmay Bagade, Sally Sweeney, Jessie M Sutherland","doi":"10.1080/14647273.2025.2506790","DOIUrl":"10.1080/14647273.2025.2506790","url":null,"abstract":"Adolescents require a specific set of fertility information and services to promote reproductive health and wellbeing extending into adulthood. Due to a common focus on preventing unplanned pregnancy in adolescents, fertility education can be perceived as antithetical. This study explores awareness and attitudes about fertility in adolescents to guide relevant inclusion of fertility in future information and service delivery. Twenty-five adolescents aged 15 to 18 years who had attended secondary schooling in Australia were recruited to participate in nine focus groups. Reflexive thematic analysis revealed three themes (with seven sub-themes) in the transcripts. The importance of fertility education, stigma associated with infertility, and gender roles in the context of reproductive health were identified as being key themes. Broadly, awareness of infertility was seen as important, to navigate potential health consequences and to emotionally support stigmatised people experiencing infertility. This is the first qualitative study about perspectives of fertility and infertility in adolescents aged 18 and under in an Australian context. We make recommendations for developing age-appropriate fertility education, regarding the incorporation of appropriate frameworks in adolescent education to enhance discussions around sex and gender in fertility to align with contemporary preferences.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2506790"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Fertility Education Initiative: responding to the need for enhanced fertility and reproductive health awareness amongst young people in the United Kingdom. 生育教育倡议：满足英国年轻人提高生育和生殖健康意识的需求。

IF 2.1 4区医学

Human Fertility Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1080/14647273.2024.2417940

James Cheshire, Justin Chu, Jacky Boivin, Grace Dugdale, Joyce Harper, Adam Balen

引用次数: 0