Haeun Kim, Venkatesh Subramanian, Freya Baird, Yusuf Beebeejaun, Ippokratis Sarris, Mohan S Kamath, Sesh K Sunkara
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引用次数: 0
摘要
身体质量指数(BMI)升高的女性寻求辅助受孕治疗的比例越来越高。现有研究评估了女性体重指数对宫腔内人工授精(IUI)治疗效果的影响,但结果仍不一致。本系统综述和荟萃分析评估了女性体重指数对宫腔内人工授精治疗效果的影响。两位作者独立进行了数据提取和研究质量评估。采用 Mantel-Haenszel 方法计算二分结果的风险比 (RR) 和 95% 置信区间。符合荟萃分析纳入标准的研究共有 11 项,涉及 23,145 例人工授精治疗事件,其中 8 项研究涉及 21,211 个周期,3 项研究涉及 1,934 名参与者。对两组接受人工授精治疗的女性进行了比较,一组是体重指数(BMI)正常的女性,另一组是体重指数(BMI)≥25 kg/m2的女性。在活产率(LBR)(RR 1.06,95% CI 0.86-1.307)、临床妊娠率(CPR)(RR 0.94,95% CI 0.78-1.13)、流产率(RR 0.92,95% CI 0.31-2.74)或异位妊娠率(RR 2.20,95% CI 0.78-6.23)方面均无统计学差异。我们的荟萃分析表明,女性体重指数的升高不会影响人工授精的治疗效果。不过,应为接受人工授精的体重指数升高的女性提供减肥咨询,以降低相关的产科发病率。
Effect of female body mass index on intrauterine insemination outcomes: a systematic review and meta-analysis.
The prevalence of women with a raised body mass index (BMI) seeking assisted conception treatment is increasing. Findings of existing studies evaluating the effect of female BMI on intrauterine insemination (IUI) treatment outcomes remain inconsistent. This systematic review and meta-analysis evaluate the effect of female BMI on IUI treatment outcomes. Two authors independently conducted data extraction and assessed study quality. Risk ratios (RR) and 95% confidence intervals were calculated using the Mantel-Haenszel approach for dichotomous outcomes. 11 studies involving 23,145 IUI treatment events, comprising 21,211 cycles from 8 studies, and 1,934 participants in three studies, met the inclusion criteria for the meta-analysis. Two cohorts of women undergoing IUI treatment were compared - women with normal BMI < 25 kg/m2 were compared with a second cohort of women with a BMI category ≥ 25 kg/m2. There was no statistically significant difference in live birth rate (LBR) (RR 1.06, 95% CI 0.86-1.307); clinical pregnancy rate (CPR) (RR 0.94, 95% CI 0.78-1.13); miscarriage (RR 0.92, 95% CI 0.31-2.74) or ectopic pregnancy rate (RR 2.20, 95% CI 0.78-6.23). Our meta-analysis showed that a raised female BMI did not affect IUI treatment outcomes. Nevertheless, weight loss counselling should be offered to women with a raised BMI undergoing IUI, to reduce the associated obstetric morbidity.
期刊介绍:
Human Fertility is a leading international, multidisciplinary journal dedicated to furthering research and promoting good practice in the areas of human fertility and infertility. Topics included span the range from molecular medicine to healthcare delivery, and contributions are welcomed from professionals and academics from the spectrum of disciplines concerned with human fertility. It is published on behalf of the British Fertility Society.
The journal also provides a forum for the publication of peer-reviewed articles arising out of the activities of the Association of Biomedical Andrologists, the Association of Clinical Embryologists, the Association of Irish Clinical Embryologists, the British Andrology Society, the British Infertility Counselling Association, the Irish Fertility Society and the Royal College of Nursing Fertility Nurses Group.
All submissions are welcome. Articles considered include original papers, reviews, policy statements, commentaries, debates, correspondence, and reports of sessions at meetings. The journal also publishes refereed abstracts from the meetings of the constituent organizations.