Human Fertility最新文献

Can a lack of knowledge of the ovulatory cycle result in primary infertility? Evidence from selected South Asian countries.

IF 2.1 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2024-12-19 DOI: 10.1080/14647273.2024.2441832

Pratyashee Ojah, Manas Ranjan Pradhan

{"title":"Can a lack of knowledge of the ovulatory cycle result in primary infertility? Evidence from selected South Asian countries.","authors":"Pratyashee Ojah, Manas Ranjan Pradhan","doi":"10.1080/14647273.2024.2441832","DOIUrl":"https://doi.org/10.1080/14647273.2024.2441832","url":null,"abstract":"Knowledge of ovulatory cycle (KOC) is a crucial factor for successful conception. Despite sizable number of women suffering from infertility, empirical evidence on the relation between infertility and KOC is rare in South Asia. This study assesses the association between primary infertility and KOC. The data of ever-married women aged 20-49 gathered in the recent rounds of Demographic and Health Survey (DHS) for India (2019-2021), Bangladesh (2017-2018), Pakistan (2017-2018) and Nepal (2022) were analyzed. Bivariate analysis and binary logistic regression were conducted through Stata (V.17) with a 5% significance level. Women with no KOC in India [AOR:1.71, C.I.: (1.54, 1.9)] and Bangladesh [AOR:2.6, C.I.: (1.67, 4.06)] had higher odds of primary infertility than their counterparts with correct KOC. The study concludes that correct KOC is a significant predictor of primary infertility in India and Bangladesh and is insignificant in Pakistan and Nepal. Moreover, higher age at marriage and no-visit to healthcare facility were the other significant predictors of primary infertility in all four countries. Women who are struggling to conceive would benefit from education related to the timing and identification of the fertile window, which may be provided through primary healthcare providers.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2441832"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do very young oocyte donors negatively impact live birth rates in their recipients?

IF 2.1 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2024-12-04 DOI: 10.1080/14647273.2024.2434524

Luisa Kahn, Sara Aziz, Benjamin Jones, Meen-Yau Thum, James Nicopoullos, Raef Faris, Srdjan Saso, Tim Bracewell-Milnes

{"title":"Do very young oocyte donors negatively impact live birth rates in their recipients?","authors":"Luisa Kahn, Sara Aziz, Benjamin Jones, Meen-Yau Thum, James Nicopoullos, Raef Faris, Srdjan Saso, Tim Bracewell-Milnes","doi":"10.1080/14647273.2024.2434524","DOIUrl":"https://doi.org/10.1080/14647273.2024.2434524","url":null,"abstract":"To understand whether there was an association between very young oocyte donors and adverse outcomes, this was a single centre retrospective study (Lister Fertility Clinic, London) examining data collected between 1st January 2010 and 31st December 2021. A total of 1,182 oocyte donors were included in the final analysis. Data was categorised by donor age in years; ≤22, 23-25, 26-28, 29-31, 32-34. Statistical analysis was performed using SPSS. Donors aged ≤22 years showed increased live birth rates (LBR) in fresh In Vitro Fertilisation (IVF) cycles when compared to donors aged 26-28 (p < 0.0136), 29-31 (p < 0.0044), and 32-34 (p < 0.0003) years, respectively. There was also an increased positive pregnancy rate in fresh IVF cycles for donor oocytes ≤22 years when compared to all other groups. The LBR and positive pregnancy rates decreased with increasing oocyte age with fresh IVF cycles. There was no significant difference in the LBR with frozen IVF cycles compared to fresh IVF cycles. Our data showed that very young oocyte donors are in fact associated with improved IVF outcomes, especially in fresh IVF cycles.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2434524"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mpox in assisted conception: should we be worried about this monkey wrench? 辅助受孕中的 Mpox：我们是否应该担心这个 "猴子扳手"？

IF 2.1 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2024-12-16 DOI: 10.1080/14647273.2024.2441825

Michael B Yakass, Bryan J Woodward

引用次数: 0

The infected blood inquiry report-lessons for gamete donation.

IF 2.1 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2024-12-08 DOI: 10.1080/14647273.2024.2438650

Sharon Zahra, Marc L Turner

引用次数: 0

DNA damage in prepared semen is negatively associated with semen quality and fertilisation rate in assisted reproduction technology (ART) treatment.

IF 2.1 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2024-12-19 DOI: 10.1080/14647273.2024.2442450

Bashar Altakroni, Helen Hunter, Greg Horne, Daniel R Brison, Andrew C Povey

{"title":"DNA damage in prepared semen is negatively associated with semen quality and fertilisation rate in assisted reproduction technology (ART) treatment.","authors":"Bashar Altakroni, Helen Hunter, Greg Horne, Daniel R Brison, Andrew C Povey","doi":"10.1080/14647273.2024.2442450","DOIUrl":"https://doi.org/10.1080/14647273.2024.2442450","url":null,"abstract":"Sperm DNA contains strand breaks and base damage that can potentially affect reproductive health. This study aims to determine to what extent sperm DNA integrity and alkylation is associated with semen quality and assisted reproduction technology (ART) treatment outcomes, in particular fertilisation and cleavage rates. Male partners of couples attending for infertility treatment were recruited. DNA integrity (% tail DNA, sperm with either low (LDD) or high (HDD) damage levels) was measured by a neutral Comet assay and N7-methyldeoxyguanosine (N7-MedG) DNA levels by an immunoslotblot in sperm prepared by density gradient centrifugation. Associations between DNA damage, semen quality and ART treatment outcomes were assessed. N7-MedG levels were lower and the proportion of LDD sperm higher in prepared than in neat sperm samples. The proportion of HDD sperm and % tail DNA were significantly negatively associated and the proportion of LDD sperm positively associated with semen quality. Fertilisation, but not cleavage, rate nor live birth, was significantly negatively associated with N7-MedG levels, the proportion of HDD sperm and % tail DNA and was positively associated with the proportion of LDD sperm. These results confirm that DNA damage, even in prepared sperm, is associated with adverse semen quality and suggest that sperm DNA damage affects the early stages of embryo formation.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2442450"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstetric and perinatal outcomes of singleton pregnancy from donated frozen versus fresh oocytes.

IF 2.1 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2024-12-11 DOI: 10.1080/14647273.2024.2430234

Yuhuan Wang, Qiaoqiao Ding, Jialin Zou, Yue Niu, Daimin Wei

{"title":"Obstetric and perinatal outcomes of singleton pregnancy from donated frozen versus fresh oocytes.","authors":"Yuhuan Wang, Qiaoqiao Ding, Jialin Zou, Yue Niu, Daimin Wei","doi":"10.1080/14647273.2024.2430234","DOIUrl":"https://doi.org/10.1080/14647273.2024.2430234","url":null,"abstract":"To evaluate whether oocyte cryopreservation affects obstetric and perinatal outcomes, 350 donor oocyte recipients with live-born singletons were divided into three groups: frozen embryo transfer (FET) with fresh oocytes (n = 101), fresh embryo transfer (ET) with frozen oocytes (n = 190), FET with frozen oocytes (n = 59). Gestational age differed significantly (P = 0.025), with the FET with frozen oocytes group showing longer gestational age than FET with fresh oocytes group (276 days vs. 272 days, P = 0.04). Other outcomes were comparable among groups. Subgroup analysis of FET pregnancies revealed no significant differences between frozen and fresh oocyte groups in gestational age (B 1.38, P = 0.749), birth weight (B -0.11, P = 0.530), premature birth rates (6.8% vs. 11.9%, P = 0.746), low birth weight (LBW) (5.1% vs. 12.9%, P = 0.865), macrosomia (5.1% vs. 4.0%, P = 0.976), small for gestational age (SGA) (6.8% vs. 11.9%, P = 0.599), large for gestational age (LGA) (22.0% vs. 18.8%, P = 0.943), gestational diabetes mellitus (GDM) (10.2% vs. 11.9%, P = 0.343), hypertensive disorders of pregnancy (HDP) (8.5% vs. 17.8%, P = 0.143) or placental abnormalities (8.5% vs. 19.8%, P = 0.133). The study confirmed oocyte cryopreservation did not affect birth weight or obstetrical complications in donor oocyte recipients.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2430234"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevention of ovarian hyperstimulation syndrome (OHSS): British Fertility Society policy and practice guideline.

IF 2.1 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2024-12-19 DOI: 10.1080/14647273.2024.2441827

N Tsampras, K Palinska-Rudzka, Y Alebrahim, L Craciunas, R Mathur

{"title":"Prevention of ovarian hyperstimulation syndrome (OHSS): British Fertility Society policy and practice guideline.","authors":"N Tsampras, K Palinska-Rudzka, Y Alebrahim, L Craciunas, R Mathur","doi":"10.1080/14647273.2024.2441827","DOIUrl":"https://doi.org/10.1080/14647273.2024.2441827","url":null,"abstract":"This British Fertility Society (BFS) Policy and Practice guideline aims to support clinicians in preventing ovarian hyperstimulation syndrome (OHSS) in patients undergoing gonadotropin ovarian stimulation. A systematic literature search of the medical databases was performed. The Guideline Development Group (GDG) identified the risk factors of OHSS before and during ovarian stimulation. The relation of different pre-treatment measures and different ovarian stimulation protocols with OHSS was evaluated. The optimal monitoring during treatment was assessed. The current evidence on preventive strategies during and after ovarian stimulation and the available adjuvant preventive agents were examined. Based on this, the GDG developed evidence-based, graded recommendations for clinical practice. The evidence was evaluated within context, considering the effectiveness, cost and practical problems of assisted reproductive technology for patients and healthcare providers. Early identification and application of preventive measures identified in this guideline may reduce the incidence of OHSS or reduce its severity. Suggestions for future research on OHSS prevention are provided.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2441827"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Switching to intracytoplasmic sperm injection provides no benefit in couples of poor embryonic development in the previous in vitro fertilization cycle.

IF 2.1 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2024-12-19 DOI: 10.1080/14647273.2024.2442451

Shuai Liu, Junjie Zhong, Yu Jiang, Lin Wang, Yudi Luo, Bowen Luo, Zengyu Yang

{"title":"Switching to intracytoplasmic sperm injection provides no benefit in couples of poor embryonic development in the previous in vitro fertilization cycle.","authors":"Shuai Liu, Junjie Zhong, Yu Jiang, Lin Wang, Yudi Luo, Bowen Luo, Zengyu Yang","doi":"10.1080/14647273.2024.2442451","DOIUrl":"https://doi.org/10.1080/14647273.2024.2442451","url":null,"abstract":"This study aimed to evaluate the effectiveness of changing the insemination method in women who experienced poor embryonic development during the preceding cycle. A total of 15,886 conventional IVF in 9,311 women, performed between August 2015 and June 2023, were included in this study. Of these, 270 couples experienced IVF failure due to poor embryonic development in the first oocyte retrieval (OR) cycle, which was cancelled before transfer. The patients were stratified based on whether or not they switched to ICSI for subsequent attempts. Cumulative live birth rates (CLBRs) and a series of secondary outcomes were compared. The embryo utilization, high-quality embryo, blastocyst formation, implantation, cumulative clinical pregnancy, CLBR and miscarriage rates were comparable between the two groups, whereas the fertilization rate per oocyte retrieved was significantly lower in the ICSI group during the second OR cycle (60.76% vs. 70.42%, p < 0.001) and all OR cycles (60.02% vs. 71.69%, p < 0.001). Furthermore, the CLBRs in the ICSI and IVF groups after up to seven OR cycles were 41.35% and 36.84%, respectively. Most patients achieved live births during the second OR cycle (58.33%, ICSI vs. 62.86%, IVF). ICSI did not improve clinical or embryonic outcomes in women who experienced poor embryonic development in their preceding cycle.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2442451"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Fertility Education Initiative: responding to the need for enhanced fertility and reproductive health awareness amongst young people in the United Kingdom. 生育教育倡议：满足英国年轻人提高生育和生殖健康意识的需求。

IF 2.1 4区医学

Human Fertility Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1080/14647273.2024.2417940

James Cheshire, Justin Chu, Jacky Boivin, Grace Dugdale, Joyce Harper, Adam Balen

引用次数: 0

Elevated luteinizing hormone levels during the artificial endometrial preparation cycle do not impact pregnancy outcomes in patients undergoing single vitrified-warmed blastocyst transfer. 人工子宫内膜准备周期中黄体生成素水平的升高不会影响单个玻璃化温化囊胚移植患者的妊娠结局。

IF 2.1 4区医学

Human Fertility Pub Date : 2024-12-01 Epub Date: 2024-11-08 DOI: 10.1080/14647273.2024.2424336

Haengjun Jeon, Woo Sik Lee, Ji Won Kim

{"title":"Elevated luteinizing hormone levels during the artificial endometrial preparation cycle do not impact pregnancy outcomes in patients undergoing single vitrified-warmed blastocyst transfer.","authors":"Haengjun Jeon, Woo Sik Lee, Ji Won Kim","doi":"10.1080/14647273.2024.2424336","DOIUrl":"https://doi.org/10.1080/14647273.2024.2424336","url":null,"abstract":"The effect of an increase in luteinizing hormone levels on pregnancy outcomes in patients undergoing artificial endometrial preparation for frozen embryo transfer has not been definitively elucidated. We aimed to investigate the effect of elevated luteinizing hormone levels, measured prior to progesterone administration, on the ongoing pregnancy rate in patients undergoing artificial endometrial preparation for single vitrified-warmed blastocyst transfer. Patients began taking oral oestradiol valerate on menstrual day 2-3. When the endometrial thickness reached ≥7 mm, they were tested for oestradiol, progesterone, and luteinizing hormone, and luteal phase support was started. The participants were divided into four groups based on luteinizing hormone percentiles, and differences in pregnancy outcomes were examined. No significant differences were observed for on-going pregnancy rate and the other pregnancy outcomes between the groups. In multivariate logistic regression analysis, not the luteinizing hormone levels but the quality of embryo had a significant influence on ongoing pregnancy (p = 0.004; adjusted odds ratio, 1.8; 95% confidence interval, 1.213-2.675). The elevation of luteinizing hormone levels during artificial endometrial preparation did not have an impact on the ongoing pregnancy or the other pregnancy outcomes.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"27 1","pages":"2424336"},"PeriodicalIF":2.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0