Human Fertility最新文献

{"title":"Can a lack of knowledge of the ovulatory cycle result in primary infertility? Evidence from selected South Asian countries.","authors":"Pratyashee Ojah, Manas Ranjan Pradhan","doi":"10.1080/14647273.2024.2441832","DOIUrl":"https://doi.org/10.1080/14647273.2024.2441832","url":null,"abstract":"<p><p>Knowledge of ovulatory cycle (KOC) is a crucial factor for successful conception. Despite sizable number of women suffering from infertility, empirical evidence on the relation between infertility and KOC is rare in South Asia. This study assesses the association between primary infertility and KOC. The data of ever-married women aged 20-49 gathered in the recent rounds of Demographic and Health Survey (DHS) for India (2019-2021), Bangladesh (2017-2018), Pakistan (2017-2018) and Nepal (2022) were analyzed. Bivariate analysis and binary logistic regression were conducted through Stata (V.17) with a 5% significance level. Women with no KOC in India [AOR:1.71, C.I.: (1.54, 1.9)] and Bangladesh [AOR:2.6, C.I.: (1.67, 4.06)] had higher odds of primary infertility than their counterparts with correct KOC. The study concludes that correct KOC is a significant predictor of primary infertility in India and Bangladesh and is insignificant in Pakistan and Nepal. Moreover, higher age at marriage and no-visit to healthcare facility were the other significant predictors of primary infertility in all four countries. Women who are struggling to conceive would benefit from education related to the timing and identification of the fertile window, which may be provided through primary healthcare providers.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2441832"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of adverse pregnancy outcomes after abnormal hysterosalpingography.","authors":"Erika Gandelsman, Leonti Grin, Tamar Wainstock, Roza Berkovitz Shperling, Elena Scherbina, Bozhena Saar-Ryss","doi":"10.1080/14647273.2024.2431109","DOIUrl":"10.1080/14647273.2024.2431109","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between an abnormal hysterosalpingogram (HSG) and obstetrical and neonatal outcomes.</p><p><strong>Design: </strong>A retrospective cohort study comparing outcomes between women with normal versus abnormal tubal patency and uterine cavity on HSG.</p><p><strong>Results: </strong>Among 2181 women included in the study, 494 (22.6%) had an abnormal HSG. Of these, 207 (42%) presented with uterine abnormalities, 336 (68%) with tubal abnormalities and 49 (10%) with both. The study identified 232 clinical pregnancies in the abnormal HSG group and 814 pregnancies in controls. Women with abnormal HSG showed higher rates of preterm labour (PTL) compared to controls (13.6% vs. 7.7%, <i>p</i> < 0.05, <i>n</i> = 1687). Multivariate analysis revealed that any HSG abnormality was associated with an increased risk of PTL (aOR 2.39, 1.04-5.51). When analysing by type of abnormality, uterine abnormalities increased the risk of preeclampsia (aOR 2.86, 1.06-7.7) and low birthweight (aOR 2.31, 1.0-5.35), while tubal abnormalities were specifically associated with increased risk of PTL (aOR 3.87, 1.63-9.19).</p><p><strong>Conclusion: </strong>An abnormal HSG study was associated with adverse obstetrical outcomes. Specifically, uterine abnormalities increased the risk of preeclampsia and birthweight below 10th percentile, while tubal abnormalities were associated with a heightened risk of PTL.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2431109"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143055882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women, Wombs and Warnock: 40 years after the Warnock Report, is legislation fit for purpose for uterus transplantation?","authors":"Natasha Hammond-Browning","doi":"10.1080/14647273.2025.2492115","DOIUrl":"https://doi.org/10.1080/14647273.2025.2492115","url":null,"abstract":"<p><p>This article examines and evaluates the adequacy of current legislation regarding uterus transplants in light of the Warnock Committee's foundational work on reproductive ethics and technology. With increasing advancements in reproductive technology, the potential for uterus transplants to provide opportunities for cisgender women with absolute uterine factor infertility (AUFI) to gestate has garnered significant attention. However, existing legal frameworks often lag behind medical innovations, leading to disparities in access, regulation, and patient rights. Questions also arise regarding applying existing legislation to novel medical innovations, such as the potential to provide a uterus transplant to transgender women. As uterus transplantation emerges as a viable treatment option for cisgender women with absolute uterine factor infertility, the need for comprehensive legal frameworks becomes increasingly urgent and so this article assesses whether existing assisted reproduction laws are fit for purpose or whether reform is required given advances in reproductive medicine such as uterus transplantation.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2492115"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Concern: Comparison of macroscopic one-layer over number 1 nylon suture vasovasostomy with the standard two-layer microsurgical procedure.","authors":"","doi":"10.1080/14647273.2025.2480402","DOIUrl":"https://doi.org/10.1080/14647273.2025.2480402","url":null,"abstract":"","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2480402"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do very young oocyte donors negatively impact live birth rates in their recipients?","authors":"Luisa Kahn, Sara Aziz, Benjamin Jones, Meen-Yau Thum, James Nicopoullos, Raef Faris, Srdjan Saso, Tim Bracewell-Milnes","doi":"10.1080/14647273.2024.2434524","DOIUrl":"https://doi.org/10.1080/14647273.2024.2434524","url":null,"abstract":"<p><p>To understand whether there was an association between very young oocyte donors and adverse outcomes, this was a single centre retrospective study (Lister Fertility Clinic, London) examining data collected between 1st January 2010 and 31st December 2021. A total of 1,182 oocyte donors were included in the final analysis. Data was categorised by donor age in years; ≤22, 23-25, 26-28, 29-31, 32-34. Statistical analysis was performed using SPSS. Donors aged ≤22 years showed increased live birth rates (LBR) in fresh In Vitro Fertilisation (IVF) cycles when compared to donors aged 26-28 <i>(p</i> < 0.0136), 29-31 (<i>p</i> < 0.0044), and 32-34 (<i>p</i> < 0.0003) years, respectively. There was also an increased positive pregnancy rate in fresh IVF cycles for donor oocytes ≤22 years when compared to all other groups. The LBR and positive pregnancy rates decreased with increasing oocyte age with fresh IVF cycles. There was no significant difference in the LBR with frozen IVF cycles compared to fresh IVF cycles. Our data showed that very young oocyte donors are in fact associated with improved IVF outcomes, especially in fresh IVF cycles.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2434524"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How do coping strategies influence fertility-related information seeking/avoidance?","authors":"Chloe May Smith, Mei Yee Tang, Gavin Clark, Suzanne Madgwick","doi":"10.1080/14647273.2025.2488759","DOIUrl":"https://doi.org/10.1080/14647273.2025.2488759","url":null,"abstract":"<p><p>Despite the rise in discussions around fertility and reproductive health, recent evidence indicates that women's fertility awareness (FA) remains low, with many avoiding essential fertility-related information (FRI). Existing research has linked low awareness to demographic factors, yet psychological and behavioural determinants have received less attention. This study, therefore, explores the influence of coping strategies (avoidant and problem-focused) on FRI-seeking and avoidance behaviours and their effect on FA. A cross-sectional survey gathered data from 216 UK-based female participants aged 18-68 (<i>M</i> = 31.69, <i>SD</i> = 10.42), measuring demographics, FA, FRI-seeking and avoidance, and coping strategies. Data underwent multiple regression and moderation analyses. The average FA score was 17.87/29 (62%). FRI-seeking positively predicted FA (<i>p</i> < 0.001), while FRI-avoidance negatively predicted FA (<i>p</i> < 0.001). Avoidant coping significantly predicted increased FRI-avoidance (<i>p</i> < 0.001), moderating the relationship between FRI-avoidance and FA (<i>p</i> < 0.001). Problem-focused coping significantly predicted FRI-seeking (<i>p</i> < 0.001), moderating the relationship between FRI-seeking and FA (<i>p</i> < 0.001). Results suggest that coping strategies influence motivation to seek and avoid FRI. Future FRI and fertility education should be tailored to suit women's coping strategies to facilitate active engagement, which may enhance awareness and support more informed fertility decision-making.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2488759"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mpox in assisted conception: should we be worried about this monkey wrench?","authors":"Michael B Yakass, Bryan J Woodward","doi":"10.1080/14647273.2024.2441825","DOIUrl":"10.1080/14647273.2024.2441825","url":null,"abstract":"<p><p>Following reports of mpox infections in Europe and the Americas, the World Health Organisation has declared that mpox constitutes a public health emergency of international concern. Since the mpox virus (MPXV) has been detected in semen of MPX-infected men, this puts healthcare professionals in medically assisted reproduction clinics, such as clinical embryologists and andrologists, at risk of MPX infection by handling semen from infected men. This commentary provides information about MPXV and highlights vigilance steps with regards to processing semen, oocytes, pre-implantation embryos and pregnancies of MPXV infected persons.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2441825"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peer reviewers for <i>Human Fertility</i> in 2024.","authors":"","doi":"10.1080/14647273.2025.2455862","DOIUrl":"https://doi.org/10.1080/14647273.2025.2455862","url":null,"abstract":"","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2455862"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of vitamin D supplementation on frozen embryo transfer cycle outcomes.","authors":"Nikolaos Christoforidis, Michail Papapanou, Dimitrios Michalakis, Marina Dimitraki, Alexia Chatziparasidou, Charalampos Siristatidis","doi":"10.1080/14647273.2025.2493251","DOIUrl":"https://doi.org/10.1080/14647273.2025.2493251","url":null,"abstract":"<p><p>The role of serum 25-OH D3 (D3) in the physiology and regulation of the female genital system has gained significant research interest. Recent data have suggested that sufficient D3 levels are associated with improved outcomes of <i>in vitro</i> fertilization (IVF), although other studies failed to confirm so. Screening for D3 levels before IVF is becoming common practice in many IVF centres, and D3 insufficiency is treated with supplements before treatment. However, little is known about the effect of this intervention on D3 levels during endometrial preparation for frozen-embryo transfer (FET) cycles, especially regarding clinical outcomes. To examine the effect of vitamin D supplementation and the impact of vitamin D status in women undergoing FET cycles, a prospective study of infertile women undergoing FET cycles was carried out. Initial screening of D3 levels was performed in 252 infertile women before a FET cycle, and where insufficiency was found (<30 ng/mL) [115 (45.6%)], supplements were prescribed according to a standardized protocol. Serum D3 levels were measured at three distinct time-points: at the initiation of endometrial preparation (T1), embryo transfer (T2), and beta-hCG testing (T3). We found no significant difference in ongoing pregnancy [40 (34.8%) <i>vs.</i> 51 (37.2%); odds ratio (OR) 0.90, 95% confidence interval (CI) 0.54-1.51; adjusted OR 1.04, 95% CI 0.58-1.83], live birth, positive β-hCG, clinical pregnancy, miscarriage, and ectopic pregnancy rates between D3-insufficient participants at T1 receiving vitamin D and D3-replete ones not receiving any supplementation (<i>p</i>-values >0.05). We also found no significant difference in ongoing pregnancy [21 (30.9%) <i>vs.</i> 66 (40.2%), and 17 (34.0%) <i>vs.</i> 51 (41.5%)] and the rest of the outcomes between D3-insufficient and replete participants at T2 and T3, respectively (<i>p</i>-values >0.05). In conclusion, this prospective cohort study of women undergoing FET cycles found no significant difference in ongoing pregnancy rates between D3-insufficient participants receiving supplementation at the beginning of endometrial preparation and replete ones receiving no supplementation. Large, high-quality trials are required to further investigate this hypothesis and compare the IVF outcomes between replete participants, insufficient participants receiving no supplementation, and insufficient participants receiving supplementation.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2493251"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Kahana et al. (2024) Enhancing predictions of embryo implantation in thin endometrium: a comparative analysis of endometrial thickness in frozen versus fresh IVF cycles.","authors":"Swati Dhar, Vidyashree Ganesh Poojari, Anjali Mundkur, Prashanth Adiga","doi":"10.1080/14647273.2025.2503885","DOIUrl":"https://doi.org/10.1080/14647273.2025.2503885","url":null,"abstract":"","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2503885"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}