Human Fertility最新文献

Effects of E2/ERβ on follicular granulosa cells and on AMH/Smad signalling in endometriosis. E2/ERβ对子宫内膜异位症卵泡颗粒细胞和AMH/Smad信号的影响

IF 2 4区医学

Human Fertility Pub Date : 2026-12-01 Epub Date: 2026-03-06 DOI: 10.1080/14647273.2026.2638250

Xueying Li, Chang Liu, Lukanxuan Wu, Yujing Li, Li Xiao, Wei Huang

{"title":"Effects of E2/ERβ on follicular granulosa cells and on AMH/Smad signalling in endometriosis.","authors":"Xueying Li, Chang Liu, Lukanxuan Wu, Yujing Li, Li Xiao, Wei Huang","doi":"10.1080/14647273.2026.2638250","DOIUrl":"10.1080/14647273.2026.2638250","url":null,"abstract":"Patients with endometriosis have greater risk of infertility, which is associated with compromised ovarian function. Dysfunction in follicular granulosa cells and hyperactivation of oestrogen receptor beta (ERβ) are evident in endometriosis. It is also known that anti-Müllerian hormone (AMH)/Smad signalling pathway regulates ovarian activity. In this study, we aimed to explore effects of oestradiol (E2)/ERβ on follicular granulosa cells and on AMH/Smad signalling in endometriosis. The human ovarian granulosa cells were obtained from patients with tubal factor infertility and ovarian endometriosis, respectively, who underwent IVF/ICSI-ET using GnRH antagonist protocol in our hospital. A human ovarian granulosa tumour cell line (KGN) was cultured and subject to treatments with oestradiol and/or PHTPP (a selective ERβ antagonist). Cell viability, apoptosis, migration, and invasion were assessed. The mRNA and protein expressions were also investigated. It was found that AMH/Smad signalling pathway was suppressed in human ovarian granulosa cells in patients with ovarian endometriosis. Then, in KGN cells, E2 treatment (10-10 mol/L for 72 h) did not alter cell viability or apoptosis, but E2 decreased migration and invasion via ERβ. Further, E2 inhibited AMH/Smad signalling pathway via ERβ in KGN cells. Conversely, selective inhibition of ERβ could reverse these effects. In conclusion, activation of E2/ERβ compromised the function of follicular granulosa cells in endometriosis, which may be mediated by AMH/Smad signalling pathway.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"29 1","pages":"2638250"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147364995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How years of schooling affect fertility intentions by delaying age at first marriage. 受教育年限如何通过推迟初婚年龄来影响生育意愿。

IF 2 4区医学

Human Fertility Pub Date : 2026-12-01 Epub Date: 2026-10-15 DOI: 10.1080/14647273.2026.2741543

Zhong Fei, Jialu Wu

{"title":"How years of schooling affect fertility intentions by delaying age at first marriage.","authors":"Zhong Fei, Jialu Wu","doi":"10.1080/14647273.2026.2741543","DOIUrl":"https://doi.org/10.1080/14647273.2026.2741543","url":null,"abstract":"China's persistently low fertility is linked to educational expansion and delayed marriage. Using data from the Chinese General Social Survey (2015, 2017, 2018, and 2021, N = 6,310) of ever-married individuals aged 20-40 years, this study examines the direct and mediating effects of the number of years of schooling and age at first marriage on fertility intentions. The results indicate the following: (1) Years of schooling indirectly reduce fertility intentions by delaying first marriage, with a mediating effect of 38.5%, confirming an 'education→delayed marriage→lower fertility intentions' pathway. (2) The effect of delayed first marriage on fertility intentions is substantially greater than the independent effect of education. (3) Gender heterogeneity exists: for men, the effect of education is fully mediated by marriage timing, whereas for women, it is only partial. (4) Subgroup analyses reveal that the mediating pathway is more pronounced among agricultural hukou holders and medium-status families, and serial mediation further shows that delayed marriage lowers fertility intentions partly through matching with more educated spouses, accounting for an additional 23.1% of the total effect. We conclude that China's low-fertility crisis is a systemic outcome of educational expansion, marriage postponement, and conflicting policy goals, with marriage and assortative mating serving as key transmission channels.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"29 1","pages":"2741543"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UK guidelines for the medical and laboratory procurement and use of sperm, egg and embryo donors (2025)*,*. 联合王国医疗和实验室采购和使用精子、卵子和胚胎供体准则（2025年）*,*。

IF 2 4区医学

Human Fertility Pub Date : 2026-12-01 Epub Date: 2026-04-27 DOI: 10.1080/14647273.2026.2639020

Sarah Martins da Silva, Helen Clarke, Marta Jansa Perez, Nicola E Mackie, Tristan J Barber, Jackson C Kirkman-Brown

{"title":"UK guidelines for the medical and laboratory procurement and use of sperm, egg and embryo donors (2025)*,*.","authors":"Sarah Martins da Silva, Helen Clarke, Marta Jansa Perez, Nicola E Mackie, Tristan J Barber, Jackson C Kirkman-Brown","doi":"10.1080/14647273.2026.2639020","DOIUrl":"10.1080/14647273.2026.2639020","url":null,"abstract":"These guidelines replace the previous (2019) UK guidelines for the medical and laboratory screening of sperm, egg and embryo donors and were achieved by a joint working group composed of representatives from the Association of Reproductive and Clinical Scientists (ARCS), the British Fertility Society (BFS), the British Association for Sexual Health and HIV (BASHH) and the British HIV Association (BHIVA), with review and comments from their respective memberships. It was written to guide best practice in clinics but is not intended as a tool to judge the practice of centres within the UK or beyond. Guidance on core information that should be supplied to all parties involved in donation is provided. Screening tests and standards required are summarised, as are specific considerations for known donation and embryo donation. The assessment of genetic risk and heritable disorders has been fundamentally reviewed in light of technological advances. Extended carrier screening is also discussed, although we do not suggest that this is routinely performed.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"29 1","pages":"2639020"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147769907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the effect of preconception untreated subclinical hypothyroidism (TSH above normal range and below 6.0 mIU/L) on assisted reproductive technology (ART) outcomes. 探讨孕前未经治疗的亚临床甲状腺功能减退症（TSH高于正常范围，低于6.0 mIU/L）对辅助生殖技术（ART）结果的影响。

IF 2 4区医学

Human Fertility Pub Date : 2026-12-01 Epub Date: 2026-07-02 DOI: 10.1080/14647273.2026.2691185

Sophie Walter, Shiao Chan, Naimah Raza, Rima K Dhillon-Smith

{"title":"Investigating the effect of preconception untreated subclinical hypothyroidism (TSH above normal range and below 6.0 mIU/L) on assisted reproductive technology (ART) outcomes.","authors":"Sophie Walter, Shiao Chan, Naimah Raza, Rima K Dhillon-Smith","doi":"10.1080/14647273.2026.2691185","DOIUrl":"https://doi.org/10.1080/14647273.2026.2691185","url":null,"abstract":"Subclinical hypothyroidism (SCH) is a biochemical diagnosis with ongoing uncertainty regarding management in reproductive medicine. We performed a retrospective cohort study evaluating fertility and pregnancy outcomes in women undergoing assisted reproductive technology (ART), focusing on untreated preconception SCH with TSH up to 6.0mIU/L. Secondary analysis used data from women screened for thyroid function and thyroid peroxidase antibodies (TPOAb) during the TABLET trial at Birmingham Women's Hospital, UK (June 2012-December 2013). Women with TSH ≥6.0mIU/L received levothyroxine. The primary outcome was live birth. The main comparison was 'total SCH' (TSH >3.63mIU/L) versus 'euthyroid-1' (TSH 0.44-3.63mIU/L), with subgroup analyses comparing 'untreated SCH' (TSH 3.64-5.99mIU/L) to 'euthyroid-1' women, and a stricter euthyroid threshold ('euthyroid-2'; TSH 0.44-2.5mIU/L) versus 'untreated high-normal-mild SCH' (TSH 2.5-5.99mIU/L). Multivariable logistic regression adjusted for key confounders. Of 944 women screened, 560 had outcome data; 60 had SCH. SCH was associated with fewer oocytes retrieved (9.0 vs 10.4, p = 0.02) and mature oocytes (7.4 vs 8.4, p = 0.05), but no difference in live birth was seen across comparisons: 'untreated SCH' vs euthyroid-1 (aOR 1.01, 95% CI 0.54-1.87, p = 1.0) and 'untreated high-normal-mild-SCH' vs euthyroid-2 (aOR 0.96, 95% CI 0.65-1.42, p = 0.8). In women with untreated SCH achieving live birth, TSH normalised spontaneously in 8/15 cases, with no adverse outcomes observed. Untreated TSH <6.0 mIU/L does not appear to adversely affect ART or live birth outcomes, although larger prospective studies are needed.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"29 1","pages":"2691185"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148375285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction Statement: The effects of autologous platelet-rich plasma in repeated implantation failure: a randomized controlled trial. 撤回声明：自体富血小板血浆在反复植入失败中的作用：一项随机对照试验。

IF 2 4区医学

Human Fertility Pub Date : 2026-12-01 Epub Date: 2026-09-22 DOI: 10.1080/14647273.2026.2731720

引用次数: 0

Being a solo mother without the involvement of a partner: an exploration of parenting experiences and support needs. 作为一个没有伴侣参与的单身母亲：对育儿经验和支持需求的探索。

IF 2 4区医学

Human Fertility Pub Date : 2026-12-01 Epub Date: 2026-07-25 DOI: 10.1080/14647273.2026.2708222

Penny Chamberlain, Vasanti Jadva, Suzanne Buckley

{"title":"Being a solo mother without the involvement of a partner: an exploration of parenting experiences and support needs.","authors":"Penny Chamberlain, Vasanti Jadva, Suzanne Buckley","doi":"10.1080/14647273.2026.2708222","DOIUrl":"https://doi.org/10.1080/14647273.2026.2708222","url":null,"abstract":"An increasingly common family type, often referred to as 'solo mothers', 'single mothers by choice' or 'choice mothers', comprises women who intentionally become mothers without the involvement of a partner. Although solo mothers are often described as self-determined, motivated and well prepared for parenting, with both economic and social resources, little is known about their parenting experiences and emotional and practical support needs. This cross-sectional exploratory study used an online survey to examine sources of emotional and practical parenting support, ease of asking for help and parenting confidence. A total of 139 participants responded between July 2021 and February 2022. The most used sources of support were family networks and friendship groups of non-solo mothers. Paid childcare was also frequently used, with many solo mothers accessing it at least a few times per week. While most participants felt confident in their parenting, many occasionally struggled to ask for help and required additional practical, emotional and/or financial support. Positive correlations were found between feeling supported and parenting confidence (r = 0.405, p < 0.001) and between ease of asking for help and feeling supported (r = 0.458, p < 0.001). Greater efforts are needed to ensure solo mothers have equitable access to tailored emotional and practical support resources.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"29 1","pages":"2708222"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148590918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Donor conception and psychosocial support provisions across jurisdictions - what's out there? 跨司法管辖区的捐赠受孕和社会心理支持条款——那里有什么？

IF 2 4区医学

Human Fertility Pub Date : 2026-12-01 Epub Date: 2026-02-01 DOI: 10.1080/14647273.2025.2595800

Sonja Goedeke, Astrid Indekeu, Marilyn Crawshaw

{"title":"Donor conception and psychosocial support provisions across jurisdictions - what's out there?","authors":"Sonja Goedeke, Astrid Indekeu, Marilyn Crawshaw","doi":"10.1080/14647273.2025.2595800","DOIUrl":"10.1080/14647273.2025.2595800","url":null,"abstract":"As demand for donor conception (DC) rises the landscape is becoming increasingly complex. DC-linking now occurs through various means, including direct-to-consumer DNA testing, which may reveal DC where this has not been disclosed and make those genetically related known to each other, including earlier than is possible through identity-release provisions in many jurisdictions. Early contact between donors and recipient parents, as well as same-donor siblings is becoming more common. Large sibling groups within and across jurisdictions are increasingly being identified and there is also growing reliance on imported gametes and online donor recruitment platforms. These developments can be associated with challenges for donor-conceived people (DCP), parents, donors and their families, and have led to calls for more accessible and responsive psycho-social support services. This paper maps the DC context in ten Western countries, including the availability of psychosocial support and counselling. Given the growing complexity of DC and its lifelong impact on all involved, we pay particular attention to post-donation counselling support related to disclosure, long-term psychosocial wellbeing, and DC-linking. We identify key challenges in existing DC provisions and support systems and propose improvements that support DCP, donors, parents, siblings, and their families in managing the longer-term implications of DC.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"29 1","pages":"2595800"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146099739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The global evaluation of the effects of antioxidants on seminal outcomes in infertile men: a systematic review and meta-analysis. 抗氧化剂对不育男性精子结局影响的全球评估：系统回顾和荟萃分析。

IF 2 4区医学

Human Fertility Pub Date : 2026-12-01 Epub Date: 2026-04-15 DOI: 10.1080/14647273.2026.2650222

Qinyan Xu, Zhongying Wan, Zhiyuan Xiong, Xiaoyun Zhu, Qin Han, Yiya Wang, Jiayu Zhao, Feihu Yu

{"title":"The global evaluation of the effects of antioxidants on seminal outcomes in infertile men: a systematic review and meta-analysis.","authors":"Qinyan Xu, Zhongying Wan, Zhiyuan Xiong, Xiaoyun Zhu, Qin Han, Yiya Wang, Jiayu Zhao, Feihu Yu","doi":"10.1080/14647273.2026.2650222","DOIUrl":"10.1080/14647273.2026.2650222","url":null,"abstract":"The aim of the current review is to summarise information from publications on the impact of antioxidants on seminal outcomes in infertile men. A systematic search was performed in the five valid databases (Scopus, PubMed, Medline, Embase, and Web of Science) utilizing two sets of keywords up to September 2025, according to the PRISMA approach. Of the 11749 papers identified, 101 papers were included in this review, for a total of 11889 infertile men. Sperm concentration, normal sperm morphology, progressive sperm motility, and total sperm motility, were considerably higher in experimental groups compared with control groups. Both sperm concentration (106 mL-1) and total motility (%) were higher in experimental groups compared to control groups with an overall pooled standardised mean difference (SMD) of 2.33 (95% CI: 1.73, 2.94) for sperm concentration and SMD of 1.62 (95% CI: 1.20, 2.04) for total motility (%). Subgroup analysis demonstrated that duration of treatments of more than 6 months were more effective than those of less than 3 months. Based on the findings of this review, no definitive recommendation can be made regarding the use of antioxidants as a therapy for male infertility, and further research is necessary.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"29 1","pages":"2650222"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147689451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of gametes from donors who have undergone expanded carrier screening: a guidance for UK practice. 使用接受过扩大携带者筛查的捐赠者的配子：英国实践指南。

IF 2 4区医学

Human Fertility Pub Date : 2026-12-01 Epub Date: 2026-09-29 DOI: 10.1080/14647273.2026.2733076

Valerie Shaikly, Mariano Mascarenhas, Anneke Lucassen, Debra Bloor, Saffron Townsend Browne, Karen Thompson, Harish Bhandari

引用次数: 0

Contact experiences among donor conception parties: donor conceived persons, donors, parents and same-donor siblings - a mixed methods systematic review. 受赠方的接触经验：受赠人、捐赠者、父母和同捐赠者兄弟姐妹——一项混合方法的系统回顾。

IF 2 4区医学

Human Fertility Pub Date : 2026-12-01 Epub Date: 2026-06-18 DOI: 10.1080/14647273.2026.2686159

K Hall, S Goedeke, K van Kessel

{"title":"Contact experiences among donor conception parties: donor conceived persons, donors, parents and same-donor siblings - a mixed methods systematic review.","authors":"K Hall, S Goedeke, K van Kessel","doi":"10.1080/14647273.2026.2686159","DOIUrl":"10.1080/14647273.2026.2686159","url":null,"abstract":"As more jurisdictions allow donor-conceived persons (DCPs) access to their genetic information and direct-to-consumer DNA testing becomes increasingly popular, contact between those involved in donor conception, including DCPs, donors, parents and same-donor families, has grown. This mixed methods systematic review (MSSR) collates and examines research on how contact is experienced by these groups in the context of donation from donors previously unknown to recipients prior to donation. A bibliographic search of English-language, peer-reviewed studies was conducted following PRISMA 2020 guidelines across several databases, including CINAHL, JSTOR, MEDLINE, PsycINFO, PubMed, Scopus, Ovid Emcare and Google Scholar. Studies were included if they used empirical methods (quantitative, qualitative, or mixed) and involved participants with post-birth contact experiences following donation to recipients from donors not known to recipients prior to donation. These could include clinic-recruited donors (both anonymous/non-identified and identity-release) and donors recruited by recipients, such as through online platforms. From 1,397 initial records, 231 were full text screened. 57 studies meeting inclusion criteria and varying in methodology and sample size were assessed using the Joanna Briggs Institute (JBI) Checklist for Systematic Reviews and Research Synthesis. Findings were synthesised by stakeholder groups (DCPs, donors, parents), examining the form, frequency and experience of contact, as well as influencing factors. Contact ranged from occasional online interactions to regular in-person meetings, with experiences generally positive across all groups. Variations in experience were associated with attitudes towards and expectations of contact, and the size of donor networks. Further research is needed on how contact evolves over time, particularly regarding early linking (before the legislated age of access in identity-release jurisdictions) and connections made via DNA testing.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"29 1","pages":"2686159"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0