Human Fertility最新文献

{"title":"Response to Kahana et al. (2024) Enhancing predictions of embryo implantation in thin endometrium: a comparative analysis of endometrial thickness in frozen versus fresh IVF cycles.","authors":"Swati Dhar, Vidyashree Ganesh Poojari, Anjali Mundkur, Prashanth Adiga","doi":"10.1080/14647273.2025.2503885","DOIUrl":"10.1080/14647273.2025.2503885","url":null,"abstract":"","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2503885"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peer reviewers for <i>Human Fertility</i> in 2024.","authors":"","doi":"10.1080/14647273.2025.2455862","DOIUrl":"https://doi.org/10.1080/14647273.2025.2455862","url":null,"abstract":"","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2455862"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Warnock and its contested legacy in relation to donor conceived families: the case for regulatory reform.","authors":"Caroline A B Redhead, Nicola Barker, Marie Fox, Lucy Frith","doi":"10.1080/14647273.2025.2493252","DOIUrl":"10.1080/14647273.2025.2493252","url":null,"abstract":"<p><p>A generation on from the Warnock Report, the regulatory system it proposed remains largely intact, despite significant changes in the fertility sector, legal culture and wider society. In this article, we trace Warnock's legacy, focusing on the context of gamete donor conception. Drawing on illustrative examples from the ConnectedDNA research project, we analyse two aspects of Warnock's proposals - its recommendation that gamete donors should be anonymous and its key assumption that only the 'triad' of donor, recipient(s) and donor-conceived people have an interest in receiving information about each other. The jettisoning of donor anonymity coupled with a questioning of Warnock's assumptions about the meaning of 'family', illustrate the challenges inherent in a key Warnock objective: to 'future proof' fertility law. Both the global market in gametes and embryos and the accessibility of Direct-to-Consumer Genetic Testing (DTCGT) technologies were wholly unforeseen by Warnock. Similarly, contemporary understandings of donation, families, kinship and relatedness exist in tension with Warnock's original assumptions and, thus, with the principles underpinning the legislative framework. Given this, we recommend three specific reforms to the regulation of donor conception: (1) an urgent review and reformulation of information-sharing provisions, particularly with regard to donor-siblings; (2) an expansion of counselling and support provisions for those affected by donor conception; and (3) the effective imposition of a global ten-family limit. More generally, we suggest that piecemeal and <i>ad hoc</i> reforms to the Human Fertilisation and Embryology Act 1990 have often appeared contradictory and have failed to grapple with the global nature of fertility practice. Thus, we conclude by arguing that a comprehensive review of the legislative framework is needed to create a system of legal governance which meets the needs of the donor conceived community and remains fit for purpose in the twenty-first century.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2493252"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of combined oral contraceptive pills (COCs) in preventing persistent corpus luteal cysts following oocyte retrieval: a randomized controlled trial.","authors":"Pavarit Humart, Somsin Petyim, Dittakarn Boriboonhirunsan","doi":"10.1080/14647273.2025.2505634","DOIUrl":"10.1080/14647273.2025.2505634","url":null,"abstract":"<p><p>The objective was to compare the preventive effect of combined oral contraceptive pills (COCs) to the expectant management approach on the incident of corpus luteal cysts following oocyte retrieval in in vitro fertilization (IVF). A total of 130 IVF patients at the Infertility Unit of Siriraj Hospital were randomized into two groups following ovarian stimulation and oocyte retrieval. Participants in the study group received COCs containing 0.15 mg desogestrel and 0.02 mg ethinyl oestradiol per pill for 21 days (<i>n</i> = 65), while the comparison group underwent expectant management (<i>n</i> = 65). Transvaginal ultrasonography was performed to detect corpus luteal cysts (mean cyst diameter ≥ 10 mm) at 2 and 4 weeks after oocyte retrieval. Baseline characteristics were similar between groups. At 2 weeks, the incidence of persistent corpus luteal cysts was 58.4% in the COC group and 69.2% in the expectant management group (<i>p</i> = 0.2). A comparable, non-significant difference was also observed at 4 weeks (26.2% vs. 36.9%, <i>p</i> = 0.19). However, the mean cyst diameter at 4 weeks was significantly smaller in the COC group (5.74 mm vs. 9.39 mm, <i>p</i> < 0.01). The use of COCs does not effectively prevent the formation of corpus luteal cysts at 2 and 4 weeks after oocyte retrieval in the IVF process.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2505634"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovating reproductive health education: testing the concept of reproductive identity.","authors":"Yasmin Butt, Lisa Sholomon, Kelly Moffitt-Hawasly, Gwen Walsh, Diana McGlory, Taylor D Orlandoni, Riddhi Sandil, Aurélie Athan","doi":"10.1080/14647273.2025.2533256","DOIUrl":"https://doi.org/10.1080/14647273.2025.2533256","url":null,"abstract":"<p><p>Sexual and reproductive health (SRH) education in the United States has undergone significant change in the past fifty years, driven by shifting global fertility trends and an increased emphasis on identity-related topics. It has traditionally emphasized biological function, disease prevention, and risk reduction, often overlooking identity development and the psychosocial dimensions of reproductive decision-making. Reproductive Identity (RI) is an emerging construct that may provide a new direction that expands SRH education by integrating reproductive self-concept, future reproductive intentions and social justice perspectives that is strengths-based and inclusive of all genders and sexualities. This study examined how SRH educators conceptualize RI, its perceived novelty, familiarity and relevance for SRH curricula, and its alignment with the National Sex Education Standards (NSES). A mixed methods design analyzed survey responses from SRH educators who participated in a fully-funded, six-week, online professional development training programme in RI. Findings indicate that while RI was largely unfamiliar pre-training (62%), it was considered somewhat novel (65%) and relevant (78%) for SRH curricula post-training. Thematic analysis of pre- and post-training responses demonstrated that educators shifted their conceptualizations of RI from viewing RI through biologically-oriented perspectives to recognizing its broader relevance to self-concept, decision-making and reproductive justice. Although RI demonstrated partial alignment with the NSES, gaps remained in areas such as reproductive life planning and future parenting intentions. RI complements existing approaches by addressing the psychosocial and developmental aspects of reproductive decision-making. While RI has not yet been tested with adolescents, the parallel learning process observed among educators suggests its feasibility for integration into SRH curricula.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2533256"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What are the characteristics, motivations and experiences of people who use online sperm donation platforms? A systematic review and thematic synthesis.","authors":"Francesca Taylor-Phillips, Georgina Forshall, Georgina Jones, Rhys Turner-Moore","doi":"10.1080/14647273.2025.2553529","DOIUrl":"10.1080/14647273.2025.2553529","url":null,"abstract":"<p><p>In recent years, there has been an increase in people using websites, social media groups and mobile apps to connect with potential sperm donors or recipients. We undertook a systematic review of existing research which sought to: explore the characteristics, motivations and experiences of people who use online sperm donation platforms; assess the quality of the existing literature; identify gaps in the evidence base; and make recommendations for future research. Ten academic and grey literature databases and search engines (MEDLINE, CINAHL, PsycINFO, Scopus, Core, Google Scholar, Open Access Theses and Dissertations, NICE Evidence, Open Grey and Google) were searched in December 2019 and again in June 2024. The quality of the studies was assessed using the Mixed Methods Appraisal Tool and we undertook a thematic synthesis of the findings. The searches produced 18,614 results, of which 30 reports were included in the synthesis. The reports were published between 2010 and 2024, by authors from nine countries, and were qualitative (<i>n =</i> 19), quantitative (<i>n =</i> 7) and mixed methods (<i>n =</i> 4) in design. Four themes and two subthemes pertaining to participants' motivations and experiences were constructed from the data. The themes demonstrate that OSD is an improvised practice that is laden with stigma and can produce imbalances of power between donors and recipients. The findings point to a need for further research, including prospective research, to be undertaken with more diverse samples, including populations in the Global South, Black and minority ethnic populations, and inexperienced donors.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2553529"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The infected blood inquiry report-lessons for gamete donation.","authors":"Sharon Zahra, Marc L Turner","doi":"10.1080/14647273.2024.2438650","DOIUrl":"10.1080/14647273.2024.2438650","url":null,"abstract":"<p><p>Donation of substances of human origin (SoHO) is essential for the treatment of many patients and ranges from the donation of whole organs to the donation of tissue or cell products, including also gamete donation. In order to ensure the safety of recipients of SoHOs there are multiple steps taken in the donation pathway of all such substances to ensure the quality and safety of the donation. However, despite this, there is always a residual risk associated with SoHOs. The recent Infected Blood Inquiry (IBI) report has described in detail the background to the inadvertent transmission of HIV and hepatitis C to many patients in the past and has provided a number of recommendations. While the IBI focused on blood donation and the risk of blood borne virus transmission, the underlying principles are pertinent to all SoHOs, including gamete donation, and to all risks associated with SoHOs not just the risk of blood borne virus transmission.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2438650"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA damage in prepared semen is negatively associated with semen quality and fertilisation rate in assisted reproduction technology (ART) treatment.","authors":"Bashar Altakroni, Helen Hunter, Greg Horne, Daniel R Brison, Andrew C Povey","doi":"10.1080/14647273.2024.2442450","DOIUrl":"https://doi.org/10.1080/14647273.2024.2442450","url":null,"abstract":"<p><p>Sperm DNA contains strand breaks and base damage that can potentially affect reproductive health. This study aims to determine to what extent sperm DNA integrity and alkylation is associated with semen quality and assisted reproduction technology (ART) treatment outcomes, in particular fertilisation and cleavage rates. Male partners of couples attending for infertility treatment were recruited. DNA integrity (% tail DNA, sperm with either low (LDD) or high (HDD) damage levels) was measured by a neutral Comet assay and N7-methyldeoxyguanosine (N7-MedG) DNA levels by an immunoslotblot in sperm prepared by density gradient centrifugation. Associations between DNA damage, semen quality and ART treatment outcomes were assessed. N7-MedG levels were lower and the proportion of LDD sperm higher in prepared than in neat sperm samples. The proportion of HDD sperm and % tail DNA were significantly negatively associated and the proportion of LDD sperm positively associated with semen quality. Fertilisation, but not cleavage, rate nor live birth, was significantly negatively associated with N7-MedG levels, the proportion of HDD sperm and % tail DNA and was positively associated with the proportion of LDD sperm. These results confirm that DNA damage, even in prepared sperm, is associated with adverse semen quality and suggest that sperm DNA damage affects the early stages of embryo formation.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2442450"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstetric and perinatal outcomes in singleton pregnancies following medicated, stimulated and natural, frozen embryo transfer cycles: an updated systematic review and meta-analysis.","authors":"Freya Baird, Emilia Smith, Yusuf Beebeejaun, Venkatesh Subramanian, Mahua Bhaduri, Nick Kametas, Ippokratis Sarris, Sesh K Sunkara","doi":"10.1080/14647273.2024.2448131","DOIUrl":"10.1080/14647273.2024.2448131","url":null,"abstract":"<p><p>Frozen embryo transfer (FET) has been associated with higher risks of hypertensive disorders of pregnancy (HDP), large for gestational age and high birth weight. This systematic review and meta-analysis evaluates obstetric and perinatal outcomes in medicated, stimulated and natural FET cycles. A literature search was performed using MEDLINE, EMBASE, CINAHL and the Cochrane Library database; 152,590 FET cycles were analysed from 31 included studies. Risk ratios (RR) and 95% confidence intervals (CI) were calculated using fixed and random effects models determined by the heterogeneity (I²). There was significantly higher risk of obstetric and perinatal complications, including HDP (RR 1.84, CI:1.48-2.29, I² 87%) and low birth weight (LBW) (RR 1.25, CI:1.12-1.39, I² 57%) following medicated compared to natural FET cycles. A higher risk of HDP (RR 1.50, CI:1.33-1.64, I² 32%) and macrosomia (RR 1.28, CI:1.17-1.40, I² 37%) was noted following medicated compared to stimulated cycles. Natural demonstrated lower risk of HDP (RR 0.77, CI:0.60-0.99, I² 32%), gestational diabetes (RR 0.78, CI:0.68-0.89, I² 43%), LBW (RR 0.78, CI:0.64-0.95, I² 48%) and small for gestational age (RR 0.83, CI:0.70-0.98, I² 12%) than stimulated cycles. These findings indicate that medicated FET cycles convey greater risks of obstetric and perinatal complications than natural or stimulated cycles.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2448131"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#misinformation: The perils of using social media for medical advice regarding infertility.","authors":"Tanveer Dhanoya, Kathleen O'Marcaigh, Tanvi Sambare, Ippokratis Sarris, Kugajeevan Vigneswaran","doi":"10.1080/14647273.2025.2506787","DOIUrl":"10.1080/14647273.2025.2506787","url":null,"abstract":"<p><p>To systematically evaluate the quality, credibility, accuracy, and readability of fertility-related content generated by users providing education, advice, and medical information on Twitter/X and Instagram. We selected Instagram and Twitter/X for data collection, as these platforms are commonly used by women of reproductive age. Using the terms 'fertility' and 'infertility', we collected posts both prospectively and retrospectively between April 21 and 28, 2024, using Keyhole and Brand Mentions. Posts were screened for eligibility, excluding non-English language posts, personal stories, advertisements, non-medical opinions, and peer-support posts. We assessed the accuracy, credibility, quality, and readability of the posts using validated instruments. Accuracy was evaluated based on current guidelines and the authors' expertise in infertility. Credibility was measured using a 10-point system that considered the source, context, currency, and editorial review. Quality was assessed using the 16-item DISCERN criteria with a five-point Likert scale. Readability was measured using the Flesch-Kincaid reading-ease test, which assigns a U.S. grade level to each post. Of the 15,214 posts identified, 939 were included in the final analysis. Fertility doctors generated 29% of the posts; others came from doctors of other specialties (11%), holistic practitioners (17%), and laypeople (39%). Seventy-four percent (74%) of posts did not cite sources or academic references, and 45% of posts contained inaccurate information. Only 11% of the posts were deemed credible. Of posts related to treatment, 19% were of high quality, while 53% of non-treatment posts met the same standard. Most posts (80%) were categorized as difficult to read based on readability scores. Only two posts (0.2%) were accurate, credible, high-quality, and easily readable. Social media posts about fertility often provide incomplete or misleading information, with a significant focus on naturopathy, dietary advice, and unproven theories about the effect of the COVID-19 vaccine on fertility. Clinicians and social media platforms must take responsibility for improving the accuracy and accessibility of health information online.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2506787"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}