Human Fertility最新文献_第2页

Prevention of ovarian hyperstimulation syndrome (OHSS): British Fertility Society policy and practice guideline. 预防卵巢过度刺激综合征（OHSS）：英国生育学会政策和实践指南。

IF 2.1 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2024-12-19 DOI: 10.1080/14647273.2024.2441827

N Tsampras, K Palinska-Rudzka, Y Alebrahim, L Craciunas, R Mathur

{"title":"Prevention of ovarian hyperstimulation syndrome (OHSS): British Fertility Society policy and practice guideline.","authors":"N Tsampras, K Palinska-Rudzka, Y Alebrahim, L Craciunas, R Mathur","doi":"10.1080/14647273.2024.2441827","DOIUrl":"10.1080/14647273.2024.2441827","url":null,"abstract":"This British Fertility Society (BFS) Policy and Practice guideline aims to support clinicians in preventing ovarian hyperstimulation syndrome (OHSS) in patients undergoing gonadotropin ovarian stimulation. A systematic literature search of the medical databases was performed. The Guideline Development Group (GDG) identified the risk factors of OHSS before and during ovarian stimulation. The relation of different pre-treatment measures and different ovarian stimulation protocols with OHSS was evaluated. The optimal monitoring during treatment was assessed. The current evidence on preventive strategies during and after ovarian stimulation and the available adjuvant preventive agents were examined. Based on this, the GDG developed evidence-based, graded recommendations for clinical practice. The evidence was evaluated within context, considering the effectiveness, cost and practical problems of assisted reproductive technology for patients and healthcare providers. Early identification and application of preventive measures identified in this guideline may reduce the incidence of OHSS or reduce its severity. Suggestions for future research on OHSS prevention are provided.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2441827"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstetric and perinatal outcomes of singleton pregnancy from donated frozen versus fresh oocytes. 捐赠冷冻卵母细胞与新鲜卵母细胞单胎妊娠的产科和围产儿结局。

IF 2.1 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2024-12-11 DOI: 10.1080/14647273.2024.2430234

Yuhuan Wang, Qiaoqiao Ding, Jialin Zou, Yue Niu, Daimin Wei

{"title":"Obstetric and perinatal outcomes of singleton pregnancy from donated frozen versus fresh oocytes.","authors":"Yuhuan Wang, Qiaoqiao Ding, Jialin Zou, Yue Niu, Daimin Wei","doi":"10.1080/14647273.2024.2430234","DOIUrl":"https://doi.org/10.1080/14647273.2024.2430234","url":null,"abstract":"To evaluate whether oocyte cryopreservation affects obstetric and perinatal outcomes, 350 donor oocyte recipients with live-born singletons were divided into three groups: frozen embryo transfer (FET) with fresh oocytes (n = 101), fresh embryo transfer (ET) with frozen oocytes (n = 190), FET with frozen oocytes (n = 59). Gestational age differed significantly (P = 0.025), with the FET with frozen oocytes group showing longer gestational age than FET with fresh oocytes group (276 days vs. 272 days, P = 0.04). Other outcomes were comparable among groups. Subgroup analysis of FET pregnancies revealed no significant differences between frozen and fresh oocyte groups in gestational age (B 1.38, P = 0.749), birth weight (B -0.11, P = 0.530), premature birth rates (6.8% vs. 11.9%, P = 0.746), low birth weight (LBW) (5.1% vs. 12.9%, P = 0.865), macrosomia (5.1% vs. 4.0%, P = 0.976), small for gestational age (SGA) (6.8% vs. 11.9%, P = 0.599), large for gestational age (LGA) (22.0% vs. 18.8%, P = 0.943), gestational diabetes mellitus (GDM) (10.2% vs. 11.9%, P = 0.343), hypertensive disorders of pregnancy (HDP) (8.5% vs. 17.8%, P = 0.143) or placental abnormalities (8.5% vs. 19.8%, P = 0.133). The study confirmed oocyte cryopreservation did not affect birth weight or obstetrical complications in donor oocyte recipients.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2430234"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enable families with donor-conceived children to tailor their family story. Recommendations for policy and practice regarding legal age limits for accessing donor information in The Netherlands.

IF 2.1 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2025-02-25 DOI: 10.1080/14647273.2025.2470360

A Indekeu, I van Nistelrooij, N O M Woestenburg, A J B M Maas

{"title":"Enable families with donor-conceived children to tailor their family story. Recommendations for policy and practice regarding legal age limits for accessing donor information in The Netherlands.","authors":"A Indekeu, I van Nistelrooij, N O M Woestenburg, A J B M Maas","doi":"10.1080/14647273.2025.2470360","DOIUrl":"https://doi.org/10.1080/14647273.2025.2470360","url":null,"abstract":"In 2020, the Dutch government issued a call to investigate age limits for donor-conceived people to access donor information because there was insufficient justification for such limits in the Dutch law. This question is equally important in a changing landscape of donor conception due to searching using direct-to-consumer genetic tests and social media. This paper describes recommendations for policy and practice based on an interdisciplinary (ethical, legal, psychosocial and empirical) research. Findings show that no age limits can be adequately justified, including the current ones. Consequently, we recommended modification of the law by dropping age limits and by making donor information accessible upon the birth of a donor-conceived person. Moreover, we set forth recommendations for due diligence in providing donor information. Integrating donor information into one's life's story is a gradual process that should be tailored to a child's development and individual needs. Because this process is more than a single moment of accessing donor information, we see parents as being best suited to align accessing donor information with their child's needs. We recommend that donor-conceived people, parents and donors are given support in this process, provided by professionals with experience and knowledge about donor conception.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2470360"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Switching to intracytoplasmic sperm injection provides no benefit in couples of poor embryonic development in the previous in vitro fertilization cycle. 对于先前体外受精周期中胚胎发育不良的夫妇，改用卵胞浆内单精子注射没有任何益处。

IF 2.1 4区医学

Human Fertility Pub Date : 2025-12-01 Epub Date: 2024-12-19 DOI: 10.1080/14647273.2024.2442451

Shuai Liu, Junjie Zhong, Yu Jiang, Lin Wang, Yudi Luo, Bowen Luo, Zengyu Yang

{"title":"Switching to intracytoplasmic sperm injection provides no benefit in couples of poor embryonic development in the previous in vitro fertilization cycle.","authors":"Shuai Liu, Junjie Zhong, Yu Jiang, Lin Wang, Yudi Luo, Bowen Luo, Zengyu Yang","doi":"10.1080/14647273.2024.2442451","DOIUrl":"https://doi.org/10.1080/14647273.2024.2442451","url":null,"abstract":"This study aimed to evaluate the effectiveness of changing the insemination method in women who experienced poor embryonic development during the preceding cycle. A total of 15,886 conventional IVF in 9,311 women, performed between August 2015 and June 2023, were included in this study. Of these, 270 couples experienced IVF failure due to poor embryonic development in the first oocyte retrieval (OR) cycle, which was cancelled before transfer. The patients were stratified based on whether or not they switched to ICSI for subsequent attempts. Cumulative live birth rates (CLBRs) and a series of secondary outcomes were compared. The embryo utilization, high-quality embryo, blastocyst formation, implantation, cumulative clinical pregnancy, CLBR and miscarriage rates were comparable between the two groups, whereas the fertilization rate per oocyte retrieved was significantly lower in the ICSI group during the second OR cycle (60.76% vs. 70.42%, p < 0.001) and all OR cycles (60.02% vs. 71.69%, p < 0.001). Furthermore, the CLBRs in the ICSI and IVF groups after up to seven OR cycles were 41.35% and 36.84%, respectively. Most patients achieved live births during the second OR cycle (58.33%, ICSI vs. 62.86%, IVF). ICSI did not improve clinical or embryonic outcomes in women who experienced poor embryonic development in their preceding cycle.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2442451"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Fertility Education Initiative: responding to the need for enhanced fertility and reproductive health awareness amongst young people in the United Kingdom. 生育教育倡议：满足英国年轻人提高生育和生殖健康意识的需求。

IF 2.1 4区医学

Human Fertility Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1080/14647273.2024.2417940

James Cheshire, Justin Chu, Jacky Boivin, Grace Dugdale, Joyce Harper, Adam Balen

引用次数: 0

Elevated luteinizing hormone levels during the artificial endometrial preparation cycle do not impact pregnancy outcomes in patients undergoing single vitrified-warmed blastocyst transfer. 人工子宫内膜准备周期中黄体生成素水平的升高不会影响单个玻璃化温化囊胚移植患者的妊娠结局。

IF 2.1 4区医学

Human Fertility Pub Date : 2024-12-01 Epub Date: 2024-11-08 DOI: 10.1080/14647273.2024.2424336

Haengjun Jeon, Woo Sik Lee, Ji Won Kim

{"title":"Elevated luteinizing hormone levels during the artificial endometrial preparation cycle do not impact pregnancy outcomes in patients undergoing single vitrified-warmed blastocyst transfer.","authors":"Haengjun Jeon, Woo Sik Lee, Ji Won Kim","doi":"10.1080/14647273.2024.2424336","DOIUrl":"https://doi.org/10.1080/14647273.2024.2424336","url":null,"abstract":"The effect of an increase in luteinizing hormone levels on pregnancy outcomes in patients undergoing artificial endometrial preparation for frozen embryo transfer has not been definitively elucidated. We aimed to investigate the effect of elevated luteinizing hormone levels, measured prior to progesterone administration, on the ongoing pregnancy rate in patients undergoing artificial endometrial preparation for single vitrified-warmed blastocyst transfer. Patients began taking oral oestradiol valerate on menstrual day 2-3. When the endometrial thickness reached ≥7 mm, they were tested for oestradiol, progesterone, and luteinizing hormone, and luteal phase support was started. The participants were divided into four groups based on luteinizing hormone percentiles, and differences in pregnancy outcomes were examined. No significant differences were observed for on-going pregnancy rate and the other pregnancy outcomes between the groups. In multivariate logistic regression analysis, not the luteinizing hormone levels but the quality of embryo had a significant influence on ongoing pregnancy (p = 0.004; adjusted odds ratio, 1.8; 95% confidence interval, 1.213-2.675). The elevation of luteinizing hormone levels during artificial endometrial preparation did not have an impact on the ongoing pregnancy or the other pregnancy outcomes.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"27 1","pages":"2424336"},"PeriodicalIF":2.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing predictions of embryo implantation in thin endometrium: a comparative analysis of endometrial thickness in frozen versus fresh IVF cycles. 增强薄子宫内膜对胚胎着床的预测：冷冻与新鲜试管婴儿周期子宫内膜厚度的比较分析。

IF 2.1 4区医学

Human Fertility Pub Date : 2024-12-01 Epub Date: 2024-09-23 DOI: 10.1080/14647273.2024.2404852

Adiel Kahana, Ittai Many, Yuval Fouks, Benny Almog, Yoav Baruch, Emily Hamilton, Foad Azem, Yoni Cohen

{"title":"Enhancing predictions of embryo implantation in thin endometrium: a comparative analysis of endometrial thickness in frozen versus fresh IVF cycles.","authors":"Adiel Kahana, Ittai Many, Yuval Fouks, Benny Almog, Yoav Baruch, Emily Hamilton, Foad Azem, Yoni Cohen","doi":"10.1080/14647273.2024.2404852","DOIUrl":"https://doi.org/10.1080/14647273.2024.2404852","url":null,"abstract":"This study investigated whether the difference between endometrial thickness in the frozen embryo transfer (FET) cycle and the preceding fresh stimulated cycle predicts clinical pregnancy in women with thin endometrium. A retrospective analysis of 335 cycles in 227 women (age < 43) with endometrium < 8 mm in the FET cycle was conducted. Endometrial thickness was assessed using the ratio (ETfrozen/fresh) and absolute difference (ETfresh-frozen) between the maximal endometrial thickness measured during the stimulated IVF cycle and that measured in the FET cycle. We hypothesized that a smaller difference and higher ratio during FET will be associated with higher pregnancy rate. No embryo implantation occurred in women with an FET endometrial thickness < 5.9 mm and an ETfrozen/fresh < 0.86. Cycles with a positive beta-human chorionic gonadotropin (ß-hCG) showed a significantly lower mean ETfresh-frozen (1.89 ± 1.78 vs 2.30 ± 1.81, p = 0.03), and a significantly higher ETfrozen/fresh ratio (0.82 ± 0.17 vs. 0.77 ± 0.15, p = 0.024). Endometrial thickness in the FET cycle normalized to the preceding stimulated cycle is associated with implantation and may constitute a novel predictor of FET success in women with thin endometrium.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"27 1","pages":"2404852"},"PeriodicalIF":2.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do sperm and lubricants gel well with each other? A systematic review. 精子和润滑剂能很好地相互结合吗?系统回顾。

IF 1.9 4区医学

Human Fertility Pub Date : 2024-12-01 Epub Date: 2024-01-08 DOI: 10.1080/14647273.2023.2285349

E Gumerova, M P Rimmer, S A Gellatly

{"title":"Do sperm and lubricants gel well with each other? A systematic review.","authors":"E Gumerova, M P Rimmer, S A Gellatly","doi":"10.1080/14647273.2023.2285349","DOIUrl":"10.1080/14647273.2023.2285349","url":null,"abstract":"Vaginal lubricants are commonly used to aid sexual pleasure and/or to help combat vaginal dryness and dyspareunia. Several studies have reported their impact on sperm function, however there are no published guidelines to help healthcare professionals and couples select a vaginal lubricant that is 'sperm-safe'. To address this, we conducted a literature search using both PubMed and Scopus to identify and appraise manuscripts that reported the impact of lubricants on sperm function. We did not restrict the literature search by year of publication, and we only included manuscripts that looked at the impact of vaginal lubricants on human sperm. The quality of the eligible studies was assessed using the Björndahl et al., (2016) checklist for semen analysis, as most of the studies reported the findings of a basic semen analysis. A total of 24 articles were eligible for analysis with a total of 35 vaginal lubricants (that were available to buy over the counter) being included, 2 of which studied the effect of vaginal lubricants on sperm function in vivo, and 22 being conducted in vitro. KY Jelly, PreSeed and Astroglide were most studied, with most manuscripts focussing on their impact on sperm motility. A paucity of data on most lubricants combined with methodological variations between studies and limited/no reporting on pregnancy outcomes means greater efforts are required before an evidence-based guideline can be published.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":" ","pages":"2285349"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138477579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Best practice for embryology staffing in HFEA licensed assisted conception centres-guidance from Association of Reproductive & Clinical Scientists. HFEA 许可的辅助受孕中心胚胎学人员配备的最佳实践--生殖与临床科学家协会提供的指导。

IF 1.9 4区医学

Human Fertility Pub Date : 2024-12-01 Epub Date: 2024-03-14 DOI: 10.1080/14647273.2024.2322729

Jason Kasraie, Hannah Kennedy

{"title":"Best practice for embryology staffing in HFEA licensed assisted conception centres-guidance from Association of Reproductive & Clinical Scientists.","authors":"Jason Kasraie, Hannah Kennedy","doi":"10.1080/14647273.2024.2322729","DOIUrl":"10.1080/14647273.2024.2322729","url":null,"abstract":"The Association of Reproductive and Clinical Scientists (ARCS) has long promoted the importance of externally accredited training and assessment of scientific staff within assisted conception centres to ensure professional registration and relevant training at all levels. This not only gives scientific staff the opportunity to empower themselves but also acts to ensure assisted conception centres maintain the highest standards of care and quality for patients whilst meeting HFEA requirements for staffing and training. It also provides assurance to patients that treatment is being delivered by highly trained and competent staff. Clinical embryology practice requires intense concentration, with increasingly complex treatment plans and options coupled with the ever-present consequences of clinical error at the forefront of practitioners' minds, exhaustion and burn out are very real risks. Overloading embryology teams is likely to lead to increased error rates and serious incidents. This guideline aims to bring the sector in line with other Clinical Science specialities to optimise patient care, increase safety, reduce risk (including the risk of legal action against centres and individuals), ensure the use of recognised job titles with appropriate levels of remuneration, and provide centres with a template to work towards for appropriate levels of scientific staffing.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"27 1","pages":"2322729"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140119330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global DNA methylation level in spermatozoa is not associated with ICSI fertilization outcome and embryo quality in donor oocyte programme. 精子中的 DNA 甲基化水平与 ICSI 受精结果和供卵计划中的胚胎质量无关。

IF 2.1 4区医学

Human Fertility Pub Date : 2024-12-01 Epub Date: 2024-11-06 DOI: 10.1080/14647273.2024.2421191

Riddhi Kirit Pandya, Sujith Raj Salian, Vani R Lakshmi, Shubhashree Uppangala, Guruprasad Kalthur, Sanjay Gupta, Satish Kumar Adiga

{"title":"Global DNA methylation level in spermatozoa is not associated with ICSI fertilization outcome and embryo quality in donor oocyte programme.","authors":"Riddhi Kirit Pandya, Sujith Raj Salian, Vani R Lakshmi, Shubhashree Uppangala, Guruprasad Kalthur, Sanjay Gupta, Satish Kumar Adiga","doi":"10.1080/14647273.2024.2421191","DOIUrl":"https://doi.org/10.1080/14647273.2024.2421191","url":null,"abstract":"Epigenetic mechanisms, including DNA methylation and histone modifications, govern chromatin arrangement in sperm, enhancing motility and safeguarding DNA integrity for accurate epigenetic inheritance. Abnormal methylation is linked to poor sperm quality and fertility issues, underscoring the need to study sperm DNA methylation and its impact on sperm function and embryo development in assisted reproductive technology. In this study, processed spermatozoa from 75 normozoospermic and 15 abnormal ejaculates were examined for sperm global DNA methylation levels using a colourimetric absorbance method. Although semen characteristics were poor in abnormal ejaculates, no significant correlation was found between sperm global DNA methylation levels and sperm characteristics in either normozoospermic or abnormal cohorts. However, mean global DNA methylation levels were significantly lowered in abnormal sperm samples compared to normozoospermic samples (p < 0.05). Furthermore, injecting spermatozoa from these patients (N = 50) into donor oocytes did not show a significant relationship between sperm global DNA methylation and embryo developmental competence. These findings highlight the limitation of sperm global DNA methylation as a biomarker for embryo development and quality.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"27 1","pages":"2421191"},"PeriodicalIF":2.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0