Human Fertility最新文献

{"title":"Playing a serious game to increase fertility awareness: perceptions of adolescents, parents and teachers.","authors":"Mariana V Martins, Luísa Pereira, Zdravka Veleva, Irina Popova, Satu Rautakallio-Hokkanen, Ana Galhardo","doi":"10.1080/14647273.2025.2451334","DOIUrl":"10.1080/14647273.2025.2451334","url":null,"abstract":"<p><p>Infertility is increasing globally, affecting one in six adults due to factors like delayed childbearing and lifestyle changes. Despite the recognition of the importance of increasing fertility awareness, levels remain low. This study evaluated the perceptions of 'FActs!', a serious game aimed at improving adolescents' fertility awareness. The narratives of adolescents, parents and teachers about the utility of this tool and its educational potential were also addressed using focus groups. The game (https://myfacts.eu/) comprises 12 questions (birth year, biological sex, country and nine questions addressing fertility topics (probability of conceiving, the definition of infertility, and fertility risk factors such as age, smoking, alcohol, drugs and physical exercise). These questions emerge from four scenarios: a school playground, a party, a gym and a sibling's house. Players receive immediate feedback about their answers and brief educational information to improve their knowledge. Players accumulate stars for correct answers as they progress through the scenarios and answer the questions. Findings revealed that 'FActs!' effectively engages adolescents and enhances their understanding of fertility. Adolescents, parents and teachers responded positively, appreciating its interactive nature and ability to facilitate discussions on reproductive health. However, limitations such as the need for more comprehensive information and high reading requirements were noted. The study highlights the importance of integrating comprehensive fertility education into health curricula using diverse, engaging methods. It also underscores the necessity of supporting parents and teachers to improve their comfort and capability in discussing fertility. \"FActs!\" is a valuable tool with the potential for broader educational contexts. Future research should quantitatively assess \"FActs!\" across various demographics and include interventions to boost fertility awareness among parents and teachers, thereby enhancing their support for adolescents' informed reproductive choices.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2451334"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint association of dietary and lifestyle oxidative balance score with infertility among reproductive-aged US female: a cross-sectional study.","authors":"Houmin Ou, Huanping Cai, Zhuzhu Wang","doi":"10.1080/14647273.2025.2480079","DOIUrl":"https://doi.org/10.1080/14647273.2025.2480079","url":null,"abstract":"<p><p>Infertility affects one in six individuals globally, with oxidative stress-modifiable through diet and lifestyle-being a key factor in female infertility. This study examines associations between dietary/lifestyle Oxidative Balance Scores (OBS) and infertility risk in reproductive-aged women. Using 2013-2018 NHANES data from 2,447 women aged 20-44, we calculated OBS (16 dietary and 4 lifestyle components) reflecting antioxidant vs. pro-oxidant exposure. Higher scores indicate antioxidant dominance. Weighted logistic regression models adjusted for sociodemographic and health covariates revealed an inverse linear relationship: each 1-unit OBS increase correlated with 4.7% lower infertility risk (95% CI: 0.929-0.977, <i>p</i> < 0.001). Women in the highest OBS tertile had 6.4% reduced odds versus lower tertiles (95% CI: 0.897-0.977, <i>p</i> = 0.003). Joint analyses showed higher lifestyle OBS mitigated infertility risk among women with low dietary OBS. Results remained consistent across subgroups and sensitivity analyses. These findings underscore the potential of antioxidant-rich diets and healthy lifestyles in reducing oxidative stress-related infertility, advocating for targeted interventions to improve reproductive health outcomes.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2480079"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bladder haematoma after transvaginal ultrasound-guided oocyte retrieval: a retrospective analysis and comprehensive review of the literature.","authors":"Ju Huang, Wenjuan Liu, Li Huang, Jianxing Ruan, Qianwen Huang, Lijia Zhang, Fenghua Liu","doi":"10.1080/14647273.2025.2488770","DOIUrl":"https://doi.org/10.1080/14647273.2025.2488770","url":null,"abstract":"<p><p>Bladder hematoma following transvaginal ultrasound-guided oocyte retrieval (TVOR) is rare. We conducted a retrospective analysis of 33,271 patients who underwent TVOR procedures during in vitro fertilization and embryo transfer (IVF-ET) at our centre between January 2015 and June 2023. Additionally, a systematic literature search on bladder haematoma after TVOR was performed. Data on clinical symptoms, diagnostic processes, and treatment interventions for patients with bladder injurie or haematoma were collected and analyzed. We identified six cases (0.018%) of bladder injury following TVOR procedures at our centre. Nine studies reporting 12 cases of bladder haematoma, yielding a pooled incidence of approximately 0.02%. Bladder haematoma occurred at various times after the procedure, ranging from immediate to a maximum of seven days post TVOR. Of the 18 cases examined, four patients received conventional conservative treatment, while 12 patients underwent urinary catheter irrigation and drainage. The most common clinical symptoms included lower abdominal pain, urinary frequency, dysuria, visible haematuria, and urinary retention. Bladder haematoma resulting from bladder injury after TVOR is a rare complication. To reduce the risks associated with such complications, it is crucial to develop protocols that ensure appropriate prophylaxis, monitoring, and treatment for patients undergoing TVOR procedures.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2488770"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring fertility treatment add-on use, information transparency and costs in the UK: Insights from a patient survey.","authors":"Manuela Perrotta, Marcin Smietana, Melody Adesina, Jack Wilkinson","doi":"10.1080/14647273.2025.2469533","DOIUrl":"10.1080/14647273.2025.2469533","url":null,"abstract":"<p><p>This study presents the findings from a UK-based survey exploring fertility treatment add-ons, treatment costs, and information transparency. The online survey, distributed via social media, targeted current and prospective IVF patients, yielding 304 eligible responses. Results indicate an increase in the use of fertility treatment add-ons compared to previous data. Respondents primarily relied on multiple sources for information about these add-ons, with search engines being the most frequently used, followed by fertility clinic websites, the HFEA website, and medical or scientific articles. These sources were also deemed the most reliable. In contrast, social media, online forums, and blogs were less frequently used and rated as less reliable. Respondents reported significant variation in the total cost per cycle of privately funded treatment, ranging from £5,000 to £13,000, with an average of £11,950. Although there was a slight upward trend in costs with rising household income, no strong correlation was observed. Fertility clinic websites were the primary source of cost-related information, with 99% of respondents emphasising the importance of clinics providing accurate and up-to-date information on their websites. The findings also reveal respondents' views on potential policy actions to improve transparency around information and costs in the fertility sector.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2469533"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of ovarian hyperstimulation syndrome (OHSS): British Fertility Society policy and practice guideline.","authors":"N Tsampras, K Palinska-Rudzka, Y Alebrahim, L Craciunas, R Mathur","doi":"10.1080/14647273.2024.2441827","DOIUrl":"10.1080/14647273.2024.2441827","url":null,"abstract":"<p><p>This British Fertility Society (BFS) Policy and Practice guideline aims to support clinicians in preventing ovarian hyperstimulation syndrome (OHSS) in patients undergoing gonadotropin ovarian stimulation. A systematic literature search of the medical databases was performed. The Guideline Development Group (GDG) identified the risk factors of OHSS before and during ovarian stimulation. The relation of different pre-treatment measures and different ovarian stimulation protocols with OHSS was evaluated. The optimal monitoring during treatment was assessed. The current evidence on preventive strategies during and after ovarian stimulation and the available adjuvant preventive agents were examined. Based on this, the GDG developed evidence-based, graded recommendations for clinical practice. The evidence was evaluated within context, considering the effectiveness, cost and practical problems of assisted reproductive technology for patients and healthcare providers. Early identification and application of preventive measures identified in this guideline may reduce the incidence of OHSS or reduce its severity. Suggestions for future research on OHSS prevention are provided.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2441827"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstetric and perinatal outcomes of singleton pregnancy from donated frozen versus fresh oocytes.","authors":"Yuhuan Wang, Qiaoqiao Ding, Jialin Zou, Yue Niu, Daimin Wei","doi":"10.1080/14647273.2024.2430234","DOIUrl":"https://doi.org/10.1080/14647273.2024.2430234","url":null,"abstract":"<p><p>To evaluate whether oocyte cryopreservation affects obstetric and perinatal outcomes, 350 donor oocyte recipients with live-born singletons were divided into three groups: frozen embryo transfer (FET) with fresh oocytes (n = 101), fresh embryo transfer (ET) with frozen oocytes (n = 190), FET with frozen oocytes (n = 59). Gestational age differed significantly (P = 0.025), with the FET with frozen oocytes group showing longer gestational age than FET with fresh oocytes group (276 days vs. 272 days, P = 0.04). Other outcomes were comparable among groups. Subgroup analysis of FET pregnancies revealed no significant differences between frozen and fresh oocyte groups in gestational age (B 1.38, P = 0.749), birth weight (B -0.11, P = 0.530), premature birth rates (6.8% vs. 11.9%, P = 0.746), low birth weight (LBW) (5.1% vs. 12.9%, P = 0.865), macrosomia (5.1% vs. 4.0%, P = 0.976), small for gestational age (SGA) (6.8% vs. 11.9%, P = 0.599), large for gestational age (LGA) (22.0% vs. 18.8%, P = 0.943), gestational diabetes mellitus (GDM) (10.2% vs. 11.9%, P = 0.343), hypertensive disorders of pregnancy (HDP) (8.5% vs. 17.8%, P = 0.143) or placental abnormalities (8.5% vs. 19.8%, P = 0.133). The study confirmed oocyte cryopreservation did not affect birth weight or obstetrical complications in donor oocyte recipients.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2430234"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enable families with donor-conceived children to tailor their family story. Recommendations for policy and practice regarding legal age limits for accessing donor information in The Netherlands.","authors":"A Indekeu, I van Nistelrooij, N O M Woestenburg, A J B M Maas","doi":"10.1080/14647273.2025.2470360","DOIUrl":"10.1080/14647273.2025.2470360","url":null,"abstract":"<p><p>In 2020, the Dutch government issued a call to investigate age limits for donor-conceived people to access donor information because there was insufficient justification for such limits in the Dutch law. This question is equally important in a changing landscape of donor conception due to searching using direct-to-consumer genetic tests and social media. This paper describes recommendations for policy and practice based on an interdisciplinary (ethical, legal, psychosocial and empirical) research. Findings show that no age limits can be adequately justified, including the current ones. Consequently, we recommended modification of the law by dropping age limits and by making donor information accessible upon the birth of a donor-conceived person. Moreover, we set forth recommendations for due diligence in providing donor information. Integrating donor information into one's life's story is a gradual process that should be tailored to a child's development and individual needs. Because this process is more than a single moment of accessing donor information, we see parents as being best suited to align accessing donor information with their child's needs. We recommend that donor-conceived people, parents and donors are given support in this process, provided by professionals with experience and knowledge about donor conception.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2470360"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor.","authors":"Adiel Kahana, Ittai Many, Yuval Fouks, Benny Almog, Yoav Baruch, Emily Hamilton, Foad Azem, Yoni Cohen","doi":"10.1080/14647273.2025.2506175","DOIUrl":"10.1080/14647273.2025.2506175","url":null,"abstract":"","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2506175"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of mitochondrial DNA content and embryo morphology in fully expanded euploid blastocysts.","authors":"Ivo Karač, Gary G Ramsey, Romana Gračan, Sanja Vujisić Živković, Kristian Bodulić","doi":"10.1080/14647273.2025.2501547","DOIUrl":"https://doi.org/10.1080/14647273.2025.2501547","url":null,"abstract":"<p><p>Over the past two decades, mitochondrial DNA (mtDNA) content has been studied as a potential biomarker for embryo viability and implantation success during in vitro fertilization (IVF) procedures. However, its reliability for embryo selection remains uncertain. Therefore, our study aimed to examine the relationship between blastocyst mtDNA content and blastocyst quality, timing of fully expanded blastocyst formation, and cleavage-stage embryo quality in blastocysts biopsied at the uniform expansion stage. We analyzed bioinformatics data from 125 day-5 and day-6 blastocysts from women aged 18 to 35 years. Each blastocyst was biopsied at expansion stage 4 and classified as euploid through preimplantation genetic testing for aneuploidy using next-generation sequencing. Blastocysts were categorized into four groups based on quality and the day of biopsy. Poor-quality day-6 blastocysts exhibited lower mtDNA levels compared to good-quality day-5 blastocysts (<i>p</i> = 0.006), poor-quality day-5 blastocysts (<i>p</i> = 0.008), and good-quality day-6 blastocysts (<i>p</i> = 0.003). Embryos with day-3 grades lower than 2.5 displayed lower blastocyst mtDNA levels compared to those graded 1 (<i>p</i> < 0.001), 1.5 (<i>p</i> < 0.001), and 2 (<i>p</i> < 0.001). These findings suggest further insights into the interplay between blastocyst mtDNA content and preimplantation embryo morphology. Nonetheless, mtDNA remains an unreliable biomarker for assessing embryo viability, warranting further investigation to determine its clinical relevance.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2501547"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Switching to intracytoplasmic sperm injection provides no benefit in couples of poor embryonic development in the previous <i>in vitro</i> fertilization cycle.","authors":"Shuai Liu, Junjie Zhong, Yu Jiang, Lin Wang, Yudi Luo, Bowen Luo, Zengyu Yang","doi":"10.1080/14647273.2024.2442451","DOIUrl":"https://doi.org/10.1080/14647273.2024.2442451","url":null,"abstract":"<p><p>This study aimed to evaluate the effectiveness of changing the insemination method in women who experienced poor embryonic development during the preceding cycle. A total of 15,886 conventional IVF in 9,311 women, performed between August 2015 and June 2023, were included in this study. Of these, 270 couples experienced IVF failure due to poor embryonic development in the first oocyte retrieval (OR) cycle, which was cancelled before transfer. The patients were stratified based on whether or not they switched to ICSI for subsequent attempts. Cumulative live birth rates (CLBRs) and a series of secondary outcomes were compared. The embryo utilization, high-quality embryo, blastocyst formation, implantation, cumulative clinical pregnancy, CLBR and miscarriage rates were comparable between the two groups, whereas the fertilization rate per oocyte retrieved was significantly lower in the ICSI group during the second OR cycle (60.76% vs. 70.42%, <i>p</i> < 0.001) and all OR cycles (60.02% vs. 71.69%, <i>p</i> < 0.001). Furthermore, the CLBRs in the ICSI and IVF groups after up to seven OR cycles were 41.35% and 36.84%, respectively. Most patients achieved live births during the second OR cycle (58.33%, ICSI vs. 62.86%, IVF). ICSI did not improve clinical or embryonic outcomes in women who experienced poor embryonic development in their preceding cycle.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2442451"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}