Joint association of dietary and lifestyle oxidative balance score with infertility among reproductive-aged US female: a cross-sectional study.

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Human Fertility Pub Date : 2025-12-01 Epub Date: 2025-04-15 DOI:10.1080/14647273.2025.2480079

Houmin Ou, Huanping Cai, Zhuzhu Wang

{"title":"Joint association of dietary and lifestyle oxidative balance score with infertility among reproductive-aged US female: a cross-sectional study.","authors":"Houmin Ou, Huanping Cai, Zhuzhu Wang","doi":"10.1080/14647273.2025.2480079","DOIUrl":null,"url":null,"abstract":"Infertility affects one in six individuals globally, with oxidative stress-modifiable through diet and lifestyle-being a key factor in female infertility. This study examines associations between dietary/lifestyle Oxidative Balance Scores (OBS) and infertility risk in reproductive-aged women. Using 2013-2018 NHANES data from 2,447 women aged 20-44, we calculated OBS (16 dietary and 4 lifestyle components) reflecting antioxidant vs. pro-oxidant exposure. Higher scores indicate antioxidant dominance. Weighted logistic regression models adjusted for sociodemographic and health covariates revealed an inverse linear relationship: each 1-unit OBS increase correlated with 4.7% lower infertility risk (95% CI: 0.929-0.977, p < 0.001). Women in the highest OBS tertile had 6.4% reduced odds versus lower tertiles (95% CI: 0.897-0.977, p = 0.003). Joint analyses showed higher lifestyle OBS mitigated infertility risk among women with low dietary OBS. Results remained consistent across subgroups and sensitivity analyses. These findings underscore the potential of antioxidant-rich diets and healthy lifestyles in reducing oxidative stress-related infertility, advocating for targeted interventions to improve reproductive health outcomes.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2480079"},"PeriodicalIF":2.1000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Fertility","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/14647273.2025.2480079","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/15 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Infertility affects one in six individuals globally, with oxidative stress-modifiable through diet and lifestyle-being a key factor in female infertility. This study examines associations between dietary/lifestyle Oxidative Balance Scores (OBS) and infertility risk in reproductive-aged women. Using 2013-2018 NHANES data from 2,447 women aged 20-44, we calculated OBS (16 dietary and 4 lifestyle components) reflecting antioxidant vs. pro-oxidant exposure. Higher scores indicate antioxidant dominance. Weighted logistic regression models adjusted for sociodemographic and health covariates revealed an inverse linear relationship: each 1-unit OBS increase correlated with 4.7% lower infertility risk (95% CI: 0.929-0.977, p < 0.001). Women in the highest OBS tertile had 6.4% reduced odds versus lower tertiles (95% CI: 0.897-0.977, p = 0.003). Joint analyses showed higher lifestyle OBS mitigated infertility risk among women with low dietary OBS. Results remained consistent across subgroups and sensitivity analyses. These findings underscore the potential of antioxidant-rich diets and healthy lifestyles in reducing oxidative stress-related infertility, advocating for targeted interventions to improve reproductive health outcomes.

查看原文本刊更多论文

美国育龄女性饮食和生活方式氧化平衡评分与不孕症的联合关联：一项横断面研究。

全球有六分之一的人患有不孕症，氧化应激可通过饮食和生活方式改变，是女性不孕症的关键因素。本研究探讨了育龄妇女饮食/生活方式氧化平衡评分（OBS）与不孕风险之间的关系。利用2013-2018年2447名20-44岁女性的NHANES数据，我们计算了反映抗氧化剂与促氧化剂暴露的OBS（16种饮食成分和4种生活方式成分）。分数越高表明抗氧化剂优势。经社会人口统计学和健康协变量调整的加权logistic回归模型显示出反比线性关系：每增加1个单位的OBS与不孕风险降低4.7%相关（95% CI: 0.929-0.977, p = 0.003）。联合分析显示，高生活方式OBS降低了低饮食OBS妇女的不孕风险。结果在亚组和敏感性分析中保持一致。这些发现强调了富含抗氧化剂的饮食和健康的生活方式在减少氧化应激相关不孕症方面的潜力，提倡有针对性的干预措施，以改善生殖健康结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Human Fertility OBSTETRICS & GYNECOLOGY-REPRODUCTIVE BIOLOGY

CiteScore

3.30

自引率

5.30%

发文量

期刊介绍： Human Fertility is a leading international, multidisciplinary journal dedicated to furthering research and promoting good practice in the areas of human fertility and infertility. Topics included span the range from molecular medicine to healthcare delivery, and contributions are welcomed from professionals and academics from the spectrum of disciplines concerned with human fertility. It is published on behalf of the British Fertility Society. The journal also provides a forum for the publication of peer-reviewed articles arising out of the activities of the Association of Biomedical Andrologists, the Association of Clinical Embryologists, the Association of Irish Clinical Embryologists, the British Andrology Society, the British Infertility Counselling Association, the Irish Fertility Society and the Royal College of Nursing Fertility Nurses Group. All submissions are welcome. Articles considered include original papers, reviews, policy statements, commentaries, debates, correspondence, and reports of sessions at meetings. The journal also publishes refereed abstracts from the meetings of the constituent organizations.