Human Fertility最新文献

{"title":"Enable families with donor-conceived children to tailor their family story. Recommendations for policy and practice regarding legal age limits for accessing donor information in The Netherlands.","authors":"A Indekeu, I van Nistelrooij, N O M Woestenburg, A J B M Maas","doi":"10.1080/14647273.2025.2470360","DOIUrl":"10.1080/14647273.2025.2470360","url":null,"abstract":"<p><p>In 2020, the Dutch government issued a call to investigate age limits for donor-conceived people to access donor information because there was insufficient justification for such limits in the Dutch law. This question is equally important in a changing landscape of donor conception due to searching using direct-to-consumer genetic tests and social media. This paper describes recommendations for policy and practice based on an interdisciplinary (ethical, legal, psychosocial and empirical) research. Findings show that no age limits can be adequately justified, including the current ones. Consequently, we recommended modification of the law by dropping age limits and by making donor information accessible upon the birth of a donor-conceived person. Moreover, we set forth recommendations for due diligence in providing donor information. Integrating donor information into one's life's story is a gradual process that should be tailored to a child's development and individual needs. Because this process is more than a single moment of accessing donor information, we see parents as being best suited to align accessing donor information with their child's needs. We recommend that donor-conceived people, parents and donors are given support in this process, provided by professionals with experience and knowledge about donor conception.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2470360"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of ovarian hyperstimulation syndrome (OHSS): British Fertility Society policy and practice guideline.","authors":"N Tsampras, K Palinska-Rudzka, Y Alebrahim, L Craciunas, R Mathur","doi":"10.1080/14647273.2024.2441827","DOIUrl":"10.1080/14647273.2024.2441827","url":null,"abstract":"<p><p>This British Fertility Society (BFS) Policy and Practice guideline aims to support clinicians in preventing ovarian hyperstimulation syndrome (OHSS) in patients undergoing gonadotropin ovarian stimulation. A systematic literature search of the medical databases was performed. The Guideline Development Group (GDG) identified the risk factors of OHSS before and during ovarian stimulation. The relation of different pre-treatment measures and different ovarian stimulation protocols with OHSS was evaluated. The optimal monitoring during treatment was assessed. The current evidence on preventive strategies during and after ovarian stimulation and the available adjuvant preventive agents were examined. Based on this, the GDG developed evidence-based, graded recommendations for clinical practice. The evidence was evaluated within context, considering the effectiveness, cost and practical problems of assisted reproductive technology for patients and healthcare providers. Early identification and application of preventive measures identified in this guideline may reduce the incidence of OHSS or reduce its severity. Suggestions for future research on OHSS prevention are provided.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2441827"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstetric and perinatal outcomes of singleton pregnancy from donated frozen versus fresh oocytes.","authors":"Yuhuan Wang, Qiaoqiao Ding, Jialin Zou, Yue Niu, Daimin Wei","doi":"10.1080/14647273.2024.2430234","DOIUrl":"https://doi.org/10.1080/14647273.2024.2430234","url":null,"abstract":"<p><p>To evaluate whether oocyte cryopreservation affects obstetric and perinatal outcomes, 350 donor oocyte recipients with live-born singletons were divided into three groups: frozen embryo transfer (FET) with fresh oocytes (n = 101), fresh embryo transfer (ET) with frozen oocytes (n = 190), FET with frozen oocytes (n = 59). Gestational age differed significantly (P = 0.025), with the FET with frozen oocytes group showing longer gestational age than FET with fresh oocytes group (276 days vs. 272 days, P = 0.04). Other outcomes were comparable among groups. Subgroup analysis of FET pregnancies revealed no significant differences between frozen and fresh oocyte groups in gestational age (B 1.38, P = 0.749), birth weight (B -0.11, P = 0.530), premature birth rates (6.8% vs. 11.9%, P = 0.746), low birth weight (LBW) (5.1% vs. 12.9%, P = 0.865), macrosomia (5.1% vs. 4.0%, P = 0.976), small for gestational age (SGA) (6.8% vs. 11.9%, P = 0.599), large for gestational age (LGA) (22.0% vs. 18.8%, P = 0.943), gestational diabetes mellitus (GDM) (10.2% vs. 11.9%, P = 0.343), hypertensive disorders of pregnancy (HDP) (8.5% vs. 17.8%, P = 0.143) or placental abnormalities (8.5% vs. 19.8%, P = 0.133). The study confirmed oocyte cryopreservation did not affect birth weight or obstetrical complications in donor oocyte recipients.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2430234"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor.","authors":"Adiel Kahana, Ittai Many, Yuval Fouks, Benny Almog, Yoav Baruch, Emily Hamilton, Foad Azem, Yoni Cohen","doi":"10.1080/14647273.2025.2506175","DOIUrl":"10.1080/14647273.2025.2506175","url":null,"abstract":"","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2506175"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of mitochondrial DNA content and embryo morphology in fully expanded euploid blastocysts.","authors":"Ivo Karač, Gary G Ramsey, Romana Gračan, Sanja Vujisić Živković, Kristian Bodulić","doi":"10.1080/14647273.2025.2501547","DOIUrl":"https://doi.org/10.1080/14647273.2025.2501547","url":null,"abstract":"<p><p>Over the past two decades, mitochondrial DNA (mtDNA) content has been studied as a potential biomarker for embryo viability and implantation success during in vitro fertilization (IVF) procedures. However, its reliability for embryo selection remains uncertain. Therefore, our study aimed to examine the relationship between blastocyst mtDNA content and blastocyst quality, timing of fully expanded blastocyst formation, and cleavage-stage embryo quality in blastocysts biopsied at the uniform expansion stage. We analyzed bioinformatics data from 125 day-5 and day-6 blastocysts from women aged 18 to 35 years. Each blastocyst was biopsied at expansion stage 4 and classified as euploid through preimplantation genetic testing for aneuploidy using next-generation sequencing. Blastocysts were categorized into four groups based on quality and the day of biopsy. Poor-quality day-6 blastocysts exhibited lower mtDNA levels compared to good-quality day-5 blastocysts (<i>p</i> = 0.006), poor-quality day-5 blastocysts (<i>p</i> = 0.008), and good-quality day-6 blastocysts (<i>p</i> = 0.003). Embryos with day-3 grades lower than 2.5 displayed lower blastocyst mtDNA levels compared to those graded 1 (<i>p</i> < 0.001), 1.5 (<i>p</i> < 0.001), and 2 (<i>p</i> < 0.001). These findings suggest further insights into the interplay between blastocyst mtDNA content and preimplantation embryo morphology. Nonetheless, mtDNA remains an unreliable biomarker for assessing embryo viability, warranting further investigation to determine its clinical relevance.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2501547"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Definition and diagnostic criteria of retained products of conception following first-trimester pregnancy loss: a systematic review.","authors":"Ursula Blyth, Hanine Fourie, Lydia Akinola, Carolyn Smith, Pedro Melo, Ingrid Granne","doi":"10.1080/14647273.2025.2522054","DOIUrl":"https://doi.org/10.1080/14647273.2025.2522054","url":null,"abstract":"<p><p>Retained products of conception (RPOC) is a common complication following first-trimester pregnancy loss. However, there are no formal recommendations regarding the diagnosis of RPOC. This systematic review aimed to synthesise and critically appraise the existing evidence on the definition and diagnostic criteria for RPOC. We registered this systematic review prospectively with PROSPERO (CRD42023444456). A comprehensive literature search was conducted in October 2024 using the following databases: Embase (OVID), Medline (OVID), Global Health, CINAHL on EBSCOhost, Cochrane Central and Web of Science. Databases were searched using free-text keywords and subject headings for the key concepts of 'early', 'miscarriage' and 'retained'. Data were extracted and 2 by 2 tables populated. Risk of bias and quality assessments were performed using the QUADAS-2 tool. The literature search yielded 2,014 articles that were screened for eligibility, resulting in the inclusion of 17 studies in the final analysis. Ultrasound scan was the primary diagnostic tool, used in 16 of the 17 included studies. Ultrasound diagnostic markers included: endometrial thickness (ET), the presence of hyperechoic or echogenic material, and colour flow Doppler. One study used persistent bleeding for more than 14 days as the primary diagnostic marker. There was significant variation in the diagnostic thresholds used and no single ultrasound marker demonstrated consistent reliability in diagnosing RPOC. The findings of this review highlight the limitations of ultrasound as a standalone diagnostic tool for RPOC. Given the lack of clear diagnostic criteria, clinicians should integrate ultrasound findings with clinical symptoms to improve diagnostic accuracy. RPOC appears to be a distinct pathology within the spectrum of early pregnancy loss, characterised by the persistence of pregnancy tissue within the uterine cavity despite initial management which distinguishes it from incomplete miscarriage. This review provides a foundation for future research and calls for a Delphi consensus to refine the diagnosis and management of RPOC.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2522054"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Switching to intracytoplasmic sperm injection provides no benefit in couples of poor embryonic development in the previous <i>in vitro</i> fertilization cycle.","authors":"Shuai Liu, Junjie Zhong, Yu Jiang, Lin Wang, Yudi Luo, Bowen Luo, Zengyu Yang","doi":"10.1080/14647273.2024.2442451","DOIUrl":"https://doi.org/10.1080/14647273.2024.2442451","url":null,"abstract":"<p><p>This study aimed to evaluate the effectiveness of changing the insemination method in women who experienced poor embryonic development during the preceding cycle. A total of 15,886 conventional IVF in 9,311 women, performed between August 2015 and June 2023, were included in this study. Of these, 270 couples experienced IVF failure due to poor embryonic development in the first oocyte retrieval (OR) cycle, which was cancelled before transfer. The patients were stratified based on whether or not they switched to ICSI for subsequent attempts. Cumulative live birth rates (CLBRs) and a series of secondary outcomes were compared. The embryo utilization, high-quality embryo, blastocyst formation, implantation, cumulative clinical pregnancy, CLBR and miscarriage rates were comparable between the two groups, whereas the fertilization rate per oocyte retrieved was significantly lower in the ICSI group during the second OR cycle (60.76% vs. 70.42%, <i>p</i> < 0.001) and all OR cycles (60.02% vs. 71.69%, <i>p</i> < 0.001). Furthermore, the CLBRs in the ICSI and IVF groups after up to seven OR cycles were 41.35% and 36.84%, respectively. Most patients achieved live births during the second OR cycle (58.33%, ICSI vs. 62.86%, IVF). ICSI did not improve clinical or embryonic outcomes in women who experienced poor embryonic development in their preceding cycle.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2442451"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A qualitative study of Australian adolescent perceptions of fertility and infertility.","authors":"Emmalee A Ford, Ava Medley, Catherine Chojenta, Tanmay Bagade, Sally Sweeney, Jessie M Sutherland","doi":"10.1080/14647273.2025.2506790","DOIUrl":"10.1080/14647273.2025.2506790","url":null,"abstract":"<p><p>Adolescents require a specific set of fertility information and services to promote reproductive health and wellbeing extending into adulthood. Due to a common focus on preventing unplanned pregnancy in adolescents, fertility education can be perceived as antithetical. This study explores awareness and attitudes about fertility in adolescents to guide relevant inclusion of fertility in future information and service delivery. Twenty-five adolescents aged 15 to 18 years who had attended secondary schooling in Australia were recruited to participate in nine focus groups. Reflexive thematic analysis revealed three themes (with seven sub-themes) in the transcripts. The importance of fertility education, stigma associated with infertility, and gender roles in the context of reproductive health were identified as being key themes. Broadly, awareness of infertility was seen as important, to navigate potential health consequences and to emotionally support stigmatised people experiencing infertility. This is the first qualitative study about perspectives of fertility and infertility in adolescents aged 18 and under in an Australian context. We make recommendations for developing age-appropriate fertility education, regarding the incorporation of appropriate frameworks in adolescent education to enhance discussions around sex and gender in fertility to align with contemporary preferences.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2506790"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of education, training and continuous performance monitoring to ART professionals, particularly embryologists.","authors":"Martine Nijs, Ellen Armstrong, Steven Fleming","doi":"10.1080/14647273.2025.2529372","DOIUrl":"https://doi.org/10.1080/14647273.2025.2529372","url":null,"abstract":"<p><p>Assisted reproductive technology (ART) is a fast-moving, innovative, and exciting field. Education and training of new as well as experienced ART professionals is vital, not only to obtain the fundamental learning of reproductive sciences but to keep abreast of advances in technology and strategies, and to guarantee the best care for our patients. Providing a clear road map of training to gain competence, followed by continual, high-quality education and competence evaluation, aims to improve performance and time efficiency of daily practice. This review article aims to summarise the essential points to consider when planning education, training, and ongoing competency assessment.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2529372"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Fertility Education Initiative: responding to the need for enhanced fertility and reproductive health awareness amongst young people in the United Kingdom.","authors":"James Cheshire, Justin Chu, Jacky Boivin, Grace Dugdale, Joyce Harper, Adam Balen","doi":"10.1080/14647273.2024.2417940","DOIUrl":"https://doi.org/10.1080/14647273.2024.2417940","url":null,"abstract":"<p><p>The need for fertility education arises from changing patterns of family formation in recent times. Young people feel unprepared for how best to plan their career and family and have little idea of the various factors that may influence their fertility later in their life. Research shows young people would like to know more and need the information to be conveyed in a way that is engaging and helps them to integrate it at their current life stage. The Fertility Education Initiative (FEI) was founded in 2016 to address the need for improved fertility and reproductive health awareness and ensure young people are equipped with the relevant information to meet their reproductive and family building needs. This paper serves as a historical record of the genesis of the FEI and its impact to date.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"27 1","pages":"2417940"},"PeriodicalIF":2.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}