Human Fertility最新文献

{"title":"Addendum.","authors":"Virginia Bolton","doi":"10.1080/14647273.2026.2627807","DOIUrl":"https://doi.org/10.1080/14647273.2026.2627807","url":null,"abstract":"","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"29 1","pages":"2627807"},"PeriodicalIF":1.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147305192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single mothers by choice in Hungary: motivations for solo motherhood and the importance of genetic ties.","authors":"Adrienn Bognár, Boglárka Herke, Ivett Szalma","doi":"10.1080/14647273.2026.2682158","DOIUrl":"10.1080/14647273.2026.2682158","url":null,"abstract":"<p><p>This article examines the reproductive decisions and concept of kinship of single mothers by choice (SMBC) in Hungary who pursued motherhood through assisted reproductive technologies (ART). Twenty-one women in Hungary participated in interviews examining their decisions to become SMBCs, to select ART, and whether to seek information or contact with their child's genetic relatives. The findings show that genetic ties were central to reproductive decisions. All reported a strong desire to have a child; most had hoped to conceive within a relationship but, approaching the end of their reproductive years, had opted for ART. The use of donor eggs was considered as a last resort; maintaining genetic links to the child was important for their sense of motherhood. Many described their child's interest in knowing about genetic relatives. Most participants attempted to identify donor-conceived half-siblings, and several were successful. In the Hungarian context, this study highlights the increasing importance of digital technologies in challenging the legal framework of anonymity, enabling women to locate donors or their children's half-siblings. The study contributes to debates on family, kinship, and reproductive autonomy, and provides insights into how SMBCs navigate donor conception under conditions of strict donor anonymity and constrained access to ART.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"29 1","pages":"2682158"},"PeriodicalIF":1.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The need for transparency in the promotion of popular period tracker applications (apps): a content analysis of their app store descriptions.","authors":"Alice Graham, Brooke Nickel, Xinyao Chen, Tessa Copp","doi":"10.1080/14647273.2025.2607988","DOIUrl":"10.1080/14647273.2025.2607988","url":null,"abstract":"<p><p>Period tracking applications (apps) are increasingly being used by people who menstruate to predict the timing of their next period, monitor symptoms, and avoid or plan pregnancy. Despite their growing popularity, there has been a lack of critical engagement regarding their development, usage, regulation, claimed benefits, and unintended harms. This study aimed to explore how popular international period trackers are promoted, including the quality of the information provided and the communication strategies used in the app descriptions and websites. 'Period tracker' and 'Menstrual cycle calculator' were searched in the Apple and Google app stores and results were combined with Statista's report on the most downloaded period trackers and women's health apps globally. The top ten recurring apps were selected and analysed using an inductive content analysis. The content extracted was categorised into four overarching themes: (1) function and abilities, (2) marketing language, (3) health claims made, and (4) any caveats described. Most apps (60%) featured empowerment language and claimed that users would gain knowledge and understanding of their bodies (60%), yet few (40%) disclosed that they should not replace professional medical advice, diagnosis or treatment. None of the apps included a caveat that their predictions may be inaccurate and should only be interpreted as a guide. By summarising the quality of information and questioning the use of non-evidence-based claims in the promotion of period tracking apps, our findings highlight the need for greater transparency and regulation. Improving information quality, disclosing how predictions are generated, and openly communicating limitations is vital in setting realistic user expectations, enhancing menstrual health literacy, and maximising the benefits of period tracking apps for women and people who menstruate overall.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"29 1","pages":"2607988"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of total fertility rate between 2011 and 2023 in Türkiye: a comparative panel analysis.","authors":"Nilüfer Pekin Alakoç","doi":"10.1080/14647273.2026.2716116","DOIUrl":"10.1080/14647273.2026.2716116","url":null,"abstract":"<p><p>This study investigates the socioeconomic determinants of the total fertility rate (TFR) in Türkiye, with a particular focus on regional disparities. A comprehensive panel data analysis, including the fixed effect regression analyses, was conducted by using a dataset from all 81 provinces over the years 2011 to 2023. TFR exhibits substantial variation across the provinces and regions. To have more homogeneous data, the provinces were classified into two groups based on their 2024 TFR values: high-TFR (>1.5) and low-TFR (≤1.5). This classification also aligns with regional categorisation as higher TFR levels are predominantly concentrated in southeastern Türkiye. The analysis investigates the effects of eight key variables on TFR. The results indicate that female marriage age, marriages between cousins, infant mortality rate, and the number of health care professionals are significant factors across provinces, although the strength of these relationships varies across estimation methods. The findings also reveal important divergence between the province groups. While crude death rate and educational attainment emerge as influencing factors in the low-TFR provinces, no significant evidence is found to support their role in high-TFR provinces. The study provides valuable insights into the fertility behaviour in Türkiye and contributes to a better understanding of the fertility pattern in other countries or regions facing similar demographic transitions. The findings can play an important role in developing relevant policies.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"29 1","pages":"2716116"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148721052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dietary quality indices and female infertility: a population-based study using NHANES 2013-2020.","authors":"Donglin Chen, Lixia Xu, Lin Cheng, Aifang Su","doi":"10.1080/14647273.2026.2686144","DOIUrl":"https://doi.org/10.1080/14647273.2026.2686144","url":null,"abstract":"<p><p>This study investigated the association between dietary quality indices and female infertility using data from the National Health and Nutrition Examination Survey (NHANES) 2013-2020. A total of 5,477 women aged 18-59 years were included. Dietary quality was assessed using 24-hour dietary recall data and summarised by four predefined indices: the alternate Mediterranean diet score (MED), the Healthy Eating Index-2020 (HEI-2020), the Alternate Healthy Eating Index (AHEI), and the Dietary Approaches to Stop Hypertension (DASH) score. Weighted logistic regression models were used to estimate the associations between dietary quality and infertility, and restricted cubic spline (RCS) analyses were used to examine potential dose-response patterns. After adjustment for age, race/ethnicity, education level, body mass index (BMI), smoking status, alcohol consumption, marital status, menstrual regularity, age at menarche, history of pelvic inflammatory disease, and total energy intake, higher MED, HEI-2020, AHEI, and DASH scores were inversely associated with infertility. RCS analyses suggested approximately linear inverse associations for these indices (all <i>P</i> for nonlinearity >0.05). Higher overall diet quality was associated with lower odds of infertility among adult women in the United States (US). Because this was a cross-sectional study using self-reported infertility, the findings should be interpreted as associative rather than causal.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"29 1","pages":"2686144"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early contact experiences between embryo donors and recipients (parents) in Aotearoa New Zealand.","authors":"Emma Hurley, Sonja Goedeke","doi":"10.1080/14647273.2026.2633987","DOIUrl":"10.1080/14647273.2026.2633987","url":null,"abstract":"<p><p>In New Zealand, embryo donors and recipients meet in a joint counselling session before donation where their needs and expectations for future contact are discussed. However, the extent and experience of contact - including that occurring before the mandated age of identity release at 18 - has received little international research attention and has not been explored in New Zealand. This study, based on interviews with nine participants who had donated or received embryos, examined donor and recipient expectations and experiences of early contact, including the nature of their relationships, how boundaries and expectations are managed and their role in each other's lives. Thematic analysis identified that contact was experienced as overwhelmingly positive, with many participants describing strong, meaningful connections between families. Relationships between children in both families were particularly valued, and extended family often became part of these networks. Contact arrangements were flexible, combining in-person and digital communication. Joint counselling was viewed as instrumental in establishing contact expectations and fostering positive relationships. Although participants were satisfied with the pre-donation counselling process, findings suggest the value of ongoing access to support for issues which may emerge after donation.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"29 1","pages":"2633987"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147270770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of sperm DNA fragmentation (SDF) in predicting reproductive outcomes - a systematic review and meta-analysis.","authors":"Srisailesh Vitthala, Silvia Nedelcu, Tarek El-Toukhy, Abha Maheshwari","doi":"10.1080/14647273.2026.2618228","DOIUrl":"10.1080/14647273.2026.2618228","url":null,"abstract":"<p><p>Male infertility is commonly diagnosed by semen analysis, but it often fails to distinguish fertile from infertile men unless abnormalities are marked. Sperm DNA fragmentation (SDF) testing is becoming a diagnostic aid. High SDF-defined as values higher than assay-specific cut-offs-predicts adverse reproductive outcomes in natural conception and after IUI, IVF, and ICSI, as shown in this systematic review and meta-analysis. From inception to March 2025, we searched MEDLINE, EMBASE, CINAHL, Google Scholar, Web of Science, and SCISEARCH for COMET, SCSA, TUNEL, or SCD studies that reported pregnancy or miscarriage. Assay cut-offs were used to extract data into 2x2 tables. Pooled sensitivity, specificity, likelihood ratios, and diagnostic odds ratios were evaluated using random-effects HSROC models following PRISMA and QUADAS-2 guidelines. In 52 trials with 19,930 subjects, all reported pregnancies and 41 reported miscarriages. High SDF had low sensitivity and higher specificity across natural and assisted conception, with modest likelihood and diagnostic odds ratios indicating limited discrimination. With significant heterogeneity, HSROC curves showed poor-to-moderate discrimination. High SDF had low sensitivity and high specificity for miscarriage, indicating poor prediction. Evaluating high SDF alone to predict pregnancy or miscarriage is limited. Its clinical value needs to be determined through well-designed trials.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"29 1","pages":"2618228"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146201464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Statement: Probiotic effects on sperm parameters, oxidative stress index, inflammatory factors and sex hormones in infertile men.","authors":"","doi":"10.1080/14647273.2026.2663617","DOIUrl":"https://doi.org/10.1080/14647273.2026.2663617","url":null,"abstract":"","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"29 1","pages":"2663617"},"PeriodicalIF":1.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147769897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Dimensional ultrasound parameters in assessing endometrial receptivity: a prospective study of novel scoring systems in frozen embryo transfer cycles.","authors":"Ayushi Agarwal, Anjali Mundkur, Vidyashree G Poojari, Prashanth Adiga, Pratap Kumar","doi":"10.1080/14647273.2025.2609464","DOIUrl":"10.1080/14647273.2025.2609464","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Accurate prediction of endometrial receptivity remains a key challenge in assisted reproductive technology (ART), with implantation failure often attributed to suboptimal endometrial conditions. This prospective observational study was conducted at the Department of Reproductive Medicine & Surgery, Kasturba Hospital, Manipal, between September 2024 and June 2025, to develop novel ultrasound-based scoring systems for predicting clinical pregnancy in frozen embryo transfer (FET) cycles. A total of 256 women aged 21-50 years undergoing FET with embryo(s) derived using their own gametes in natural, stimulated, or hormone replacement cycles were recruited, provided they had at least one good-quality embryo transferred. Patients with Müllerian anomalies or acquired intrauterine pathologies were excluded. Endometrial parameters including thickness, echogenicity, vascularity, peristalsis, uterine artery pulsatility index and 3D endometrial volume were evaluated on the day of FET using standardised ultrasonography. The primary outcome was clinical pregnancy, confirmed by visualisation of a gestational sac at six weeks. The study was registered with the Clinical Trials Registry - India (CTRI/2024/10/075117). The trial was approved on 11/10/2024. Of the 256 FETs, 103 resulted in clinical pregnancy (40.23%). Women who conceived had significantly greater endometrial volume (median 4.40 vs 3.60 mm³; &lt;i&gt;p&lt;/i&gt; &lt; 0.01), higher vascularity (74.8% vs 62.1%; &lt;i&gt;p&lt;/i&gt; = 0.0417), and lower peristalsis (2 vs 3 waves/min; &lt;i&gt;p&lt;/i&gt; = 0.0231) than those who did not conceive. Male factor infertility was more frequent in the pregnant than in the non-pregnant cohort (32.03% vs 10.45%; &lt;i&gt;p&lt;/i&gt; &lt; 0.01). Logistic regression confirmed endometrial volume, vascularity, and reduced peristalsis as independent predictors of pregnancy (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). Three scoring systems were developed: the Total Screening Score (all predictors), the Targeted Endometrial Receptivity Score (volume, vascularity, peristalsis), and the Endometrial Volume Score. The Total Screening Score (≥14) offered the highest specificity (0.712) but poor sensitivity (0.097) and overall accuracy (0.464). The Targeted Score (≥7) achieved balanced performance, with sensitivity 0.631, specificity 0.621, accuracy 0.625, and the highest positive likelihood ratio (1.665). The Endometrial Volume Score (≥2) demonstrated the best sensitivity (0.796) and negative predictive value (0.727), serving as a strong screening tool, though limited by low specificity (0.366). This study introduces the first multiparametric ultrasound-based scoring framework for FET outcomes developed in the Indian context. The Targeted Endometrial Receptivity Score provides a balanced, reproducible tool for FET planning and patient counselling, while endometrial volume alone can serve as a rapid screening parameter. These systems offer a cost-effective, non-invasive approach to optimise FET outcomes, though validation in larger, multicentre coho","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"29 1","pages":"2609464"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thematic analysis of a United Kingdom-wide survey to explore women's perceptions and concerns about assisted reproductive technology.","authors":"Faiza Afzal, Ling Yin Fritz Wong, Mitana Purkayastha, Yan Lu, Philippa Rees, Melissa A Richard, Carrie L Williams, Philip J Lupo, Barbara Luke, Alastair G Sutcliffe","doi":"10.1080/14647273.2026.2666204","DOIUrl":"10.1080/14647273.2026.2666204","url":null,"abstract":"<p><p>Women's perceptions of long-term outcomes of assisted reproductive technology (ART) remain underexplored in the United Kingdom. National database studies investigating these outcomes may provide clearer information. This survey investigates women's perceptions of: long-term ART outcomes, information provision on these outcomes, and such national database studies. Over an 8-month period, women who had undergone ART, were considering ART, or had conceived naturally completed an anonymous, cross-sectional survey distributed via social media. Descriptive and inductive, semantic thematic analyses were performed. Of 562 respondents, most were aged 25-40 (72.4%) and underwent private ART (37.9%). Most reported no concerns about maternal health (51.8%), child health (66.9%) and child education (82.5%). Reported concerns focused on maternal reproductive, cancer and endocrine outcomes, and child reproductive, neurodevelopmental, developmental and learning outcomes. Information on long-term outcomes was frequently not provided by fertility clinics (up to 91.9%). While up to 68.3% considered national database studies useful for investigating offspring outcomes, some raised data confidentiality concerns. Dissemination via healthcare professionals sensitively pre-treatment was preferred. Overall, most women reported no concerns about and received no information on long-term ART outcomes in maternal health, child health and child education. Improving clinician-led information provision may address knowledge gaps and support research dissemination.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"29 1","pages":"2666204"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147874216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}