Human Fertility最新文献_第5页

Higher chromosomal abnormality rate in blastocysts from a subset of patients with pericentric inversion (Inv) 1 variant. 包心倒位（Inv）1 变异患者的囊胚染色体异常率较高。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-02-20 DOI: 10.1080/14647273.2023.2179896

Miaomiao Jia, Xia Xue

{"title":"Higher chromosomal abnormality rate in blastocysts from a subset of patients with pericentric inversion (Inv) 1 variant.","authors":"Miaomiao Jia, Xia Xue","doi":"10.1080/14647273.2023.2179896","DOIUrl":"10.1080/14647273.2023.2179896","url":null,"abstract":"The purpose of this study was to evaluate the incidence of unbalanced chromosome rearrangement in blastocyst-stage embryos from carriers of pericentric inversion of chromosome 1 (PEI-1). A total of 98 embryos from 22 PEI-1 carriers were tested for unbalanced rearrangements, originating from inversion carriers, and overall aneuploidy. Logistic regression analysis indicated that the ratio of inverted segment size to chromosome length was a statistically significant risk factor for unbalanced chromosome rearrangement from PEI-1 carriers (p = 0.003). The optimal cut-off values to predict the risk of unbalanced chromosome rearrangement was 36%, with the incidence being 2.0% in the <36% group and 32.7% in the ≥36% group. The unbalanced embryo rate was 24.4% in male carriers compared to 12.3% in female carriers. Inter-chromosomal effect analysis was performed using 98 blastocysts from PEI-1 carriers and 116 blastocysts from age-matched controls. PEI-1 carriers had similar sporadic aneuploidy rates compared to those of age-matched controls at 32.7 vs. 31.9%, respectively. In conclusion, the risk of unbalanced chromosome rearrangement is affected by inverted segment size in PEI-1 carriers.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10757878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of the pathophysiology and evidence-based management of varicoceles and pelvic congestion syndrome. 综述精索静脉曲张和盆腔充血综合征的病理生理学和循证管理。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-05-16 DOI: 10.1080/14647273.2023.2212846

Matteo Galea, Mark R Brincat, Jean Calleja-Agius

引用次数: 0

The case for reframing known donation. 重构已知捐赠的理由。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-01-23 DOI: 10.1080/14647273.2022.2145242

Leah Gilman, Petra Nordqvist

{"title":"The case for reframing known donation.","authors":"Leah Gilman, Petra Nordqvist","doi":"10.1080/14647273.2022.2145242","DOIUrl":"10.1080/14647273.2022.2145242","url":null,"abstract":"Contemporary UK egg and sperm donation exists in two predominant forms: (i) clinic-based, identity-release donation; and (ii) known donation, which can take place either inside or outside of the clinic context. Regulatory and clinical discussions of the latter currently focus, almost exclusively, on risk whereas identity-release is widely presented as the default route for both donors and recipients. Consequently, there is little support available for those potential donors and recipient parents who might prefer a known donor arrangement. In this commentary, we reflect on our sociological research with donors and parents through donor conception and argue that there are a number of reasons why known donation may, in some contexts, offer advantages over identity-release donation. Whilst this research also demonstrates that there can be challenges involved in known donation, these are not inevitable nor are challenges absent from identity-release routes. It is timely and important to question whether the current de-valuing of known donation compared with identity-release donation holds up to academic scrutiny. We argue for a more balanced approach in which the benefits and challenges of both known and identity-release routes are discussed with donors and recipients and for increased support for known donation in clinics and by regulatory bodies.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9127231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sperm donors versus long-term mates: a comparison of preferences of heterosexual and lesbian women. 捐精者与长期配偶：异性恋和女同性恋偏好的比较。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2022-01-13 DOI: 10.1080/14647273.2021.2022775

Ya'arit Bokek-Cohen

{"title":"Sperm donors versus long-term mates: a comparison of preferences of heterosexual and lesbian women.","authors":"Ya'arit Bokek-Cohen","doi":"10.1080/14647273.2021.2022775","DOIUrl":"10.1080/14647273.2021.2022775","url":null,"abstract":"The present study aimed to explore whether lesbian women's preferences for a sperm donor or a long-term mate show a pattern similar to those of heterosexual women. Three hundred and eighty-three donor insemination patients, of whom 278 were heterosexual and 105 were lesbian, completed a questionnaire comprising a series of 35 traits and rated the importance of each trait in a sperm donor and again in a long term mate. Results showed that traits relating to socioeconomic status, genetic background and general health, physical appearance, and personality were rated by lesbian women as more important in a long-term mate than in a sperm donor. It was further found that both heterosexual and lesbian women attached higher importance to the socioeconomic status, personality and physical appearance of the long-term mate than of the sperm donor; heterosexual women attached similar importance to the genes and health of a long-term mate and a sperm donor, while lesbian women attached greater importance to the genetic background and general health of the sperm donor than those of a long-term mate. The implications and interpretations of the findings are discussed in light of Trivers' parental investment theory.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39818157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Does being conceived by assisted reproductive technology influence adult quality of life? 通过辅助生殖技术受孕是否会影响成人的生活质量？

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2022-03-22 DOI: 10.1080/14647273.2022.2042860

Karin Hammarberg, Jane Halliday, Joanne Kennedy, David P Burgner, David J Amor, Lex W Doyle, Markus Juonala, Sarath Ranganathan, Liam Welsh, Michael Cheung, Robert McLachlan, John McBain, Sharon Lewis

{"title":"Does being conceived by assisted reproductive technology influence adult quality of life?","authors":"Karin Hammarberg, Jane Halliday, Joanne Kennedy, David P Burgner, David J Amor, Lex W Doyle, Markus Juonala, Sarath Ranganathan, Liam Welsh, Michael Cheung, Robert McLachlan, John McBain, Sharon Lewis","doi":"10.1080/14647273.2022.2042860","DOIUrl":"10.1080/14647273.2022.2042860","url":null,"abstract":"Numerous studies have investigated the physical health and development of children and adolescents conceived with assisted reproductive technology (ART). Less is known about the quality of life of ART-conceived adults. This study explores the contributions of being conceived with ART and psychosocial cofactors present in young adulthood to the quality of life of adults aged 22-35 years. Young adults conceived through ART or natural conception (NC) completed questionnaires which included a standardized measure of quality of life (World Health Organization Quality of Life - Brief assessment (WHOQoL-BREF)) when aged 18-28 years (T1) and again when aged 22-35 years (T2). The WHOQoL-BREF has four domains: (i) Physical, (ii) Psychological, (iii) Social relationships and (iv) Environment. A total of 193 ART-conceived and 86 NC individuals completed both questionnaires. When accounting for other cofactors in multivariable analyses, being ART-conceived was strongly associated with higher scores (better quality of life) on the Social relationships, and Environment WHOQoL-BREF domains at T2. In addition, less psychological distress, a better relationship with parents, a better financial situation, and perceptions of being about the right weight at T1 were associated with higher scores on one or more of the WHOQoL-BREF domains at T2. In conclusion, being ART-conceived can confer advantages in quality of life in adulthood, independent of psychosocial cofactors.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40313990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Allan Pacey: Thank you from Human Fertility and the BFS. 艾伦-佩西（Allan Pacey）：感谢人类生育研究中心和英国科学基金会。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-12-21 DOI: 10.1080/14647273.2023.2278920

Mark Hamilton, Abha Maheshwari

引用次数: 0

Endometriosis affects the number of retrieved oocytes but not early embryonic development and live birth: a retrospective analysis of 716 IVF cycles. 子宫内膜异位症会影响取出的卵母细胞数量，但不会影响早期胚胎发育和活产：对 716 个试管婴儿周期的回顾性分析。

IF 2.1 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-05-04 DOI: 10.1080/14647273.2023.2200979

Alessandro Bartolacci, Miriam dell'Aquila, Giovanni Coticchio, Giulia Intra, Federica Parodi, Gilda Patria, Carlotta Zacà, Andrea Borini

{"title":"Endometriosis affects the number of retrieved oocytes but not early embryonic development and live birth: a retrospective analysis of 716 IVF cycles.","authors":"Alessandro Bartolacci, Miriam dell'Aquila, Giovanni Coticchio, Giulia Intra, Federica Parodi, Gilda Patria, Carlotta Zacà, Andrea Borini","doi":"10.1080/14647273.2023.2200979","DOIUrl":"10.1080/14647273.2023.2200979","url":null,"abstract":"To investigate the potential effect of endometriosis on embryo development and clinical outcomes, a retrospective analysis of 716 women undergoing their first standard in vitro fertilization (sIVF) cycles (205 endometriosis and 511 with tubal factor infertility) was performed. The endometriosis group included women with an ultrasonographic or surgical diagnosis. Control subjects were women diagnosed with tubal factor infertility by laparoscopy or hysterosalpingogram. The primary outcome of the study was live birth. Cumulative live birth was also assessed in a subgroups analysis. After adjusting for confounders we found no significant difference in fertilization rate, blastulation, top-quality blastocyst, live birth, cumulative live birth (subgroups analysis) and miscarriage rate. In the endometriosis group, the number of retrieved oocytes was smaller (6.94 ± 4.06 Vs 7.50 ± 4.6, adjusted p < 0.05). We observed a statistically significant difference in the percentage of day-3 embryos with ≥8 blastomeres (33.12 ± 22.72 endometriosis vs, 40.77 ± 27.62 tubal factor, adjusted p < 0.01) and a negative correlation between the presence of endometriomas and a number of retrieved oocytes [B coefficient =-1.41, 95%CI (-2.31-0.51), adjusted p = 0.002]. Our results suggest that endometriosis affects the number of retrieved oocytes but not embryo development and live birth.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9461630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

15 and 30 min of immobilization after IUI: a randomized control trial. 人工授精后固定 15 分钟和 30 分钟：随机对照试验。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-03-21 DOI: 10.1080/14647273.2023.2191346

Yang Mengye, Tang Yan, Qian Jiarong, Liu Qing, Niu Fangfang, Zhang Yan

{"title":"15 and 30 min of immobilization after IUI: a randomized control trial.","authors":"Yang Mengye, Tang Yan, Qian Jiarong, Liu Qing, Niu Fangfang, Zhang Yan","doi":"10.1080/14647273.2023.2191346","DOIUrl":"10.1080/14647273.2023.2191346","url":null,"abstract":"The purpose of this study is to provide evidence for better guidance related to bed rest after intrauterine insemination (IUI). We conducted a randomized trial to compare the effect of 15 min versus 30 min of bed rest after IUI on pregnancy rate. A total of 204 couples were recruited from May 2021 to December 2021 and randomized to remain in the supine position for either 15 or 30 min after the procedure. The outcomes were the clinical pregnancy rate and comfort level after IUI. Ultimately, 198 couples were included in the analysis. The 15-min immobilization group consisted of 100 couples (226 cycles), and the 30-min immobilization group consisted of 98 couples (225 cycles). The clinical pregnancy rate per couple in the 15-min immobilization group (26 of 100) was not different from that in the 30-min immobilization group (23 of 98). With the use of discrete-time survival analysis, the cumulative probability of clinical pregnancy also showed no difference between these two groups. Based on the literature and on our study, the possible beneficial effect of 30-min immobilization after IUI is at least questionable, and a shorter time could be implemented depending on the results of a systematic review and the individual patient data from the currently executed trials.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9516067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is there a relationship between morphokinetic parameters and neonatal sex in fresh embryo transfers? 新鲜胚胎移植的形态动力学参数与新生儿性别之间有关系吗？

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-03-21 DOI: 10.1080/14647273.2023.2190043

Avital Wertheimer, Onit Sapir, Assaf Ben Meir, Iris Har-Vardi, Alyssa Hochberg, Avi Ben-Haroush, Roni Garor, Tamar Margalit, Tzippy Schohat, Yoel Shufaro

{"title":"Is there a relationship between morphokinetic parameters and neonatal sex in fresh embryo transfers?","authors":"Avital Wertheimer, Onit Sapir, Assaf Ben Meir, Iris Har-Vardi, Alyssa Hochberg, Avi Ben-Haroush, Roni Garor, Tamar Margalit, Tzippy Schohat, Yoel Shufaro","doi":"10.1080/14647273.2023.2190043","DOIUrl":"10.1080/14647273.2023.2190043","url":null,"abstract":"To investigate whether morphokinetic parameters differ between male and female embryos in IVF embryos resulting in live births, a retrospective cohort study was undertaken. Files of all live births resulting from a single embryo transfer (SET) cultured in time-lapse incubators between 2013 and 2019 in two tertiary care centres were reviewed. The study group consisted of 187 SETs resulted in 187 live births, of which 100 were females (53.5%) and 87 were males (46.5%). Embryo selection for transfer was based on the known implantation data (KID) score provided by the Embryoscope and morphological assessment by experienced embryologists. Neonatal sex was confirmed through live birth documentation. Morphokinetic parameters and day 3 and day 5 KID scores of male and female embryos were compared. Maternal baseline and treatment characteristics were similar between groups. Morphokinetic time-lapse parameters of male and female embryos including: pronuclei fading; cleavage timings (t2-t9); second and third cell cycle durations; synchrony of the second and third cleavages; late morphokinetic parameters and KID scores did not differ between groups. In conclusion, time-lapse morphokinetic parameters and embryo selection methods do not seem to differ between male and female embryos, and their utilization does not bias towards any neonatal sex.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9516068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weekday vs. weekend oocyte retrievals: is there a difference? 平日与周末取卵：有区别吗？

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-04-27 DOI: 10.1080/14647273.2023.2193908

Miriam Tarrash, Casey Sciandra, Alexandra Peyser, Randi H Goldman, Christine Mullin

{"title":"Weekday vs. weekend oocyte retrievals: is there a difference?","authors":"Miriam Tarrash, Casey Sciandra, Alexandra Peyser, Randi H Goldman, Christine Mullin","doi":"10.1080/14647273.2023.2193908","DOIUrl":"10.1080/14647273.2023.2193908","url":null,"abstract":"The purpose of this study was to evaluate whether there is a difference in procedure duration and time spent in the post anaesthesia care unit (PACU) between weekday (WD) and weekend (WE) oocyte retrievals (ORs). This was a retrospective cohort study of patients compared and stratified based on number of oocytes retrieved (1-10, 11-20, and >20). Student's t-test and linear regression models were used to assess the relationship between AMH, BMI, and a number of oocytes retrieved with the duration of procedure and total time spent in the PACU. 664 patients underwent OR of which 578 met inclusion criteria and were analyzed. There were 501 WD OR cases (86%) and 77 (13%) WE ORs. When stratified by number of oocytes retrieved, there was no difference in procedure duration or PACU time between WD vs. WE OR. Longer procedure times were associated with higher BMI (p = 0.04), AMH (p = 0.01) and oocytes retrieved (p < 0.01). Increased PACU times positively correlated with the number of oocytes retrieved (p = 0.04), but not AMH or BMI. While BMI, AMH, and number of oocytes retrieved are associated with longer intra-operative and post-operative recovery times, there is no difference in procedure or recovery time when comparing WD vs. WE procedures.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9707398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0