Human Fertility最新文献

{"title":"Using online platforms to offer or seek sperm donation: A systematised narrative review of donor and recipient experiences.","authors":"Isabel Côté, Claudia Fournier, Emma Bouffard, Kévin Lavoie, Mona Greenbaum","doi":"10.1080/14647273.2025.2571093","DOIUrl":"https://doi.org/10.1080/14647273.2025.2571093","url":null,"abstract":"<p><p>Online sperm donation (OSD) is reshaping donor conception by enabling direct connections between donors and recipients outside clinical settings. This systematised narrative review triangulates existing research on sperm donors and recipients who connect through OSD platforms, comparing their perceptions and experiences across different stages of the donation process. By exploring the complex interplay between donors' and recipients' motivations, it fosters dialogue between research areas often examined in isolation. Studies show that donors and recipients, who often explore alternatives alongside OSD, turn to this option to establish contact, gain flexibility, and sometimes facilitate a relationship between the donor and the child. Donors are primarily motivated by altruism or the desire to transmit their genetic heritage, while recipients often turn to OSD for its affordability and flexibility. Both parties engage in negotiations regarding expectations, insemination methods, and future contact, with both parties assessing trust and compatibility. While many report positive experiences, some-especially recipients-face challenges such as communication difficulties, unsolicited advances or sexual misconduct. In the absence of regulation, recipients bear the burden of managing risks related to safety and donor reliability, whereas donors are mainly concerned with legal parentage. Donors and recipients also differ on the donor's role in the child's life, ranging from no involvement to ongoing contact, with post-conception agreements sometimes evolving. Further research is needed to address key gaps, particularly long-term post-conception experiences and perspectives of recipients and online-donor-conceived individuals. This review highlights that rather than eliminating OSD, policies should prioritise safety, transparency, and informed decision-making while expanding access to fertility clinics and establishing a clear legal framework. A balanced approach-one that respects autonomy while mitigating risks-will be essential to fostering ethical and sustainable donor-recipient arrangements, ensuring positive outcomes, especially for recipients and their families.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2571093"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovating reproductive health education: testing the concept of reproductive identity.","authors":"Yasmin Butt, Lisa Sholomon, Kelly Moffitt-Hawasly, Gwen Walsh, Diana McGlory, Taylor D Orlandoni, Riddhi Sandil, Aurélie Athan","doi":"10.1080/14647273.2025.2533256","DOIUrl":"https://doi.org/10.1080/14647273.2025.2533256","url":null,"abstract":"<p><p>Sexual and reproductive health (SRH) education in the United States has undergone significant change in the past fifty years, driven by shifting global fertility trends and an increased emphasis on identity-related topics. It has traditionally emphasized biological function, disease prevention, and risk reduction, often overlooking identity development and the psychosocial dimensions of reproductive decision-making. Reproductive Identity (RI) is an emerging construct that may provide a new direction that expands SRH education by integrating reproductive self-concept, future reproductive intentions and social justice perspectives that is strengths-based and inclusive of all genders and sexualities. This study examined how SRH educators conceptualize RI, its perceived novelty, familiarity and relevance for SRH curricula, and its alignment with the National Sex Education Standards (NSES). A mixed methods design analyzed survey responses from SRH educators who participated in a fully-funded, six-week, online professional development training programme in RI. Findings indicate that while RI was largely unfamiliar pre-training (62%), it was considered somewhat novel (65%) and relevant (78%) for SRH curricula post-training. Thematic analysis of pre- and post-training responses demonstrated that educators shifted their conceptualizations of RI from viewing RI through biologically-oriented perspectives to recognizing its broader relevance to self-concept, decision-making and reproductive justice. Although RI demonstrated partial alignment with the NSES, gaps remained in areas such as reproductive life planning and future parenting intentions. RI complements existing approaches by addressing the psychosocial and developmental aspects of reproductive decision-making. While RI has not yet been tested with adolescents, the parallel learning process observed among educators suggests its feasibility for integration into SRH curricula.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2533256"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The infected blood inquiry report-lessons for gamete donation.","authors":"Sharon Zahra, Marc L Turner","doi":"10.1080/14647273.2024.2438650","DOIUrl":"10.1080/14647273.2024.2438650","url":null,"abstract":"<p><p>Donation of substances of human origin (SoHO) is essential for the treatment of many patients and ranges from the donation of whole organs to the donation of tissue or cell products, including also gamete donation. In order to ensure the safety of recipients of SoHOs there are multiple steps taken in the donation pathway of all such substances to ensure the quality and safety of the donation. However, despite this, there is always a residual risk associated with SoHOs. The recent Infected Blood Inquiry (IBI) report has described in detail the background to the inadvertent transmission of HIV and hepatitis C to many patients in the past and has provided a number of recommendations. While the IBI focused on blood donation and the risk of blood borne virus transmission, the underlying principles are pertinent to all SoHOs, including gamete donation, and to all risks associated with SoHOs not just the risk of blood borne virus transmission.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2438650"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA damage in prepared semen is negatively associated with semen quality and fertilisation rate in assisted reproduction technology (ART) treatment.","authors":"Bashar Altakroni, Helen Hunter, Greg Horne, Daniel R Brison, Andrew C Povey","doi":"10.1080/14647273.2024.2442450","DOIUrl":"https://doi.org/10.1080/14647273.2024.2442450","url":null,"abstract":"<p><p>Sperm DNA contains strand breaks and base damage that can potentially affect reproductive health. This study aims to determine to what extent sperm DNA integrity and alkylation is associated with semen quality and assisted reproduction technology (ART) treatment outcomes, in particular fertilisation and cleavage rates. Male partners of couples attending for infertility treatment were recruited. DNA integrity (% tail DNA, sperm with either low (LDD) or high (HDD) damage levels) was measured by a neutral Comet assay and N7-methyldeoxyguanosine (N7-MedG) DNA levels by an immunoslotblot in sperm prepared by density gradient centrifugation. Associations between DNA damage, semen quality and ART treatment outcomes were assessed. N7-MedG levels were lower and the proportion of LDD sperm higher in prepared than in neat sperm samples. The proportion of HDD sperm and % tail DNA were significantly negatively associated and the proportion of LDD sperm positively associated with semen quality. Fertilisation, but not cleavage, rate nor live birth, was significantly negatively associated with N7-MedG levels, the proportion of HDD sperm and % tail DNA and was positively associated with the proportion of LDD sperm. These results confirm that DNA damage, even in prepared sperm, is associated with adverse semen quality and suggest that sperm DNA damage affects the early stages of embryo formation.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2442450"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstetric and perinatal outcomes in singleton pregnancies following medicated, stimulated and natural, frozen embryo transfer cycles: an updated systematic review and meta-analysis.","authors":"Freya Baird, Emilia Smith, Yusuf Beebeejaun, Venkatesh Subramanian, Mahua Bhaduri, Nick Kametas, Ippokratis Sarris, Sesh K Sunkara","doi":"10.1080/14647273.2024.2448131","DOIUrl":"10.1080/14647273.2024.2448131","url":null,"abstract":"<p><p>Frozen embryo transfer (FET) has been associated with higher risks of hypertensive disorders of pregnancy (HDP), large for gestational age and high birth weight. This systematic review and meta-analysis evaluates obstetric and perinatal outcomes in medicated, stimulated and natural FET cycles. A literature search was performed using MEDLINE, EMBASE, CINAHL and the Cochrane Library database; 152,590 FET cycles were analysed from 31 included studies. Risk ratios (RR) and 95% confidence intervals (CI) were calculated using fixed and random effects models determined by the heterogeneity (I²). There was significantly higher risk of obstetric and perinatal complications, including HDP (RR 1.84, CI:1.48-2.29, I² 87%) and low birth weight (LBW) (RR 1.25, CI:1.12-1.39, I² 57%) following medicated compared to natural FET cycles. A higher risk of HDP (RR 1.50, CI:1.33-1.64, I² 32%) and macrosomia (RR 1.28, CI:1.17-1.40, I² 37%) was noted following medicated compared to stimulated cycles. Natural demonstrated lower risk of HDP (RR 0.77, CI:0.60-0.99, I² 32%), gestational diabetes (RR 0.78, CI:0.68-0.89, I² 43%), LBW (RR 0.78, CI:0.64-0.95, I² 48%) and small for gestational age (RR 0.83, CI:0.70-0.98, I² 12%) than stimulated cycles. These findings indicate that medicated FET cycles convey greater risks of obstetric and perinatal complications than natural or stimulated cycles.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2448131"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"#misinformation: The perils of using social media for medical advice regarding infertility.","authors":"Tanveer Dhanoya, Kathleen O'Marcaigh, Tanvi Sambare, Ippokratis Sarris, Kugajeevan Vigneswaran","doi":"10.1080/14647273.2025.2506787","DOIUrl":"10.1080/14647273.2025.2506787","url":null,"abstract":"<p><p>To systematically evaluate the quality, credibility, accuracy, and readability of fertility-related content generated by users providing education, advice, and medical information on Twitter/X and Instagram. We selected Instagram and Twitter/X for data collection, as these platforms are commonly used by women of reproductive age. Using the terms 'fertility' and 'infertility', we collected posts both prospectively and retrospectively between April 21 and 28, 2024, using Keyhole and Brand Mentions. Posts were screened for eligibility, excluding non-English language posts, personal stories, advertisements, non-medical opinions, and peer-support posts. We assessed the accuracy, credibility, quality, and readability of the posts using validated instruments. Accuracy was evaluated based on current guidelines and the authors' expertise in infertility. Credibility was measured using a 10-point system that considered the source, context, currency, and editorial review. Quality was assessed using the 16-item DISCERN criteria with a five-point Likert scale. Readability was measured using the Flesch-Kincaid reading-ease test, which assigns a U.S. grade level to each post. Of the 15,214 posts identified, 939 were included in the final analysis. Fertility doctors generated 29% of the posts; others came from doctors of other specialties (11%), holistic practitioners (17%), and laypeople (39%). Seventy-four percent (74%) of posts did not cite sources or academic references, and 45% of posts contained inaccurate information. Only 11% of the posts were deemed credible. Of posts related to treatment, 19% were of high quality, while 53% of non-treatment posts met the same standard. Most posts (80%) were categorized as difficult to read based on readability scores. Only two posts (0.2%) were accurate, credible, high-quality, and easily readable. Social media posts about fertility often provide incomplete or misleading information, with a significant focus on naturopathy, dietary advice, and unproven theories about the effect of the COVID-19 vaccine on fertility. Clinicians and social media platforms must take responsibility for improving the accuracy and accessibility of health information online.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2506787"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of allied health professionals in fertility care: a scoping review.","authors":"Amanda Mackay, Selina Taylor, Emma Anderson, Beverley Glass","doi":"10.1080/14647273.2025.2480074","DOIUrl":"10.1080/14647273.2025.2480074","url":null,"abstract":"<p><p>Infertility significantly impacts people worldwide, with many pursuing medical treatments including Assisted Reproductive Technologies (ART). This scoping review explores the role of allied health professionals (AHPs) in fertility care and their integration into fertility care teams. A search of six databases yielded 12 studies identifying dietitians, nutritionists, counsellors, psychologists, social workers, and physical therapists (physiotherapists) as key AHPs in fertility care. The role of AHPs was broadly divided into two main areas: providing education and monitoring related to lifestyle modifications and fertility risk factors and offering psychological and psychosocial treatment and support. Dietitians educate patients on nutrition and lifestyle modifications to improve fertility. Mental health professionals, including psychologists, social workers, and counsellors, address the emotional stress of infertility and help patients cope with ART. Physical therapists perform therapies to increase chances of conception. The integration of AHPs into fertility care teams vary by location and facility practices with some working within healthcare teams and others independently. Despite guidelines, the incorporation of AHPs into fertility care is inconsistent, highlighting the need for a standardized approach. This review highlights AHP roles in providing education, lifestyle modification guidance, and psychosocial support which are valuable in enhancing patient care and potentially improving ART outcomes.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2480074"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterosexual parents' experiences of their donor-conceived children's search for and/or contact with their donors in New Zealand prior to identity-release provisions.","authors":"Michelle A Duff, Sonja Goedeke","doi":"10.1080/14647273.2025.2510992","DOIUrl":"https://doi.org/10.1080/14647273.2025.2510992","url":null,"abstract":"<p><p>Research suggests that donor conceived persons (DCP) may not only be interested in their genetic information, but in meeting donors and other genetically related individuals. While parental disclosure to donor conceived children (DCC) appears to be increasing, limited research examines the impact of disclosure and donor linking for DCP and parents. This research explores the experiences of nine heterosexual parents in New Zealand who mostly conceived prior to identity-release provisions and whose DCC have searched for or had donor contact. Data was collected via semi-structured interviews and analysed using thematic analysis. Findings suggest that parents valued their children's access to genetic origins and viewed donor linking as a natural outcome of disclosure. Parents positioned themselves as facilitators or supporters of linking, while emphasising that linking should be DCP led. Donor and donor family willingness were noted as key in enabling contact. Early disclosure and support for linking were held to strengthen parent-child relationships, while later disclosure and difficulty in linking were associated with relationship tension. Relationships with donors ranged from distant to familial, with most parents noting that DCC valued connections with siblings. Parents reflected on the significant impacts of family-building through donor conception and the need for ongoing support.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2510992"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of insulin resistance on <i>in vitro</i> fertilization outcomes in overweight and obese women: a retrospective cohort study.","authors":"Xi Bai, RuiQi Chang, Mengjiao Qing, Beilei Jiang, Chanyu Zhang","doi":"10.1080/14647273.2025.2526768","DOIUrl":"https://doi.org/10.1080/14647273.2025.2526768","url":null,"abstract":"<p><p>This retrospective cohort study evaluated 1,193 women undergoing first fresh IVF cycles to assess the effects of insulin resistance (IR) and overweight/obesity on outcomes. Participants were stratified by BMI and IR status. Overweight/obese women without IR exhibited comparable IVF outcomes to normal-weight controls. Untreated IR, however, significantly impaired outcomes, including fewer oocytes retrieved, 2PN zygotes, available embryos, and good-quality embryos all <i>p</i> ≤ 0.002), alongside lower fresh cycle live birth rates (34.4% vs. 53.3%, <i>p</i> = 0.038), implantation rates (32.1% vs. 47.8%, <i>p</i> = 0.023), cumulative pregnancy rates (45.8% vs. 68.4%, <i>p</i> = 0.001), and cumulative live birth rates (41.7% vs. 58.4%, <i>p</i> = 0.006). Notably, IR correction improved 2PN zygote formation (<i>p</i> = 0.026), numbers of available embryos (<i>p</i> = 0.021), fresh cycle live birth rates (57.6% vs. 34.4%, <i>p</i> = 0.034), cumulative pregnancy rates (63.2% vs. 45.8%, <i>p</i> = 0.018), and cumulative live birth rates (56.8% vs. 41.7%, <i>p</i> = 0.041). Multivariate analysis confirmed homeostasis model assessment of insulin resistance (HOMA-IR) as an independent negative predictor of live birth (OR = 0.49, 95% CI 0.30-0.82, <i>p</i> = 0.006). The findings challenge BMI-centric risk stratification in ART, emphasizing IR's role in compromising embryo quality and clinical outcomes. Preemptive IR screening and treatment in overweight/obese women are crucial.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2526768"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The knowledge and attitudes of a UK based population towards ovarian reserve testing and social egg freezing.","authors":"Timothy Bracewell-Milnes, Patrycja Ostrysz, Bethan Trigg, Omar Khalil, Lorraine Kasaven, Benjamin P Jones, Srdjan Saso, Raef Faris, James Nicopoullos, Meen-Yau Thum","doi":"10.1080/14647273.2025.2543118","DOIUrl":"https://doi.org/10.1080/14647273.2025.2543118","url":null,"abstract":"<p><p>The consequences of age-related fertility decline could be prevented by an increased uptake in ovarian reserve testing and social egg freezing (SEF) at an appropriate age. This study aimed to investigate the knowledge and views of UK-based women towards age-related fertility decline, egg reserve testing and SEF. UK-based women (<i>n</i> = 973) aged 18-50 years were voluntarily recruited from social media groups by convenience sampling between September 2021 and April 2022. Participants completed a previously validated questionnaire regarding their knowledge and opinions of egg reserve testing and SEF. Only 19.5% of participants were aware of the low success rates of IVF at an advanced age. 40.9% and 94.4% of respondents were aware of ovarian reserve testing and SEF, respectively. 86.8% and 86.5% of respondents were open to the idea of having their ovarian reserve checked or to undergo SEF, respectively. When faced with a hypothetical low ovarian reserve, most respondents would seek fertility advice. The benefits of SEF ranked consistently higher than the potential issues. Women who participated in this study were open to taking advantage of ovarian reserve testing and SEF. Our findings also reveal the need for increased education of fertility topics to both the general public and healthcare professionals.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":"28 1","pages":"2543118"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}