Human Fertility最新文献_第8页

Elective single versus double blastocyst-stage embryo transfer in women aged 36 years or older: a retrospective cohort study. 36 岁或以上女性选择性单囊胚期胚胎移植与双囊胚期胚胎移植：一项回顾性队列研究。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-01-31 DOI: 10.1080/14647273.2022.2153348

He Cai, Ben Mol, Stephan Gordts, Hui Wang, Juanzi Shi

{"title":"Elective single versus double blastocyst-stage embryo transfer in women aged 36 years or older: a retrospective cohort study.","authors":"He Cai, Ben Mol, Stephan Gordts, Hui Wang, Juanzi Shi","doi":"10.1080/14647273.2022.2153348","DOIUrl":"10.1080/14647273.2022.2153348","url":null,"abstract":"We evaluated if elective single-blastocyst transfer (eSBT) could be adopted in women aged 36 or older. In this retrospective cohort, women aged ≥36 years received IVF ovarian stimulation cycles and had ≥ two blastocysts. A total of 240 women underwent eSBT and 189 double-blastocyst transfer (DBT) in the first transfer cycle. The subsequent frozen-thawed embryo transfer cycles were a combination of single- and double- blastocyst transfers. Analysis was stratified for patients in age groups 36-37, 38-39 and ≥40, considering the quality of the blastocyst transferred. The cumulative live birth rates (cLBR) were 74.2% (178/240) versus 63.0% (119/189) after eSBT versus DBT, respectively (aOR: 1.09 (0.68, 1.75)). Time to live birth did not vary significantly between the two groups (HR: 0.85 (0.68, 1.08)). The total number of children born was 194 after eSBT (162 singletons and 16 pairs of twins) versus 154 (84 singletons and 35 twins) after DBT. The odds ratios for preterm birth (0.37 (0.21-0.64)), and low birth weight (0.31 (0.16, 0.60)) were all lower in eSBT. In women aged ≥36 years, cLBR following single- versus double- blastocyst transfer was comparable while the odds of multiple live births and adverse perinatal outcomes were reduced.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10022718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The methylation status of GATA3 potentially predicts the outcomes of assisted reproductive technologies. GATA3 的甲基化状态可预测辅助生殖技术的结果。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-01-10 DOI: 10.1080/14647273.2023.2164871

Mina Beiraghdar, Mozhdeh Beiraghdar, Sharifeh Khosravi

{"title":"The methylation status of GATA3 potentially predicts the outcomes of assisted reproductive technologies.","authors":"Mina Beiraghdar, Mozhdeh Beiraghdar, Sharifeh Khosravi","doi":"10.1080/14647273.2023.2164871","DOIUrl":"10.1080/14647273.2023.2164871","url":null,"abstract":"Evaluation of methylation status of genes in sperm samples has been suggested for diagnosis of male infertility as well as prognosis of assisted reproductive technologies (ART) outcomes. In this study, we compared the methylation pattern of the GATA3 gene in infertile and fertile men as well as in infertile men with positive and negative ART outcome based on clinical pregnancy. Ejaculates were obtained from 42 infertile men with a negative ART outcome (group 1), 30 infertile men with a positive ART outcome (group 2), and 21 fertile men (control). Then, samples were subjected to genomic DNA isolation and subsequent TUNEL assay and methylation-specific PCR. The number of infertile men with at least one methylated allele of GATA3 was significantly higher compared to the control group (p = 0.022). Also, the number of patients with at least one methylated allele was significantly higher in group 1 compared to group 2 (p = 0.013). Moreover, the TUNEL assay revealed that the amount of sperm DNA fragmentation is higher in group 1 compared to group 2 (p = 0.008). The findings of our study demonstrated that the degree of GATA3 methylation can potentially differentiate between infertile and fertile men and more importantly can potentially predict the outcome of ART.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10859458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is the use of IVF add-on treatments driven by patients or clinics? Findings from a UK patient survey. 试管婴儿附加治疗的使用是由患者还是诊所推动的？英国患者调查结果。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-04-16 DOI: 10.1080/14647273.2023.2197628

Stevan Cirkovic, Jack Wilkinson, Sarah Lensen, Emily Jackson, Joyce Harper, Katy Lindemann, Joan Costa-Font

{"title":"Is the use of IVF add-on treatments driven by patients or clinics? Findings from a UK patient survey.","authors":"Stevan Cirkovic, Jack Wilkinson, Sarah Lensen, Emily Jackson, Joyce Harper, Katy Lindemann, Joan Costa-Font","doi":"10.1080/14647273.2023.2197628","DOIUrl":"10.1080/14647273.2023.2197628","url":null,"abstract":"There are conflicting narratives over what drives demand for add-ons. We undertook an online survey of IVF patients to determine whether patients perceive that use of IVF add-ons is driven by patients or practitioners. People who underwent IVF in the UK in the previous five years were recruited via social media Survey questions focussed on the roles of clinician offer and patient request, including who first suggested use of add-ons in IVF consultations, where patients first heard about them, and which information sources they trusted. From a total of 261 responses, 224 met the inclusion criteria. Overall, 67% of respondents had used one or more IVF add-ons, most commonly: time-lapse imaging (27%), EmbryoGlue (27%), and endometrial scratching (26%). Overall, 81% of the add-ons used were offered to participants by clinicians (compared to 19% requested by themselves). Half (54%) reported being offered add-ons during consultations, compared to 24% who initiated discussion about add-ons. Higher proportions of private patients reported being offered (90%), requesting (47%) and using (74%) add-ons than those with NHS funding (74%, 29%, 52%, respectively). The main limitations of this study are the small sample size, recruitment via a convenience sample, and the self-reported data capture which is subject to recall bias.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9790570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How low is too low? Postwash total motile sperm count effect on pregnancy outcomes in intrauterine insemination. 多低才算太低？清洗后总活动精子数对宫腔内人工授精妊娠结局的影响。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2022-11-10 DOI: 10.1080/14647273.2022.2137858

Melissa Mathes, Elizabeth Kastrick, Harlan Sayles, Stephanie Gustin

{"title":"How low is too low? Postwash total motile sperm count effect on pregnancy outcomes in intrauterine insemination.","authors":"Melissa Mathes, Elizabeth Kastrick, Harlan Sayles, Stephanie Gustin","doi":"10.1080/14647273.2022.2137858","DOIUrl":"10.1080/14647273.2022.2137858","url":null,"abstract":"Intrauterine insemination (IUI) is a frequently used method to treat couples with infertility. There is evidence of decreased pregnancy rates with a total motile sperm count (TMSC) of less than 10 million, yet there remains to be a consensus on semen parameters for which to recommend IUI in the infertile population. The aim of this study was to determine a minimum threshold of TMSC on semen analysis to offer IUI cycles. This is a retrospective cohort study of all IUI cycles at a private practice infertility centre over four years. Our primary outcome of interest was the presence of clinical pregnancy after each cycle. A total of 999 women underwent 2,169 IUI cycles. The overall clinical pregnancy rate was 19.8% per cycle. During the first IUI each woman underwent, there was an increase in clinical pregnancy with increasing TMSC (OR 0.44) for TMSC ≤1 M to (OR 0.99) for TMSC 6-10 M, compared to TMSC >10 M. Among all IUI with a TMSC between 6 and 10 M, pregnancy outcomes improved with morphology >4% (OR 0.84), compared to morphology <4% (OR 0.25), relative to TMSC >10 M. Using receiver operating characteristic curves, we did not identify a TMSC threshold to offer IUI, although there was a positive correlation between TMSC and IUI success.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40458597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous transfer of one good-quality and one poor-quality cleavage stage embryo does not improve pregnancy outcomes. 同时移植一个优质和一个劣质分裂期胚胎不会改善妊娠结局。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2022-11-15 DOI: 10.1080/14647273.2022.2144484

Jiane Liu, Ishan Kumar, Teng Li, Yu Ding, Quan Tian, Xiuming Tang, Xiaoli Huang, Weihong Hu, Yifei Liu, Zheng Wang

{"title":"Simultaneous transfer of one good-quality and one poor-quality cleavage stage embryo does not improve pregnancy outcomes.","authors":"Jiane Liu, Ishan Kumar, Teng Li, Yu Ding, Quan Tian, Xiuming Tang, Xiaoli Huang, Weihong Hu, Yifei Liu, Zheng Wang","doi":"10.1080/14647273.2022.2144484","DOIUrl":"10.1080/14647273.2022.2144484","url":null,"abstract":"Embryo quality and quantity are key factors that determine the success of IVF-ET. Yet it is still unclear if, for those patients with only one good-quality embryo in an IVF cycle, the inclusion of a poor-quality embryo increases the procedure's success rate. This is a common question for both clinicians and patients in determining their course of treatment. The purpose of this work was to answer this intriguing question in the context of prognosis of patients undergoing fresh cycles with only one good-quality and more than one poor-quality cleavage-stage embryos. To control for confounding effects, we only included patients at similar age, body mass index (BMI), level of basal follicle stimulating hormone (FSH) and endometrial thickness from January 2015 to June 2021. A propensity score-matched analysis was performed to extract the matched pairs. Then we evaluated pregnancy outcome, including the rate of clinical pregnancy, live birth, embryo implantation, early miscarriage, and ectopic pregnancy. We found that the clinical pregnancy rate (34.8 vs. 38.0%, p = 0.553), live birth rate (27.1 vs. 29.9%, p = 0.598), early miscarriage rate (18.1 vs. 9.5%, p = 0.171) and ectopic pregnancy rate (1.3 vs. 1.2%, p = 1.000) did not significantly differ between those two groups, notwithstanding significant difference of the implantation rate (34.8 vs. 21.3%, p <0.001). Our work indicates that, for prognosis patients at approximately 34 years old with only one good-quality embryo, having additional poor-quality embryos does not seem to help to improve ART success rates per intended embryo transfer. In conclusion, we found that simultaneous transfer of one good-quality and one poor-quality cleavage stage embryo does not improve pregnancy outcomes.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40465154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative stress and female infertility: the role of follicular fluid soluble receptor of advanced glycation end-products (sRAGE) in women with endometriosis. 氧化应激与女性不孕：晚期糖化终产物卵泡液可溶性受体（sRAGE）在子宫内膜异位症女性中的作用。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2024-01-24 DOI: 10.1080/14647273.2023.2230360

Foteini Sopasi, Isabella Spyropoulou, Marianthi Kourti, Stavros Vasileiadis, Grigorios Tripsianis, Georgios Galazios, Nikoleta Koutlaki

{"title":"Oxidative stress and female infertility: the role of follicular fluid soluble receptor of advanced glycation end-products (sRAGE) in women with endometriosis.","authors":"Foteini Sopasi, Isabella Spyropoulou, Marianthi Kourti, Stavros Vasileiadis, Grigorios Tripsianis, Georgios Galazios, Nikoleta Koutlaki","doi":"10.1080/14647273.2023.2230360","DOIUrl":"10.1080/14647273.2023.2230360","url":null,"abstract":"Oxidative Stress (OS) relates to the pathophysiology of endometriosis by activation of the inflammation process in the ovary, abdomen, peritoneum and endometrium. Advanced Glycation end-products (AGEs) cause oxidative damage to the follicles of the ovary. This study aims to investigate the correlation of follicular fluid soluble receptor of AGEs (FF sRAGE) with fertility-related parameters in infertile women with endometriosis. From January 2012 to July 2015 twenty-four women diagnosed with mild to moderate endometriosis aged 28-38 years underwent assisted reproduction. sRAGE levels measured in FF were related to lifestyle factors, sociodemographic characteristics, gynaecological and obstetric parameters, hormonal status and fertilization. sRAGE was inversely associated with BMI (r = -0.503, p = 0.012). No significant association of sRAGE with age (p = 0.714) or alcohol consumption (p = 0.882) was found. Pearson's r correlation coefficient revealed that sRAGE was positively associated with serum AMH (r = 0.518, p = 0.009), FF AMH (r = 0.630, p = 0.001), number of follicles >15mm (r = 0.601, p = 0.002), total number of follicles aspirated (r = 0.698, p < 0.001), total number of MII oocytes obtained, (r = 0.757, p < 0.001) and the number of embryos with good embryo scoring (suitable for ET) (r = 0.522, p = 0.009). It seems that measurement of FF RAGE might be a useful predictive marker for IVF success in infertile women with endometriosis undergoing assisted reproduction.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41118383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The paradox of the Italian clinical embryologist in the national public health system: hints towards harmonization of a postgraduate educational curriculum. 意大利临床胚胎学家在国家公共卫生系统中的悖论：暗示研究生教育课程的协调。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2022-03-07 DOI: 10.1080/14647273.2022.2045040

Alessandra Alteri, Liana Bosco, Sandrine Chamayou, Valentina Casciani, Marta Cervi, Anna Cecchele, Yoon Sung Cho, Maria Paola Costantini, Maria Beatrice Dal Canto, Silvia De Stefani, Alessandra Fraioli, Valentina Furlan, Filippo Giacone, Cristina Guarneri, Antonino Guglielmino, Mirella Iaccarino, Alessandro Miceli, Maria Giulia Minasi, Luigi Montano, Tiziana Notari, Alessio Paffoni, Simone Palini, Marco Reschini, Giovanni Ruvolo, Paola Viganó, Aldo Volpes

{"title":"The paradox of the Italian clinical embryologist in the national public health system: hints towards harmonization of a postgraduate educational curriculum.","authors":"Alessandra Alteri, Liana Bosco, Sandrine Chamayou, Valentina Casciani, Marta Cervi, Anna Cecchele, Yoon Sung Cho, Maria Paola Costantini, Maria Beatrice Dal Canto, Silvia De Stefani, Alessandra Fraioli, Valentina Furlan, Filippo Giacone, Cristina Guarneri, Antonino Guglielmino, Mirella Iaccarino, Alessandro Miceli, Maria Giulia Minasi, Luigi Montano, Tiziana Notari, Alessio Paffoni, Simone Palini, Marco Reschini, Giovanni Ruvolo, Paola Viganó, Aldo Volpes","doi":"10.1080/14647273.2022.2045040","DOIUrl":"10.1080/14647273.2022.2045040","url":null,"abstract":"Clinical embryologists are highly trained laboratory professionals with multiple roles, including laboratory, clinical, biobanking and quality system management. In most European countries, clinical embryologists are trained to work in Medically Assisted Reproduction (MAR) centres without a specifically dedicated educational path. The criteria required for employment vary according to the educational structure and the public or private nature of the centre. We have herein described the educational profile required by Italian clinical embryologists to work in MAR centres of the National Health System (NHS). Public centres currently represent 36% of all the Italian MAR clinics. According to the Italian law, a future clinical embryologist must achieve a 3-4 year unpaid post-graduate specialization in a different field, choosing from Genetics, Microbiology, Clinical Pathology or Nutrition. Accesses to the above-mentioned post-graduate courses are themselves very limited. Clinical embryologists are basically trained by senior colleagues. This situation makes inevitably difficult to recruit laboratory staff in NHS centres. Moreover, it represents an emblematic example of the need for an equal training curriculum, possibly ensuring a comparable education quality, mobility of trainees and dissemination of skills for clinical embryologists all over Europe.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45582426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fertility preservation in women with haematological malignancies. 患有血液恶性肿瘤的妇女的生育能力保护。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2022-02-21 DOI: 10.1080/14647273.2022.2042605

Rafael Ferro, Ana Sofia Pais, Ana Paula Sousa, Teresa Almeida Santos

{"title":"Fertility preservation in women with haematological malignancies.","authors":"Rafael Ferro, Ana Sofia Pais, Ana Paula Sousa, Teresa Almeida Santos","doi":"10.1080/14647273.2022.2042605","DOIUrl":"10.1080/14647273.2022.2042605","url":null,"abstract":"The incidence of haematological malignancies is increasing in women of childbearing age. Survival rates accompany this increase, making it essential to assess the impact of treatments on their future quality of life, evaluate the impact of each treatment on ovarian reserve and define the fertility preservation techniques used by women with haematologic malignancies. A retrospective study was conducted after data collection from 61 women diagnosed with haematological malignancies and followed-up in a fertility preservation centre between January 2008 and June 2019. Cancer treatments caused a decrease in ovarian reserve, demonstrated by an increase in FSH levels and a decrease in AMH levels. When assessing which treatments have the greatest impact on AMH levels, we found that the BEACOPP regimen, and the agents vincristine, etoposide, procarbazine, prednisone and the haematopoietic stem cell transplantation were mainly responsible. Regarding pregnancy after oncological treatments, of the eleven women who became pregnant, ten did so spontaneously. This study reinforces the importance of referring patients to a fertility preservation consultation before starting oncological treatment, as most of them opt to preserve fertility. This work also helps to clarify the impact of each chemotherapeutic agent on the ovarian reserve.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39938672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

In vitro effects of pentoxifylline and coenzyme Q10 on the sperm of oligoasthenoteratozoospermia patients. 喷托维林和辅酶Q10对少精症患者精子的体外影响

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2021-12-21 DOI: 10.1080/14647273.2021.2017024

Mohammad Jafar Rezaie, Azra Allahveisi, Amir Raoofi, Masomeh Rezaei, Bahram Nikkhoo, Amin Mousavi Khaneghah

{"title":"In vitro effects of pentoxifylline and coenzyme Q10 on the sperm of oligoasthenoteratozoospermia patients.","authors":"Mohammad Jafar Rezaie, Azra Allahveisi, Amir Raoofi, Masomeh Rezaei, Bahram Nikkhoo, Amin Mousavi Khaneghah","doi":"10.1080/14647273.2021.2017024","DOIUrl":"10.1080/14647273.2021.2017024","url":null,"abstract":"The effect of in-vitro sperm incubation with Pentoxifylline (PTX) and Coenzyme Q10 (CoQ10) in Oligoasthenoteratozoospermia (OAT) patients was evaluated. Semen samples were obtained from men with Normozoospermia and men with OAT. Motile sperm from the two groups were subdivided into four subgroups: (i) without incubation with PTX + CoQ10; (ii) incubation with PTX; (iii) Incubation with CoQ10; and (iv) incubation with a combination of PTX + CoQ10. Then, sperm parameters, chromatin, DNA and membrane integrity, protamine deficiency, apoptosis, mitochondrial activity, sperm chromatin dispersion test (SCD), hypo-osmotic swelling test (HOS), chromomycin A3 (CMA3), Terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL), and diaminobenzidine (DAB) assays were evaluated, respectively. Sperm incubated with CoQ10 and a combination of CoQ10 and PTX resulted in a significant increase in the sperm parameters. Also, a significant decrease was noted with a combination of PTX and CoQ10 in normal men. There was a significant difference between CoQ10 treated and CoQ10 + PTX treated groups in comparison with the OAT group in the percentage of the DNA fragmentation, sperm apoptosis, AB+, HOS test + and sperm mitochondrial activity. Incubated sperm with CoQ10, PTX, and in combination with each other can improve sperm parameters in OAT patients.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39622390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Development and psychometric evaluation of a Risky Sexual Behaviour Scale for Married Women (RSBS-MW) in Iran: a mixed-method study. 伊朗已婚妇女危险性行为量表（RSBS-MW）的开发和心理测量评估：一项混合方法研究。

IF 1.9 4区医学

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-01-16 DOI: 10.1080/14647273.2023.2164940

Fereshteh Jahdi, Abbas Ebadi, Fatemeh Oskouie, Maryam Kashanian, Effat Merghati-Khoei

{"title":"Development and psychometric evaluation of a Risky Sexual Behaviour Scale for Married Women (RSBS-MW) in Iran: a mixed-method study.","authors":"Fereshteh Jahdi, Abbas Ebadi, Fatemeh Oskouie, Maryam Kashanian, Effat Merghati-Khoei","doi":"10.1080/14647273.2023.2164940","DOIUrl":"10.1080/14647273.2023.2164940","url":null,"abstract":"A valid and reliable culture-based scale for the evaluation of risky sexual behaviours for married Iranian women is lacking. This study aimed to develop, and psychometrically test, a risky sexual behaviour scale for married Iranian women. A mixed-method sequential exploratory design was conducted from 2016 to 2020 in Tehran, Iran. First, a qualitative study was employed to define the concept of risky sexual behaviour using 16 semi-structured individual interviews and 10 focus group discussions (n = 100). Then, an item pool was generated, and the scale was developed. Finally, in the quantitative study, the psychometric properties of the scale were evaluated by validity and reliability tests. A maximum likelihood extraction with promax rotation was performed on 400 sexually active married women to assess the construct validity. The six components: (i) 'quality of sexual relations'; (ii) 'unusual pleasures in sexual relations'; (iii) 'sexual coercion'; (iv) 'verbal violence in sexual relations'; (v) 'self-care in sexual relations'; and (vi) 'concealment in sexual relations' could explain 57.49% of the total observed variance. The findings showed that the 27-item Risky Sexual Behaviour Scale (RSBS-MW) for married women in Iran has excellent internal consistency (α = 0.94) and stability (ICC = 0.98). Health care providers can use it to access risky sexual behaviours in married Iranian women.","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9095388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0