15 and 30 min of immobilization after IUI: a randomized control trial.

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Human Fertility Pub Date : 2023-12-01 Epub Date: 2023-03-21 DOI:10.1080/14647273.2023.2191346

Yang Mengye, Tang Yan, Qian Jiarong, Liu Qing, Niu Fangfang, Zhang Yan

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引用次数: 0

Abstract

The purpose of this study is to provide evidence for better guidance related to bed rest after intrauterine insemination (IUI). We conducted a randomized trial to compare the effect of 15 min versus 30 min of bed rest after IUI on pregnancy rate. A total of 204 couples were recruited from May 2021 to December 2021 and randomized to remain in the supine position for either 15 or 30 min after the procedure. The outcomes were the clinical pregnancy rate and comfort level after IUI. Ultimately, 198 couples were included in the analysis. The 15-min immobilization group consisted of 100 couples (226 cycles), and the 30-min immobilization group consisted of 98 couples (225 cycles). The clinical pregnancy rate per couple in the 15-min immobilization group (26 of 100) was not different from that in the 30-min immobilization group (23 of 98). With the use of discrete-time survival analysis, the cumulative probability of clinical pregnancy also showed no difference between these two groups. Based on the literature and on our study, the possible beneficial effect of 30-min immobilization after IUI is at least questionable, and a shorter time could be implemented depending on the results of a systematic review and the individual patient data from the currently executed trials.

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人工授精后固定 15 分钟和 30 分钟：随机对照试验。

本研究的目的是提供证据，为宫腔内人工授精（IUI）后卧床休息提供更好的指导。我们进行了一项随机试验，比较人工授精后卧床休息 15 分钟与 30 分钟对妊娠率的影响。从 2021 年 5 月到 2021 年 12 月，我们共招募了 204 对夫妇，并随机让他们在术后保持仰卧位 15 或 30 分钟。研究结果为人工授精后的临床妊娠率和舒适度。最终，198对夫妇被纳入分析。15分钟固定组有100对夫妇（226个周期），30分钟固定组有98对夫妇（225个周期）。固定 15 分钟组每对夫妇的临床妊娠率（100 例中的 26 例）与固定 30 分钟组每对夫妇的临床妊娠率（98 例中的 23 例）没有差异。通过离散时间生存分析，两组临床妊娠的累积概率也没有差异。根据文献和我们的研究，人工授精后 30 分钟固定可能带来的益处至少是值得怀疑的，可以根据系统回顾的结果和目前进行的试验中患者的个体数据来缩短固定时间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Fertility OBSTETRICS & GYNECOLOGY-REPRODUCTIVE BIOLOGY

CiteScore

3.30

自引率

5.30%

发文量

期刊介绍： Human Fertility is a leading international, multidisciplinary journal dedicated to furthering research and promoting good practice in the areas of human fertility and infertility. Topics included span the range from molecular medicine to healthcare delivery, and contributions are welcomed from professionals and academics from the spectrum of disciplines concerned with human fertility. It is published on behalf of the British Fertility Society. The journal also provides a forum for the publication of peer-reviewed articles arising out of the activities of the Association of Biomedical Andrologists, the Association of Clinical Embryologists, the Association of Irish Clinical Embryologists, the British Andrology Society, the British Infertility Counselling Association, the Irish Fertility Society and the Royal College of Nursing Fertility Nurses Group. All submissions are welcome. Articles considered include original papers, reviews, policy statements, commentaries, debates, correspondence, and reports of sessions at meetings. The journal also publishes refereed abstracts from the meetings of the constituent organizations.