接受乳腺癌化疗的 18-40 岁年轻女性的血清雄激素动态:法国的一项多中心前瞻性观察研究。

IF 2.1 4区 医学 Q2 OBSTETRICS & GYNECOLOGY
Human Fertility Pub Date : 2024-12-01 Epub Date: 2024-07-03 DOI:10.1080/14647273.2024.2350758
S Loubersac, M Chaillot, A Reignier, T Lefebvre, A Dezellus, A Colombel, P Barriere, D Masson, T Freour
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引用次数: 0

摘要

尽管用于治疗育龄女性乳腺癌的化疗方案对卵巢储备功能的有害影响已被广泛研究,但关于这些方案对雌激素细胞功能和卵巢雄激素分泌的影响却鲜有报道。这项前瞻性多中心队列研究旨在描述 250 名患者在化疗期间和 24 个月随访期间的血清总睾酮和雄烯二酮水平:ClinicalTrial.gov 标识符 NCT01114464。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum androgen dynamics in young women aged 18-40 treated with chemotherapy for breast cancer: an observational, multicentric, prospective study in France.

Although the deleterious impact of chemotherapy regimen used to treat women of reproductive age with breast cancer on ovarian reserve has been extensively studied, hardly anything has been reported on the effect of these protocols on theca cell function and ovarian androgen secretion. The aim of this prospective multicentric cohort study was to describe serum levels of total testosterone and androstenedione during chemotherapy and 24-month follow-up in 250 patients <40 years treated for breast cancer. Mean basal levels of androstenedione and total testosterone at diagnosis were 1.68 ng/mL and 0.20 ng/mL respectively. No correlation with age was found. Serum levels of androstenedione and total testosterone rapidly decreased after chemotherapy completion, before slowly increasing and almost returning to basal levels in all patients during 2-year follow-up. In conclusion our study demonstrates a chemotherapy-induced alteration of ovarian thecal function, resulting in a significant decrease in serum androgen levels. This alteration of theca cell function adds to the well-known alteration of granulosa cell function, resulting in a global, but partly transient, ovarian failure in young women treated for breast cancer. These data bring new insight into ovarian physiology and emphasize the need for pre and post-treatment ovarian follow-up. Trial registration: ClinicalTrial.gov identifier NCT01114464.

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来源期刊
Human Fertility
Human Fertility OBSTETRICS & GYNECOLOGY-REPRODUCTIVE BIOLOGY
CiteScore
3.30
自引率
5.30%
发文量
50
期刊介绍: Human Fertility is a leading international, multidisciplinary journal dedicated to furthering research and promoting good practice in the areas of human fertility and infertility. Topics included span the range from molecular medicine to healthcare delivery, and contributions are welcomed from professionals and academics from the spectrum of disciplines concerned with human fertility. It is published on behalf of the British Fertility Society. The journal also provides a forum for the publication of peer-reviewed articles arising out of the activities of the Association of Biomedical Andrologists, the Association of Clinical Embryologists, the Association of Irish Clinical Embryologists, the British Andrology Society, the British Infertility Counselling Association, the Irish Fertility Society and the Royal College of Nursing Fertility Nurses Group. All submissions are welcome. Articles considered include original papers, reviews, policy statements, commentaries, debates, correspondence, and reports of sessions at meetings. The journal also publishes refereed abstracts from the meetings of the constituent organizations.
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