Spermatogonial quantity in prepubertal boys undergoing fertility preservation is comparable between haematological and non-haematological cancers.

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Human Fertility Pub Date : 2024-12-01 Epub Date: 2024-06-06 DOI:10.1080/14647273.2024.2362980

Prathima Tholeti, Sindhura L Koulmane Laxminarayana, Vani R Lakshmi, Vasudeva K Bhat, Vijay Kumar P, Shubhashree Uppangala, Guruprasad Kalthur, Norah Spears, Satish Kumar Adiga

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Abstract

Fertility restoration potential of immature testicular tissue (ITT) depends on the number of spermatogonial cells in the retrieved tissue prior to cryopreservation in oncofertility programme. There are limited data on the association between type of malignancy and testicular germ cell population. Hence, this study is aimed to investigate the spermatogonial and Sertoli cell population in ITT retrieved from 14 pre-pubertal boys who opted for fertility preservation. Histopathological and immunochemical analysis of seminiferous tubules from haematological (N = 7) and non-haematological (N = 7) malignant patients revealed 3.43 ± 2.92 and 1.71 ± 1.81 spermatogonia per tubular cross section (S/T), respectively. The Sertoli cell number was comparable between haematological and non-haematological group (18.42 ± 3.78 and 22.03 ± 10.43). Spermatogonial quantity in ITT did not vary significantly between haematological and non-haematological cancers. This observation, though preliminary, would contribute to the limited literature on paediatric male oncofertility.

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接受生育力保存的青春期前男孩的精原细胞数量在血癌和非血癌之间具有可比性。

未成熟睾丸组织（ITT）的生育力恢复潜力取决于在非生育计划中冷冻保存前取回的组织中精原细胞的数量。关于恶性肿瘤类型与睾丸生精细胞数量之间关系的数据十分有限。因此，本研究旨在调查从14名选择生育力保存的青春期前男孩体内提取的ITT中的精原细胞和Sertoli细胞数量。对血液病（7 例）和非血液病（7 例）恶性肿瘤患者的曲细精管进行组织病理学和免疫化学分析后发现，每个精管横截面（S/T）的精原细胞数分别为 3.43 ± 2.92 和 1.71 ± 1.81。血液病组和非血液病组的 Sertoli 细胞数量相当（18.42 ± 3.78 和 22.03 ± 10.43）。ITT中的精原细胞数量在血液癌症和非血液癌症之间没有明显差异。这一观察结果虽然是初步的，但有助于丰富有关儿科男性共不育症的有限文献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Fertility OBSTETRICS & GYNECOLOGY-REPRODUCTIVE BIOLOGY

CiteScore

3.30

自引率

5.30%

发文量

期刊介绍： Human Fertility is a leading international, multidisciplinary journal dedicated to furthering research and promoting good practice in the areas of human fertility and infertility. Topics included span the range from molecular medicine to healthcare delivery, and contributions are welcomed from professionals and academics from the spectrum of disciplines concerned with human fertility. It is published on behalf of the British Fertility Society. The journal also provides a forum for the publication of peer-reviewed articles arising out of the activities of the Association of Biomedical Andrologists, the Association of Clinical Embryologists, the Association of Irish Clinical Embryologists, the British Andrology Society, the British Infertility Counselling Association, the Irish Fertility Society and the Royal College of Nursing Fertility Nurses Group. All submissions are welcome. Articles considered include original papers, reviews, policy statements, commentaries, debates, correspondence, and reports of sessions at meetings. The journal also publishes refereed abstracts from the meetings of the constituent organizations.