{"title":"Complications of Gastroenteritis By Typhoid Fever in Amazonia: Clinical Cases Genetic Evaluation from Intestinal Drilling, Pneumonia and Cholestatic Hepatitis","authors":"A. R. Marinho","doi":"10.31031/GMR.2020.05.000607","DOIUrl":"https://doi.org/10.31031/GMR.2020.05.000607","url":null,"abstract":"Typhoid fever is a systemic disease caused by Salmonella enterica serotype Typhi, characterized by high fever accompanied by intestinal disorders, whose transmission occurs through the consumption of contaminated water and food [1,2]. The method used for the diagnosis is culture, which can result in false negatives due to previous use of antibiotics. Failure to diagnose the outcome makes therapeutic conduct unfeasible, constituting an aggravating factor in the clinic than some cases. One way around this problem is to use assays based on the amplification of nucleic acids [3,4]. Typhoid fever remains one of the most important infectious diseases in the world, which has seen little decrease in mortality rates since the 1990s [5]. Countries in East and Southeast Asia, Africa, the Caribbean, Central and South America currently suffer from this public health problem [6]. The World Health Organization (WHO) estimates that there are 11 to 20 million new cases in the world and approximately 128,000 to 161,000 deaths each year [7]. In Brazil, between 2001 and 2019, 1,745 cases of typhoid fever were confirmed, the Brazilian Amazon, although it represents 59% of the Brazilian territory, but with the lowest population density, 12.83% of the total population, reported the largest number of cases at all parents with 1,491 (85.44% of the national total) [8]. Thus, the Evandro Chagas Institute (IEC) invests in the program aimed at the surveillance of gastroenteric diseases and their complications with a focus on laboratory diagnosis of patients with suspected typhoid fever from all over the Brazilian Amazon [9].","PeriodicalId":130011,"journal":{"name":"Gastroenterology: Medicine & Research","volume":"50 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130382572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Obscure Cause of Upper Gastrointestinal Hemorrhage","authors":"J. Koch","doi":"10.31031/GMR.2020.05.000606","DOIUrl":"https://doi.org/10.31031/GMR.2020.05.000606","url":null,"abstract":"A 31year-old man presented to an outside institution’s emergency department with headache, vomiting and no signs of bleeding. With decreased hemoglobin (hgb) of 4.6g/dl and normal head computerized tomography (CT), he was discharged on iron supplement. He presented to our emergency department 3 weeks later with weakness, tachycardia, hypotension, hgb of 5g/dl and a positive fecal occult blood test. With a normal colonoscopy and CT enterography, the patient was discharged to receive biweekly transfusions, and later underwent an outpatient small bowel capsule. Two months later the patient presented with weakness with no overt signs of bleeding and hgb was 4.2g/dl. Push enteroscopy identified a nearly circumferential mass in the proximal jejunum with stigmata of recent hemorrhage. Subsequently six months from the initial presentation, the patient underwent laparoscopic small bowel resection of a 7.3cm friable mass. The histopathology confirmed the endoscopic biopsy findings of a benign lymph vascular proliferation, favoring lymphangioma and an adjacent mesenteric lymph node with marked sinusoidal lymphangiectasia. One week post-surgery, the patient reported feeling well with an increased hgb of 7.1g/dl.","PeriodicalId":130011,"journal":{"name":"Gastroenterology: Medicine & Research","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132037659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intestinal Microbiota Transplantation in Children","authors":"Á. Tiburcio","doi":"10.31031/gmr.2020.05.000604","DOIUrl":"https://doi.org/10.31031/gmr.2020.05.000604","url":null,"abstract":"The use of excellent donors makes the transplanted microbiota have a higher incidence in children [1]. We must not forget that COVID-19 infection forces us to follow the recommendations of the FDA [2]. Likewise, the use of probiotics, prebiotics and symbiotics and a special diet can improve various childhood disorders [3]. Next, a good number of topics not all will be addressed that will undoubtedly expand knowledge about children, their diseases and their management.","PeriodicalId":130011,"journal":{"name":"Gastroenterology: Medicine & Research","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122468658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of a Modified Jejunoileal Bypass Technique (Lazzarotto and Souza Procedure): Causes of Reversal and Types of Possible Procedures","authors":"S. Almazeedi","doi":"10.31031/gmr.2020.05.000603","DOIUrl":"https://doi.org/10.31031/gmr.2020.05.000603","url":null,"abstract":"Obesity became a pandemic according to WHO in a world where more than one billion people are classified as overweight or obese. Many procedures have been developed in the past years, some of them were effective, while others caused major side effects and morbidity to patient. Lazzarotto and Souza procedure is modified jejunoileal bypass in which a silastic ring is placed at the remnant jejunum to control the amount of food content reaching the bypassed small bowel. This is a retrospective evaluation of data collected from two hospitals located in Curitiba, Parana state, 21 patients underwent Lazzarotto and Souza procedure from year 2002 to 2014. Here we present the results and outcomes of these patients.","PeriodicalId":130011,"journal":{"name":"Gastroenterology: Medicine & Research","volume":"442 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127605350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Giant Fecaloma Causing Large Bowel Obstruction: A Case Report","authors":"Arcelia Guerson Gil","doi":"10.31031/gmr.2020.05.000602","DOIUrl":"https://doi.org/10.31031/gmr.2020.05.000602","url":null,"abstract":"Fecaloma is an accumulation of hardened impacted stool typically located in the sigmoid colon and rectum [1-3]. The accumulation of fecal matter builds up in the intestine and stagnates, further increasing in size and volume taking on the characteristics of a tumour [4,5]. Symptoms of a fecaloma are commonly nonspecific including chronic constipation, vague abdominal pain after meals, and weight loss [6]. In cases of large fecaloma, patients may feel a palpable hardened mass in their abdomen. Fecalomas have been associated with elderly patients with chronic constipation, psychiatric conditions, Hirschsprung’s disease, and Chagas disease [7]. Fecaloma is diagnosed radiologically through x-rays, barium enema, abdominal ultrasound, or abdominal computed tomography (CT) scans [8]. Most cases are managed conservatively with laxatives and enemas. However, some cases are refractory to conservative management [9], as in this case, requiring surgical intervention for removal of the fecaloma preventing further complications. We report a case of a giant fecaloma causing a complete large bowel obstruction requiring surgical management.","PeriodicalId":130011,"journal":{"name":"Gastroenterology: Medicine & Research","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129678636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"EUS-Guided Micro-Forceps Biopsy for the Diagnosis of Lymphoma: A Case Series","authors":"Arcelia Guerson Gil","doi":"10.31031/gmr.2020.05.000601","DOIUrl":"https://doi.org/10.31031/gmr.2020.05.000601","url":null,"abstract":"","PeriodicalId":130011,"journal":{"name":"Gastroenterology: Medicine & Research","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121073823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Unusual Case of Rectal Bleeding due to Metastasis from Cholangiocarcinoma","authors":"Arcelia Guerson Gil","doi":"10.31031/gmr.2020.04.000599","DOIUrl":"https://doi.org/10.31031/gmr.2020.04.000599","url":null,"abstract":"Cholangiocarcinoma (CCA) is a rare, yet aggressive form of cancer that can originate from the epithelium to anywhere along the bile ducts (BD). Depending on the locations of the CCA, the treatment, prognosis, and diagnosis can be greatly impacted. The primary risk factors are sclerosing cholangitis and choledochal cysts. Anatomically, CCA are classified as intrahepatic (IH) and extrahepatic (EH). EH further divided into distal and perihilar. These subtypes have common features but also important differences that affect the pathogenesis and outcome. Histologically, a great majority of these (90%) are adenocarcinomas with the remainder being mostly squamous cell carcinomas. It is possible to support a diagnosis of malignant biliary epithelium through immunohistochemical staining. Specifically, cytokeratin-7 (CK-7) positivity is consistent with biliary tract origin. The clinical presentation of CCA varies, with some patients presenting with jaundice. However, most cases are silent and are not diagnosed until the advanced stage. Common sites of metastasis include the liver, peritoneum, and brain. Although rare, colon metastasis has been reported and requires a high index of suspicion for early detection. Here, we present a rare case of a patient with intermittent rectal bleeding secondary to colon metastasis from CCA.","PeriodicalId":130011,"journal":{"name":"Gastroenterology: Medicine & Research","volume":"25 13","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120859526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Colonoscopic Results in Patients with Hartmann’s Colostomy","authors":"K. Kim","doi":"10.31031/gmr.2020.04.000597","DOIUrl":"https://doi.org/10.31031/gmr.2020.04.000597","url":null,"abstract":"Purpose: Colonoscopy in patients with colostomy after Hartmann’s procedure could be a quite challenging or special situation. This study aimed to analyze the Colonoscopic results in patients with Hartmann’s colostomy. Methods: Total 79 consecutive patients undergoing colonoscopy before reversal of Hartmann’s operation were retrospectively reviewed. The procedure was performed first through the anus for evaluation of distal colonic/rectal stump, and then through the colostomy to the cecum or terminal ileum for proximal colon evaluation. Results: Cecal insertion was possible in 72 patients; the success rate was 91.1%. The causes of failure were poor or inadequate bowel preparation in 4 patients, colostomy stricture, colonic stenosis, and angulation in 1 patient, respectively. Completeness of the bowel preparation was poor in 21 patients and inadequate in 6 patients, showing bad preparation in 33.3%. Mean Cecal insertion time from colostomy was 5.1 minute. The Colonoscopic finding of proximal part to colostomy was nonspecific in 38 patients, polyp(s) detection in 15 patients, and diverticulosis in 15 patients. In the examination of distal stump, mean length was 18.4cm, two patients couldn’t evaluate the full length of distal stump, and 11 patients showed abnormal findings including polyps, diverticular, and inflammation. Conclusion: These results suggest that most patients with colostomy can evaluate the remained colon or rectum without technical difficulty. However bowel preparation is the most important point to complete the evaluation of the colon in patients with colostomy.","PeriodicalId":130011,"journal":{"name":"Gastroenterology: Medicine & Research","volume":"100 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128965013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hypogonadism and Hepatic Steatosis in Heterozygous Hemochromatosis","authors":"L. Cohen","doi":"10.31031/gmr.2020.04.000596","DOIUrl":"https://doi.org/10.31031/gmr.2020.04.000596","url":null,"abstract":"brief Abstract A 52-year-old gentleman with a compound heterozygote genotype (C282Y/H63D) of hereditary hemochromatosis (HH) complicated by hypogonadism and hepatic steatosis underwent successful resolution of these clinical problems with phlebotomy and hormone replacement therapy. The patient had no features of metabolic syndrome nor did he consume significant amounts of alcohol. Investigations revealed normal HbA1c, lipid panel, and liver biochemistry. Comprehensive review of current literature indicates that the clinical significance of compound heterozygosity for HH is controversial and that other aetiologies for hepatic steatosis and hypogonadism must be ruled out initially. Low testosterone levels have been associated with hepatic steatosis in non-alcoholic fatty liver disease (NAFLD) attributed to low circulating sex hormone binding globulin. There is also an association between HH compound heterozygosity and the development of NAFLD and hepatocellular carcinoma (HCC) with or without cirrhosis. Depletion of iron stores by phlebotomy and complete abstinence from alcohol likely contributed to resolution this patient’s severe hepatic steatosis.","PeriodicalId":130011,"journal":{"name":"Gastroenterology: Medicine & Research","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125726031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hartmut Schmidt, C. Wilms, H. Gerth, M. Hinz, S. Koball, Alexandra Rivera Luna, Victoria Rivera Luna, Claudia Pfensig, Adrian Dominik, S. Klammt, Kristin Bruederlein, S. Mitzner, Raoul Benedikt Sauer, J. Stange, A. Kortgen, C. Sponholz, M. Dollinger
{"title":"The Effect of Extracorporeal Albumin Dialysis (ECAD) on Pruritus Using MARS Versus New Adsorbent Recirculation (OPAL)","authors":"Hartmut Schmidt, C. Wilms, H. Gerth, M. Hinz, S. Koball, Alexandra Rivera Luna, Victoria Rivera Luna, Claudia Pfensig, Adrian Dominik, S. Klammt, Kristin Bruederlein, S. Mitzner, Raoul Benedikt Sauer, J. Stange, A. Kortgen, C. Sponholz, M. Dollinger","doi":"10.31031/GMR.2020.04.000600","DOIUrl":"https://doi.org/10.31031/GMR.2020.04.000600","url":null,"abstract":"Hartmut Schmidt1, Christian Wilms1, Hans Ulrich Gerth1, Michael Hinz2, Sebastian Koball2, Alexandra Rivera Luna2, Victoria Rivera Luna2, Claudia Pfensig2, Adrian Dominik2, Andreas Kortgen3, Christoph Sponholz3, Matthias Dollinger4, Sebastian Klammt2, Kristin Bruederlein2, Steffen Mitzner2, Raoul Benedikt Sauer2 and Jan Stange2* 1Department Internal Medicine, University of Muenster, Germany 2Department Internal Medicine, University of Rostock, Germany 3Department Intensive Care and Anesthesiology, University of Jena, Germany 4Department Internal Medicine University of Ulm, Germany","PeriodicalId":130011,"journal":{"name":"Gastroenterology: Medicine & Research","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127250998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}