Gastroenterology: Medicine & Research最新文献_第3页

Hypoglycemia Refractory in Patient with Metastatic Gastrointestinal Stromal Tumor (GIST): Case Report and Literature Review 转移性胃肠道间质瘤(GIST)患者难治性低血糖:病例报告及文献复习

Gastroenterology: Medicine & Research Pub Date : 2021-02-24 DOI: 10.31031/GMR.2021.05.000619

M. Camandaroba

{"title":"Hypoglycemia Refractory in Patient with Metastatic Gastrointestinal Stromal Tumor (GIST): Case Report and Literature Review","authors":"M. Camandaroba","doi":"10.31031/GMR.2021.05.000619","DOIUrl":"https://doi.org/10.31031/GMR.2021.05.000619","url":null,"abstract":"A case of NICTH secondary to gastrointestinal stromal tumor (GIST) is described, male patient admitted to the emergency referring asthenia and drowsiness, and measured blood glucose of 20mg/dL. Patient continued to present episodes of recurrent hypoglycemia: 33/55/32mg/dL, even with continuous reposition of 10% glucose solution. Hypoglycemia can be related to several tumors, including islet cell and non-islet cell tumors. Non-islet cell tumor hypoglycemia (NICTH) is a rare and serious complication of malignancy, and its presence is usually associated with a poor prognosis. The most common cause of this type of hypoglycemia is tumor overproduction of insulin-like growth factor II (IGF-II), which stimulates the insulin receptor, leading to decreased insulin and glucagon levels. The diagnosis of NICTH is based on clinical and laboratory findings. Patients with NICTH have low serum concentrations of insulin and C-peptide during hypoglycemia. The treatment of this condition is related to the control of the underlying neoplasia. In patients who are unable to undergo invasive procedures, the use of corticosteroids is a good treatment option, leading to normalization of glycemia. Its management is of unquestionable importance to ensure the patient’s quality of life. A review of the literature on epidemiology, diagnosis and treatment of this complication follows.","PeriodicalId":130011,"journal":{"name":"Gastroenterology: Medicine & Research","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133695531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does Vitamin D Deficiency Correlates with Metabolic Syndrome in Egyptian Population 维生素D缺乏与埃及人群代谢综合征相关吗

Gastroenterology: Medicine & Research Pub Date : 2021-02-17 DOI: 10.31031/GMR.2021.05.000618

Rasha Ibrahem Salama, A. Mahros

{"title":"Does Vitamin D Deficiency Correlates with Metabolic Syndrome in Egyptian Population","authors":"Rasha Ibrahem Salama, A. Mahros","doi":"10.31031/GMR.2021.05.000618","DOIUrl":"https://doi.org/10.31031/GMR.2021.05.000618","url":null,"abstract":"Background : Metabolic syndrome (MS) has become a serious health problem worldwide and it is a major cause of morbidity and mortality especially from cardiovascular diseases. Different factors involved in pathogenesis like environmental, genetic, and sedentary life. Recent studies demonstrates that Vitamin D3 deficiency has a growing role in pathogenesis of MS. Many studies had addressed the relationship between serum Vitamin D3 and metabolic syndrome but to the best of our knowledge, few studies about this relationship in Egyptian population. Aims: To assess the relationship between deficiency of Vitamin D3 with metabolic syndrome in Egyptian population. Patients and methods: This is cross sectional study invite 200 participants from healthy clubs but only 180 accept to participate. According to the presence or absence of metabolic syndrome, our participant were divided into two groups. All participants were subjected to detailed medical history, clinical and anthropometric assessment, and laboratory analysis including serum Vitamin D3 level. Result: The mean age of the studied patients was 40.91±8.72, and majority were female (66.7%). Metabolic syndrome cases were significantly higher as regard the age, SBP, DBP, TG, FBS, WC and BMI but significantly lower regard HDL and Vitamin D3, and no significant association with sex. Vitamin D deficiency cases were significantly higher as regard Age, SBP, DBP, TG, FBS, WC and BMI but sig lower regard HDL. There was significant different between patients with and without Vitamin D3 deficiency as regard the presence of metabolic syndrome (P value=.00). There was moderate negative correlation between Vitamin D3 deficiency and age, SBP, DBP, FBS, WC and BMI with positive weak correlation with HDL level. Vitamin D3 deficiency < 20ng/ml and BMI >35 were significant predictors for metabolic syndrome with (P value 0.00, 0.04) respectively. Conclusion: Vitamin correlates with the presence of metabolic syndrome in Egyptian Population","PeriodicalId":130011,"journal":{"name":"Gastroenterology: Medicine & Research","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127302419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of 68Ga-labeled TPP-1: A Targeted PD-L1 Probe for PET Imaging of Colorectal Cancer 68ga标记的TPP-1:一种靶向PD-L1探针用于结直肠癌PET成像的评价

Gastroenterology: Medicine & Research Pub Date : 2021-02-15 DOI: 10.31031/GMR.2021.05.000617

Xiaojiao Wang, Xiao Li, Danni Li, Beibei Zhang

引用次数: 0

Role of Biofield Energy Healing Treatment Based Test Formulation on Colon Cytokines Using TNBS-Induced Ulcerative Colitis in Sprague Dawley Rats 基于生物场能量治疗的实验性制剂对大鼠溃疡性结肠炎结肠细胞因子的影响

Gastroenterology: Medicine & Research Pub Date : 2021-02-11 DOI: 10.31031/GMR.2021.05.000616

M. Trivedi, S. Jana

{"title":"Role of Biofield Energy Healing Treatment Based Test Formulation on Colon Cytokines Using TNBS-Induced Ulcerative Colitis in Sprague Dawley Rats","authors":"M. Trivedi, S. Jana","doi":"10.31031/GMR.2021.05.000616","DOIUrl":"https://doi.org/10.31031/GMR.2021.05.000616","url":null,"abstract":"A novel test formulation was formulated and the study aimed to evaluate the therapeutic effect of Biofield Energy Healing (the Trivedi Effect ® -Consciousness Energy Healing) based test formulation on the colon cytokines. Each ingredient of the test formulation was divided into two parts, one part was defined as control and the other part was described group. The level of TNF-α was significantly reduced by 12.2%, 30% ( p< 0.001), 59.1% ( p <0.001), 49.2%, and 15.5% ( p< 0.001) in the G5, G6, G7, G8, and G9 groups, respectively as compared with the G2 group. Further, the level of IFN-γ was significantly decreased by 15.6%, 40.5% ( p< 0.001), 62.1% ( p <0.001), 52.6% ( p< 0.001), and 28.4% by G5, G6, G7, G8, and G9 respectively, as compared with the G2. Besides, IL-10 level was significantly increased by 31.7% ( p <0.001), 14.3%, and 18.7% ( p <0.05) in the G5, G6, and G9 groups, respectively as compared with the G2. Thus, it can be concluded that the Trivedi Effect®-Consciousness Energy Healing significantly modulates the colon cytokines after treatment with the test formulation and Biofield Energy Treatment per se . Thus, the Biofield Energy Treated test formulation can be utilized against many inflammatory bowel diseases (IBDs), including Crohn’s disease and ulcerative colitis, hepatic, colitis, gastrointestinal, and neurodegenerative along with various other factors such as microbial, parasitic and viral inflammatory responses.","PeriodicalId":130011,"journal":{"name":"Gastroenterology: Medicine & Research","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124085529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Associated with the Occurrence of Metastatic Dissemination in Rectal Cancer 直肠癌转移扩散发生的相关因素

Gastroenterology: Medicine & Research Pub Date : 2021-01-25 DOI: 10.31031/GMR.2020.05.000614

Ana Lazarova

引用次数: 0

Case of Sister Mary Joseph’s Nodule Inpatient Who Underwent A Whipple Procedure 玛丽约瑟夫修女的结节住院病人行惠普尔手术一例

Gastroenterology: Medicine & Research Pub Date : 2020-12-16 DOI: 10.31031/GMR.2020.05.000613

Ana Lazarova

引用次数: 0

Peritoneal Carcinomatosis Present in Signet Ring Cells Gastric Carcinoma-Case Report 印戒细胞中存在腹膜癌病——胃癌1例报告

Gastroenterology: Medicine & Research Pub Date : 2020-12-10 DOI: 10.31031/GMR.2020.05.000612

Ana Lazarova

{"title":"Peritoneal Carcinomatosis Present in Signet Ring Cells Gastric Carcinoma-Case Report","authors":"Ana Lazarova","doi":"10.31031/GMR.2020.05.000612","DOIUrl":"https://doi.org/10.31031/GMR.2020.05.000612","url":null,"abstract":"Peritoneal carcinomatosis (PC) is an important and not rare cause of morbidity and mortality among patients with gastric cancer. Younger age(less than 65 years) female gender, advanced Tand N-stage, a primary tumor of signet ring cells or linitis plastica, and primary tumors covering multiple anatomical locations of the stomach were all associated with a higher odds ratios of developing PC. PC is a frequent condition in patients presenting with gastric cancer, especially in younger patients with advanced tumor stages. In this article, we present a case of a 63 years old woman who was operatively treated for gastric cancer. Total gastrectomy was obtained and the patohistology report was signet ring cell carcinoma, stage T3N3M0. Computer tomography (CT) was done before the operative treatment and 6 months after the treatment. The CT before the treatment did not show any presents of peritoneal metastasis, there were no signs of peritoneal involvement. The next CT was done 6 months after the treatment where there was a sign of peritoneal involvement, with the diffuse spread of metastatic deposits (MS) all over the peritoneum. The present study showed a positive correlation between a more advanced T-stage and N-stage and the risk of presenting with PC. In literature, these factors were also associated with worse survival. This patient survival period was 4 months after diagnosis of peritoneal carcinomatosis with correlate with the data from the literature were median survival of patients with other metastases was 14 months, but only 4 months for patients with PC.","PeriodicalId":130011,"journal":{"name":"Gastroenterology: Medicine & Research","volume":"128 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120929728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relation between 25-Hydroxyvitamin D, Systemic Inflammation and Endothelial Function Biomarkers in Diabetic Nephropathy 25-羟基维生素D与糖尿病肾病全身性炎症和内皮功能生物标志物的关系

Gastroenterology: Medicine & Research Pub Date : 2020-12-02 DOI: 10.31031/GMR.2020.05.000611

M. S. Al-dahr

{"title":"Relation between 25-Hydroxyvitamin D, Systemic Inflammation and Endothelial Function Biomarkers in Diabetic Nephropathy","authors":"M. S. Al-dahr","doi":"10.31031/GMR.2020.05.000611","DOIUrl":"https://doi.org/10.31031/GMR.2020.05.000611","url":null,"abstract":"Background: Diabetic nephropathy (DN) is a microvascular diabetic complications that leads to renal failure worldwide. However, vitamin D is essential to maintain health of vascular system. Objective:The target of this study was to measure the association between 25-hydroxyvitamin D, systemic inflammation and endothelial function biomarkers in patients with type 2 diabetic nephropathy. Material and Methods: Two hundred Saudi obese type 2 diabetes mellitus (T2DM) patients (114 males and 86 females), their body mass index (BMI) was 31-35Kg/m2and the chronicity of diabetes was 11.87±2.95 year enrolled in the present study. Smokers and patients with renal insufficiency, congestive heart failure, pregnancy, respiratory failure and hepatitis were excluded. Participants were enrolled into three equal groups: group (A) 25-OHD<20ng/ml (deficiency of vitamin D), group (B): 25-OHD=20-30 ng/ml (insufficiency of vitamin D) and group(C) 25-OHD >30ng/ml (normal vitamin D). Consent from was signed by participants. Results: Mean values of VCAM-1, ICAM-1, E-selectin, TNF-α, IL-6 and CRP were significantly greater in group(A) compared to group(B) and group(C). However, vitamin D showed a strong inverse relationship with these parameters in the three groups (P<0.05). Conclusion: Level of vitamin D closely related to systemic inflammation and endothelial function biomarkers in Saudi patients with diabetic nephropathy","PeriodicalId":130011,"journal":{"name":"Gastroenterology: Medicine & Research","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130122973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tyrosine Kinase Inhibitors (TKIs) for the Treatment of Concurrent Colorectal and Renal Cell Carcinomas 酪氨酸激酶抑制剂(TKIs)治疗并发结直肠癌和肾细胞癌

Gastroenterology: Medicine & Research Pub Date : 2020-10-09 DOI: 10.31031/GMR.2020.05.000608

A. Karampeazis

引用次数: 0

Gastric Metastasis at the First Presentation of Breast Cancer May Mimic Primary Carcinoma: A Case Report and Literature Review 乳腺癌首次出现胃转移可能与原发癌相似:1例报告及文献复习

Gastroenterology: Medicine & Research Pub Date : 2020-10-09 DOI: 10.31031/GMR.2020.05.000609

Jiayu Wang

引用次数: 0