Arthritis & Rheumatology最新文献

{"title":"Longitudinal Associations Between Baseline Sarcopenia and Knee Osteoarthritis Progression and Risk of Knee Replacement","authors":"Tianxing Wu, Xiaoshuai Wang, Zhuojian Cai, Peihua Cao, Qin Dang, Weijie Zhou, Jiawei Xie, Jie Chen, Taiwei Wang, Gaochenzi Tao, Weiyu Han, Zhaohua Zhu, Jian Wang, David J Hunter, Rocco Barazzoni, Changhai Ding, Jia Li","doi":"10.1002/art.43213","DOIUrl":"https://doi.org/10.1002/art.43213","url":null,"abstract":"ObjectivesSarcopenia and knee osteoarthritis (KOA) are common conditions in older adults, but the relationship is controversial. We aimed to examine the potential role of sarcopenia in KOA progression and subsequent knee replacement (KR).MethodsUsing data from the Osteoarthritis Initiative (OAI), baseline sarcopenia was first screened according to the EWGSOP2 algorithm using the SARC‐F questionnaire (screened sarcopenia, Scre‐S), then further assessed combined with the five times chair‐stand‐test (probable sarcopenia, Prob‐S). Radiographic KOA progression was evaluated by changes in Kellgren‐Lawrence Grade (KLG) and Osteoarthritis Research Society International (OARSI) atlas scores from baseline to 24‐ and 48‐month follow‐up. Symptomatic progression was evaluated similarly using the Western Ontario McMaster Osteoarthritis Index (WOMAC). The associations of sarcopenia with radiographic or symptomatic progression and subsequent KR were analyzed before and after adjusting for potential confounders and propensity score (PS)‐matching.Results4316 participants were included with 27.2% being Scre‐S and 16.8% being Prob‐S. Baseline Scre‐S and Prob‐S were positively associated with both radiographic and symptomatic progression in KOA, over 24 and 48 months. Both Scre‐S and Prob‐S were associated with a higher risk of subsequent KR (HR 3.84, 95% CI 3.18 to 4.62 for Scre‐S and HR 2.29, 95% CI 1.87 to 2.81 for Prob‐S). These results remained significant in the PS‐matched cohort.ConclusionsScre‐S and Prob‐S were significantly and longitudinally associated with both radiographic and symptomatic progression in KOA and subsequent KR. Our findings indicated a potential causal role of sarcopenia in KOA progression, and highlighted its potentially therapeutic effect in KOA management.<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mimetype=\"image/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic/art43213-toc-0001-m.png\"><jats:alt-text>image</jats:alt-text></jats:graphic></jats:boxed-text>","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"99 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations and Diagnostic Accuracy of Ultrasound Features in Knee Osteoarthritis: Cross‐sectional Results from a Large Community‐based Cohort: comment on the article by Yates KA et al.","authors":"Haojie Guan, Haidong Zhou, Hongyu Xu, Hejing Pan","doi":"10.1002/art.43211","DOIUrl":"https://doi.org/10.1002/art.43211","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"113 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paradoxical Activation of Entheseal Myeloid Cells by JAK1 and TYK2 Inhibitors via IL10 Antagonism","authors":"Sami Giryes, Chi Wong, Charlie Bridgewood, Mark Harland, Ala Altaie, Nicole McDermott, Kerem Abacar, Abhay Rao, Almas Khan, Tristan McMillan, Peter Loughenbery, Robert Dunsmuir, Vishal Borse, Tom Macleod, Dennis McGonagle","doi":"10.1002/art.43210","DOIUrl":"https://doi.org/10.1002/art.43210","url":null,"abstract":"BackgroundJAK inhibition (JAKi) is effective in seronegative spondyloarthropathy (SpA) spectrum disorders, but TYK2 inhibition failed in SpA spectrum ulcerative colitis, and tofacitinib showed minimal benefit in Crohn's Disease, which highlights the complex role for JAK‐STAT signaling in different inflammatory processes. In this study, we investigated whether JAKi might paradoxically activate entheseal innate immunity and aimed to identify the key regulatory cytokines involved in this process.MethodsSpinal entheseal tissue was activated with TLR agonists, including TLR4 and IL‐1 family proteins and entheseal T cell were activated with anti‐CD3/anti‐CD28 plus IL‐23/IL‐1β. JAKi via upadacitinib (JAK1/JAK2), deucravacitinib (TYK2) and ritlecitinib (JAK3) inhibition was evaluated using multiplex cytokine assays, intracellular flow and bulk RNAseq and cytokine blocking or stimulation.ResultsFollowing IFNγ stimulation, JAK1 inhibition blocked STAT1 phosphorylation in entheseal cells and strongly blocked activated entheseal T cell TNFα, IL‐17A and IL‐17F production. The opposite effect was evident in entheseal myeloid cell with exaggerated TLR4 and other adjuvant‐mediated cytokine production including IL‐23 (~10‐fold increase; p &lt; 0.001) or TNFα (~10‐fold increase; p &lt; 0.0001). This myeloid effect was induced by upadacitinib and deucravacitinib, but not ritlecitinib, suggesting IL‐10R JAK1/TYK2 signaling. Bulk RNAseq showed multifaceted impact of JAKi on myeloid activation with strong M1 type monocyte polarisation under TLR4 stimulation and JAK1 inhibition confirmed by flow cytometry. Direct IL‐10 inhibition recapitulated inflammatory cytokine elevations and IL‐10R agonist largely, but not completely, rescued this phenotype.ConclusionsThese findings help explain the emergent efficacy of TYK2 blockade in SpA spectrum related arthritis that is not IL‐10 dependent but indicates why such strategies may not be a panacea for SpA spectrum disorder related intestinal inflammation.<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mimetype=\"image/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic/art43210-toc-0001-m.png\"><jats:alt-text>image</jats:alt-text></jats:graphic></jats:boxed-text>","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"15 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gout and NLRP3 inflammasome biology","authors":"Raewyn Poulsen, Nicola Dalbeth","doi":"10.1002/art.43215","DOIUrl":"https://doi.org/10.1002/art.43215","url":null,"abstract":"This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilisation, and self-resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal-induced inflammation is reviewed in detail. Treatment strategies for gout are outlined in the context of the mechanisms of NLRP3 inflammasome-mediated acute inflammation.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"23 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of long‐term voclosporin treatment on renal histology in patients with active lupus nephritis with repeat renal biopsies","authors":"Brad H. Rovin, Clarissa Cassol, Samir V. Parikh, Amit Saxena, Neil Solomons, Vanessa Birardi, Ernie Yap, Clint W. Abner, David R.W. Jayne, Robert B. Huizinga","doi":"10.1002/art.43209","DOIUrl":"https://doi.org/10.1002/art.43209","url":null,"abstract":"ObjectiveThis study characterized the impact of voclosporin on kidney histology in patients with lupus nephritis (LN) who had protocolized repeat kidney biopsies in the AURORA clinical trials.MethodsPatients were randomized to voclosporin or placebo treatment for up to three years; all patients received mycophenolate mofetil and low‐dose glucocorticoids. Patients had baseline kidney biopsies within 6 months prior to study start and repeat biopsies after approximately 18 months of study treatment. The revised NIH indices for LN activity (AI) and chronicity (CI) were calculated, in addition to semi‐quantitative assessment of vascular and tubular lesions.ResultsSixteen patients in the voclosporin group and 10 patients in the control group had both baseline and repeat kidney biopsies. Patient clinical characteristics were similar at baseline. In the voclosporin group, most (n=13) patients had pure class IV lesions (pure class V, n=1; mixed, n=2). In the control group, three patients had pure class IV (pure class III, n=3; pure class V, n=1; mixed, n=3). Most of the voclosporin‐treated patients had no change in CI (n=8) or a change ≤2 (n=6); control‐treated patients also had no change in CI (n=3) or a change ≤2 (n=6). No trends in vascular lesions or tubular compartment changes were observed.ConclusionOutcomes from this small subgroup show exposure to study treatment was not associated with nephrotoxicity based on histopathologic evaluation after 18 months. These data are reassuring and further contribute to the safety profile of voclosporin for the treatment of adults with active LN.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"55 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor regarding \"Plasma Proteomic Profiles Predict Individual Future Osteoarthritis Risk\"","authors":"Qing Wang, Shuxing Xing","doi":"10.1002/art.43203","DOIUrl":"https://doi.org/10.1002/art.43203","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"5 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voclosporin nephrotoxicity: a myth debunked?","authors":"Anthony Chang","doi":"10.1002/art.43208","DOIUrl":"https://doi.org/10.1002/art.43208","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"10 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Connections","authors":"","doi":"10.1002/art.43192","DOIUrl":"https://doi.org/10.1002/art.43192","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"77 5","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/art.43192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Journal Club","authors":"","doi":"10.1002/art.43191","DOIUrl":"https://doi.org/10.1002/art.43191","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"77 5","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/art.43191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Journal Club","authors":"","doi":"10.1002/art.43191","DOIUrl":"https://doi.org/10.1002/art.43191","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"77 5","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/art.43191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}