Arthritis & Rheumatology最新文献

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More Than Just ANA: Antibody Sialylation May Tip the Balance in Autoimmunity. 不仅仅是ANA:抗体唾液化可能会改变自身免疫的平衡。
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-09-11 DOI: 10.1002/art.43379
Raquel M Centeio,Taia T Wang
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引用次数: 0
Reply to Letter to the Editor: "Systemic autoimmune rheumatic disease risk is associated with long-term exposure to fine particulate matter". 回复致编辑的信:“系统性自身免疫性风湿病风险与长期暴露于细颗粒物有关”。
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-09-11 DOI: 10.1002/art.43378
Sasha Bernatsky,Naizhuo Zhao
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引用次数: 0
Where we Live matters: Varied Disease Burden and Treatment Patterns in Psoriatic Arthritis in the United States. 我们生活的地方很重要:美国银屑病关节炎的各种疾病负担和治疗模式。
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-09-11 DOI: 10.1002/art.43377
Brittany Banbury,Sharon Dowell,Christopher Jenkins,Emily E Holladay,Fenglong Xie,Jingyi Zhang,Grace C Wright,Jeffrey R Curtis,Gail S Kerr
{"title":"Where we Live matters: Varied Disease Burden and Treatment Patterns in Psoriatic Arthritis in the United States.","authors":"Brittany Banbury,Sharon Dowell,Christopher Jenkins,Emily E Holladay,Fenglong Xie,Jingyi Zhang,Grace C Wright,Jeffrey R Curtis,Gail S Kerr","doi":"10.1002/art.43377","DOIUrl":"https://doi.org/10.1002/art.43377","url":null,"abstract":"OBJECTIVETo evaluate the clinical characteristics, social deprivation, insurance coverage, and medication use across regional subsets of patients with psoriatic arthritis (PsA) in the US.METHODSA cross-sectional study of PsA patients in the Rheumatology Informatics System for Effectiveness (RISE) registry between January 2020 and March2023 was conducted. Distribution of high disease activity (HDA - RAPID3>12), high comorbidity (RxRisk ≥90th percentile), high Area Deprivation Index (ADI ≥80), insurance coverage, prednisone ≥10mg daily, and all DMARD therapies across geographic regions were evaluated. Logistic regression models were used to identify regional correlates of HDA and comorbidity.RESULTSOf 32,732 PsA RISE patients, 58.8% were White females [mean (SD) age 57.7(13.5) years] with private insurance (60%); 55.8% resided in the South. A majority (81.8%) had a BMI of ≥25, highest in the Midwest (32.4 ±7.8). Women, despite prevalent HDA, received less bDMARD therapy. Both HDA and ADI ≥80 were more prevalent in the South and Midwest. Compared to the Northeast, Midwest patients had a higher burden of comorbidity [aOR:1.59, 95% CI 0.98 - 2.59] with frequent use of prednisone in conjunction with conventional DMARDs (31.3% vs. Northeast 20.5%, South 13.6%, West 17.6%). Uveitis affected 1.2% of the cohort. Only 14 (7.1%) and 20 (10.1%) RISE practices provided care for half of all Medicaid and high deprivation patients, respectively.CONCLUSIONSPsA disease characteristics and care vary across the US, with higher-than-expected prednisone use, and unequal provider care burden in some regions. Further work is needed to assess the impact of varied regional care on disease outcomes.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"14 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on: Time-Dependent Effect of Prophylactic Trimethoprim-Sulfamethoxazole on the Incidence of Serious Infections in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Target Trial Emulation Study. 预防性甲氧苄啶-磺胺甲恶唑对抗中性粒细胞细胞质抗体相关血管炎严重感染发生率的时间依赖性影响:一项目标试验模拟研究。
IF 10.9 1区 医学
Arthritis & Rheumatology Pub Date : 2025-09-11 DOI: 10.1002/art.43373
Ivana Capuano, Eleonora Riccio, Pasquale Buonanno, Antonio Pisani
{"title":"Comment on: Time-Dependent Effect of Prophylactic Trimethoprim-Sulfamethoxazole on the Incidence of Serious Infections in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Target Trial Emulation Study.","authors":"Ivana Capuano, Eleonora Riccio, Pasquale Buonanno, Antonio Pisani","doi":"10.1002/art.43373","DOIUrl":"https://doi.org/10.1002/art.43373","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to Comment by Capuano et al. 回复Capuano等人的评论。
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-09-11 DOI: 10.1002/art.43374
Yun Kyu Kim,Jeffrey R Curtis,Eun Bong Lee,Jun Won Park
{"title":"Reply to Comment by Capuano et al.","authors":"Yun Kyu Kim,Jeffrey R Curtis,Eun Bong Lee,Jun Won Park","doi":"10.1002/art.43374","DOIUrl":"https://doi.org/10.1002/art.43374","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"59 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to Letter to the editor A&R: "Negative" finding supports two-hit model, by Ronald van Vollenhoven. 回复A&R编辑的信:“否定”的发现支持罗纳德·范·沃伦霍芬的两首热门歌曲模型。
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-09-11 DOI: 10.1002/art.43381
Johanna M Kroese,Bernd W Brandt,Mark J Buijs,Wim Crielaard,Frank Lobbezoo,Bruno G Loos,Laurette van Boheemen,Dirkjan van Schaardenburg,Egija Zaura,Catherine M C Volgenant
{"title":"Reply to Letter to the editor A&R: \"Negative\" finding supports two-hit model, by Ronald van Vollenhoven.","authors":"Johanna M Kroese,Bernd W Brandt,Mark J Buijs,Wim Crielaard,Frank Lobbezoo,Bruno G Loos,Laurette van Boheemen,Dirkjan van Schaardenburg,Egija Zaura,Catherine M C Volgenant","doi":"10.1002/art.43381","DOIUrl":"https://doi.org/10.1002/art.43381","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"33 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytokine pathways driving diverse tissue pathologies in rheumatoid arthritis. 细胞因子通路驱动不同组织病理在类风湿关节炎。
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-09-09 DOI: 10.1002/art.43376
Aurelie Najm,Lyn D Ferguson,Iain B McInnes
{"title":"Cytokine pathways driving diverse tissue pathologies in rheumatoid arthritis.","authors":"Aurelie Najm,Lyn D Ferguson,Iain B McInnes","doi":"10.1002/art.43376","DOIUrl":"https://doi.org/10.1002/art.43376","url":null,"abstract":"Rheumatoid arthritis is a complex systemic disorder characterised primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra-articular disease e.g. of the lung with potentially devastating clinical consequences. The critical importance of co-morbidities, and consequent multi-morbidity, in determining outcomes in RA has now been recognised, not least as novel therapeutics have emerged with attendant increased life expectancy. The primary role of cytokine networks in mediating RA pathogenesis was established in extensive pre-clinical and clinical trials and in the adoption of cytokine targeted therapeutics in clinical care over three decades. Herein we briefly review those pivotal cytokine pathways that are associated with RA articular disease, and extend these insights to include extra-articular RA and its common co-morbidities.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"71 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ROS‐induced modifications of fibrin clots connect immune responses to atherothrombosis in systemic lupus erythematosus ROS诱导的纤维蛋白凝块修饰将系统性红斑狼疮患者的免疫反应与动脉粥样硬化血栓形成联系起来
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-09-03 DOI: 10.1002/art.43371
Matteo Becatti, Giacomo Emmi, Alessandra Bettiol, Amanda Mannucci, Flavia Rita Argento, Eleonora Fini, Serena Borghi, Francesca Nencini, Maria Nicastro, Irene Mattioli, Elena Silvestri, Augusto Vaglio, Domenico Prisco, Claudia Fiorillo
{"title":"ROS‐induced modifications of fibrin clots connect immune responses to atherothrombosis in systemic lupus erythematosus","authors":"Matteo Becatti, Giacomo Emmi, Alessandra Bettiol, Amanda Mannucci, Flavia Rita Argento, Eleonora Fini, Serena Borghi, Francesca Nencini, Maria Nicastro, Irene Mattioli, Elena Silvestri, Augusto Vaglio, Domenico Prisco, Claudia Fiorillo","doi":"10.1002/art.43371","DOIUrl":"https://doi.org/10.1002/art.43371","url":null,"abstract":"ObjectiveCardiovascular events are major determinants of morbidity and mortality in systemic lupus erythematosus (SLE), particularly in patients with renal involvement. While oxidative stress has been implicated in driving vascular and renal damage in SLE, the specific mechanisms remain unclear. This study investigated the potential role of oxidative stress‐induced alterations in fibrinogen structure and function in the pathogenesis of atherothrombosis in SLE.MethodsIn this cross‐sectional study, we enrolled 144 adult patients with SLE and 90 matched controls. We measured blood leukocyte reactive oxygen species (ROS) production, systemic redox status, and the structural and functional features of purified fibrinogen. Correlations between these parameters and disease activity were also investigated. <jats:italic>In vitro</jats:italic> experiments to clarify the causal relationships among ROS levels, protein oxidation, and fibrin abnormalities provided mechanistic insights of the observed alterations.ResultsSLE patients showed increased leukocyte ROS production, mainly due to neutrophil NADPH oxidase activation. Interestingly, renal biopsies from SLE patients with active proliferative lupus nephritis exhibited the NADPH oxidase enzyme complex p22phox overexpression. This was accompanied by plasma oxidative stress as indicated by elevated plasma lipid peroxidation and reduced antioxidant defenses. Fibrinogen oxidation was associated with structural and functional changes, leading to the formation of denser fibrin networks with lower clot porosity and reduced susceptibility to plasmin‐mediated fibrin lysis. Interestingly, these fibrinogen modifications correlated with alterations in redox status and disease activity.ConclusionOxidative stress may drive structural and functional modifications of fibrinogen in SLE, potentially acting as a novel pathogenetic mechanism in atherothrombosis among these patients.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"24 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Journal Club 杂志俱乐部
IF 10.9 1区 医学
Arthritis & Rheumatology Pub Date : 2025-09-01 DOI: 10.1002/art.43363
{"title":"Journal Club","authors":"","doi":"10.1002/art.43363","DOIUrl":"10.1002/art.43363","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"77 9","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://acrjournals.onlinelibrary.wiley.com/doi/epdf/10.1002/art.43363","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144927641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Connections 临床联系
IF 10.9 1区 医学
Arthritis & Rheumatology Pub Date : 2025-09-01 DOI: 10.1002/art.43365
{"title":"Clinical Connections","authors":"","doi":"10.1002/art.43365","DOIUrl":"10.1002/art.43365","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"77 9","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://acrjournals.onlinelibrary.wiley.com/doi/epdf/10.1002/art.43365","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144927642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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