Arthritis & Rheumatology最新文献

{"title":"Reply to Comment by Capuano et al.","authors":"Yun Kyu Kim,Jeffrey R Curtis,Eun Bong Lee,Jun Won Park","doi":"10.1002/art.43374","DOIUrl":"https://doi.org/10.1002/art.43374","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"59 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Letter to the editor A&R: \"Negative\" finding supports two-hit model, by Ronald van Vollenhoven.","authors":"Johanna M Kroese,Bernd W Brandt,Mark J Buijs,Wim Crielaard,Frank Lobbezoo,Bruno G Loos,Laurette van Boheemen,Dirkjan van Schaardenburg,Egija Zaura,Catherine M C Volgenant","doi":"10.1002/art.43381","DOIUrl":"https://doi.org/10.1002/art.43381","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"33 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytokine pathways driving diverse tissue pathologies in rheumatoid arthritis.","authors":"Aurelie Najm,Lyn D Ferguson,Iain B McInnes","doi":"10.1002/art.43376","DOIUrl":"https://doi.org/10.1002/art.43376","url":null,"abstract":"Rheumatoid arthritis is a complex systemic disorder characterised primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra-articular disease e.g. of the lung with potentially devastating clinical consequences. The critical importance of co-morbidities, and consequent multi-morbidity, in determining outcomes in RA has now been recognised, not least as novel therapeutics have emerged with attendant increased life expectancy. The primary role of cytokine networks in mediating RA pathogenesis was established in extensive pre-clinical and clinical trials and in the adoption of cytokine targeted therapeutics in clinical care over three decades. Herein we briefly review those pivotal cytokine pathways that are associated with RA articular disease, and extend these insights to include extra-articular RA and its common co-morbidities.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"71 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ROS‐induced modifications of fibrin clots connect immune responses to atherothrombosis in systemic lupus erythematosus","authors":"Matteo Becatti, Giacomo Emmi, Alessandra Bettiol, Amanda Mannucci, Flavia Rita Argento, Eleonora Fini, Serena Borghi, Francesca Nencini, Maria Nicastro, Irene Mattioli, Elena Silvestri, Augusto Vaglio, Domenico Prisco, Claudia Fiorillo","doi":"10.1002/art.43371","DOIUrl":"https://doi.org/10.1002/art.43371","url":null,"abstract":"ObjectiveCardiovascular events are major determinants of morbidity and mortality in systemic lupus erythematosus (SLE), particularly in patients with renal involvement. While oxidative stress has been implicated in driving vascular and renal damage in SLE, the specific mechanisms remain unclear. This study investigated the potential role of oxidative stress‐induced alterations in fibrinogen structure and function in the pathogenesis of atherothrombosis in SLE.MethodsIn this cross‐sectional study, we enrolled 144 adult patients with SLE and 90 matched controls. We measured blood leukocyte reactive oxygen species (ROS) production, systemic redox status, and the structural and functional features of purified fibrinogen. Correlations between these parameters and disease activity were also investigated. <jats:italic>In vitro</jats:italic> experiments to clarify the causal relationships among ROS levels, protein oxidation, and fibrin abnormalities provided mechanistic insights of the observed alterations.ResultsSLE patients showed increased leukocyte ROS production, mainly due to neutrophil NADPH oxidase activation. Interestingly, renal biopsies from SLE patients with active proliferative lupus nephritis exhibited the NADPH oxidase enzyme complex p22phox overexpression. This was accompanied by plasma oxidative stress as indicated by elevated plasma lipid peroxidation and reduced antioxidant defenses. Fibrinogen oxidation was associated with structural and functional changes, leading to the formation of denser fibrin networks with lower clot porosity and reduced susceptibility to plasmin‐mediated fibrin lysis. Interestingly, these fibrinogen modifications correlated with alterations in redox status and disease activity.ConclusionOxidative stress may drive structural and functional modifications of fibrinogen in SLE, potentially acting as a novel pathogenetic mechanism in atherothrombosis among these patients.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"24 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Journal Club","authors":"","doi":"10.1002/art.43363","DOIUrl":"10.1002/art.43363","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"77 9","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://acrjournals.onlinelibrary.wiley.com/doi/epdf/10.1002/art.43363","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144927641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Connections","authors":"","doi":"10.1002/art.43365","DOIUrl":"10.1002/art.43365","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"77 9","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://acrjournals.onlinelibrary.wiley.com/doi/epdf/10.1002/art.43365","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144927642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Connections","authors":"","doi":"10.1002/art.43365","DOIUrl":"10.1002/art.43365","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"77 9","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://acrjournals.onlinelibrary.wiley.com/doi/epdf/10.1002/art.43365","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144927377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Journal Club","authors":"","doi":"10.1002/art.43363","DOIUrl":"10.1002/art.43363","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"77 9","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://acrjournals.onlinelibrary.wiley.com/doi/epdf/10.1002/art.43363","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144927378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin biopsies enhance prediction of clinical trajectory in diffuse cutaneous systemic sclerosis","authors":"Kimberly S. Lakin, John Spivack, Jessica K. Gordon, Yaxia Zhang, Deanna Jannat‐Khah, Hiranmayi Ravichandran, Niroshana Anandasabapathy, Dana E. Orange, Robert F. Spiera","doi":"10.1002/art.43370","DOIUrl":"https://doi.org/10.1002/art.43370","url":null,"abstract":"ObjectivesTo evaluate the relationship of skin fibroblast CD34 and aSMA and immune cell infiltration with disease duration in diffuse cutaneous systemic sclerosis (dcSSc) and identify predictors of improvement.MethodsSkin biopsies and clinical data were analyzed from dcSSc patients enrolled in Lenabasum (n=79), Belimumab (n=18), or Nilotinib (n=8) trials. CD34 and aSMA were scored semi‐quantitatively. Immune cells (CD20+, CD3+, CD123+) were counted. Clinical and histological features were compared between those with early (&lt;18 months) versus later disease (≥18 months). 52‐week clinical improvement was defined as &gt;5‐point decrease in modified Rodnan skin score (mRSS). An AIC‐optimal multiple logistic regression model for clinical improvement among 68 mycophenolate mofetil (MMF) users was developed. Fibroblast spatial organization was visualized using imaging mass cytometry (IMC) in a representative sample.ResultsDespite similar baseline mRSS, early disease was associated with lower CD34, higher aSMA, increased B cells, and greater mRSS improvement compared to later SSc. IMC demonstrated regions of CD34<jats:sup>+</jats:sup> fibroblasts in superficial dermis and aSMA<jats:sup>+</jats:sup> fibroblasts in deeper, collagen‐dense regions. Among MMF users, high CD34 and aSMA predicted improvement in early SSc; however, high aSMA predicted lower odds of improvement in later SSc. The probability of improvement was lowest in early SSc with aSMA<jats:sup>low</jats:sup>/CD34<jats:sup>low</jats:sup> immunophenotype and later SSc with aSMA<jats:sup>high</jats:sup>. In later SSc, B cells were higher in aSMA<jats:sup>high</jats:sup> versus aSMA<jats:sup>low</jats:sup> skin.ConclusionFibroblast immunophenotype varied by baseline disease duration and improved model performance for identifying those with improvement on MMF. Skin biopsies may be useful for refining prognosis and guiding patient management decisions.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"25 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JAK inhibitors did not increase the risk of major adverse cardiovascular events in patients with rheumatoid arthritis within the first two years of treatment","authors":"Hao Xing, Ya‐zhen Su","doi":"10.1002/art.43369","DOIUrl":"https://doi.org/10.1002/art.43369","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"41 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}