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Reply to: Short-term risk of cardiovascular events in people newly diagnosed with gout: comment on the article by Cipolletta et al.
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2024-12-16 DOI: 10.1002/art.43092
Edoardo Cipolletta, Laila J. Tata, Abhishek Abhishek
{"title":"Reply to: Short-term risk of cardiovascular events in people newly diagnosed with gout: comment on the article by Cipolletta et al.","authors":"Edoardo Cipolletta, Laila J. Tata, Abhishek Abhishek","doi":"10.1002/art.43092","DOIUrl":"https://doi.org/10.1002/art.43092","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"120 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142825161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cross‐Phenotype Genome‐Wide Association Study Supports Shared Genetic Susceptibility to Systemic Sclerosis and Primary Biliary Cholangitis
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2024-12-16 DOI: 10.1002/art.43081
Yiming Luo, Atlas Khan, Lili Liu, Cue Hyunkyu Lee, Gabriel J Perreault, Sydney F Pomenti, Pravitt Gourh, Krzysztof Kiryluk, Elana J Bernstein
{"title":"Cross‐Phenotype Genome‐Wide Association Study Supports Shared Genetic Susceptibility to Systemic Sclerosis and Primary Biliary Cholangitis","authors":"Yiming Luo, Atlas Khan, Lili Liu, Cue Hyunkyu Lee, Gabriel J Perreault, Sydney F Pomenti, Pravitt Gourh, Krzysztof Kiryluk, Elana J Bernstein","doi":"10.1002/art.43081","DOIUrl":"https://doi.org/10.1002/art.43081","url":null,"abstract":"ObjectiveAn increased risk of primary biliary cholangitis (PBC) has been reported in patients with systemic sclerosis (SSc). Our study aims to investigate the shared genetic susceptibility between the two disorders and to define candidate causal genes using cross‐phenotype GWAS meta‐analysis.MethodsWe performed cross‐phenotype GWAS meta‐analysis and Bayesian colocalization analysis for SSc and PBC. We performed both genome‐wide and locus‐based analysis, including tissue and pathway enrichment analyses, fine‐mapping, Bayesian colocalization analyses with expression quantitative trait loci (eQTL) and protein quantitative trait loci (pQTL) datasets, and phenome‐wide association studies (PheWAS). Finally, we used an integrative approach to prioritize candidate causal genes from the novel loci.ResultsWe detected a strong genetic correlation between SSc and PBC (rg = 0.84, p = 1.7 x 10<jats:sup>‐6</jats:sup>). In the cross‐phenotype GWAS meta‐analysis, we identified 44 non‐HLA loci that reached genome‐wide significance (p &lt; 5 x 10<jats:sup>‐8</jats:sup>). Evidence of shared causal variants between SSc and PBC was found for nine loci, five of which were novel. Integrating multiple sources of evidence, we prioritized <jats:italic>CD40</jats:italic>, <jats:italic>ERAP1</jats:italic>, <jats:italic>PLD4</jats:italic>, <jats:italic>SPPL3,</jats:italic> and <jats:italic>CCDC113</jats:italic> as novel candidate causal genes. The <jats:italic>CD40</jats:italic> risk locus colocalized with trans‐pQTLs of multiple plasma proteins involved in B cell function.ConclusionOur study supports a strong shared genetic susceptibility between SSc and PBC. Through cross‐phenotype analyses, we have prioritized several novel candidate causal genes and pathways for these disorders.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"47 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142825169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in descending pain modulation during anti-TNF therapy. A prospective study in rheumatoid arthritis and spondyloarthritis
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2024-12-16 DOI: 10.1002/art.43084
Anne-Priscille Trouvin, Arielle Simunek, Joël Coste, Terkia Medkour, Alice Combier, Lucile Poiroux, François Vidal, Sandrine Carvès, Didier Bouhassira, Serge Perrot
{"title":"Changes in descending pain modulation during anti-TNF therapy. A prospective study in rheumatoid arthritis and spondyloarthritis","authors":"Anne-Priscille Trouvin, Arielle Simunek, Joël Coste, Terkia Medkour, Alice Combier, Lucile Poiroux, François Vidal, Sandrine Carvès, Didier Bouhassira, Serge Perrot","doi":"10.1002/art.43084","DOIUrl":"https://doi.org/10.1002/art.43084","url":null,"abstract":"In rheumatoid arthritis (RA) and spondyloarthritis (SpA), managing persistent pain remains challenging. Little is known regarding impaired pain pathways in these patients and the impact of bDMARDs. The objective of the RAPID (Rheumatism Pain Inhibitory Descending pathways) study was to assess pain thresholds and descending pain modulation in patients with active RA or SpA following introduction of a TNF inhibitor. (TNFi)","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"46 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142825164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to the Comment by Guo et al. on Enhancing Knee Osteoarthritis Prediction
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2024-12-16 DOI: 10.1002/art.43085
Shengfa Li, Changhai Ding
{"title":"Response to the Comment by Guo et al. on Enhancing Knee Osteoarthritis Prediction","authors":"Shengfa Li, Changhai Ding","doi":"10.1002/art.43085","DOIUrl":"https://doi.org/10.1002/art.43085","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"21 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142825167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing Knee Osteoarthritis Prediction: Comment on the Article by Li et al
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2024-12-16 DOI: 10.1002/art.43087
Qin Guo, Hui Li, Chengshan Guo
{"title":"Enhancing Knee Osteoarthritis Prediction: Comment on the Article by Li et al","authors":"Qin Guo, Hui Li, Chengshan Guo","doi":"10.1002/art.43087","DOIUrl":"https://doi.org/10.1002/art.43087","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"21 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142825163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revisiting the Synovium as a Structural Correlate of Pain in Osteoarthritis
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2024-12-16 DOI: 10.1002/art.43086
Rachel E. Miller, Richard F. Loeser
{"title":"Revisiting the Synovium as a Structural Correlate of Pain in Osteoarthritis","authors":"Rachel E. Miller, Richard F. Loeser","doi":"10.1002/art.43086","DOIUrl":"https://doi.org/10.1002/art.43086","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"3 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142825166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The oral microbiota in persons at risk for rheumatoid arthritis: follow-up data
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2024-12-16 DOI: 10.1002/art.43090
Johanna M. Kroese, Bernd W. Brandt, Mark J. Buijs, Wim Crielaard, Frank Lobbezoo, Bruno G. Loos, Laurette van Boheemen, Dirkjan van Schaardenburg, Egija Zaura, Catherine M.C. Volgenant
{"title":"The oral microbiota in persons at risk for rheumatoid arthritis: follow-up data","authors":"Johanna M. Kroese, Bernd W. Brandt, Mark J. Buijs, Wim Crielaard, Frank Lobbezoo, Bruno G. Loos, Laurette van Boheemen, Dirkjan van Schaardenburg, Egija Zaura, Catherine M.C. Volgenant","doi":"10.1002/art.43090","DOIUrl":"https://doi.org/10.1002/art.43090","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"42 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142825160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcome of lupus nephritis patients treated with an anti-CD40 monoclonal antibody according to kidney biopsy features
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2024-12-08 DOI: 10.1002/art.43076
Martina Uzzo, Helmut Schumacher, Juergen Steffgen, Simone Deutschel, David Jayne, Ingeborg Bajema
{"title":"Outcome of lupus nephritis patients treated with an anti-CD40 monoclonal antibody according to kidney biopsy features","authors":"Martina Uzzo, Helmut Schumacher, Juergen Steffgen, Simone Deutschel, David Jayne, Ingeborg Bajema","doi":"10.1002/art.43076","DOIUrl":"https://doi.org/10.1002/art.43076","url":null,"abstract":"A phase II trial tested different doses of the anti-CD40 monoclonal antibody BI655064 as add-on therapy to the standard of care in class III or IV Lupus Nephritis (LN) patients with active disease. A post-hoc analysis showed a potential benefit of the higher tested doses (180mg/240mg) versus low dose (120mg)/placebo. We investigated whether the treatment effect of BI655064 on kidney outcomes may be modified by the presence of glomerular monocytes, a target for this drug with a well-known role in LN pathogenesis.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"140 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topical mupirocin treatment reduces interferon and myeloid signatures in cutaneous lupus erythematous lesions through targeting of Staphylococcus species
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2024-12-08 DOI: 10.1002/art.43079
Lisa Abernathy-Close, Joseph Mears, Allison C. Billi, Sirisha Sirobhushanam, Celine Berthier, Annie Lu, Zeran Zhang, Amy Hurst, Johann E. Gudjonsson, J. Michelle Kahlenberg
{"title":"Topical mupirocin treatment reduces interferon and myeloid signatures in cutaneous lupus erythematous lesions through targeting of Staphylococcus species","authors":"Lisa Abernathy-Close, Joseph Mears, Allison C. Billi, Sirisha Sirobhushanam, Celine Berthier, Annie Lu, Zeran Zhang, Amy Hurst, Johann E. Gudjonsson, J. Michelle Kahlenberg","doi":"10.1002/art.43079","DOIUrl":"https://doi.org/10.1002/art.43079","url":null,"abstract":"Cutaneous lupus erythematosus (CLE) is an inflammatory skin manifestation of systemic lupus erythematosus (SLE). Type I interferons (IFNs) promote inflammatory responses and are elevated in CLE lesions. We recently reported that CLE lesions are frequently colonized with <i>Staphylococcus aureus</i> (<i>S. aureus</i>). Here, we follow up in a proof-of-concept study to investigate whether type I IFN and inflammatory gene signatures in CLE lesions can be modulated with mupirocin, a topical antibiotic treatment against <i>S. aureus</i>-mediated skin infections.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"10 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply.
IF 11.4 1区 医学
Arthritis & Rheumatology Pub Date : 2024-12-05 DOI: 10.1002/art.43078
Sho Fukui, Masato Okada, Daniel H Solomon
{"title":"Reply.","authors":"Sho Fukui, Masato Okada, Daniel H Solomon","doi":"10.1002/art.43078","DOIUrl":"10.1002/art.43078","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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