Arthritis & Rheumatology最新文献

{"title":"Addressing methodological concerns on the JAK-pot MACE analysis.","authors":"Romain Aymon, Delphine S Courvoisier, Axel Finckh, Kim Lauper","doi":"10.1002/art.43372","DOIUrl":"https://doi.org/10.1002/art.43372","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144936788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive calcinosis cutis universalis involving the intrapelvic muscles in systemic lupus erythematosus","authors":"Takeshi Zoshima, Yasunori Iwata","doi":"10.1002/art.43368","DOIUrl":"https://doi.org/10.1002/art.43368","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"102 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A phase 2 trial of hydroxychloroquine in individuals at risk for rheumatoid arthritis","authors":"Kevin D. Deane, Christopher C. Striebich, Marie L. Feser, James R. O'Dell, Judith A. James, Jeffrey A. Sparks, John M. Davis, Jonathan Graf, Maureen A. McMahon, Elizabeth B. Solow, Lindsy Forbess, Athan Tiliakos, Elena Schiopu, Maria I. Danila, Diane L. Horowitz, Jonathan Kay, Colin D. Strickland, Joel M. Guthridge, Cristina Arriens, Jennifer M. Grossman, M. Kristen Demoruelle, Elizabeth A. Bemis, Ashley Frazer‐Abel, Chelsie L. Fleischer, David A. Fox, Ted R. Mikuls, Melissa Greenleaf, Kate York, Sarah Walker, Lynette Keyes‐Elstein, Margie Byron, Janel Fedler, Ellen A. Goldmuntz, V. Michael Holers","doi":"10.1002/art.43366","DOIUrl":"https://doi.org/10.1002/art.43366","url":null,"abstract":"BackgroundIndividuals with serum elevations of anti‐cyclic citrullinated peptide (anti‐CCP) antibodies are at increased risk for future rheumatoid arthritis (RA). No pharmacologic interventions have been approved for the prevention of RA in such ‘at‐risk’ individuals. However, hydroxychloroquine (HCQ) is used without supporting clinical trial evidence.MethodsIn this phase 2 randomized trial, individuals at‐risk for RA with anti‐CCP ≥2 times the upper limit of normal (ULN) were assigned to receive HCQ or placebo for 12 months, with up to 24 months of post‐drug follow‐up. The primary outcome was the development of clinical RA, as defined in the protocol, at 36 months. Secondary outcomes included safety, development of inflammatory arthritis (IA), and participant‐reported joint symptoms.ResultsOf 144 randomized participants, 71 were assigned to HCQ and 73 to placebo. In the modified intent‐to‐treat population, clinical RA occurred in 21 of 69 (30.4%) participants in the HCQ group and 24 of 73 (32.9%) in the placebo group. The risk of clinical RA at 36 months was 0.336 with HCQ and 0.394 with placebo (difference ‐0.058; 95% confidence interval ‐0.336 to 0.220; P=0.52). Results for IA were similar. The occurrence and severity of joint symptoms were not observed to differ between groups. Adverse event incidence was similar between groups.ConclusionsIn this trial involving individuals with anti‐CCP levels ≥2 times the ULN, 12 months of HCQ did not prevent the development of clinical RA at 36 months. (Funded by the National Institute of Allergy and Infectious Diseases; <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"http://ClinicalTrials.gov\">ClinicalTrials.gov</jats:ext-link> number, NCT02603146.)<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mimetype=\"image/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic/art43366-toc-0001-m.png\"><jats:alt-text>image</jats:alt-text></jats:graphic></jats:boxed-text>","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"121 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spermidine reproduces the anti‐inflammatory effects of intermittent fasting and prevents urate and calcium pyrophosphate crystal‐induced inflammation","authors":"Chinh Nghia Pham, Florence Castelli, Flora Finet, Charles Leroy, Céline Chollet, Twinu Wilson Chirayath, Subhalaxmi Moitra, Mylène Zarka, Agnès Ostertag, François Brial, Christèle Combes, Augustin Latourte, Thomas Bardin, François Fenaille, Pascal Richette, Hang Korng Ea","doi":"10.1002/art.43367","DOIUrl":"https://doi.org/10.1002/art.43367","url":null,"abstract":"BackgroundGout due to the formation of monosodium urate (MSU) crystals and calcium pyrophosphate (CPP) deposition disease are two major types of microcrystalline pathologies in adults. They are responsible for recurrent flares that rely on interleukin (IL)‐1β via activation of the NLRP3 inflammasome. Intermittent fasting (IF) is a non‐pharmacological intervention that improves age‐related diseases and reduces inflammation.MethodsIn air pouch model, crystal‐induced inflammation was compared between mice fed ad libitum and mice under IF. Systemic (liver and serum) and local (air pouch cavity) modifications were evaluated by metabolomics analysis. The anti‐inflammatory potential of metabolites was tested in vitro and in vivo.Resultswe observe that 2 non‐consecutive days of fasting during one week significantly prevents the inflammation provoked by MSU and CPP crystal injection into air pouch cavity in mouse model. This short‐term fasting is associated with increased serum abundances of numerous anti‐inflammatory metabolites, including β‐hydroxybutyrate and spermidine (SPD), a polyamine able to reproduce biological effects of IF. Conversely, crystal stimulation in <jats:italic>ad libitum</jats:italic> fed mice decreases the local production of these metabolites in the air pouch membrane. Supplementation of SPD reproduces the anti‐inflammatory effect of IF and prevents crystal‐induced inflammation through inhibition of NF‐κB and NLRP3 inflammasome. Finally, downregulation of <jats:italic>SAT1</jats:italic> (spermidine/spermine acetyltransferase 1), which encodes the enzyme that degrades SPD, reduces IL‐1β production induced by crystal stimulation.ConclusionIn summary, we have identified several metabolites that recapitulate the anti‐inflammatory effects of IF and could be used as IF mimetics to prevent microcrystal inflammation.<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mimetype=\"image/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic/art43367-toc-0001-m.png\"><jats:alt-text>image</jats:alt-text></jats:graphic></jats:boxed-text>","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"83 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic syndrome presenting as aseptic pustular dermatosis: A rare clinical manifestation.","authors":"Peter Chen, Héloïse Briançon, Deborah Eshagh, Tali-Anne Szwebel, Pierre Sohier, Rudy Birsen, Benjamin Terrier","doi":"10.1002/art.43361","DOIUrl":"10.1002/art.43361","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide DNA methylation study reveals specific signatures in the affected arterial tissue of giant cell arteritis patients.","authors":"Gonzalo Borrego-Yaniz, Ana Márquez, Elkyn Estupiñán-Moreno, Laura C Terrón-Camero, Miguel A González-Gay, Santos Castañeda, Giuliana Guggino, David Saadoun, Pietro Lio, Simona Fontana, Martina Bonacini, Alessandro Rossi, Alberto Cavazza, Francesco Muratore, Carlo Salvarani, Nicolo Pipitone, Javier Martin, Stefania Croci, Lourdes Ortiz-Fernández","doi":"10.1002/art.43358","DOIUrl":"10.1002/art.43358","url":null,"abstract":"<p><strong>Objectives: </strong>Giant cell arteritis (GCA) is a large-vessel vasculitis, potentially causing complications such as blindness and strokes. This study aims to gain insights into the pathogenesis of GCA by identifying specific DNA methylation signatures in the arterial tissue of patients with this vasculitis.</p><p><strong>Methods: </strong>DNA methylation profiling was analyzed in 79 temporal artery biopsy samples (69 patients with GCA and 10 controls) by performing an epigenome-wide association study (EWAS). Differential analysis was performed to identify differentially methylated positions (DMPs) and regions (DMRs). Lastly, we compared our findings with previous transcriptomics and epigenomics studies on GCA-affected arteries.</p><p><strong>Results: </strong>EWAS identified 3,644 DMPs (FDR < 0.05, |Δβ| > 0.3), indicating a profound alteration within GCA-affected arterial tissue. These DMPs were annotated to 1,517 potentially dysregulated genes. 282 additional genes were identified by annotation of significant DMRs. Pathway enrichment analysis revealed a significant alteration of inflammatory mechanisms, such as interleukins 2 and 7, as well as pathways related to vascular remodeling. Omics study comparison revealed 37 genes consistently affected across datasets, many of them linked to immune signaling and T cell regulation. Notably, markers of exhausted T cells, including SLAMF6 and HAVCR2, were present among them.</p><p><strong>Conclusions: </strong>Our study identified GCA-specific DNA methylation signatures in arterial tissue, revealing disrupted inflammatory and vascular pathways, and suggesting the involvement of exhausted T cells in this condition. These findings offer new insights into GCA pathogenesis and provide new potential targets for the treatment of this debilitating disease.</p>","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcoidosis revealed by recurrent dactylitis.","authors":"Thomas Subervie, Thibault Willaume, Amin Maazouzi, Jacques-Eric Gottenberg, Jean Sibilia, Noëlle Weingertner, Eden Sebbag, Marc Scherlinger","doi":"10.1002/art.43355","DOIUrl":"https://doi.org/10.1002/art.43355","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syphilis as the great imitator; Behcet's disease mimic.","authors":"Ken Fukuda, Kenji Yamashiro","doi":"10.1002/art.43353","DOIUrl":"https://doi.org/10.1002/art.43353","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Significance of Gut Microbiota Community Types for Long-term Response to Fecal Microbiota Transplantation in Patients with Psoriatic Arthritis.","authors":"Panpan Qin,Maja S Kragsnaes,Dorte K Holm,Hans Christian Horn,Anna Christine Nilsson,Jens Kjeldsen,Karsten Kristiansen,Torkell Ellingsen","doi":"10.1002/art.43359","DOIUrl":"https://doi.org/10.1002/art.43359","url":null,"abstract":"OBJECTIVEFecal microbiota transplantation (FMT) holds promises as a beneficial supplement to methotrexate in patients with psoriatic arthritis (PsA). We therefore investigated how gut bacterial signatures in patients and donor strain engraftment associated with long-term response to FMT.METHODSThis exploratory study is based on the FLORA trial cohort encompassing 31 patients with moderate-to-high PsA disease activity and four FMT donors. Out of fifteen patients receiving one single-donor FMT, thirteen were included in the per-protocol (PP) population. Stool samples were collected before and after FMT (week 4, 12, and 26). We performed shotgun metagenomics to characterize gut microbiota features.RESULTSAt baseline, 17 patients (55%) had a gut microbiota community type dominated by the Bacteroides genus (B-type) while 14 (45%) had a Prevotella-driven community type (P-type). The B- and P-type patients did not differ in disease activity nor demographics, but the B-type had a significantly higher species diversity compared to the P-type (P=0.005). In the PP population, five out of seven B-type patients vs none out of six P-type patients (P=0.021) achieved a long-term clinical beneficial response at week 26. Bacterial strain richness increased significantly from baseline to week 4 and 26 in B-type (P=0.016), but not in P-type, patients. Eighteen engrafted strains persisted only in B-type recipients by week 26, including a Bacteroides clarus strain, which demonstrated a negative effect size regarding arthritis pain and the patients' global assessment of disease.CONCLUSIONRecipients with a Bacteroides-dominated community structure were more likely to achieve long-term beneficial response following one FMT.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"79 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trimethoprim/sulfamethoxazole in clinical trials for Granulomatosis with Polyangiitis.","authors":"Jan Willem Cohen Tervaert","doi":"10.1002/art.43360","DOIUrl":"https://doi.org/10.1002/art.43360","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"146 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144851209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}