Arthritis & Rheumatology最新文献

{"title":"Stirring Up Plasma Cells in SLE","authors":"Georg Schett","doi":"10.1002/art.70200","DOIUrl":"https://doi.org/10.1002/art.70200","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"24 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147733286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of epigenetic trajectory with development of clinical rheumatoid arthritis in anti‐citrullinated protein antibody positive individuals: Targeting Immune Responses for Prevention of Rheumatoid Arthritis ( TIP ‐ RA )","authors":"E. Barton Prideaux, David L. Boyle, Eunice Choi, Jane H. Buckner, William H. Robinson, V. Michael Holers, Kevin D. Deane, Gary S. Firestein, Wei Wang","doi":"10.1002/art.70193","DOIUrl":"https://doi.org/10.1002/art.70193","url":null,"abstract":"Objective The presence of anti‐citrullinated protein antibodies (ACPAs) in the absence of clinical inflammatory arthritis (IA) identifies individuals at risk for rheumatoid arthritis (RA). We examined whether epigenetic remodeling of DNA methylation distinguishes those who ultimately develop RA (“Converters”) from individuals who remain asymptomatic (“Non‐converters”). Methods Genome‐wide DNA methylation was quantified in peripheral blood mononuclear cells separated into CD4 T memory and naïve cells and B cells collected at baseline and longitudinally over up to 5 years from anti‐CCP3+ “Converters” (n=21), anti‐CCP3+ “Non‐converters” (n=50), and anti‐CCP3‐ “Controls” (n=69), as well as “Early RA” patients (n=29). Differentially methylated loci (DMLs) were identified, followed by pathway enrichment analysis. Machine‐learning algorithms assessed the predictive value of individual CpG sites for future RA onset. Results At baseline, DMLs clearly separated Converters from Non‐converters and patients with Early RA. Among the pathways associated with differentially methylated genes, enrichment of aberrant NOTCH‐signaling and DNA‐repair pathways was particularly prominent in B‐cells. Longitudinally, methylomes remained stable in controls and Non‐converters but underwent progressive remodeling in Converters, tracing a “RA methylome trajectory” towards the Early RA methylome involving regulatory elements. Machine‐learning models incorporating top CpG predictors accurately classified future RA converters. Conclusion DNA methylation is a dynamic process that continuously remodels in asymptomatic anti‐CCP3–positive individuals as they progress to disease, while remaining relatively stable in Non‐converters and Controls. Progressive epigenetic remodeling during the trajectory from At‐Risk to clinical arthritis highlights pathogenic pathways and yields biomarkers that may inform prognostic testing and preventive intervention in preclinical RA.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"70 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147733621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"autoscoRA: Deep Learning to Automate Sharp/van der Heijde Scoring of Radiographic Damage in Rheumatoid Arthritis.","authors":"Thomas Deimel,Paul J Weiser,Martin Urschler,Christian Payer,Peter Mandl,Georg Langs,Daniel Aletaha","doi":"10.1002/art.70196","DOIUrl":"https://doi.org/10.1002/art.70196","url":null,"abstract":"OBJECTIVERegular imaging by conventional radiography to assess for joint damage is a cornerstone in the management of rheumatoid arthritis (RA). Scoring systems to quantify such damage, such as the widely used Sharp/van der Heijde (SvdH) score, are limited by the requirement of time and experienced staff as well as intra- and inter-rater variability. To alleviate these problems, autoscoRA, a fully automated scoring system to assign SvdH scores to radiographs of the hands and feet was developed.METHODSUsing the hitherto largest dataset of adult rheumatoid arthritis patients, autoscoRA, a deep learning-based system, was trained to automatically perform joint extraction and scoring of joint space narrowing and bone erosion.RESULTSThe dataset included 769 patients (155 of which in the test set) with 3437 visits (707) and 12144 radiographs (2507). The model reached excellent agreement with a human scorer for joint space narrowing, erosion, and combined scores both on the joint level and for summed total SvdH scores (ICC 0.9). On a subset of data scored by a second human reader, the model outperformed the former in terms of agreement with the first human reader. In addition, autoscoRA demonstrated good agreement with a human reader for detecting longitudinal progression of joint damage across different SvdH score cut-offs defining the presence of progression (average agreement of 70 %).CONCLUSIONAutomated systems like autoscoRA could be used to facilitate scoring of radiographic joint damage in clinical trials, registries and observational studies, and, eventually, routine clinical care.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"11 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Entering the Era of Somatic Variant Sequencing in Immune Dysregulation.","authors":"Willem Roosens,Catho Colson,Isabelle Meyts,Rik Schrijvers","doi":"10.1002/art.70199","DOIUrl":"https://doi.org/10.1002/art.70199","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"65 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-resolution deep learning DIXON MRI of the sacroiliac joints is non-inferior to standard MRI in patients with suspected axial Spondyloarthritis.","authors":"Dominik Deppe,Mariam Koka,Fabian Proft,Sevtap Tugce Ulas,Kay-Geert Hermann,Denis Poddubnyy,Mikhail Protopopov,Henriette Baum,Hildrun Haibel,Mehrgan Shahryari,Valeria Rios Rodriguez,Jens Vogel-Claussen,Torsten Diekhoff","doi":"10.1002/art.70195","DOIUrl":"https://doi.org/10.1002/art.70195","url":null,"abstract":"OBJECTIVETo compare the standard multi-sequence MRI protocol (sMRI) of the sacroiliac joints with a single high-resolution deep learning-reconstructed DIXON sequence (DL-DIXON) in patients with suspected axial spondyloarthritis (axSpA).METHODSSeventy-six patients with chronic low back pain and suspected axSpA underwent clinical, laboratory, and genetic assessment followed by 3T sMRI (T1, T2-FS, VIBE, STIR; 19:49 min) and high-resolution DL-DIXON imaging (1 mm isotropic; 5:24 min). Three blinded readers assessed overall imaging diagnosis, diagnostic confidence, and lesion presence (osteitis, fat metaplasia, erosions, sclerosis, joint space changes). DL was used solely for image reconstruction. The clinical diagnosis served as the reference for diagnostic accuracy; sMRI served as the reference for lesion analysis. Diagnostic accuracy was expressed as AUC (balanced accuracy). Non-inferiority was tested using a predefined margin of 0.05. A decrease of ≤0.05 compared to sMRI was defined as clinically acceptable.RESULTSNineteen patients were diagnosed with axSpA. DL-DIXON showed similar diagnostic performance (AUC 0.86 [95% CI 0.76-0.96]) compared to sMRI (0.87 [0.78-0.96]) and met non-inferiority criteria. Interreader agreement was almost perfect for sMRI (κ = 0.81) and substantial for DL-DIXON (κ = 0.71). At the lesion level, DL-DIXON achieved good performance for erosions (AUC 0.83), fat metaplasia (0.80), and joint space changes (0.80), and fair performance for osteitis (0.73) and sclerosis (0.64). Using DL-DIXON, scan time was reduced by 73%.CONCLUSIONSDL-DIXON provides clinically acceptable diagnostic performance while substantially reducing scan time. This approach may improve efficiency and accessibility of MRI for axSpA assessment.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"324 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147726075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-33 Promotes Interstitial Lung Disease in Idiopathic Inflammatory Myopathy via ERK-Mediated EMT.","authors":"Jumei Yang,Wenjun Li,Jiarui Zhu,Xi Cui,Hui Chai,Qiyan Su,Yingyue Feng,Sigong Zhang","doi":"10.1002/art.70198","DOIUrl":"https://doi.org/10.1002/art.70198","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"17 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Repair of Atlantoaxial Joint Destruction in Rheumatoid Arthritis with IL ‐6 Blockade","authors":"Satoshi Yamaguchi, Takafumi Onose, Masaru Kato","doi":"10.1002/art.70191","DOIUrl":"https://doi.org/10.1002/art.70191","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"135 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147719636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A painful bipartite patella","authors":"Olivier Fakih, Frank Verhoeven, Clément Prati, Daniel Wendling","doi":"10.1002/art.70192","DOIUrl":"https://doi.org/10.1002/art.70192","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"14 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147719634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clock genes regulate Ca2+ signaling and mitochondrial bioenergetics to inhibit Sjogren's disease.","authors":"Viktor R Drel,Manigandan Venkatesan,Rahul S Jasrotia,Yuyang Sun,Viviane Nascimento Da Conceicao,Neelanjan Vishnu,Shankara N Varadarajan,Venugopal R Bovilla,Rajender K Motiani,Shobhan Gaddameedhi,Bibhuti B Mishra,Muniswamy Madesh,Brij B Singh","doi":"10.1002/art.70183","DOIUrl":"https://doi.org/10.1002/art.70183","url":null,"abstract":"OBJECTIVEAlthough Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjogren's disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood.METHODSFluorescence-based Ca2+ imaging, RNA seq, and mitochondrial activity were used to investigate the effects of circadian rhythm and in salivary gland dysfunction. Critical findings were confirmed by studying mouse models of SjD and human salivary gland samples.RESULTSWe identified that Ca2+ entry is essential in modulating Clock genes and circadian rhythm, which also modulate salivary gland secretion and the expression of Stim and Orai genes. Mechanistically, our data show that Bmal2 binding in the promoter region of Stim1 modulates its expression, thereby regulating Ca2+ entry, mitochondrial bioenergetics, and providing cyclic rhythm-mediated regulation of cellular physiology. To assess Ca2+-dependent circadian rhythms, we used diet perturbation, where a Ca2+-deficient diet specifically impacts the Clock gene's rhythm, which was reversed by Ca2+ supplementation. Circadian rhythm-mediated regulation of fluid secretion, as well as STIM1 genes, was also altered in an SjD mouse model. In addition, human SjD patients also showed dysregulation of CLOCK and STIM1 genes, which could alter salivary physiology, leading to the development of the SjD phenotype.CONCLUSIONOur results provide the first comprehensive evidence of a reciprocal relationship between circadian rhythm, Ca2+ signaling, and metabolism, which is critical for cellular physiology and disease development/progression.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"29 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147719590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative Multi-omics Approaches Identify Biomarkers Associated with Progression from Arthralgia to Rheumatoid Arthritis.","authors":"Min Li,Yipeng Han,Minghua Zhan,Xiaomei Zhang,Haoxiang Wang,Xi Wang,Xuyang Zhao,Gong Cheng,Siyue Yu,Bo Huang,Rui Yan,Qinghong Liu,Xiaoyan Xing,Sitian Zang,Jing Chi,Yuebo Jin,Yuan Jia,Yin Su,Qingwen Wang,Xiaobo Yu,Zhanguo Li,Yudong Liu,Jing He","doi":"10.1002/art.70194","DOIUrl":"https://doi.org/10.1002/art.70194","url":null,"abstract":"BACKGROUNDArthralgia, an early manifestation preceding definite rheumatoid arthritis (RA), represents a critical window to identify high-risk individuals and implement timely interventions. However, the immunopathological mechanisms underlying the transition from arthralgia to established RA remain incompletely defined.METHODSWe employed a multi-omics strategy integrating peripheral immune cell phenotyping, serum proteomics, and autoantibody profiling to investigate the immunopathological continuum from preclinical to established RA. A prospective cohort of 346 patients with recent-onset arthralgia was enrolled. Participants included healthy controls, self-limiting arthralgia (SLA), arthralgia at risk of RA (ARI), early RA, and established RA. RA development in ARI was ascertained through 24-month follow-up.RESULTSCompared with SLA, ARI showed immune dysregulation, including reduced Tregs and a lower Treg/Th17 ratio, with related changes persisting into early RA. Serum proteomics revealed upregulation of C5, A1BG, RPUSD4, WDR87 and FUBP2, which showed inverse associations with Tregs. Autoantibody profiling identified stage-specific reactivity, with ARI showing elevated antibodies against stress-related proteins. Within 24 months, 18.4% of ARI progressed to RA (converters). Baseline immunophenotypic differences between converters and non-converters were comparable, while longitudinal paired analyses revealed a reduction in Tregs and Treg/Th17 ratio. Treg/Th17 ratio (AUC = 0.734) outperformed anti-CCP (AUC = 0.611) in discriminating ARI from SLA, particularly in ACPA-negative patients (AUC = 0.729). Combining Tregs, anti-CCP and Treg/Th17 ratio improved classification performance (AUC = 0.783).CONCLUSIONSThese findings delineate a critical transition from reversible immune dysregulation to established autoimmunity along the arthralgia-RA continuum, suggesting that Treg-related dysregulation may be associated with progression toward persistent inflammatory arthritis.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"16 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}