Arthritis & Rheumatology最新文献

{"title":"Pregnancy outcomes in women with systemic sclerosis before and/or after diagnosis, and by parity - A Swedish population-based cohort study.","authors":"Weng Ian Che,Luigi Annicchiarico,Laura Andreoli,Olof Stephansson,Marie Holmqvist,Karin Hellgren","doi":"10.1002/art.43312","DOIUrl":"https://doi.org/10.1002/art.43312","url":null,"abstract":"OBJECTIVETo assess risks of adverse pregnancy outcomes (APO) in a contemporary cohort of women with systemic sclerosis (SSc) in relation to the timing of SSc diagnosis and by parity.METHODSFrom the nationwide Swedish Medical Birth Register, we assembled pregnancies with births in women with SSc and in comparator women from the general population 1998-2021. We classified pregnancies according to the timing of SSc diagnosis at birth: post-SSc; after SSc diagnosis (n=94), and pre-SSc; 0-3 years (n=39) or >3 years (n=839) before diagnosis of SSc. We used regression models estimating relative risks (RR) of APO in post-SSc, and odds ratios (OR) in pre-SSc pregnancies with 95% confidence interval (CI), respectively.RESULTSFor post-SSc pregnancies, RR of preeclampsia (3.8; 1.8-7.8), preterm birth (3.3; 1.8-6.1), and caesarean delivery (2.5; 1.8-3.5) were increased. By contrast, there were no indications of increased proportions of maternal or neonatal death, nor stillbirth. Stratifying on parity, risks were considerably higher among primiparous post-SSc women; RR of preeclampsia (7.5; 3.5-16.1) and of preterm birth (5.1; 2.5-10.5). We also noted increased odds of APO in pre-SSc pregnancies, with the highest estimates in the 0-3 years pre-SSc pregnancies.CONCLUSIONContemporary women with SSc displayed markedly increased risks of several APO after SSc diagnosis; the risk of some APO was already increased before diagnosis, particularly within 3 years. Our findings suggest that both preclinical and overt SSc have a substantial impact on pregnancy outcomes, especially in the first pregnancy, highlighting the importance of specialized care and close monitoring.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"33 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monocyte-derived macrophages-synovial fibroblasts crosstalk unravels oncostatin signaling network as a driver of synovitis in osteoarthritis.","authors":"Damien Laouteouet,Olivier Bortolotti,Léa Marineche,Nicole Hannemann,Manon Chambon,Yaël Glasson,Anne-Sophie Dumé,Julien De Lima,Maud Fournial,Dylan Touchet,Dany Séverac,Felicia Leccia,Christophe Duperray,Henri-Alexandre Michaud,Farida Djouad,Benoît Le Goff,Frédéric Blanchard,Florence Apparailly,Gabriel Courties","doi":"10.1002/art.43299","DOIUrl":"https://doi.org/10.1002/art.43299","url":null,"abstract":"OBJECTIVEOsteoarthritis (OA) is a debilitating joint disease characterized by cartilage degradation, synovial inflammation, and pain. Macrophages have been implicated in OA pathology, but the origins and functions of diverse macrophage subsets seeding the synovial joint tissue remain incompletely understood. This study investigates macrophage heterogeneity, ontogeny, fate, and communication with stromal niche cells in OA.METHODSSingle-cell RNA sequencing was employed on synovial cells isolated from mice with collagenase-induced OA (CiOA) and CD14+ macrophages from four OA patients. We combined flow cytometry, genetic fate mapping, and imaging mass cytometry to profile synovial macrophage subsets. Cell-cell communication analyses were performed to investigate interactions cellular networks.RESULTSThree macrophage subsets with distinct gene signatures and origins were identified in CiOA, including contributions to synovial inflammation and tissue remodeling. Fate mapping via CCR2-creER and CX3CR1-creER mice revealed the expansion of monocyte-derived TIM4- MHCIIlow/high macrophages. Monocyte-independent TIM4+ CX3CR1+ macrophages operated a synovial niche shift, migrating near vascularized structures in the synovial sub-intima. Notably, the OSM/OSMR signaling network emerged as a critical pathway linking recruited CCR2-derived macrophages to fibroblast activation. In individuals with OA, single-cell transcriptomics identified a conserved MertKlow CD48high CCR2pos macrophage subpopulation as a key source of OSM.CONCLUSIONOur study provides insights into macrophage subsets and their interplay with the joint microenvironment, bridging the gap between their origins, transcriptomic profiles, and roles in OA. Specifically, the OSM/OSMR axis represents a pivotal mechanism in recruited macrophage-fibroblast crosstalk, offering potential targets for novel biomarkers and therapies to manage OA-related synovitis.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"2 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibodies targeting G protein-coupled receptors in systemic sclerosis. Comment on the article by van Oostveen WM et al.","authors":"Reza Akbarzadeh,Alexander Hackel,Jens Y Humrich,Kristina Kusche-Vihrog,Gabriela Riemekasten","doi":"10.1002/art.43300","DOIUrl":"https://doi.org/10.1002/art.43300","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"78 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence to Efficacy of a Tumor Necrosis Factor Inhibitor in Chronic Low‐Back Pain With Modic Type 1 Changes: A Randomized Controlled Trial","authors":"Qu Zheng, Bao‐qiang DONG, Xingxing Lin, Yiyan Han","doi":"10.1002/art.43308","DOIUrl":"https://doi.org/10.1002/art.43308","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"47 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Connections","authors":"","doi":"10.1002/art.43282","DOIUrl":"https://doi.org/10.1002/art.43282","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"77 7","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/art.43282","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Circulating and Synovial Immune Cells in Early Untreated Rheumatoid Arthritis and their relationship with molecular pathology and disease outcomes: Comment on the Article by Rivellese et al.","authors":"Chun‐Chieh Chen, Shiuan‐Chih Chen","doi":"10.1002/art.43304","DOIUrl":"https://doi.org/10.1002/art.43304","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"27 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Comment on ‘Comparative Analysis of Circulating and Synovial Immune Cells in Early Untreated Rheumatoid Arthritis and their relationship with molecular pathology and disease outcomes’","authors":"Felice Rivellese, Elena Pontarini, Costantino Pitzalis","doi":"10.1002/art.43307","DOIUrl":"https://doi.org/10.1002/art.43307","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"46 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic autoimmune rheumatic disease risk is associated with long‐term exposure to fine particulate matter: Comment on the Article by Geslin et al.","authors":"Shiuan‐Chih Chen, Chun‐Chieh Chen","doi":"10.1002/art.43301","DOIUrl":"https://doi.org/10.1002/art.43301","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"33 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Absence of functional autoantibodies in systemic sclerosis: is now the right time to broaden reactome analysis? Comment on “Absence of Functional Autoantibodies Targeting Angiotensin II Receptor Type 1 and Endothelin‐1 Type A Receptor in Circulation and Purified IgG From Patients With Systemic Sclerosis” published in Arthritis Rheumatology.","authors":"Aurélien Chepy, Sylvain Dubucquoi, David Launay, Vincent Sobanski","doi":"10.1002/art.43305","DOIUrl":"https://doi.org/10.1002/art.43305","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"35 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor on “2024 American College of Rheumatology (ACR) Guideline for the Screening, Treatment, and Management of Lupus Nephritis”","authors":"Luciana P C Seguro, Eloisa Bonfa","doi":"10.1002/art.43306","DOIUrl":"https://doi.org/10.1002/art.43306","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"51 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}