{"title":"细胞因子通路驱动不同组织病理在类风湿关节炎。","authors":"Aurelie Najm,Lyn D Ferguson,Iain B McInnes","doi":"10.1002/art.43376","DOIUrl":null,"url":null,"abstract":"Rheumatoid arthritis is a complex systemic disorder characterised primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra-articular disease e.g. of the lung with potentially devastating clinical consequences. The critical importance of co-morbidities, and consequent multi-morbidity, in determining outcomes in RA has now been recognised, not least as novel therapeutics have emerged with attendant increased life expectancy. The primary role of cytokine networks in mediating RA pathogenesis was established in extensive pre-clinical and clinical trials and in the adoption of cytokine targeted therapeutics in clinical care over three decades. Herein we briefly review those pivotal cytokine pathways that are associated with RA articular disease, and extend these insights to include extra-articular RA and its common co-morbidities.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"71 1","pages":""},"PeriodicalIF":10.9000,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cytokine pathways driving diverse tissue pathologies in rheumatoid arthritis.\",\"authors\":\"Aurelie Najm,Lyn D Ferguson,Iain B McInnes\",\"doi\":\"10.1002/art.43376\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Rheumatoid arthritis is a complex systemic disorder characterised primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra-articular disease e.g. of the lung with potentially devastating clinical consequences. The critical importance of co-morbidities, and consequent multi-morbidity, in determining outcomes in RA has now been recognised, not least as novel therapeutics have emerged with attendant increased life expectancy. The primary role of cytokine networks in mediating RA pathogenesis was established in extensive pre-clinical and clinical trials and in the adoption of cytokine targeted therapeutics in clinical care over three decades. Herein we briefly review those pivotal cytokine pathways that are associated with RA articular disease, and extend these insights to include extra-articular RA and its common co-morbidities.\",\"PeriodicalId\":129,\"journal\":{\"name\":\"Arthritis & Rheumatology\",\"volume\":\"71 1\",\"pages\":\"\"},\"PeriodicalIF\":10.9000,\"publicationDate\":\"2025-09-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Arthritis & Rheumatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/art.43376\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arthritis & Rheumatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/art.43376","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
Cytokine pathways driving diverse tissue pathologies in rheumatoid arthritis.
Rheumatoid arthritis is a complex systemic disorder characterised primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra-articular disease e.g. of the lung with potentially devastating clinical consequences. The critical importance of co-morbidities, and consequent multi-morbidity, in determining outcomes in RA has now been recognised, not least as novel therapeutics have emerged with attendant increased life expectancy. The primary role of cytokine networks in mediating RA pathogenesis was established in extensive pre-clinical and clinical trials and in the adoption of cytokine targeted therapeutics in clinical care over three decades. Herein we briefly review those pivotal cytokine pathways that are associated with RA articular disease, and extend these insights to include extra-articular RA and its common co-morbidities.
期刊介绍:
Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.