Cytokine pathways driving diverse tissue pathologies in rheumatoid arthritis.

IF 10.9 1区 医学 Q1 RHEUMATOLOGY
Aurelie Najm,Lyn D Ferguson,Iain B McInnes
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引用次数: 0

Abstract

Rheumatoid arthritis is a complex systemic disorder characterised primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra-articular disease e.g. of the lung with potentially devastating clinical consequences. The critical importance of co-morbidities, and consequent multi-morbidity, in determining outcomes in RA has now been recognised, not least as novel therapeutics have emerged with attendant increased life expectancy. The primary role of cytokine networks in mediating RA pathogenesis was established in extensive pre-clinical and clinical trials and in the adoption of cytokine targeted therapeutics in clinical care over three decades. Herein we briefly review those pivotal cytokine pathways that are associated with RA articular disease, and extend these insights to include extra-articular RA and its common co-morbidities.
细胞因子通路驱动不同组织病理在类风湿关节炎。
类风湿性关节炎是一种复杂的全身性疾病,其主要特征是关节炎症和破坏,伴有相关的功能丧失和生活质量下降。类风湿性关节炎还与关节外疾病有关,例如肺部疾病,具有潜在的破坏性临床后果。现在已经认识到,合并症和随之而来的多发病在决定RA预后方面的关键重要性,尤其是随着新治疗方法的出现,预期寿命也随之增加。细胞因子网络在类风湿关节炎发病机制中的主要作用是在广泛的临床前和临床试验以及在临床护理中采用细胞因子靶向治疗中建立的。在此,我们简要回顾了与类风湿性关节炎关节疾病相关的关键细胞因子通路,并将这些见解扩展到关节外类风湿性关节炎及其常见合并症。
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来源期刊
Arthritis & Rheumatology
Arthritis & Rheumatology RHEUMATOLOGY-
CiteScore
20.90
自引率
3.00%
发文量
371
期刊介绍: Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.
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