Hepato-gastroenterology最新文献_第4页

Correlation of computed tomography imaging features and pathological features of 41 patients with pancreatic neuroendocrine tumors. 41例胰腺神经内分泌肿瘤的ct影像特征与病理特征的相关性分析。

Hepato-gastroenterology Pub Date : 2015-03-01 DOI: 10.5754/HGE14388

M. Utsumi, Y. Umeda, K. Takagi, Kuise Takashi, D. Nobuoka, R. Yoshida, S. Shinoura, H. Sadamori, T. Yagi, T. Fujiwara

{"title":"Correlation of computed tomography imaging features and pathological features of 41 patients with pancreatic neuroendocrine tumors.","authors":"M. Utsumi, Y. Umeda, K. Takagi, Kuise Takashi, D. Nobuoka, R. Yoshida, S. Shinoura, H. Sadamori, T. Yagi, T. Fujiwara","doi":"10.5754/HGE14388","DOIUrl":"https://doi.org/10.5754/HGE14388","url":null,"abstract":"BACKGROUND/AIMS\u0000Pancreatic neuroendocrine tumors (PNET) are relatively rare. Here, we present clinical and pathological characteristics of PNETs to show a relationship between computed tomography (CT) imaging and the 2010 World Health Organization (WHO) classification.\u0000\u0000\u0000METHODOLOGY\u0000We retrospectively reviewed the records of 41 PNET patients who were treated between 2002 and 2012. All tumors were classified as neuroendocrine tumor (NET) grade 1 (G1), NET grade 2 (G2), or neuroendocrine carcinoma (NEC) grade 3 (G3) on the basis of the 2010 WHO classification system.\u0000\u0000\u0000RESULTS\u0000Twenty-five tumors were classified as G1, 11 as G2, and five as G3. Mean sizes of the G1, G2 and G3 tumors were 1.84 ± 0.54, 4.90 ± 0.84, and 5.62 ± 1.18 cm, respectively, (P < 0.01). A PNET is typically hypervascular and exhibits contrast enhancement on enhanced CT. Higher percentage of G1 tumors demonstrated typical imaging and showed a significantly greater distinct mass compared with G2 and G3 tumors.\u0000\u0000\u0000CONCLUSIONS\u0000Although PNET has many imaging features that appear on CT, G2 and G3 tumors often show atypical imaging features, particularly with large sizes and/or ill-defined features, when compared with G1 tumors. If a PNET has atypical imaging features, possibility of malignancy should be considered.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"16 1","pages":"441-6"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71081571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Tumor-to-muscle ratio of 8F-FDG PET for predicting histologic features and recurrence of HCC. 8F-FDG PET的肿瘤-肌肉比预测HCC的组织学特征和复发。

Hepato-gastroenterology Pub Date : 2015-03-01

Yang Hyun Baek, Sung-Wook Lee, Young-Jin Jeong, Jin-Sook Jeong, Young-Hoon Roh, Sang-Young Han

{"title":"Tumor-to-muscle ratio of 8F-FDG PET for predicting histologic features and recurrence of HCC.","authors":"Yang Hyun Baek, Sung-Wook Lee, Young-Jin Jeong, Jin-Sook Jeong, Young-Hoon Roh, Sang-Young Han","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: Hepatocellular carcinoma (HCC) recurrence is observed in up to 70-80% of patients despite a curative treatment. Microvascular invasion (MVI) and poor differentiation are strong risk factors for recurrence, but these cannot be known preoperatively. The aim of this study was to investigate the correlation of 18F-FDG PET with MVI and differentiation, and predictive role of tumor-to-background ratio of PET for recurrence in HCC.Methodology: Fifty-four patients had 18F-FDG PET/CT study before surgical resection as a first treatment of HCC between December 2008 and December 2012. We analyzed the predictive role of metabolic parameters of PET for recurrence of HCC. Maximal standardized uptake value, tumor-to-nontumor ratio, tumor-to-muscle ratio (TMR) and tumor-to-blood ratio were tested as metabolic index of 18F-FDG PET.Results: Twenty-seven patients had increased uptake in preoperative PET and 14 (51.9%) of them experienced the recurrence. Increased uptake in PET and TMR were associated with MVI (p = 0.04, p = 0.005) and histologic differentiation (p = 0.018, p = 0.002). MVI was the only predictive factor for re- currence in multivariate analysis although TMR ≥ 6.36 showed a favorable result despite no statistical significance (p = 0.061).Conclusions: Increased 18F-FDG uptake of HCC, especially high TMR might be correlated with MVI and poor differentiation, and tends to have a risk for recurrence in HCC.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 138","pages":"383-8"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33134077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emergent triglyceride-lowering therapy for hypertriglyceridemic pancreatitis. 紧急降低甘油三酯治疗高甘油三酯血症性胰腺炎。

Hepato-gastroenterology Pub Date : 2015-03-01

Wenhua He, Nonghua Lu

{"title":"Emergent triglyceride-lowering therapy for hypertriglyceridemic pancreatitis.","authors":"Wenhua He, Nonghua Lu","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: Hypertriglyceridemia (HTG) is recognized as a main cause of acute pancreatitis. The clinical course of hypertriglyceridemic pancreatitis (HTGP) is usually severe and often associated with complications. Patients with HTGP need therapeutic strategies aimed at rapidly reducing triglyceride (TG) serum levels. Here we review the effects of Emergent triglyceride-lowering therapies as well as their ad vantages and controversies.Methodology: PubMed and MEDLINE were searched for articles using the keywords hypertriglyceridemia\", \"hyperlipidemia and \"pancreatitis until September 2012.Results: In sulin is a non-invasive, economic and safe treatment but the efficiency of insulin is still limited. Combined use of insulin and heparin, especially low molecular weight heparin (LMWH), remains an acceptable therapeutic option in early stages of HTGP. Therapeutic plasma exchange (TPE) and double-filtration (DF) provides a direct option for the removal of pathogenic substances. However, both of these therapies are expensive and not widely available, and TPE has risks for infection and allergic reactions. Medium chain triglycerides, omega-3-fatty acids, fibrates, niacin, microsomal transport protein inhibitors and gene therapy may be potential adjuvant therapies for achieving per- manent control of HTGP.Conclusions: Insulin, LMWH combined with insulin, TPE and DF could be used as emergent therapies for HTCP.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 138","pages":"429-34"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33252307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of GLP-1 analogue on oxidative damage and hepatic regeneration in experimental 70% hepatectomy model. GLP-1类似物对实验性70%肝切除模型氧化损伤和肝再生的影响。

Hepato-gastroenterology Pub Date : 2015-03-01

Muharrem Battal, Bulent Çitgez, Abdulcabbar Kartal, Ahu Kemik, Pinar Yildirim, Yasar Ozdenkaya, Ahmet Yilmaz, Oguzhan Karatepe

{"title":"Impact of GLP-1 analogue on oxidative damage and hepatic regeneration in experimental 70% hepatectomy model.","authors":"Muharrem Battal, Bulent Çitgez, Abdulcabbar Kartal, Ahu Kemik, Pinar Yildirim, Yasar Ozdenkaya, Ahmet Yilmaz, Oguzhan Karatepe","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: The purpose of our study is researching into impact of glucagon like peptide 1 (GLP 1) analogue on liver regeneration after major hepatectomy.Methodology: 24 wistar albino rats were consecutively divided into 3 groups. Group 1: Control (sham) group day 14 (n = 8), Group 2: Liver resection group day 14 (n = 8); 70% Liver resection was performed, Group 3: Study group day 14 (n = 8); Subsequent to performing 70% liver resection, GLP-1 analogue was administered 2 times a day. (10 μgr/70 kg x 2 times). After 14 day, rats were sacrificed. Oxi- dative stress and antioxidant enzymes and mitochon- drial permeability transition, cytochrome-c, Bax, Bcl- 2, caspase-3, caspase-8 and caspase-3 activity were examined.Results: 70% Liver resection induced oxi- dative stress of liver tissue was ameliorated by GLP-1 induction. Administration of GLP increased Bcl-2 ex- pression. Decreased expression of cytochrome-c was accompanied by a decrease caspase-3, caspase-8, and Bax expression and caspase-3 activity.Conclusions: Glp 1 induction plays a regenerative role in the major hepatectomy. This effect is dependent on modulation of the antiapoptotic and antioxidative pathways by GLP 1 expression.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 138","pages":"257-60"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33253464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

C-reactive protein level as a possible predictor for early postoperative ileus following elective surgery for colorectal cancer. c反应蛋白水平可作为结肠直肠癌择期手术后早期肠梗阻的预测指标。

Hepato-gastroenterology Pub Date : 2015-03-01

Takaaki Fujii, Toshinaga Sutoh, Wakako Kigure, Hiroki Morita, Toshihide Katoh, Reina Yajima, Soichi Tsutsumi, Takayuki Asao, Hiroyuki Kuwano

{"title":"C-reactive protein level as a possible predictor for early postoperative ileus following elective surgery for colorectal cancer.","authors":"Takaaki Fujii, Toshinaga Sutoh, Wakako Kigure, Hiroki Morita, Toshihide Katoh, Reina Yajima, Soichi Tsutsumi, Takayuki Asao, Hiroyuki Kuwano","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: Inflammatory reactions are par- tially responsible for postoperative ileus (POI). Serum C-reactive protein (CRP) is an acknowledged marker of inflammation. In this study the CRP response with respect to POI in elective colorectal surgery was exam- ined to define the role of serum CRP as an early predic- tor of POI.Methodology: Three hundred eighty-three patients who underwent elective colorectal resection were identified for inclusion in this study. We defined early POI as that occurring within 30 days following the surgery. Thirty-five patients with POI were com- pared to a subgroup of 348 patients with an unevent- ful postoperative course, and the correlation between postoperative serum CRP levels and POI in colorectal surgery was investigated.Results: In the univariate analysis, length of operation, surgical blood loss, and serum CRP were factors significantly associated with POI following colorectal surgery; however, these fac- tors lost their significance on multivariate analysis.Conclusion: Our results suggest that an increase in CRP levels alone is not a predictor for POI following surgery for colorectal surgery. Although inflammatory responses are known to contribute to the ileus, ad- ditional study is required to identify risk factors that would be more useful for prediction of POI.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 138","pages":"283-5"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33253470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perioperative administration of Daikenchuto (TJ-100) reduces the postoperative paralytic ileus in patients with pancreaticoduodenectomy. 围手术期给予大根泻(TJ-100)可减少胰十二指肠切除术患者术后麻痹性肠梗阻。

Hepato-gastroenterology Pub Date : 2015-03-01

Ken-Ichi Okada, Manabu Kawai, Seiko Hirono, Motoki Miyazawa, Atsushi Shimizu, Yuji Kitahata, Hiroki Yamaue

{"title":"Perioperative administration of Daikenchuto (TJ-100) reduces the postoperative paralytic ileus in patients with pancreaticoduodenectomy.","authors":"Ken-Ichi Okada, Manabu Kawai, Seiko Hirono, Motoki Miyazawa, Atsushi Shimizu, Yuji Kitahata, Hiroki Yamaue","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: No study has reported whether perioperative administration of Daikenchuto (TJ-100) reduced paralytic ileus after pancreaticoduodenectomy (PD).Methodology: Forty-five consecutive patients that were scheduled to undergo PD at Wakayama Medical University Hospital between August 2010 and August 2011 were enrolled in this study including the first cohort (n = 15) as the control group and the subsequent cohort (n = 30) as the TJ-100 group. This trial was registered at UMIN-CTR ID# 000005056.Results: Postoperative paralytic ileus occurred more frequently in the control group (73.3% of the control group and 20.0% of the TJ-100 group; p = 0.001). The first passages of flatus significantly improved earlier in the TJ-100 group than in the control group (p = 0.014). A multiple cytokine assay of the drainage and serum showed that IL-9 and IL-10 in the drainage was significantly higher on postoperative day 1 in the TJ-100 group. There were no complications associated with the preoperative administration of TJ-100 before surgery, and no significant differences were observed between the two groups in the incidence of postoperative Gradel-2 diarrhea (CTCAE4.0).Conclusions: Perioperative administration of TJ-100 was feasible and reduced the incidence of paralytic ileus in PD, and further randomized controlled trials should be conducted.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 138","pages":"466-71"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33254688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early effects of oral administration of esomeprazole and omeprazole on the intragastric pH. 口服埃索美拉唑和奥美拉唑对胃内pH值的早期影响。

Hepato-gastroenterology Pub Date : 2015-03-01

Hiroshi Iida, Masahiko Inamori, Kotone Okuno, Yusuke Sekino, Eiji Sakai, Hidenori Okubo, Takuma Higurashi, Hiroki Endo, Kunihiro Hosono, Masato Yoneda, Tomoko Koide, Hirokazu Takahashi, Ayumu Goto, Kensuke Kubota, Satoru Saito, Shin Maeda, Atsushi Nakajima, Eiji Gotoh

{"title":"Early effects of oral administration of esomeprazole and omeprazole on the intragastric pH.","authors":"Hiroshi Iida, Masahiko Inamori, Kotone Okuno, Yusuke Sekino, Eiji Sakai, Hidenori Okubo, Takuma Higurashi, Hiroki Endo, Kunihiro Hosono, Masato Yoneda, Tomoko Koide, Hirokazu Takahashi, Ayumu Goto, Kensuke Kubota, Satoru Saito, Shin Maeda, Atsushi Nakajima, Eiji Gotoh","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral dose of a proton pump inhibitor, esomeprazole 20 mg and omeprazole 20 mg.Methodology: A total of 14 Helicobacter pylori-negative male subjects participated in this study. Intragastric pH was monitored continuously for 6 hours after a single oral dose of omeprazole 20 mg and a single oral dose of esomeprazole 20 mg. Each administration was separated by a 7-day washout period.Results: During the 6-hour study period, the average pH after administration of esomeprazole was higher than that after the administration of omeprazole. Also during the 6-hour study period, each of pH > 2, 3, 3.5, 4, and 5 was maintained for a longer duration after administration of esomeprazole 20 mg than after administration of omeprazole 20 mg (median: 75.4% vs. 53.8%, p = 0.0138; 52.1% vs. 33.4%, p = 0.0188; 45.8% vs. 28.2%, p = 0.0262; 42.5% vs. 20.7%, p = 0.0414; 35.8% vs. 11.6%, p = 0.0262; respectively).Conclusions: In Helicobacter pylori-negative healthy male subjects, single oral administration of esomeprazole 20 mg increased the intragastric pH more rapidly than single oral administration of omeprazole 20 mg.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 138","pages":"493-6"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33254692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of AGBL2 on cell proliferation and chemotherapy resistance of gastric cancer. AGBL2对胃癌细胞增殖及化疗耐药的影响。

Hepato-gastroenterology Pub Date : 2015-03-01

Haitao Zhu, Zhichao Zheng, Jianjun Zhang, Xiaoping Liu, Yang Liu, Wei Yang, Yong Liu, Tao Zhang, Yan Zhao, Yanqing Liu, Xiaohui Su, Xiaohu Gu

{"title":"Effects of AGBL2 on cell proliferation and chemotherapy resistance of gastric cancer.","authors":"Haitao Zhu, Zhichao Zheng, Jianjun Zhang, Xiaoping Liu, Yang Liu, Wei Yang, Yong Liu, Tao Zhang, Yan Zhao, Yanqing Liu, Xiaohui Su, Xiaohu Gu","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: The present study aimed to investigate the expression status of AGBL2 and its inhibitor latexin, and elucidate their clinical implications in gastric cancer.Methodology: AGBL2 expression status was examined in gastric cancer cells and 256 gastric cancer specimens by immunohistochemistry staining. The relationship between AGBL2 protein expression and clinicopathological parameters and prognosis was subsequently determined.Results: AGBL2 expression was determined to be related to pathological tumor and nodal stages by Spearman's regression correlation analysis. The Cox regression test identified AGBL2 protein expression as an independent prognostic factor. AGBL2 and latexin were- found to be related to proliferation and chemotherapy resistance. The 2 proteins also formed immune com- plexes in immunoprecipitation experiments.Conclusions: Our results demonstrate that AGBL2 interacts with latexin, regulating the tubulin tyrosination cycle. It is therefore a potential target for intervention.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 138","pages":"497-502"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33254693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lymph node ratio may predict relapse free survival and overall survival in patients with stage II & III colorectal carcinoma. 淋巴结比例可以预测II期和III期结直肠癌患者的无复发生存期和总生存期。

Hepato-gastroenterology Pub Date : 2015-03-01

Jamal Zekri, Imran Ahmad, Ehab Fawzy, Tawfik R Elkhodary, Aboelkhair Al-Gahmi, Ashraf Hassouna, Mohamed E El Sayed, Jalil Ur Rehman, Syed M Karim, Bakr Bin Sadiq

{"title":"Lymph node ratio may predict relapse free survival and overall survival in patients with stage II & III colorectal carcinoma.","authors":"Jamal Zekri, Imran Ahmad, Ehab Fawzy, Tawfik R Elkhodary, Aboelkhair Al-Gahmi, Ashraf Hassouna, Mohamed E El Sayed, Jalil Ur Rehman, Syed M Karim, Bakr Bin Sadiq","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: Lymph node ratio (LNR) defined as the number of lymph nodes (LNs) involved with metastases divided by number of LNs examined, has been shown to be an independent prognostic factor in breast, stomach and various other solid tumors. Its significance as a prognostic determinant in colorectal cancer (CRC) is still under investigation. This study investigated the prognostic value of LNR in patients with resected CRC.Methodology: We retrospectively ex- amined 145 patients with stage II & III CRC diagnosed and treated at a single institution during 9 years pe- riod. Patients were grouped according to LNR in three groups. Group 1; LNR < 0.05, Group 2; LNR = 0.05-0.19 & Group 3 > 0.19. Chi square, life table analysis and multivariate Cox regression were used for statistical analysis.Results: On multivariate analysis, number of involved LNs (NILN) (HR = 1.15, 95% CI 1.055-1.245; P = 0.001) and pathological T stage (P = 0.002) were statistically significant predictors of relapse free survival (RFS). LNR as a continuous variable (but not as a categorical variable) was statistically significant predictor of RFS (P = 0.02). LNR was also a statistically significant predictor of overall survival (OS) (P = 0.02).Conclusion: LNR may predict RFS and OS in patients with resected stage II & III CRC. Studies with larger cohorts and longer follow up are needed to further examine and validate theprognostic value of LNR.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 138","pages":"291-4"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33255013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of anesthetic techniques on survival for patients with colorectal cancer: evidence based on six studies. 麻醉技术对结直肠癌患者生存的影响:基于六项研究的证据。

Hepato-gastroenterology Pub Date : 2015-03-01

Xizhi Sun, Changzhao Yang, Kezhong Li, Suchun Ding

{"title":"The impact of anesthetic techniques on survival for patients with colorectal cancer: evidence based on six studies.","authors":"Xizhi Sun, Changzhao Yang, Kezhong Li, Suchun Ding","doi":"","DOIUrl":"","url":null,"abstract":"Background/aims: Epidural-supplemented general anesthesia is perceived as a more beneficial method over general anesthesia since it reduces incidence of side effects, provides better postoperative pain relief and lowers the possibility to use immunosuppressive anesthetics. However, previous prospective and retrospective studies reported conflicting results in the effects of epidural anesthesia on post-operative outcomes of colorectal cancer surgery. Therefore, this study aims to pool available evidence to assess the association between epidural anesthesia and the post- operative outcomes in this group of patients.Methodology: Relevant studies were searched in databases and a meta-analysis was performed to estimate the association between epidural anesthesia and overall survival and recurrence free survival.Results: Compared with the anesthetic choice without epidural anesthesia, epidural-supplemented anesthesia is associated with significantly longer overall survival (HR: 0.72, 95% CI: 0.55-0.94, p = 0.01) but not with prolonged recurrence free survival (HR: 1.06, 95% CI: 0.96-1.16, p = 0.23). These results showed a highlevel of robustness in sensitive test.Conclusion: Although epidural anesthesia might not lead to improved recurrence free survival, it had significant benefit in improving overall survival and reducing all-cause of death. It might be a useful anesthetic technique for colorectal cancer patients undergoing surgery. However, prospective studies are required to confirm whether this benefit is causative with epidural anesthesia.","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 138","pages":"299-302"},"PeriodicalIF":0.0,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33255015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0