Tumor-to-muscle ratio of 8F-FDG PET for predicting histologic features and recurrence of HCC.

Hepato-gastroenterology Pub Date : 2015-03-01
Yang Hyun Baek, Sung-Wook Lee, Young-Jin Jeong, Jin-Sook Jeong, Young-Hoon Roh, Sang-Young Han
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引用次数: 0

Abstract

Background/aims: Hepatocellular carcinoma (HCC) recurrence is observed in up to 70-80% of patients despite a curative treatment. Microvascular invasion (MVI) and poor differentiation are strong risk factors for recurrence, but these cannot be known preoperatively. The aim of this study was to investigate the correlation of 18F-FDG PET with MVI and differentiation, and predictive role of tumor-to-background ratio of PET for recurrence in HCC.

Methodology: Fifty-four patients had 18F-FDG PET/CT study before surgical resection as a first treatment of HCC between December 2008 and December 2012. We analyzed the predictive role of metabolic parameters of PET for recurrence of HCC. Maximal standardized uptake value, tumor-to-nontumor ratio, tumor-to-muscle ratio (TMR) and tumor-to-blood ratio were tested as metabolic index of 18F-FDG PET.

Results: Twenty-seven patients had increased uptake in preoperative PET and 14 (51.9%) of them experienced the recurrence. Increased uptake in PET and TMR were associated with MVI (p = 0.04, p = 0.005) and histologic differentiation (p = 0.018, p = 0.002). MVI was the only predictive factor for re- currence in multivariate analysis although TMR ≥ 6.36 showed a favorable result despite no statistical significance (p = 0.061).

Conclusions: Increased 18F-FDG uptake of HCC, especially high TMR might be correlated with MVI and poor differentiation, and tends to have a risk for recurrence in HCC.

8F-FDG PET的肿瘤-肌肉比预测HCC的组织学特征和复发。
背景/目的:肝细胞癌(HCC)的复发率高达70-80%,尽管有根治性治疗。微血管侵犯(MVI)和分化不良是复发的重要危险因素,但术前无法得知。本研究的目的是探讨18F-FDG PET与MVI和分化的相关性,以及PET的肿瘤与背景比对HCC复发的预测作用。方法:2008年12月至2012年12月间,54例HCC首次手术切除前进行了18F-FDG PET/CT检查。我们分析了PET代谢参数对HCC复发的预测作用。以最大标准化摄取值、肿瘤与非肿瘤比值、肿瘤与肌肉比值(TMR)和肿瘤与血液比值作为18F-FDG PET的代谢指标。结果:术前PET摄取增高27例,复发14例(51.9%)。PET和TMR摄取增加与MVI (p = 0.04, p = 0.005)和组织学分化(p = 0.018, p = 0.002)相关。多因素分析中MVI是复发的唯一预测因素,TMR≥6.36虽无统计学意义(p = 0.061),但结果有利。结论:HCC中18F-FDG摄取增高,尤其是TMR增高可能与MVI和分化不良相关,且有HCC复发的危险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Hepato-gastroenterology
Hepato-gastroenterology 医学-外科
自引率
0.00%
发文量
1
审稿时长
1.9 months
期刊介绍: Hepato-Gastroenterology has been discontinued as of 2015. Extremely limited quantities of back issues in print available for sale.
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