C-reactive protein level as a possible predictor for early postoperative ileus following elective surgery for colorectal cancer.

Hepato-gastroenterology Pub Date : 2015-03-01
Takaaki Fujii, Toshinaga Sutoh, Wakako Kigure, Hiroki Morita, Toshihide Katoh, Reina Yajima, Soichi Tsutsumi, Takayuki Asao, Hiroyuki Kuwano
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引用次数: 0

Abstract

Background/aims: Inflammatory reactions are par- tially responsible for postoperative ileus (POI). Serum C-reactive protein (CRP) is an acknowledged marker of inflammation. In this study the CRP response with respect to POI in elective colorectal surgery was exam- ined to define the role of serum CRP as an early predic- tor of POI.

Methodology: Three hundred eighty-three patients who underwent elective colorectal resection were identified for inclusion in this study. We defined early POI as that occurring within 30 days following the surgery. Thirty-five patients with POI were com- pared to a subgroup of 348 patients with an unevent- ful postoperative course, and the correlation between postoperative serum CRP levels and POI in colorectal surgery was investigated.

Results: In the univariate analysis, length of operation, surgical blood loss, and serum CRP were factors significantly associated with POI following colorectal surgery; however, these fac- tors lost their significance on multivariate analysis.

Conclusion: Our results suggest that an increase in CRP levels alone is not a predictor for POI following surgery for colorectal surgery. Although inflammatory responses are known to contribute to the ileus, ad- ditional study is required to identify risk factors that would be more useful for prediction of POI.

c反应蛋白水平可作为结肠直肠癌择期手术后早期肠梗阻的预测指标。
背景/目的:炎症反应是术后肠梗阻(POI)的部分原因。血清c反应蛋白(CRP)是公认的炎症标志物。在本研究中,我们检测了选择性结直肠手术中CRP对POI的反应,以确定血清CRP作为POI早期预测因子的作用。方法:本研究确定了383例接受择期结肠直肠切除术的患者。我们将早期POI定义为手术后30天内发生的POI。将35例POI患者与348例术后无事件的患者进行比较,研究结直肠手术术后血清CRP水平与POI的相关性。结果:在单因素分析中,手术时间、手术出血量和血清CRP是结直肠手术后POI的显著相关因素;然而,这些因素在多变量分析中失去了意义。结论:我们的研究结果表明,单纯的CRP水平升高并不能预测结直肠手术后POI的发生。虽然已知炎症反应有助于肠梗阻,但需要进一步的研究来确定对预测POI更有用的危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Hepato-gastroenterology
Hepato-gastroenterology 医学-外科
自引率
0.00%
发文量
1
审稿时长
1.9 months
期刊介绍: Hepato-Gastroenterology has been discontinued as of 2015. Extremely limited quantities of back issues in print available for sale.
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