Perioperative administration of Daikenchuto (TJ-100) reduces the postoperative paralytic ileus in patients with pancreaticoduodenectomy.

Hepato-gastroenterology Pub Date : 2015-03-01
Ken-Ichi Okada, Manabu Kawai, Seiko Hirono, Motoki Miyazawa, Atsushi Shimizu, Yuji Kitahata, Hiroki Yamaue
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引用次数: 0

Abstract

Background/aims: No study has reported whether perioperative administration of Daikenchuto (TJ-100) reduced paralytic ileus after pancreaticoduodenectomy (PD).

Methodology: Forty-five consecutive patients that were scheduled to undergo PD at Wakayama Medical University Hospital between August 2010 and August 2011 were enrolled in this study including the first cohort (n = 15) as the control group and the subsequent cohort (n = 30) as the TJ-100 group. This trial was registered at UMIN-CTR ID# 000005056.

Results: Postoperative paralytic ileus occurred more frequently in the control group (73.3% of the control group and 20.0% of the TJ-100 group; p = 0.001). The first passages of flatus significantly improved earlier in the TJ-100 group than in the control group (p = 0.014). A multiple cytokine assay of the drainage and serum showed that IL-9 and IL-10 in the drainage was significantly higher on postoperative day 1 in the TJ-100 group. There were no complications associated with the preoperative administration of TJ-100 before surgery, and no significant differences were observed between the two groups in the incidence of postoperative Gradel-2 diarrhea (CTCAE4.0).

Conclusions: Perioperative administration of TJ-100 was feasible and reduced the incidence of paralytic ileus in PD, and further randomized controlled trials should be conducted.

围手术期给予大根泻(TJ-100)可减少胰十二指肠切除术患者术后麻痹性肠梗阻。
背景/目的:没有研究报道围手术期给药Daikenchuto (TJ-100)是否能减少胰十二指肠切除术(PD)后的麻痹性肠梗阻。方法:本研究纳入2010年8月至2011年8月在和歌山医科大学附属医院接受PD治疗的45例患者,其中第一组(n = 15)为对照组,第二组(n = 30)为TJ-100组。该试验注册在UMIN-CTR ID# 000005056。结果:对照组术后麻痹性肠梗阻发生率高于对照组(73.3%)和TJ-100组(20.0%);P = 0.001)。TJ-100组首次排气量明显早于对照组(p = 0.014)。术后第1天,TJ-100组引流液及血清中IL-9、IL-10含量显著升高。术前给药TJ-100无并发症,两组术后2级腹泻发生率(CTCAE4.0)无显著差异。结论:围手术期给予TJ-100可降低PD患者麻痹性肠梗阻的发生率,需进一步开展随机对照试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Hepato-gastroenterology
Hepato-gastroenterology 医学-外科
自引率
0.00%
发文量
1
审稿时长
1.9 months
期刊介绍: Hepato-Gastroenterology has been discontinued as of 2015. Extremely limited quantities of back issues in print available for sale.
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