Lymph node ratio may predict relapse free survival and overall survival in patients with stage II & III colorectal carcinoma.

Hepato-gastroenterology Pub Date : 2015-03-01

Jamal Zekri, Imran Ahmad, Ehab Fawzy, Tawfik R Elkhodary, Aboelkhair Al-Gahmi, Ashraf Hassouna, Mohamed E El Sayed, Jalil Ur Rehman, Syed M Karim, Bakr Bin Sadiq

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Abstract

Background/aims: Lymph node ratio (LNR) defined as the number of lymph nodes (LNs) involved with metastases divided by number of LNs examined, has been shown to be an independent prognostic factor in breast, stomach and various other solid tumors. Its significance as a prognostic determinant in colorectal cancer (CRC) is still under investigation. This study investigated the prognostic value of LNR in patients with resected CRC.

Methodology: We retrospectively ex- amined 145 patients with stage II & III CRC diagnosed and treated at a single institution during 9 years pe- riod. Patients were grouped according to LNR in three groups. Group 1; LNR < 0.05, Group 2; LNR = 0.05-0.19 & Group 3 > 0.19. Chi square, life table analysis and multivariate Cox regression were used for statistical analysis.

Results: On multivariate analysis, number of involved LNs (NILN) (HR = 1.15, 95% CI 1.055-1.245; P = 0.001) and pathological T stage (P = 0.002) were statistically significant predictors of relapse free survival (RFS). LNR as a continuous variable (but not as a categorical variable) was statistically significant predictor of RFS (P = 0.02). LNR was also a statistically significant predictor of overall survival (OS) (P = 0.02).

Conclusion: LNR may predict RFS and OS in patients with resected stage II & III CRC. Studies with larger cohorts and longer follow up are needed to further examine and validate theprognostic value of LNR.

本刊更多论文

淋巴结比例可以预测II期和III期结直肠癌患者的无复发生存期和总生存期。

背景/目的:淋巴结比(LNR)定义为淋巴结转移数除以检查的淋巴结数，已被证明是乳腺、胃和其他各种实体肿瘤的独立预后因素。它作为结直肠癌(CRC)预后决定因素的意义仍在研究中。本研究探讨了LNR在结直肠癌切除术患者中的预后价值。方法:我们回顾性分析了145例在同一机构诊断和治疗的II期和III期CRC患者，时间跨度为9年。根据LNR分为三组。组1;LNR < 0.05，第2组;LNR = 0.05 ~ 0.19，第3组> 0.19。采用卡方分析、生命表分析和多变量Cox回归进行统计分析。结果:在多因素分析中，涉及的LNs数(NILN) (HR = 1.15, 95% CI 1.055 ~ 1.245;P = 0.001)和病理性T分期(P = 0.002)是无复发生存(RFS)的有统计学意义的预测因子。LNR作为连续变量(而不是分类变量)是RFS的有统计学意义的预测因子(P = 0.02)。LNR也是总生存(OS)的有统计学意义的预测因子(P = 0.02)。结论:LNR可以预测切除的II期和III期结直肠癌患者的RFS和OS。需要更大的队列和更长的随访研究来进一步检查和验证LNR的预后价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hepato-gastroenterology 医学-外科

自引率

0.00%

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审稿时长

1.9 months

期刊介绍： Hepato-Gastroenterology has been discontinued as of 2015. Extremely limited quantities of back issues in print available for sale.