{"title":"Early effects of oral administration of esomeprazole and omeprazole on the intragastric pH.","authors":"Hiroshi Iida, Masahiko Inamori, Kotone Okuno, Yusuke Sekino, Eiji Sakai, Hidenori Okubo, Takuma Higurashi, Hiroki Endo, Kunihiro Hosono, Masato Yoneda, Tomoko Koide, Hirokazu Takahashi, Ayumu Goto, Kensuke Kubota, Satoru Saito, Shin Maeda, Atsushi Nakajima, Eiji Gotoh","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/aims: </strong>The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral dose of a proton pump inhibitor, esomeprazole 20 mg and omeprazole 20 mg.</p><p><strong>Methodology: </strong>A total of 14 Helicobacter pylori-negative male subjects participated in this study. Intragastric pH was monitored continuously for 6 hours after a single oral dose of omeprazole 20 mg and a single oral dose of esomeprazole 20 mg. Each administration was separated by a 7-day washout period.</p><p><strong>Results: </strong>During the 6-hour study period, the average pH after administration of esomeprazole was higher than that after the administration of omeprazole. Also during the 6-hour study period, each of pH > 2, 3, 3.5, 4, and 5 was maintained for a longer duration after administration of esomeprazole 20 mg than after administration of omeprazole 20 mg (median: 75.4% vs. 53.8%, p = 0.0138; 52.1% vs. 33.4%, p = 0.0188; 45.8% vs. 28.2%, p = 0.0262; 42.5% vs. 20.7%, p = 0.0414; 35.8% vs. 11.6%, p = 0.0262; respectively).</p><p><strong>Conclusions: </strong>In Helicobacter pylori-negative healthy male subjects, single oral administration of esomeprazole 20 mg increased the intragastric pH more rapidly than single oral administration of omeprazole 20 mg.</p>","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 138","pages":"493-6"},"PeriodicalIF":0.0000,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hepato-gastroenterology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background/aims: The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral dose of a proton pump inhibitor, esomeprazole 20 mg and omeprazole 20 mg.
Methodology: A total of 14 Helicobacter pylori-negative male subjects participated in this study. Intragastric pH was monitored continuously for 6 hours after a single oral dose of omeprazole 20 mg and a single oral dose of esomeprazole 20 mg. Each administration was separated by a 7-day washout period.
Results: During the 6-hour study period, the average pH after administration of esomeprazole was higher than that after the administration of omeprazole. Also during the 6-hour study period, each of pH > 2, 3, 3.5, 4, and 5 was maintained for a longer duration after administration of esomeprazole 20 mg than after administration of omeprazole 20 mg (median: 75.4% vs. 53.8%, p = 0.0138; 52.1% vs. 33.4%, p = 0.0188; 45.8% vs. 28.2%, p = 0.0262; 42.5% vs. 20.7%, p = 0.0414; 35.8% vs. 11.6%, p = 0.0262; respectively).
Conclusions: In Helicobacter pylori-negative healthy male subjects, single oral administration of esomeprazole 20 mg increased the intragastric pH more rapidly than single oral administration of omeprazole 20 mg.
背景/目的:本研究旨在探讨质子泵抑制剂埃索美拉唑20mg和奥美拉唑20mg单次口服对胃酸分泌的抑制作用。方法:共有14名男性幽门螺杆菌阴性受试者参与本研究。在单次口服奥美拉唑20 mg和单次口服埃索美拉唑20 mg后连续监测胃内pH值6小时。每次给药间隔7天洗脱期。结果:在6小时的研究期间,给予埃索美拉唑后的平均pH值高于给予奥美拉唑后的平均pH值。同样,在6小时的研究期间,给予埃索美拉唑20 mg后,pH > 2、3、3.5、4和5的持续时间比给予奥美拉唑20 mg后更长(中位数:75.4% vs. 53.8%, p = 0.0138;52.1% vs. 33.4%, p = 0.0188;45.8% vs. 28.2%, p = 0.0262;42.5% vs. 20.7%, p = 0.0414;35.8% vs. 11.6%, p = 0.0262;分别)。结论:在幽门螺杆菌阴性的健康男性受试者中,单次口服埃索美拉唑20 mg比单次口服奥美拉唑20 mg更快地提高胃内pH值。