Early effects of oral administration of esomeprazole and omeprazole on the intragastric pH.

Hepato-gastroenterology Pub Date : 2015-03-01
Hiroshi Iida, Masahiko Inamori, Kotone Okuno, Yusuke Sekino, Eiji Sakai, Hidenori Okubo, Takuma Higurashi, Hiroki Endo, Kunihiro Hosono, Masato Yoneda, Tomoko Koide, Hirokazu Takahashi, Ayumu Goto, Kensuke Kubota, Satoru Saito, Shin Maeda, Atsushi Nakajima, Eiji Gotoh
{"title":"Early effects of oral administration of esomeprazole and omeprazole on the intragastric pH.","authors":"Hiroshi Iida,&nbsp;Masahiko Inamori,&nbsp;Kotone Okuno,&nbsp;Yusuke Sekino,&nbsp;Eiji Sakai,&nbsp;Hidenori Okubo,&nbsp;Takuma Higurashi,&nbsp;Hiroki Endo,&nbsp;Kunihiro Hosono,&nbsp;Masato Yoneda,&nbsp;Tomoko Koide,&nbsp;Hirokazu Takahashi,&nbsp;Ayumu Goto,&nbsp;Kensuke Kubota,&nbsp;Satoru Saito,&nbsp;Shin Maeda,&nbsp;Atsushi Nakajima,&nbsp;Eiji Gotoh","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/aims: </strong>The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral dose of a proton pump inhibitor, esomeprazole 20 mg and omeprazole 20 mg.</p><p><strong>Methodology: </strong>A total of 14 Helicobacter pylori-negative male subjects participated in this study. Intragastric pH was monitored continuously for 6 hours after a single oral dose of omeprazole 20 mg and a single oral dose of esomeprazole 20 mg. Each administration was separated by a 7-day washout period.</p><p><strong>Results: </strong>During the 6-hour study period, the average pH after administration of esomeprazole was higher than that after the administration of omeprazole. Also during the 6-hour study period, each of pH > 2, 3, 3.5, 4, and 5 was maintained for a longer duration after administration of esomeprazole 20 mg than after administration of omeprazole 20 mg (median: 75.4% vs. 53.8%, p = 0.0138; 52.1% vs. 33.4%, p = 0.0188; 45.8% vs. 28.2%, p = 0.0262; 42.5% vs. 20.7%, p = 0.0414; 35.8% vs. 11.6%, p = 0.0262; respectively).</p><p><strong>Conclusions: </strong>In Helicobacter pylori-negative healthy male subjects, single oral administration of esomeprazole 20 mg increased the intragastric pH more rapidly than single oral administration of omeprazole 20 mg.</p>","PeriodicalId":12985,"journal":{"name":"Hepato-gastroenterology","volume":"62 138","pages":"493-6"},"PeriodicalIF":0.0000,"publicationDate":"2015-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hepato-gastroenterology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background/aims: The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral dose of a proton pump inhibitor, esomeprazole 20 mg and omeprazole 20 mg.

Methodology: A total of 14 Helicobacter pylori-negative male subjects participated in this study. Intragastric pH was monitored continuously for 6 hours after a single oral dose of omeprazole 20 mg and a single oral dose of esomeprazole 20 mg. Each administration was separated by a 7-day washout period.

Results: During the 6-hour study period, the average pH after administration of esomeprazole was higher than that after the administration of omeprazole. Also during the 6-hour study period, each of pH > 2, 3, 3.5, 4, and 5 was maintained for a longer duration after administration of esomeprazole 20 mg than after administration of omeprazole 20 mg (median: 75.4% vs. 53.8%, p = 0.0138; 52.1% vs. 33.4%, p = 0.0188; 45.8% vs. 28.2%, p = 0.0262; 42.5% vs. 20.7%, p = 0.0414; 35.8% vs. 11.6%, p = 0.0262; respectively).

Conclusions: In Helicobacter pylori-negative healthy male subjects, single oral administration of esomeprazole 20 mg increased the intragastric pH more rapidly than single oral administration of omeprazole 20 mg.

口服埃索美拉唑和奥美拉唑对胃内pH值的早期影响。
背景/目的:本研究旨在探讨质子泵抑制剂埃索美拉唑20mg和奥美拉唑20mg单次口服对胃酸分泌的抑制作用。方法:共有14名男性幽门螺杆菌阴性受试者参与本研究。在单次口服奥美拉唑20 mg和单次口服埃索美拉唑20 mg后连续监测胃内pH值6小时。每次给药间隔7天洗脱期。结果:在6小时的研究期间,给予埃索美拉唑后的平均pH值高于给予奥美拉唑后的平均pH值。同样,在6小时的研究期间,给予埃索美拉唑20 mg后,pH > 2、3、3.5、4和5的持续时间比给予奥美拉唑20 mg后更长(中位数:75.4% vs. 53.8%, p = 0.0138;52.1% vs. 33.4%, p = 0.0188;45.8% vs. 28.2%, p = 0.0262;42.5% vs. 20.7%, p = 0.0414;35.8% vs. 11.6%, p = 0.0262;分别)。结论:在幽门螺杆菌阴性的健康男性受试者中,单次口服埃索美拉唑20 mg比单次口服奥美拉唑20 mg更快地提高胃内pH值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Hepato-gastroenterology
Hepato-gastroenterology 医学-外科
自引率
0.00%
发文量
1
审稿时长
1.9 months
期刊介绍: Hepato-Gastroenterology has been discontinued as of 2015. Extremely limited quantities of back issues in print available for sale.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信