High altitude medicine & biology最新文献_第7页

A Step Test to Evaluate the Susceptibility to Severe High-Altitude Illness in Field Conditions. 在野外条件下评估严重高海拔疾病易感性的步骤测试。

IF 1.6 4区医学

High altitude medicine & biology Pub Date : 2024-09-01 Epub Date: 2024-04-29 DOI: 10.1089/ham.2023.0065

Eric Hermand, Léo Lesaint, Laura Denis, Jean-Paul Richalet, François J Lhuissier

{"title":"A Step Test to Evaluate the Susceptibility to Severe High-Altitude Illness in Field Conditions.","authors":"Eric Hermand, Léo Lesaint, Laura Denis, Jean-Paul Richalet, François J Lhuissier","doi":"10.1089/ham.2023.0065","DOIUrl":"10.1089/ham.2023.0065","url":null,"abstract":"Hermand, Eric, Léo Lesaint, Laura Denis, Jean-Paul Richalet, and François J. Lhuissier. A step test to evaluate the susceptibility to severe high-altitude illness in field conditions. High Alt Med Biol. 25:158-163, 2024.-A laboratory-based hypoxic exercise test, performed on a cycle ergometer, can be used to predict susceptibility to severe high-altitude illness (SHAI) through the calculation of a clinicophysiological SHAI score. Our objective was to design a field-condition test and compare its derived SHAI score and various physiological parameters, such as peripheral oxygen saturation (SpO2), and cardiac and ventilatory responses to hypoxia during exercise (HCRe and HVRe, respectively), to the laboratory test. A group of 43 healthy subjects (15 females and 28 males), with no prior experience at high altitude, performed a hypoxic cycle ergometer test (simulated altitude of 4,800 m) and step tests (20 cm high step) at 3,000, 4,000, and 4,800 m simulated altitudes. According to tested altitudes, differences were observed in O2 desaturation, heart rate, and minute ventilation (p < 0.001), whereas the computed HCRe and HVRe were not different (p = 0.075 and p = 0.203, respectively). From the linear relationships between the step test and SHAI scores, we defined a risk zone, allowing us to evaluate the risk of developing SHAI and take adequate preventive measures in field conditions, from the calculated step test score for the given altitude. The predictive value of this new field test remains to be validated in real high-altitude conditions.","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":"158-163"},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Altitude Environment and COVID-19: SARS-CoV-2 Seropositivity in the Highest City in the World. 高海拔环境与 COVID-19：世界海拔最高城市的 SARS-CoV-2 血清阳性反应。

IF 1.6 4区医学

High altitude medicine & biology Pub Date : 2024-09-01 Epub Date: 2021-07-01 DOI: 10.1089/ham.2021.0020

Benoit Champigneulle, Ivan Hancco, Richard Renan, Stéphane Doutreleau, Emeric Stauffer, Aurélien Pichon, Julien V Brugniaux, Hélène Péré, Pierre Bouzat, David Veyer, Samuel Verges

{"title":"High-Altitude Environment and COVID-19: SARS-CoV-2 Seropositivity in the Highest City in the World.","authors":"Benoit Champigneulle, Ivan Hancco, Richard Renan, Stéphane Doutreleau, Emeric Stauffer, Aurélien Pichon, Julien V Brugniaux, Hélène Péré, Pierre Bouzat, David Veyer, Samuel Verges","doi":"10.1089/ham.2021.0020","DOIUrl":"10.1089/ham.2021.0020","url":null,"abstract":"Champigneulle, Benoit, Ivan Hancco, Richard Renan, Stéphane Doutreleau, Emeric Stauffer, Aurélien Pichon, Julien V. Brugniaux, Hélène Péré, Pierre Bouzat, David Veyer, and Samuel Verges. High-altitude environment and COVID-19: SARS-CoV-2 seropositivity in the highest city in the world. High Alt Med Biol. 22: 000-000, 2021. Background: A reduced coronavirus disease 2019 (COVID-19) diffusion has been suggested in high-altitude areas but remained questionable. Aims of this study were to estimate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seropositivity as well as the risk factors associated in La Rinconada, the highest city in the world (5,100-5,300 m), a gold-mining town located in southeastern Peru where >50,000 dwellers live in precarious sanitary conditions. Materials and Methods: We performed a cross-sectional study during a 1-week period in October 2020, using point-of-care lateral flow serological assays allowing detection of antibodies directed against SARS-CoV-2 among voluntary dwellers in La Rinconada. Participants were also questioned about potential occupational and environmental risk factors of COVID-19 occurrence. Results: In a sample of 159 dwellers tested in La Rinconada, 48.4% [95% confidence interval, CI: 40.5-56.4] were seropositive for the SARS-CoV-2. Occurrence of at least one symptom compatible with the COVID-19 over the past 6 months remained the only significant factor associated with SARS-CoV-2 seropositivity (adjusted odds ratio: 3.27; [95% CI: 1.70-6.44]; p < 0.001). Conclusions: The high rate of SARS-CoV-2 seropositivity observed in this small sample of highlanders does not support a protective effect of high-altitude against the COVID-19 spread and demonstrates its large dissemination in vulnerable populations. Clinical Trial Registration number: NCT04604249.","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":"218-222"},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39060277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rosalind Franklin Society Proudly Announces the 2023 Award Recipient for High Altitude Medicine & Biology. 罗莎琳德-富兰克林学会自豪地宣布 2023 年高海拔医学与生物学奖得主。

IF 1.6 4区医学

High altitude medicine & biology Pub Date : 2024-09-01 DOI: 10.1089/ham.2024.98765.rfs2023

Prof Susi Kriemler

引用次数: 0

Is Smoking Associated with the Risk of Acute Mountain Sickness? A Systematic Review and Meta-Analysis. 吸烟与急性晕山症的风险有关吗？系统回顾与元分析》。

IF 1.6 4区医学

High altitude medicine & biology Pub Date : 2024-09-01 Epub Date: 2024-06-07 DOI: 10.1089/ham.2022.0037

Yuelin Yu, Peng Gao, Lianke Xie, Kun Wang, Dandan Dou, Quanquan Gong

{"title":"Is Smoking Associated with the Risk of Acute Mountain Sickness? A Systematic Review and Meta-Analysis.","authors":"Yuelin Yu, Peng Gao, Lianke Xie, Kun Wang, Dandan Dou, Quanquan Gong","doi":"10.1089/ham.2022.0037","DOIUrl":"10.1089/ham.2022.0037","url":null,"abstract":"Background: Controversy remains in the association between smoking and the risk of acute mountain sickness (AMS). Therefore, a systematic review of the existing literature may help clarify this association. Methods: We conducted a systematic search of PubMed, Embase, and Cochrane Library from database inception up to October 19, 2021. Both unadjusted and adjusted relative risks (RRs) and 95% confidence intervals (CIs) were calculated to compare the risk of AMS in the smoking and nonsmoking groups. Meta-regression was conducted to explore the factors causing heterogeneity of the studies, and subsequent stratified analysis was performed to present the pooled RR in different subgroups. Publication bias was assessed using funnel plots. Results: A total of 28 eligible articles (31 studies) were included. The pooled unadjusted and adjusted RRs were 0.88 (95% CI: 0.78-1.01) and 0.87 (95% CI: 0.77-0.99), respectively, using random-effect models. Publication bias was observed owing to restrictions on the sample size. The ascending altitude and sex composition of the study population were likely sources of heterogeneity according to meta-regression. Studies on participants with an ascending altitude of over 3,500 m or composed of both males and females reported a slight but not significant protective effect of smoking on the risk of AMS, with high heterogeneity. Conclusions: Smoking had no significant effect on AMS risk in this meta-analysis. Current studies showed high heterogeneity and included little information on quantitative exposure to smoking (i.e., dose and frequency); thus, the results require careful explanation.","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":"226-237"},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141283506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of High-Altitude Polycythemia Complicated by Spontaneous Splenic Rupture. 自发性脾破裂并发高海拔多发性红细胞症的罕见病例

IF 1.6 4区医学

High altitude medicine & biology Pub Date : 2024-09-01 Epub Date: 2024-08-13 DOI: 10.1089/ham.2023.0105

Bowen Wang, Mengjia Peng, Liheng Jiang, Fei Fang, Juan Wang, Yan Li, Ruichen Zhao, Yuliang Wang

{"title":"A Rare Case of High-Altitude Polycythemia Complicated by Spontaneous Splenic Rupture.","authors":"Bowen Wang, Mengjia Peng, Liheng Jiang, Fei Fang, Juan Wang, Yan Li, Ruichen Zhao, Yuliang Wang","doi":"10.1089/ham.2023.0105","DOIUrl":"10.1089/ham.2023.0105","url":null,"abstract":"Wang, Bowen, Mengjia Peng,, Liheng Jiang,, Fei Fang,, Juan Wang,, Yan Li,, Ruichen Zhao,, and Yuliang Wang,. A Rare Case of High-Altitude Polycythemia Complicated by Spontaneous Splenic Rupture. High Alt Med Biol. 25:247-250, 2024.-High-altitude polycythemia, a condition characterized by an increase in red blood cellRBC mass, can occur after prolonged exposure to high altitudes. While several studies have explored the complications associated with high-altitude polycythemia, there is currently no literature available on spontaneous spleen rupture caused by high-altitude polycythemia. Here, we reported a case of acute abdominal pain and hemodynamic instability in a 36-year-old male who had been residing at high altitude for 6 years, without any recent history of trauma. Computed tomography imaging revealed significant fluid accumulation in the abdomen, and a tear of the splenic capsule was identified during the following laparotomy. Subsequent evaluations confirmed the presence of polycythemia secondary to prolonged high-altitude exposure as the underlying etiology. This case served as an important reminder that high-altitude polycythemia could lead to serious complications, such as spontaneous spleen rupture. Clinicians should be aware of this potential complication and consider it in the differential diagnosis of patients presenting with abdominal pain and hemodynamic instability in this population.","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":"247-250"},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Taste and Appetite at Altitude: A Comprehensive Review of Sensory and Hunger Modulation in High-Altitude Environments. 高海拔地区的味觉和食欲：高海拔环境中的感官和饥饿调节综合评述》。

IF 1.6 4区医学

High altitude medicine & biology Pub Date : 2024-08-09 DOI: 10.1089/ham.2024.0018

Joshua T Murphey, Jennifer L Temple, David Hostler

引用次数: 0

Central Retinal Artery Occlusion in Young Adults at High Altitude: Thin Air, High Stakes. 高海拔地区年轻人视网膜中央动脉闭塞：稀薄的空气，高风险。

IF 1.6 4区医学

High altitude medicine & biology Pub Date : 2024-06-01 Epub Date: 2024-03-01 DOI: 10.1089/ham.2023.0101

Vipin Rana, Pradeep Kumar, Sandeepan Bandopadhyay, Vijay K Sharma, Meenu Dangi, Dattakiran Joshi, Sanjay Kumar Mishra, Satyabrat Srikumar, V A Arun

{"title":"Central Retinal Artery Occlusion in Young Adults at High Altitude: Thin Air, High Stakes.","authors":"Vipin Rana, Pradeep Kumar, Sandeepan Bandopadhyay, Vijay K Sharma, Meenu Dangi, Dattakiran Joshi, Sanjay Kumar Mishra, Satyabrat Srikumar, V A Arun","doi":"10.1089/ham.2023.0101","DOIUrl":"10.1089/ham.2023.0101","url":null,"abstract":"Rana, Vipin, Pradeep Kumar, Sandeepan Bandopadhyay, Vijay K. Sharma, Meenu Dangi, Dattakiran Joshi, Sanjay Kumar Mishra, Satyabrat Srikumar, and V.A. Arun. Central retinal artery occlusion in young adults at high altitude: thin air, high stakes. High Alt Med Biol. 00:000-000, 2024.-We present five cases of young security personnel who were posted at high altitude (HA) for a duration of at least 6 months and presented with a sudden decrease of vision in one eye. The diagnosis of central retinal artery occlusion (CRAO) was made in all patients. Fundus fluorescein angiography and optical coherence tomography of the macula supported the diagnosis. None of these cases had any preexisting comorbidities. Erythrocytosis was noticed in all patients, and two of them had hyperhomocysteinemia. Four out of five patients showed either middle cerebral artery or internal carotid artery (ICA) thrombosis on computed tomography angiography. The patients were managed by a team of ophthalmologist, hematologist, vascular surgeon, and neurologist. In cases of incomplete ICA occlusion, patients were managed surgically. However, in the case of complete ICA occlusion, management was conservative with antiplatelet drugs. This case series highlights HA-associated erythrocytosis and hyperhomocysteinemia as important risk factors for CRAO in young individuals stationed at HA.","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":"136-139"},"PeriodicalIF":1.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of Athletic Guidelines for High-Altitude Training and Acclimatization. 高海拔训练和适应性运动指南回顾。

IF 1.6 4区医学

High altitude medicine & biology Pub Date : 2024-06-01 Epub Date: 2024-01-12 DOI: 10.1089/ham.2023.0042

Rashi Ramchandani, Ioana Tereza Florica, Zier Zhou, Aziz Alemi, Adrian Baranchuk

{"title":"Review of Athletic Guidelines for High-Altitude Training and Acclimatization.","authors":"Rashi Ramchandani, Ioana Tereza Florica, Zier Zhou, Aziz Alemi, Adrian Baranchuk","doi":"10.1089/ham.2023.0042","DOIUrl":"10.1089/ham.2023.0042","url":null,"abstract":"Ramchandani, Rashi, Ioana Tereza Florica, Zier Zhou, Aziz Alemi, and Adrian Baranchuk. Review of athletic guidelines for high-altitude training and acclimatization. High Alt Med Biol. 00:000-000, 2024. Introduction: Exposure to high altitude results in hypobaric hypoxia with physiological acclimatization changes that are thought to influence athletic performance. This review summarizes existing literature regarding implications of high-altitude training and altitude-related guidelines from major governing bodies of sports. Methods: A nonsystematic review was performed using PubMed and OVID Medline to identify articles regarding altitude training and guidelines from international governing bodies of various sports. Sports inherently involving training or competing at high altitude were excluded. Results: Important physiological compensatory mechanisms to high-altitude environments include elevations in blood pressure, heart rate, red blood cell mass, tidal volume, and respiratory rate. These responses can have varying effects on athletic performance. Governing sport bodies have limited and differing regulations for training and competition at high altitudes with recommended acclimatization periods ranging from 3 days to 3 weeks. Discussion: Physiological changes in response to high terrestrial altitude exposure can have substantial impacts on athletic performance. Major sport governing bodies have limited regulations and recommendations regarding altitude training and competition. Existing guidelines are variable and lack substantial evidence to support recommendations. Additional studies are needed to clarify the implications of high-altitude exposure on athletic ability to optimize training and competition.","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":"113-121"},"PeriodicalIF":1.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139424650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Women at Altitude: Menstrual-Cycle Phase, Menopause, and Exogenous Progesterone Are Not Associated with Acute Mountain Sickness. 高海拔地区的女性：月经周期阶段、绝经期和外源性孕酮与急性晕山症无关。

IF 1.6 4区医学

High altitude medicine & biology Pub Date : 2024-06-01 Epub Date: 2024-03-22 DOI: 10.1089/ham.2023.0100

Laurel Gardner, Linda E Keyes, Caleb Phillips, Elan Small, Tejaswi Adhikari, Nathan Barott, Ken Zafren, Rony Maharjan, James Marvel

{"title":"Women at Altitude: Menstrual-Cycle Phase, Menopause, and Exogenous Progesterone Are Not Associated with Acute Mountain Sickness.","authors":"Laurel Gardner, Linda E Keyes, Caleb Phillips, Elan Small, Tejaswi Adhikari, Nathan Barott, Ken Zafren, Rony Maharjan, James Marvel","doi":"10.1089/ham.2023.0100","DOIUrl":"10.1089/ham.2023.0100","url":null,"abstract":"Gardner, Laurel, Linda E. Keyes, Caleb Phillips, Elan Small, Tejaswi Adhikari, Nathan Barott, Ken Zafren, Rony Maharjan, and James Marvel. Women at altitude: Menstrual-cycle phase, menopause, and exogenous progesterone are not associated with acute mountain sickness. High Alt Med Biol. 00:000-000, 2024. Background: Elevated progesterone levels in women may protect against acute mountain sickness (AMS). The impact of hormonal contraception (HC) on AMS is unknown. We examined the effect of natural and exogenous progesterone on the occurrence of AMS. Methods: We conducted a prospective observational convenience study of female trekkers in Lobuche (4,940 m) and Manang (3,519 m). We collected data on last menstrual period, use of exogenous hormones, and development of AMS. Results: There were 1,161 trekkers who met inclusion criteria, of whom 307 (26%) had AMS. There was no significant difference in occurrence of AMS between women in the follicular (28%) and the luteal (25%) phases of menstruation (p = 0.48). The proportion of premenopausal (25%) versus postmenopausal women (30%) with AMS did not differ (p = 0.33). The use of HC did not influence the occurrence of AMS (HC 23% vs. no HC 26%, p = 0.47), nor did hormonal replacement therapy (HRT) (HRT 11% vs. no HRT 31%, p = 0.13). Conclusion: We found no relationship between menstrual-cycle phase, menopausal status, or use of exogenous progesterone and the occurrence of AMS in trekkers and conclude that hormonal status is not a risk factor for AMS. Furthermore, women should not be excluded from future AMS studies based on hormonal status.","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":"107-112"},"PeriodicalIF":1.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140184263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor: Lidocaine-Based Local Anesthesia Is Essential During Radial Arterial Puncture for Arterial Blood Gas Sampling in a High-Altitude Environment. 致编辑的信：在高海拔环境中进行桡动脉穿刺动脉血气采样时，基于利多卡因的局部麻醉至关重要。

IF 1.6 4区医学

High altitude medicine & biology Pub Date : 2024-06-01 Epub Date: 2024-03-21 DOI: 10.1089/ham.2024.0032

Jing Wen, Xu-Gang Tang

引用次数: 0