High altitude medicine & biology最新文献_第10页

Counseling Patients with Chronic Obstructive Pulmonary Disease Traveling to High Altitude. 为前往高海拔地区的慢性阻塞性肺病患者提供咨询。

IF 1.6 4区医学

High altitude medicine & biology Pub Date : 2023-09-01 Epub Date: 2023-08-30 DOI: 10.1089/ham.2023.0053

Konrad E Bloch, Talant M Sooronbaev, Silvia Ulrich, Mona Lichtblau, Michael Furian

{"title":"Counseling Patients with Chronic Obstructive Pulmonary Disease Traveling to High Altitude.","authors":"Konrad E Bloch, Talant M Sooronbaev, Silvia Ulrich, Mona Lichtblau, Michael Furian","doi":"10.1089/ham.2023.0053","DOIUrl":"10.1089/ham.2023.0053","url":null,"abstract":"Bloch, Konrad E., Talant M. Sooronbaev, Silvia Ulrich, Mona Lichtblau, and Michael Furian. Clinician's corner: counseling patients with chronic obstructive pulmonary disease traveling to high altitude. High Alt Med Biol. 24:158-166, 2023.-Mountain travel is increasingly popular also among patients with chronic obstructive pulmonary disease (COPD), a highly prevalent condition often associated with cardiovascular and systemic manifestations. Recent studies have shown that nonhypercapnic and only mildly hypoxemic lowlanders with moderate to severe airflow obstruction owing to COPD experience dyspnea, exercise limitation, and sleep disturbances when traveling up to 3,100 m. Altitude-related adverse health effects (ARAHE) in patients with COPD include severe hypoxemia, which may be asymptomatic but expose patients to the risk of excessive systemic and pulmonary hypertension, cardiac arrhythmia, and even myocardial or cerebral ischemia. In addition, hypobaric hypoxia may impair postural control, psycho-motor, and cognitive performance in patients with COPD during altitude sojourns. Randomized, placebo-controlled trials have shown that preventive treatment with oxygen at night or with acetazolamide reduces the risk of ARAHE in patients with COPD while preventive dexamethasone treatment improves oxygenation and altitude-induced excessive sleep apnea, and lowers systemic and pulmonary artery pressure. This clinical review provides suggestions for pretravel assessment and preparations and measures during travel that may reduce the risk of ARAHE and contribute to pleasant mountain journeys of patients with COPD.","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":"24 3","pages":"158-166"},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10296866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re: "Cardiomyopathy Following Complete Avalanche Burial: A Case Report" by Libersa et al. 回复：Libersa等人的“雪崩完全掩埋后的心肌病：一例病例报告”。

IF 2.1 4区医学

High altitude medicine & biology Pub Date : 2023-09-01 Epub Date: 2023-07-20 DOI: 10.1089/ham.2023.0069

Josef Finsterer

引用次数: 0

Hyperhomocysteinemia, High Altitude, and Varied Retinal Manifestations: Unravelling the Enigma. 高同型半胱氨酸血症、高海拔和多种视网膜表现：解开谜。

IF 2.1 4区医学

High altitude medicine & biology Pub Date : 2023-09-01 Epub Date: 2023-07-03 DOI: 10.1089/ham.2023.0028

Vipin Rana, Meenu Dangi, Sandepan Bandopadhayay, Vijay K Sharma, Satyabrat Srikumar, Jitesh Goyal, B V Rao

{"title":"Hyperhomocysteinemia, High Altitude, and Varied Retinal Manifestations: Unravelling the Enigma.","authors":"Vipin Rana, Meenu Dangi, Sandepan Bandopadhayay, Vijay K Sharma, Satyabrat Srikumar, Jitesh Goyal, B V Rao","doi":"10.1089/ham.2023.0028","DOIUrl":"10.1089/ham.2023.0028","url":null,"abstract":"Rana, Vipin, Meenu Dangi, Sandepan Bandopadhayay, Vijay K. Sharma, Satyabrat Srikumar, Jitesh Goyal, and B.V. Rao. Hyperhomocysteinemia, High Altitude, and Varied Retinal Manifestations: Unravelling the Enigma. High Alt Med Biol. 24:234-237, 2023.-We present five cases of young defense personnel, who were posted at high altitude (HA) for >6 months and presented with reduction of vision between June 2022 and February 2023. The diagnosis made were ocular ischemic syndrome, central retinal artery occlusion, central retinal vein occlusion, branch retinal vein occlusion, and branch retinal artery occlusion. There were no associated comorbidities. Hematological workup revealed increased serum homocysteine and hemoglobin in all patients. Computed tomography angiography was done in cases of ocular ischemic syndrome, and central retinal artery occlusion, which revealed occlusion of carotid artery. All patients were given tab folic acid in view of hyperhomocysteinemia (HHcy). This case series highlights that prolonged exposure to HA may lead to HHcy, which can directly or indirectly lead to various sight-threatening retinal diseases. Thus, effective preventive strategies, such as dietary or pharmacological interventions aimed at lowering serum homocysteine levels, are crucial for individuals posted at HA for longer duration.","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":"24 3","pages":"234-237"},"PeriodicalIF":2.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10664499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rosalind Franklin Society Proudly Announces the 2022 Award Recipient for High Altitude Medicine & Biology. 罗莎琳德·富兰克林学会自豪地宣布2022年高原医学与生物学奖获得者。

IF 2.1 4区医学

High altitude medicine & biology Pub Date : 2023-09-01 DOI: 10.1089/ham.2023.29030.rfs2022

Colleen G Julian

引用次数: 0

Letter to the Editor: La dug in Merak-Sakteng, Bhutan. 给编辑的信:在不丹的Merak-Sakteng挖洞。

IF 2.1 4区医学

High altitude medicine & biology Pub Date : 2023-06-01 DOI: 10.1089/ham.2023.0034

Ryota Sakamoto

引用次数: 0

Effects of Hypobaric Hypoxia on Coagulation in Healthy Subjects Exposed to 3,500 m Altitude. 低气压缺氧对暴露于海拔3500米的健康人凝血的影响。

IF 2.1 4区医学

High altitude medicine & biology Pub Date : 2023-06-01 DOI: 10.1089/ham.2022.0154

Tobias Kammerer, Anna Walzl, Thomas Müller, Philipp Groene, Giulia Roveri, Rachel Turner, Johanna Roche, Hannes Gatterer, Christoph Siebenmann, Simon T Schäfer

{"title":"Effects of Hypobaric Hypoxia on Coagulation in Healthy Subjects Exposed to 3,500 m Altitude.","authors":"Tobias Kammerer, Anna Walzl, Thomas Müller, Philipp Groene, Giulia Roveri, Rachel Turner, Johanna Roche, Hannes Gatterer, Christoph Siebenmann, Simon T Schäfer","doi":"10.1089/ham.2022.0154","DOIUrl":"https://doi.org/10.1089/ham.2022.0154","url":null,"abstract":"Kammerer, Tobias, Anna Walzl, Thomas Müller, Philipp Groene, Giulia Roveri, Rachel Turner, Johanna Roche, Hannes Gatterer, Christoph Siebenmann, and Simon T. Schäfer. Effects of hypobaric hypoxia on coagulation in healthy subjects exposed to 3,500 m altitude. High Alt Med Biol. 24:94-103, 2023. Background: Hypoxia is discussed as a trigger for prothrombotic changes both in intensive care and high altitude medicine. This research study aimed to evaluate the effect of isolated hypobaric hypoxia (HH) on coagulation in females in a highly standardized setting. Methods: Twelve healthy female subjects were studied under HH (equivalent to 3,500 m) and normoxia (NX) during two 4-day sojourns, in a strictly controlled crossover design. Nutrition, fluid intake, hormonal status (i.e., menstrual cycle variation), and physical stress were standardized. Functional coagulation and blood lysis were measured by viscoelastometry and compared between HH and NX. In addition, plasma-based coagulation tests (PBCTs), namely prothrombin time, activated partial thromboplastin time, fibrinogen, factor VIII coagulation activity (FVIII:C), von Willebrand factor antigen (vWF:Ag), and von Willebrand factor ristocetin cofactor activity (vWF:RCo) were measured. Results: Neither for Viscoelastic Haemostatic Assays nor for PBCTs significant changes were found for HH compared with NX (all p > 0.05). Specifically, the lysis ability, as well as clotting time, clot formation, clot amplitude, and maximum clot firmness unchanged were similar between HH and NX. This also applied to all other variables. Conclusion: We demonstrate that moderate HH per se has no influence on blood coagulation in healthy females.","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":"24 2","pages":"94-103"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10204993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Re: "Barometric Pressure at High Altitude: Revisiting West's Prediction Equation, and More," by Apte. 回复:Apte的“高空气压:重新审视韦斯特的预测方程，以及更多”。

IF 2.1 4区医学

High altitude medicine & biology Pub Date : 2023-06-01 DOI: 10.1089/ham.2023.0048

Tadej Debevec, Grégoire P Millet

引用次数: 0

UIAA Medical Commission Recommendations for Mountaineers, Hillwalkers, Trekkers, and Rock and Ice Climbers with Diabetes. uaa医学委员会对患有糖尿病的登山者、爬山者、徒步者和攀岩者的建议。

IF 2.1 4区医学

High altitude medicine & biology Pub Date : 2023-06-01 DOI: 10.1089/ham.2018.0043

David Hillebrandt, Anil Gurtoo, Thomas Kupper, Paul Richards, Volker Schöffl, Pankaj Shah, Rianne van der Spek, Nikki Wallis, Jim Milledge

{"title":"UIAA Medical Commission Recommendations for Mountaineers, Hillwalkers, Trekkers, and Rock and Ice Climbers with Diabetes.","authors":"David Hillebrandt, Anil Gurtoo, Thomas Kupper, Paul Richards, Volker Schöffl, Pankaj Shah, Rianne van der Spek, Nikki Wallis, Jim Milledge","doi":"10.1089/ham.2018.0043","DOIUrl":"https://doi.org/10.1089/ham.2018.0043","url":null,"abstract":"Hillebrandt, David, Anil Gurtoo, Thomas Kupper, Paul Richards, Volker Schöffl, Pankaj Shah, Rianne van der Spek, Nikki Wallis, and Jim Milledge. UIAA Medical Commission recommendations for mountaineers, hillwalkers, trekkers, and rock and ice climbers with diabetes. High Alt Med Biol. 24: 110-126.-The object of this advice article is not only to give the diabetic mountaineer general guidance but also to inform his or her medical team of practical aspects of care that may not be standard for nonmountaineers. The guidelines are produced in seven sections. The first is an introduction to the guidelines, and the second is an introduction to this medical problem and is designed to be read and understood by diabetic patients and their companions. The third section is for use in an emergency in mountains. The fourth is for rock, ice, and competition climbers operating in a less remote environment. These initial sections are deliberately written in simple language. The fifth and sixth sections are written for clinicians and those with skills to read more technical information, and the seventh looks at modern technology and its pros and cons in diabetes management in a remote area. Sections One and Two could be laminated and carried when in the mountains, giving practical advice.","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":"24 2","pages":"110-126"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/ham.2018.0043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10138397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Erythrocytes Display Metabolic Changes in High-Altitude Polycythemia. 高原红细胞增多症患者红细胞代谢变化。

IF 2.1 4区医学

High altitude medicine & biology Pub Date : 2023-06-01 DOI: 10.1089/ham.2022.0151

Muge Qile, Qiying Xu, Yi Ye, Huifang Liu, Drolma Gomchok, Juanli Liu, Tana Wuren, Ri-Li Ge

{"title":"Erythrocytes Display Metabolic Changes in High-Altitude Polycythemia.","authors":"Muge Qile, Qiying Xu, Yi Ye, Huifang Liu, Drolma Gomchok, Juanli Liu, Tana Wuren, Ri-Li Ge","doi":"10.1089/ham.2022.0151","DOIUrl":"https://doi.org/10.1089/ham.2022.0151","url":null,"abstract":"Qile, Muge, Qiying Xu, Yi Ye, Huifang Liu, Drolma Gomchok, Juanli Liu, Tana Wuren, and Ri-Li Ge. Erythrocytes display metabolic changes in high-altitude polycythemia. High Alt Med Biol. 24:104-109, 2023. Background: Sphingosine-1-phosphate (S1P) levels are increased after acute exposure to high altitude; however, whether this effect is observed in chronic high-altitude hypoxia is unknown. Methods: We studied erythrocyte S1P levels in 13 subjects with high-altitude polycythemia (HAPC) and 13 control subjects and also used a mouse model of HAPC. HAPC subjects lived in Maduo (4,300 m altitude) for 10 years, whereas control subjects lived permanently in Xining (2,260 m). The mouse model of HAPC was established by stimulating an altitude of 5,000 m in a hypobaric chamber for 30 days. Hematology and S1P, CD73, 2,3-bisphosphoglycerate (2,3-BPG), and reticulocyte levels were measured. Results: The hemoglobin concentration and number of red blood cells were significantly elevated in human and mouse HAPC groups. Blood S1P levels in HAPC subjects and mice were higher than those in control groups (p < 0.05 and p < 0.001, respectively). 2,3-BPG and CD73 levels in HAPC subjects were significantly higher than those in control subjects (p < 0.05). No significant changes in reticulocyte levels were observed. Conclusions: The critical altitude-induced metabolic changes such as S1P retained high levels even after prolonged exposure, and it may inspire future research into therapeutic strategies for hypoxia-associated illnesses.","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":"24 2","pages":"104-109"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10501943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Barometric Pressure at High Altitude: Revisiting West's Prediction Equation, and More. 高空气压:重新审视韦斯特的预测方程，以及更多。

IF 2.1 4区医学

High altitude medicine & biology Pub Date : 2023-06-01 DOI: 10.1089/ham.2022.0049

Chandrashekhar V Apte

{"title":"Barometric Pressure at High Altitude: Revisiting West's Prediction Equation, and More.","authors":"Chandrashekhar V Apte","doi":"10.1089/ham.2022.0049","DOIUrl":"https://doi.org/10.1089/ham.2022.0049","url":null,"abstract":"Apte, Chandrashekhar V. Barometric pressure at high altitude: revisiting West's prediction equation, and more. High Alt Med Biol. 24:85-93, 2023. Introduction: Since an earlier prediction equation to calculate barometric pressure at a given altitude had been tested against limited barometric pressure observations, its accuracy needed to be re-validated against additional pressure observations. Methods: Five-year (2016-2020) barometric pressure and altitude data were downloaded from an open-source website for 25 select locations. The calculated predicted pressure was compared with mean 5-year, mean monthly, and mean daily pressures. Percent prediction error and root mean square errors were used to assess accuracy of the prediction equation. Results: The original prediction equation was accurate to within 1% for locations only within 22° latitude. It was increasingly inaccurate at higher latitudes and also for means based on shorter time spans (e.g., mean monthly and daily pressures). A new prediction equation was proposed by developing a model using downloaded data. The new equation resulted in more accurate predictions for all latitudes and all time spans. The new equation also performed well when tested at seven new locations. Conclusions: Ideally, medical professionals at high altitude should rely on actual barometric pressure observations to assess hypoxic risk. In the absence of actual measurements, the suggested new prediction equation may be used to estimate, with some limitations, the ambient barometric pressure at latitudes below 47° and altitudes up to about 4,700 m.","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":"24 2","pages":"85-93"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10520899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0