Prevalence and Risk Factors of Hyperuricemia Among Young and Middle-Aged Tibetan Men Living at Ultrahigh Altitudes: A Cross-Sectional Study.

IF 1.6 4区 医学 Q4 BIOPHYSICS
High altitude medicine & biology Pub Date : 2024-03-01 Epub Date: 2024-01-04 DOI:10.1089/ham.2023.0056
Ben He, Jiayue Feng, Yan Shu, Lichun Yang, Zepin He, Kanxiu Liao, Hui Zhuo, Hui Li
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引用次数: 0

Abstract

He, Ben, Jiayue Feng, Yan Shu, Lichun Yang, Zepin He, Kanxiu Liao, Hui Zhuo, and Hui Li. Prevalence and risk factors of hyperuricemia among young and middle-aged Tibetan men living at ultrahigh altitudes: a cross-sectional study. High Alt Med Biol. 25:42-48, 2024. Background: Few studies have examined the prevalence or risk factors of hyperuricemia among populations living at ultrahigh altitudes. Here we examined the prevalence of hyperuricemia and factors associated with it among young and middle-aged Tibetan men living at ultrahigh altitudes. Methods: This cross-sectional study analyzed 672 Tibetan men 18-60 years old living on the Qinghai-Tibet Plateau (mean altitude 4,014 m) within the county of Litang in the Ganzi Tibetan autonomous prefecture of Sichuan Province, China. Demographic and clinical data were collected from self-administered questionnaires, physical examinations and laboratory tests. Participants whose blood uric acid (UA) contained >420 μmol/l were classified as having hyperuricemia. Results: Of the 672 men analyzed, 332 (49.4%) had hyperuricemia. Multivariate logistic regression showed risk of hyperuricemia to correlate positively with body mass index (per 1 U increase: odds ratio [OR] 1.172, 95% confidence interval [CI] 1.1066-1.243), triglycerides (OR 1.408, 95% CI 1.084-1.828), red blood cell count (OR 1.376, 95% CI 1.009-1.875), and creatinine level (per 1 U increase: OR 1.051, 95% CI 1.033-1.070). Conversely, risk of hyperuricemia correlated negatively with the presence of diabetes mellitus (OR 0.412, 95% CI 0.175-0.968). Subgroup analyses showed that prevalence of hyperuricemia was significantly higher among those with polycythemia than among those without it, and that UA levels correlated positively with hematocrit and hemoglobin levels. Conclusions: Hyperuricemia is an important public health problem among Tibetan men living at ultrahigh altitudes in Ganzi autonomous prefecture. The region urgently requires appropriate prevention and management efforts.

生活在超高海拔地区的藏族中青年男性高尿酸血症的患病率和风险因素:一项横断面研究
何奔、冯嘉悦、舒艳、杨丽春、何泽平、廖康秀、卓慧、李慧。生活在超高海拔地区的藏族中青年男性高尿酸血症的患病率和风险因素:一项横断面研究。24:000-000, 2024.背景:很少有研究调查生活在超高海拔地区的人群中高尿酸血症的患病率或风险因素。在此,我们研究了生活在超高海拔地区的藏族中青年男性的高尿酸血症患病率及其相关因素。研究方法这项横断面研究分析了居住在中国四川省甘孜藏族自治州理塘县境内青藏高原(平均海拔 4014 米)的 672 名 18-60 岁藏族男性。研究人员通过自填问卷、体格检查和实验室检测收集人口统计学和临床数据。血尿酸(UA)含量大于 420 μmol/l 的参与者被列为高尿酸血症患者。结果:在分析的 672 名男性中,有 332 人(49.4%)患有高尿酸血症。多变量逻辑回归显示,高尿酸血症的风险与体重指数呈正相关(每增加 1 U:几率比 [OR] 1.172,95% 置信区间 [CI] 1.1066-1.243)、甘油三酯(OR 1.408,95% CI 1.084-1.828)、红细胞计数(OR 1.376,95% CI 1.009-1.875)和肌酐水平(每增加 1 U:OR 1.051,95% CI 1.033-1.070)呈正相关。相反,高尿酸血症的风险与是否患有糖尿病呈负相关(OR 0.412,95% CI 0.175-0.968)。亚组分析表明,多血细胞症患者的高尿酸血症发病率明显高于非多血细胞症患者,而且尿酸水平与血细胞比容和血红蛋白水平呈正相关。结论是高尿酸血症是甘孜藏族自治州生活在超高海拔地区藏族男性的一个重要公共卫生问题。该地区迫切需要开展适当的预防和管理工作。
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来源期刊
High altitude medicine & biology
High altitude medicine & biology 医学-公共卫生、环境卫生与职业卫生
CiteScore
3.80
自引率
9.50%
发文量
44
审稿时长
>12 weeks
期刊介绍: High Altitude Medicine & Biology is the only peer-reviewed journal covering the medical and biological issues that impact human life at high altitudes. The Journal delivers critical findings on the impact of high altitude on lung and heart disease, appetite and weight loss, pulmonary and cerebral edema, hypertension, dehydration, infertility, and other diseases. It covers the full spectrum of high altitude life sciences from pathology to human and animal ecology.
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