High altitude medicine & biology最新文献

Effect of Altitude on Polycythemia Vera: Is it Necessary to Change Limits? 海拔对真性红细胞增多症的影响：是否有必要改变限制？

IF 1.6 4区医学

High altitude medicine & biology Pub Date : 2025-05-09 DOI: 10.1089/ham.2025.0001

Istemi Serin, Ahmet Unal, Arzu Dobral, Fatma Elif Eroglu, Erdem Ayik, Jale Oz Unal, Mehmet Barış Cengiz, Okan Kati, Toros Taskin, Vural Bastug, Abdulkadir Karismaz

{"title":"Effect of Altitude on Polycythemia Vera: Is it Necessary to Change Limits?","authors":"Istemi Serin, Ahmet Unal, Arzu Dobral, Fatma Elif Eroglu, Erdem Ayik, Jale Oz Unal, Mehmet Barış Cengiz, Okan Kati, Toros Taskin, Vural Bastug, Abdulkadir Karismaz","doi":"10.1089/ham.2025.0001","DOIUrl":"https://doi.org/10.1089/ham.2025.0001","url":null,"abstract":"Serin, Istemi, Ahmet Unal, Arzu Dobral, Fatma Elif Eroglu, Erdem Ayik, Jale Oz Unal, Mehmet Barış Cengiz, Okan Kati, Toros Taskin, Vural Bastug, and Abdulkadir Karismaz. The effect of altitude on polycythemia vera: Is it necessary to change limits? High Alt Med Biol. 00:00-00, 2025. Background: Polycythemia vera (PV) is a myeloproliferative disease characterized by high hemoglobin/hematocrit levels accompanied by JAK2 mutations. In this study, we aimed to establish a new hemoglobin cut-off value for the diagnosis and further evaluation of PV, taking into account the altitude of the regions where patients reside. In addition, we sought to examine the impact of altitude on patients diagnosed with PV and secondary polycythemia (SP) within our case series. Methods: Patients living in Istanbul and Agri who were evaluated for PV at the hematology outpatient clinic of Istanbul and Agri Training and Research Hospitals between January 20, 2023, and January 20, 2024, were included in the study. The average altitude of the center of Agri is 1,630 m, while the center of Istanbul is 30 m. Results: The mean altitude of residence for individuals diagnosed with PV was 326 ± 259 m, whereas it was significantly higher at 1,065 ± 675 m in the SP subgroup (p < 0.001). However, in subgroup analyses of patients with PV and SP, altitude was not a significant factor influencing hemoglobin levels. Conclusions: Our study results did not support the use of different hemoglobin cut-off values or correction factors for further evaluation of PV in patients living at different altitudes. Our results might not be applicable to altitudes higher than those we examined.","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

V̇O₂max, an Important Determinant of Success when Climbing High Mountains. 最大耗氧量：攀登高山成功与否的重要决定因素

IF 1.6 4区医学

High altitude medicine & biology Pub Date : 2025-05-07 DOI: 10.1089/ham.2025.0015

Martin Burtscher

引用次数: 0

Chronic Mountain Sickness: A Comprehensive Review of Current Management and Proposals for Novel Therapies. 慢性高原病：当前管理的综合综述和新疗法的建议。

IF 1.6 4区医学

High altitude medicine & biology Pub Date : 2025-05-07 DOI: 10.1089/ham.2024.0127

Edmund Adams, Tamlyn Peel

{"title":"Chronic Mountain Sickness: A Comprehensive Review of Current Management and Proposals for Novel Therapies.","authors":"Edmund Adams, Tamlyn Peel","doi":"10.1089/ham.2024.0127","DOIUrl":"https://doi.org/10.1089/ham.2024.0127","url":null,"abstract":"Chronic mountain sickness (CMS) is an acquired condition affecting 5%-10% of high-altitude residents. Lifelong exposure to chronic hypoxia triggers excessive erythrocytosis, resulting in an expanded hematocrit. Patients present with symptoms such as dyspnea, fatigue, and palpitations. Complications such as pulmonary hypertension and heart failure are often fatal. Relocation to sea level remains the only definitive management of CMS but poses an unacceptable personal burden. Long-term oxygen therapy provides symptomatic relief, but dependency issues remain a concern. Phlebotomy reduces hematocrit and offers short-term symptom relief. However, side effects and cultural conflicts continue to pose challenges. Acetazolamide, enalapril, and medroxyprogesterone have lowered hematocrit and alleviated symptoms in human trials. Further research into systemic side effects, application in women, and long-term use is required. Methylxanthines, adrenergic blockers, almitrine, and dopamine antagonists showed promise in murine and/or short-term human trials, highlighting the need for further long-term human trials. Inhibition of hypoxia-inducible factor and Janus Kinase-signal transducer and activator of transcription pathways is currently used to suppress hematocrit in polycythemia vera, demonstrating potential application in CMS. Topiramate may stimulate ventilation via acid-base modulation, thus providing therapeutic value. Similarly, the effect of aspirin and caffeine on ventilation may provide a low-cost, accessible intervention.","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter: Javier Botella de Maglia (1956-2024): In Memoriam. 信件:Javier Botella de针织(1956-2024):纪念。

IF 1.6 4区医学

High altitude medicine & biology Pub Date : 2025-04-17 DOI: 10.1089/ham.2025.0012

Eduardo Garrido, Conxita Leal, Hisao Onaga, Teresa Pagès, Antoni Ricart, Antoni Veres, Ginés Viscor, Ken Zafren

引用次数: 0

The Course of Ductus Arteriosus from the Neonatal Period to Childhood in a Moderate Altitude Region. 中等海拔地区新生儿期至儿童期动脉导管的运动轨迹。

IF 1.6 4区医学

High altitude medicine & biology Pub Date : 2025-03-27 DOI: 10.1089/ham.2024.0132

Serdar Epçaçan, Emrah Şişli, Yasemin Nuran Dönmez, Şeyma Memur

{"title":"The Course of Ductus Arteriosus from the Neonatal Period to Childhood in a Moderate Altitude Region.","authors":"Serdar Epçaçan, Emrah Şişli, Yasemin Nuran Dönmez, Şeyma Memur","doi":"10.1089/ham.2024.0132","DOIUrl":"https://doi.org/10.1089/ham.2024.0132","url":null,"abstract":"Epçaçan, Serdar, Emrah Şişli, Yasemin Nuran Dönmez, and Şeyma Memur. The course of ductus arteriosus from the neonatal period to childhood in a moderate altitude region. High Alt Med Biol. 00:00-00, 2025. Aim: The aim of the study is to evaluate the course of patent ductus arteriosus (PDA) in a moderate altitude region. Study Design: This is a retrospectively designed cross-sectional study analyzing the neonates diagnosed with PDA. Methods: Demographic and clinical data and echocardiographic, interventional, and surgical files of the subjects and follow-up findings were analyzed. Results: Overall, the mean gestational age and weight at delivery for all 711 patients were 35.7 ± 3.1 weeks (24-44 weeks) and 2712 ± 762 g (570-4,900 g). In total, 330 patients were premature. Medical closure was applied in 95/597 patients and was successful in 40 of 95 patients. The spontaneous closure rate within 2.3 ± 2.8 months (4 days-2.1 years) was 616/711 (86.6%). Overall, only 8 patients necessitated surgical PDA closure and 38 patients for transcatheter closure. Gestational age and delivery weight had a considerable influence on spontaneous closure. The duration of spontaneous PDA closure was negatively correlated with the gestational age and gestational weight. The duration of spontaneous PDA closure was higher in patients with prematurity and hypothyroidism. Conclusions: The spontaneous closure of the duct may be prolonged in moderate and high-altitude areas. Transcatheter or surgical interventions are rarely needed in the early neonatal period.","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenothiazine Confers Neuroprotection via Dpp2/7 in High Altitude Traumatic Brain Injury Mouse Model. 吩噻嗪通过Dpp2/7对高原创伤性脑损伤小鼠模型的神经保护作用

IF 1.6 4区医学

High altitude medicine & biology Pub Date : 2025-03-26 DOI: 10.1089/ham.2024.0096

Wenxin Zhang, Yuting Yang, Jing Guo, Fei Hu, Yuan Ma, Qing Ouyang

{"title":"Phenothiazine Confers Neuroprotection via Dpp2/7 in High Altitude Traumatic Brain Injury Mouse Model.","authors":"Wenxin Zhang, Yuting Yang, Jing Guo, Fei Hu, Yuan Ma, Qing Ouyang","doi":"10.1089/ham.2024.0096","DOIUrl":"https://doi.org/10.1089/ham.2024.0096","url":null,"abstract":"Zhang, Wenxin, Yuting Yang, Jing Guo, Fei Hu, Yuan Ma, and Qing Ouyang. Phenothiazine confers neuroprotection via Dpp2/7 in high altitude traumatic brain injury mouse model. High Alt Med Biol. 00:00-00, 2025. Background: Traumatic brain injury (TBI) in high altitude areas can lead to more severe cerebral edema, higher disability, and mortality than in low altitude areas. This study was designed to evaluate the neuroprotective effects and underlying mechanisms of phenothiazine on TBI at high altitudes. Methods: Mice were kept in a hypobaric chamber for 7 days under simulated conditions of 5,000 m above sea level. A controlled cortical impact (CCI) model was established and followed by phenothiazine (chlorpromazine and promethazine) and Dpp2/7 inhibitor UAMC00039 treatment. Hematoxylin-eosin (HE) staining, immunohistochemistry (IHC), western blot, label-free quantitative proteomics, and real-time quantitative polymerase chain reaction (RT-qPCR) assays were performed to assess the effects of phenothiazine and UAMC00039 on TBI. Results: HE staining confirmed that phenothiazine treatment could ameliorate CCI-induced brain injury. IHC, western blot, and RT-qPCR showed that cell apoptosis was alleviated by phenothiazine after high altitude TBI, as proved by the reduction of cleaved-Caspase-3 and increased Bcl-2 expression. Label-free quantitative proteomics, IHC, and western blot showed that phenothiazine significantly upregulated Dpp2/7 after high altitude TBI. Western blot and IHC showed that UAMC00039 treatment significantly reversed phenothiazine-mediated Bcl-2 upregulation and cleaved-Caspase-3 downregulation after high altitude TBI. Conclusions: The results indicated that phenothiazine offers neuroprotective effects via antiapoptosis after high altitude TBI, and this protective mechanism is associated with Dpp2/7-mediated Bcl-2 expression and Caspase-3 cleaving.","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Associations with the Susceptibility to High-Altitude Pulmonary Edema in the Japanese Population. 日本人群高原肺水肿易感性的遗传关联

IF 1.6 4区医学

High altitude medicine & biology Pub Date : 2025-03-17 DOI: 10.1089/ham.2024.0119

Yunden Droma, Masao Ota, Nobumitsu Kobayashi, Michiko Ito, Toshio Kobayashi, Masayuki Hanaoka

{"title":"Genetic Associations with the Susceptibility to High-Altitude Pulmonary Edema in the Japanese Population.","authors":"Yunden Droma, Masao Ota, Nobumitsu Kobayashi, Michiko Ito, Toshio Kobayashi, Masayuki Hanaoka","doi":"10.1089/ham.2024.0119","DOIUrl":"https://doi.org/10.1089/ham.2024.0119","url":null,"abstract":"Yunden Droma, Masao Ota, Nobumitsu Kobayashi, Michiko Ito, Toshio Kobayashi, and Masayuki Hanaoka. Genetic Associations with the Susceptibility to High-Altitude Pulmonary Edema in the Japanese Population. High Alt Med Biol. 00:00-00, 2025.-High-altitude pulmonary edema (HAPE) is a life-threatening, noncardiogenic pulmonary condition that may occur in individuals rapidly ascending to altitudes higher than 2,500 m above sea level. Exaggerated hypoxia-induced pulmonary hypertension plays a critical role in its pathophysiological mechanism. In addition to environmental factors such as hypoxia and hypobaria at high altitudes, individual genetic predisposition significantly influences HAPE occurrence. Several candidate genes have been proposed based on the pathophysiology of HAPE, particularly involving the hypoxia-induced factor pathway and vasodilators/vasoconstrictors. Over the past two decades, we have investigated the associations between susceptibility to HAPE and these candidate genes, including genes EPAS1 (endothelial Per-ARNT-Sim [PAS] domain protein 1), EGLN1 (egl-9 family hypoxia inducible factor 1), eNOS (endothelial nitric oxide synthase), ACE (angiotensin-converting enzyme), and TIMP3 (tissue inhibitor of metalloproteinase 3) in the Japanese population. This review summarizes the major findings of these studies, shedding light on genetic associations with HAPE in the Japanese population.","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altitude Adversities: Is It Safe for People with Cardiovascular Disease to Travel to Moderate-High Altitude? 高海拔地区的不利条件：心血管疾病患者去中高海拔地区旅行安全吗？

IF 1.6 4区医学

High altitude medicine & biology Pub Date : 2025-03-06 DOI: 10.1089/ham.2024.0097

Natalie Van Ochten, Eric W Rudofker, William K Cornwell

引用次数: 0

High-Altitude Retinopathy Presenting as Blue Spots with Prolonged Recovery: A Case Report. 高原视网膜病变表现为蓝斑，恢复时间长1例。

IF 1.6 4区医学

High altitude medicine & biology Pub Date : 2025-03-01 Epub Date: 2025-02-06 DOI: 10.1089/ham.2024.0139

Ben Smith, Nicola Wetherill, Daniel S Morris

引用次数: 0

It Is High Time: Rationale for Inclusion of Quantitative Markers for Acute Mountain Sickness Screening. 是时候了将定量标记纳入急性登山病筛查的理由。