The Effect of High-Altitude Hypoxia on Neuropsychiatric Functions.

IF 1.6 4区 医学 Q4 BIOPHYSICS
High altitude medicine & biology Pub Date : 2024-03-01 Epub Date: 2023-10-10 DOI:10.1089/ham.2022.0136
Bo Liu, Minlan Yuan, Mei Yang, Hongru Zhu, Wei Zhang
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引用次数: 0

Abstract

Liu, Bo, Minlan Yuan, Mei Yang, Hongru Zhu, and Wei Zhang. The effect of high-altitude hypoxia on neuropsychiatric functions. High Alt Med Biol. 25:26-41, 2024. Background: In recent years, there has been a growing popularity in engaging in activities at high altitudes, such as hiking and work. However, these high-altitude environments pose risks of hypoxia, which can lead to various acute or chronic cerebral diseases. These conditions include common neurological diseases such as acute mountain sickness (AMS), high-altitude cerebral edema, and altitude-related cerebrovascular diseases, as well as psychiatric disorders such as anxiety, depression, and psychosis. However, reviews of altitude-related neuropsychiatric conditions and their potential mechanisms are rare. Methods: We conducted searches on PubMed and Google Scholar, exploring existing literature encompassing preclinical and clinical studies. Our aim was to summarize the prevalent neuropsychiatric diseases induced by altitude hypoxia, the potential pathophysiological mechanisms, as well as the available pharmacological and nonpharmacological strategies for prevention and intervention. Results: The development of altitude-related cerebral diseases may arise from various pathogenic processes, including neurovascular alterations associated with hypoxia, cytotoxic responses, activation of reactive oxygen species, and dysregulation of the expression of hypoxia inducible factor-1 and nuclear factor erythroid 2-related factor 2. Furthermore, the interplay between hypoxia-induced neurological and psychiatric changes is believed to play a role in the progression of brain damage. Conclusions: While there is some evidence pointing to pathophysiological changes in hypoxia-induced brain damage, the precise mechanisms responsible for neuropsychiatric alterations remain elusive. Currently, the range of prevention and intervention strategies available is primarily focused on addressing AMS, with a preference for prevention rather than treatment.

高原低氧对神经精神功能的影响。
刘、Bo、袁敏兰、杨梅、朱鸿儒、张伟。高海拔缺氧对神经精神功能的影响。High Alt-Med Biol 00:000-0002023。背景:近年来,从事高海拔活动越来越受欢迎,如徒步旅行和工作。然而,这些高海拔环境会带来缺氧的风险,从而导致各种急性或慢性脑疾病。这些疾病包括常见的神经系统疾病,如急性山地病(AMS)、高原脑水肿和高原相关的脑血管疾病,以及焦虑、抑郁和精神病等精神疾病。然而,对海拔高度相关的神经精神状况及其潜在机制的综述很少。方法:我们在PubMed和Google Scholar上进行搜索,探索包括临床前和临床研究在内的现有文献。我们的目的是总结高原缺氧诱导的常见神经精神疾病、潜在的病理生理机制,以及可用于预防和干预的药理学和非药理学策略。结果:高原相关脑疾病的发展可能由各种致病过程引起,包括与缺氧相关的神经血管改变、细胞毒性反应、活性氧的激活以及缺氧诱导因子-1和核因子红系2相关因子2的表达失调。此外,缺氧诱导的神经和精神变化之间的相互作用被认为在脑损伤的进展中发挥了作用。结论:虽然有一些证据表明缺氧诱导的脑损伤发生了病理生理变化,但导致神经精神改变的确切机制仍然难以捉摸。目前,可用的一系列预防和干预策略主要集中在解决AMS问题上,倾向于预防而非治疗。
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来源期刊
High altitude medicine & biology
High altitude medicine & biology 医学-公共卫生、环境卫生与职业卫生
CiteScore
3.80
自引率
9.50%
发文量
44
审稿时长
>12 weeks
期刊介绍: High Altitude Medicine & Biology is the only peer-reviewed journal covering the medical and biological issues that impact human life at high altitudes. The Journal delivers critical findings on the impact of high altitude on lung and heart disease, appetite and weight loss, pulmonary and cerebral edema, hypertension, dehydration, infertility, and other diseases. It covers the full spectrum of high altitude life sciences from pathology to human and animal ecology.
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