Blood Glucose During High Altitude Trekking in Young Healthy Adults.

IF 1.6 4区 医学 Q4 BIOPHYSICS
Ly-Anh Reid, Jordan L Rees, Miranda Kimber, Marina James, Graeme M Purdy, Megan Smorschok, Lauren E Maier, Normand G Boulé, Trevor A Day, Margie H Davenport, Craig D Steinback
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Abstract

Reid, Ly-Anh, Jordan L Rees, Miranda Kimber, Marina James, Graeme M Purdy, Megan Smorschok, Lauren E Maier, Normand G. Boulé, Trevor A. Day, Margie H. Davenport, and Craig D. Steinback. Blood glucose during high altitude trekking in young healthy adults. High Alt Med Biol. 00:00-00, 2024. Introduction: High altitude trekking is becoming more popular and accessible to an increased number of people. Simultaneously, there is a worldwide rise in the prevalence of metabolic diseases. The purpose of this study was to examine the impact of a gradual trekking ascent to high altitude on continuous glucose monitoring outcomes including fasting, mean 24-hour, postprandial, and post-75 g modified oral glucose tolerance test. This study also investigated the relationship between physical activity intensity, high altitude, and glucose concentrations. Methods: Individuals (n = 9) from Alberta, Canada participated in a 2-week trek in the Khumbu Valley in Nepal, ascending by foot from 2,860 m to 5,300 m (∼65 km) over 10 days. A standardized 75 g oral glucose load was given to participants at four different altitudes (1,130 m, 3,440 m, 3,820 m, 5,160 m). Physical activity (Actigraph accelerometry) and interstitial glucose (iPro2, Medtronic) were measured continuously during the trek. Results: Fasting and mean 24-hour glucose concentrations were not different between altitudes. However, 2-hour post dinner glucose and 2-hour post lunch glucose, AUC concentrations were different between altitudes. The relationship between physical activity intensity and glucose was not influenced by increasing altitudes. Conclusion: Our findings suggest that glucose regulation is largely preserved at high altitude; however, inconsistency in our postprandial glucose concentrations at altitude warrants further investigation.

健康年轻人高海拔徒步旅行期间的血糖。
里德-里安、乔丹-里斯、米兰达-金伯、玛丽娜-詹姆斯、格雷姆-M-珀迪、梅根-斯莫斯乔克、劳伦-E-迈尔、诺曼-G-布勒、特雷弗-A-戴、玛吉-H-达文波特和克雷格-D-斯坦贝克。年轻健康成年人高海拔徒步旅行期间的血糖。00:00-00, 2024.简介:高海拔徒步旅行越来越受欢迎,越来越多的人可以参加。与此同时,全球代谢性疾病的发病率也在上升。本研究旨在探讨逐步徒步攀登高海拔地区对连续血糖监测结果的影响,包括空腹、24 小时平均血糖、餐后血糖和 75 克改良口服葡萄糖耐量试验后血糖。本研究还调查了体力活动强度、高海拔和葡萄糖浓度之间的关系。研究方法来自加拿大阿尔伯塔省的人(n = 9)参加了在尼泊尔昆布山谷进行的为期两周的徒步旅行,在 10 天内徒步从海拔 2,860 米上升到 5,300 米(65 公里)。参与者在四个不同的海拔高度(1130 米、3440 米、3820 米和 5160 米)接受了 75 克标准口服葡萄糖负荷。在徒步过程中,对参与者的体力活动(Actigraph 加速计)和血糖间质(iPro2,美敦力公司)进行了连续测量。测量结果不同海拔地区的空腹血糖和 24 小时平均血糖浓度没有差异。然而,晚餐后 2 小时血糖和午餐后 2 小时血糖的 AUC 浓度在不同海拔高度之间存在差异。体力活动强度与血糖之间的关系不受海拔升高的影响。结论我们的研究结果表明,高海拔地区的血糖调节功能基本保持不变;但是,高海拔地区餐后血糖浓度的不一致性值得进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
High altitude medicine & biology
High altitude medicine & biology 医学-公共卫生、环境卫生与职业卫生
CiteScore
3.80
自引率
9.50%
发文量
44
审稿时长
>12 weeks
期刊介绍: High Altitude Medicine & Biology is the only peer-reviewed journal covering the medical and biological issues that impact human life at high altitudes. The Journal delivers critical findings on the impact of high altitude on lung and heart disease, appetite and weight loss, pulmonary and cerebral edema, hypertension, dehydration, infertility, and other diseases. It covers the full spectrum of high altitude life sciences from pathology to human and animal ecology.
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